Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP1A2 (cytochrome P450 family 1 subfamily A member 2)

Identity

Alias_namescytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
cytochrome P450, family 1, subfamily A, polypeptide 2
Alias_symbol (synonym)P3-450
CP12
Other aliasP450(PA)
HGNC (Hugo) CYP1A2
LocusID (NCBI) 1544
Atlas_Id 40236
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74748843 and ends at 74756600 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYP1A2 (15q24.1) / SPG21 (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)CYP1A2   2596
Cards
Entrez_Gene (NCBI)CYP1A2  1544  cytochrome P450 family 1 subfamily A member 2
AliasesCP12; P3-450; P450(PA)
GeneCards (Weizmann)CYP1A2
Ensembl hg19 (Hinxton)ENSG00000140505 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140505 [Gene_View]  chr15:74748843-74756600 [Contig_View]  CYP1A2 [Vega]
ICGC DataPortalENSG00000140505
TCGA cBioPortalCYP1A2
AceView (NCBI)CYP1A2
Genatlas (Paris)CYP1A2
WikiGenes1544
SOURCE (Princeton)CYP1A2
Genetics Home Reference (NIH)CYP1A2
Genomic and cartography
GoldenPath hg38 (UCSC)CYP1A2  -     chr15:74748843-74756600 +  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP1A2  -     15q24.1   [Description]    (hg19-Feb_2009)
EnsemblCYP1A2 - 15q24.1 [CytoView hg19]  CYP1A2 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBICYP1A2 [Mapview hg19]  CYP1A2 [Mapview hg38]
OMIM124060   
Gene and transcription
Genbank (Entrez)AF182274 BC067424 BC067425 BC067426 BC067427
RefSeq transcript (Entrez)NM_000761
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP1A2
Cluster EST : UnigeneHs.1361 [ NCBI ]
CGAP (NCI)Hs.1361
Alternative Splicing GalleryENSG00000140505
Gene ExpressionCYP1A2 [ NCBI-GEO ]   CYP1A2 [ EBI - ARRAY_EXPRESS ]   CYP1A2 [ SEEK ]   CYP1A2 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP1A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1544
GTEX Portal (Tissue expression)CYP1A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05177   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05177  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05177
Splice isoforms : SwissVarP05177
PhosPhoSitePlusP05177
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP1   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP1A2
DMDM Disease mutations1544
Blocks (Seattle)CYP1A2
PDB (SRS)2HI4   
PDB (PDBSum)2HI4   
PDB (IMB)2HI4   
PDB (RSDB)2HI4   
Structural Biology KnowledgeBase2HI4   
SCOP (Structural Classification of Proteins)2HI4   
CATH (Classification of proteins structures)2HI4   
SuperfamilyP05177
Human Protein AtlasENSG00000140505
Peptide AtlasP05177
HPRD00489
IPIIPI00719591   IPI00307246   
Protein Interaction databases
DIP (DOE-UCLA)P05177
IntAct (EBI)P05177
FunCoupENSG00000140505
BioGRIDCYP1A2
STRING (EMBL)CYP1A2
ZODIACCYP1A2
Ontologies - Pathways
QuickGOP05177
Ontology : AmiGOmonooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  steroid catabolic process  porphyrin-containing compound metabolic process  xenobiotic metabolic process  electron carrier activity  toxin biosynthetic process  post-embryonic development  alkaloid metabolic process  regulation of gene expression  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  dibenzo-p-dioxin metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  lung development  organelle membrane  methylation  response to estradiol  demethylase activity  response to lipopolysaccharide  monocarboxylic acid metabolic process  caffeine oxidase activity  response to immobilization stress  drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  cellular respiration  heterocycle metabolic process  hydrogen peroxide biosynthetic process  oxidation-reduction process  aromatase activity  oxidative demethylation  cellular response to cadmium ion  cellular response to copper ion  oxidative deethylation  omega-hydroxylase P450 pathway  
Ontology : EGO-EBImonooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  steroid catabolic process  porphyrin-containing compound metabolic process  xenobiotic metabolic process  electron carrier activity  toxin biosynthetic process  post-embryonic development  alkaloid metabolic process  regulation of gene expression  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  dibenzo-p-dioxin metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  lung development  organelle membrane  methylation  response to estradiol  demethylase activity  response to lipopolysaccharide  monocarboxylic acid metabolic process  caffeine oxidase activity  response to immobilization stress  drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  cellular respiration  heterocycle metabolic process  hydrogen peroxide biosynthetic process  oxidation-reduction process  aromatase activity  oxidative demethylation  cellular response to cadmium ion  cellular response to copper ion  oxidative deethylation  omega-hydroxylase P450 pathway  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]    Mechanism of Acetaminophen Activity and Toxicity [Genes]   
Pathways : KEGG   
NDEx NetworkCYP1A2
Atlas of Cancer Signalling NetworkCYP1A2
Wikipedia pathwaysCYP1A2
Orthology - Evolution
OrthoDB1544
GeneTree (enSembl)ENSG00000140505
Phylogenetic Trees/Animal Genes : TreeFamCYP1A2
HOVERGENP05177
HOGENOMP05177
Homologs : HomoloGeneCYP1A2
Homology/Alignments : Family Browser (UCSC)CYP1A2
Gene fusions - Rearrangements
Fusion : MitelmanCYP1A2/SPG21 [15q24.1/15q22.31]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP1A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP1A2
dbVarCYP1A2
ClinVarCYP1A2
1000_GenomesCYP1A2 
Exome Variant ServerCYP1A2
ExAC (Exome Aggregation Consortium)CYP1A2 (select the gene name)
Genetic variants : HAPMAP1544
Genomic Variants (DGV)CYP1A2 [DGVbeta]
DECIPHERCYP1A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP1A2 
Mutations
ICGC Data PortalCYP1A2 
TCGA Data PortalCYP1A2 
Broad Tumor PortalCYP1A2
OASIS PortalCYP1A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP1A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP1A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP1A2
DgiDB (Drug Gene Interaction Database)CYP1A2
DoCM (Curated mutations)CYP1A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP1A2 (select a term)
intoGenCYP1A2
Cancer3DCYP1A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124060   
Orphanet20573   
MedgenCYP1A2
Genetic Testing Registry CYP1A2
NextProtP05177 [Medical]
TSGene1544
GENETestsCYP1A2
Target ValidationCYP1A2
Huge Navigator CYP1A2 [HugePedia]
snp3D : Map Gene to Disease1544
BioCentury BCIQCYP1A2
ClinGenCYP1A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1544
Chemical/Pharm GKB GenePA27093
Clinical trialCYP1A2
Miscellaneous
canSAR (ICR)CYP1A2 (select the gene name)
Probes
Litterature
PubMed429 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP1A2
EVEXCYP1A2
GoPubMedCYP1A2
iHOPCYP1A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:20 CEST 2017

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