Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1)

Identity

Other namesCP1B
CYPIB1
GLC3A
P4501B1
HGNC (Hugo) CYP1B1
LocusID (NCBI) 1545
Location 2p22.2
Location_base_pair Starts at 38294746 and ends at 38303323 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP1B1   2597
Cards
Entrez_Gene (NCBI)CYP1B1  1545  cytochrome P450, family 1, subfamily B, polypeptide 1
GeneCards (Weizmann)CYP1B1
Ensembl (Hinxton)ENSG00000138061 [Gene_View]  chr2:38294746-38303323 [Contig_View]  CYP1B1 [Vega]
ICGC DataPortalENSG00000138061
cBioPortalCYP1B1
AceView (NCBI)CYP1B1
Genatlas (Paris)CYP1B1
WikiGenes1545
SOURCE (Princeton)NM_000104
Genomic and cartography
GoldenPath (UCSC)CYP1B1  -  2p22.2   chr2:38294746-38303323 -  2p22.2   [Description]    (hg19-Feb_2009)
EnsemblCYP1B1 - 2p22.2 [CytoView]
Mapping of homologs : NCBICYP1B1 [Mapview]
OMIM231300   600975   601771   604229   
Gene and transcription
Genbank (Entrez)AK297039 AK303862 AK312686 BC012049 BP326939
RefSeq transcript (Entrez)NM_000104
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008386 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)CYP1B1
Cluster EST : UnigeneHs.154654 [ NCBI ]
CGAP (NCI)Hs.154654
Alternative Splicing : Fast-db (Paris)GSHG0017558
Alternative Splicing GalleryENSG00000138061
Gene ExpressionCYP1B1 [ NCBI-GEO ]     CYP1B1 [ SEEK ]   CYP1B1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16678 (Uniprot)
NextProtQ16678  [Medical]
With graphics : InterProQ16678
Splice isoforms : SwissVarQ16678 (Swissvar)
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450 [organisation]   Cyt_P450_CS [organisation]   Cyt_P450_E_grp-I [organisation]  
Related proteins : CluSTrQ16678
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1545
Blocks (Seattle)Q16678
PDB (SRS)3PM0   
PDB (PDBSum)3PM0   
PDB (IMB)3PM0   
PDB (RSDB)3PM0   
Human Protein AtlasENSG00000138061 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ16678
HPRD03464
IPIIPI00003451   IPI01009042   IPI01025219   
Protein Interaction databases
DIP (DOE-UCLA)Q16678
IntAct (EBI)Q16678
FunCoupENSG00000138061
BioGRIDCYP1B1
InParanoidQ16678
Interologous Interaction database Q16678
IntegromeDBCYP1B1
STRING (EMBL)CYP1B1
Ontologies - Pathways
Ontology : AmiGOangiogenesis  trabecular meshwork development  monooxygenase activity  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  cellular aromatic compound metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  nitric oxide biosynthetic process  cell adhesion  visual perception  steroid metabolic process  estrogen metabolic process  negative regulation of cell proliferation  intrinsic apoptotic signaling pathway in response to oxidative stress  toxin metabolic process  response to toxic substance  positive regulation vascular endothelial growth factor production  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  arachidonic acid metabolic process  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  heme binding  collagen fibril organization  negative regulation of cell migration  negative regulation of NF-kappaB transcription factor activity  negative regulation of cell adhesion mediated by integrin  retinol metabolic process  retinal metabolic process  positive regulation of apoptotic process  endothelial cell migration  small molecule metabolic process  positive regulation of angiogenesis  positive regulation of JAK-STAT cascade  membrane lipid catabolic process  blood vessel morphogenesis  oxidation-reduction process  retinal blood vessel morphogenesis  cellular response to hydrogen peroxide  aromatase activity  cellular response to organic cyclic compound  endothelial cell-cell adhesion  omega-hydroxylase P450 pathway  positive regulation of gene expression involved in extracellular matrix organization  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIangiogenesis  trabecular meshwork development  monooxygenase activity  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  cellular aromatic compound metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  nitric oxide biosynthetic process  cell adhesion  visual perception  steroid metabolic process  estrogen metabolic process  negative regulation of cell proliferation  intrinsic apoptotic signaling pathway in response to oxidative stress  toxin metabolic process  response to toxic substance  positive regulation vascular endothelial growth factor production  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  arachidonic acid metabolic process  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  heme binding  collagen fibril organization  negative regulation of cell migration  negative regulation of NF-kappaB transcription factor activity  negative regulation of cell adhesion mediated by integrin  retinol metabolic process  retinal metabolic process  positive regulation of apoptotic process  endothelial cell migration  small molecule metabolic process  positive regulation of angiogenesis  positive regulation of JAK-STAT cascade  membrane lipid catabolic process  blood vessel morphogenesis  oxidation-reduction process  retinal blood vessel morphogenesis  cellular response to hydrogen peroxide  aromatase activity  cellular response to organic cyclic compound  endothelial cell-cell adhesion  omega-hydroxylase P450 pathway  positive regulation of gene expression involved in extracellular matrix organization  regulation of reactive oxygen species metabolic process  
Pathways : KEGGSteroid hormone biosynthesis    Tryptophan metabolism    Metabolism of xenobiotics by cytochrome P450    Ovarian steroidogenesis    Chemical carcinogenesis    MicroRNAs in cancer   
Protein Interaction DatabaseCYP1B1
Wikipedia pathwaysCYP1B1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP1B1
snp3D : Map Gene to Disease1545
SNP (GeneSNP Utah)CYP1B1
SNP : HGBaseCYP1B1
Genetic variants : HAPMAPCYP1B1
Exome VariantCYP1B1
1000_GenomesCYP1B1 
ICGC programENSG00000138061 
Somatic Mutations in Cancer : COSMICCYP1B1 
CONAN: Copy Number AnalysisCYP1B1 
Mutations and Diseases : HGMDCYP1B1
Genomic VariantsCYP1B1  CYP1B1 [DGVbeta]
dbVarCYP1B1
ClinVarCYP1B1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM231300    600975    601771    604229   
MedgenCYP1B1
GENETestsCYP1B1
Disease Genetic AssociationCYP1B1
Huge Navigator CYP1B1 [HugePedia]  CYP1B1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCYP1B1
Homology/Alignments : Family Browser (UCSC)CYP1B1
Phylogenetic Trees/Animal Genes : TreeFamCYP1B1
Chemical/Protein Interactions : CTD1545
Chemical/Pharm GKB GenePA27094
Clinical trialCYP1B1
Cancer Resource (Charite)ENSG00000138061
Other databases
Probes
Litterature
PubMed412 Pubmed reference(s) in Entrez
CoreMineCYP1B1
iHOPCYP1B1
OncoSearchCYP1B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:50:32 CEST 2014

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