Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP1B1 (cytochrome P450 family 1 subfamily B member 1)

Identity

Other namesCP1B
CYPIB1
GLC3A
P4501B1
HGNC (Hugo) CYP1B1
LocusID (NCBI) 1545
Atlas_Id 40237
Location 2p22.2
Location_base_pair Starts at 38294746 and ends at 38303323 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CYP1B1 (2p22.2) / CYP1B1 (2p22.2)JTB (1q21.3) / CYP1B1 (2p22.2)JTB 1q21.3 / CYP1B1 2p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP1B1   2597
Cards
Entrez_Gene (NCBI)CYP1B1  1545  cytochrome P450 family 1 subfamily B member 1
GeneCards (Weizmann)CYP1B1
Ensembl hg19 (Hinxton)ENSG00000138061 [Gene_View]  chr2:38294746-38303323 [Contig_View]  CYP1B1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138061 [Gene_View]  chr2:38294746-38303323 [Contig_View]  CYP1B1 [Vega]
ICGC DataPortalENSG00000138061
TCGA cBioPortalCYP1B1
AceView (NCBI)CYP1B1
Genatlas (Paris)CYP1B1
WikiGenes1545
SOURCE (Princeton)CYP1B1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP1B1  -     chr2:38294746-38303323 -  2p22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP1B1  -     2p22.2   [Description]    (hg38-Dec_2013)
EnsemblCYP1B1 - 2p22.2 [CytoView hg19]  CYP1B1 - 2p22.2 [CytoView hg38]
Mapping of homologs : NCBICYP1B1 [Mapview hg19]  CYP1B1 [Mapview hg38]
OMIM231300   600975   601771   604229   
Gene and transcription
Genbank (Entrez)AK297039 AK303862 AK312686 BC012049 BP326939
RefSeq transcript (Entrez)NM_000104
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_008386 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)CYP1B1
Cluster EST : UnigeneHs.154654 [ NCBI ]
CGAP (NCI)Hs.154654
Alternative Splicing : Fast-db (Paris)GSHG0017558
Alternative Splicing GalleryENSG00000138061
Gene ExpressionCYP1B1 [ NCBI-GEO ]   CYP1B1 [ EBI - ARRAY_EXPRESS ]   CYP1B1 [ SEEK ]   CYP1B1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP1B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)1545
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16678 (Uniprot)
NextProtQ16678  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16678
Splice isoforms : SwissVarQ16678 (Swissvar)
PhosPhoSitePlusQ16678
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)CYP1B1    Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1545
Blocks (Seattle)CYP1B1
PDB (SRS)3PM0   
PDB (PDBSum)3PM0   
PDB (IMB)3PM0   
PDB (RSDB)3PM0   
Structural Biology KnowledgeBase3PM0   
SCOP (Structural Classification of Proteins)3PM0   
CATH (Classification of proteins structures)3PM0   
SuperfamilyQ16678
Human Protein AtlasENSG00000138061
Peptide AtlasQ16678
HPRD03464
IPIIPI00003451   IPI01009042   IPI01025219   
Protein Interaction databases
DIP (DOE-UCLA)Q16678
IntAct (EBI)Q16678
FunCoupENSG00000138061
BioGRIDCYP1B1
STRING (EMBL)CYP1B1
ZODIACCYP1B1
Ontologies - Pathways
QuickGOQ16678
Ontology : AmiGOangiogenesis  trabecular meshwork development  monooxygenase activity  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  cellular aromatic compound metabolic process  xenobiotic metabolic process  nitric oxide biosynthetic process  cell adhesion  visual perception  steroid metabolic process  estrogen metabolic process  negative regulation of cell proliferation  intrinsic apoptotic signaling pathway in response to oxidative stress  toxin metabolic process  response to toxic substance  positive regulation of vascular endothelial growth factor production  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  heme binding  collagen fibril organization  negative regulation of cell migration  negative regulation of NF-kappaB transcription factor activity  negative regulation of cell adhesion mediated by integrin  retinol metabolic process  retinal metabolic process  positive regulation of apoptotic process  intracellular membrane-bounded organelle  endothelial cell migration  positive regulation of angiogenesis  positive regulation of JAK-STAT cascade  membrane lipid catabolic process  blood vessel morphogenesis  oxidation-reduction process  retinal blood vessel morphogenesis  cellular response to hydrogen peroxide  aromatase activity  cellular response to organic cyclic compound  endothelial cell-cell adhesion  omega-hydroxylase P450 pathway  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIangiogenesis  trabecular meshwork development  monooxygenase activity  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  cellular aromatic compound metabolic process  xenobiotic metabolic process  nitric oxide biosynthetic process  cell adhesion  visual perception  steroid metabolic process  estrogen metabolic process  negative regulation of cell proliferation  intrinsic apoptotic signaling pathway in response to oxidative stress  toxin metabolic process  response to toxic substance  positive regulation of vascular endothelial growth factor production  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  heme binding  collagen fibril organization  negative regulation of cell migration  negative regulation of NF-kappaB transcription factor activity  negative regulation of cell adhesion mediated by integrin  retinol metabolic process  retinal metabolic process  positive regulation of apoptotic process  intracellular membrane-bounded organelle  endothelial cell migration  positive regulation of angiogenesis  positive regulation of JAK-STAT cascade  membrane lipid catabolic process  blood vessel morphogenesis  oxidation-reduction process  retinal blood vessel morphogenesis  cellular response to hydrogen peroxide  aromatase activity  cellular response to organic cyclic compound  endothelial cell-cell adhesion  omega-hydroxylase P450 pathway  regulation of reactive oxygen species metabolic process  
Pathways : KEGGSteroid hormone biosynthesis    Tryptophan metabolism    Metabolism of xenobiotics by cytochrome P450    Ovarian steroidogenesis    Chemical carcinogenesis    MicroRNAs in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkCYP1B1
Wikipedia pathwaysCYP1B1
Orthology - Evolution
OrthoDB1545
GeneTree (enSembl)ENSG00000138061
Phylogenetic Trees/Animal Genes : TreeFamCYP1B1
Homologs : HomoloGeneCYP1B1
Homology/Alignments : Family Browser (UCSC)CYP1B1
Gene fusions - Rearrangements
Fusion: TCGAJTB 1q21.3 CYP1B1 2p22.2 PRAD
Polymorphisms : SNP, variants
NCBI Variation ViewerCYP1B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP1B1
dbVarCYP1B1
ClinVarCYP1B1
1000_GenomesCYP1B1 
Exome Variant ServerCYP1B1
ExAC (Exome Aggregation Consortium)CYP1B1 (select the gene name)
SNP (GeneSNP Utah)CYP1B1
SNP : HGBaseCYP1B1
Genetic variants : HAPMAPCYP1B1
Genomic Variants (DGV)CYP1B1 [DGVbeta]
Mutations
ICGC Data PortalCYP1B1 
TCGA Data PortalCYP1B1 
Broad Tumor PortalCYP1B1
OASIS PortalCYP1B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP1B1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch CYP1B1
DgiDB (Drug Gene Interaction Database)CYP1B1
DoCM (Curated mutations)CYP1B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP1B1 (select a term)
intoGenCYP1B1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:38294746-38303323
CONAN: Copy Number AnalysisCYP1B1 
Mutations and Diseases : HGMDCYP1B1
OMIM231300    600975    601771    604229   
MedgenCYP1B1
Genetic Testing Registry CYP1B1
NextProtQ16678 [Medical]
TSGene1545
GENETestsCYP1B1
Huge Navigator CYP1B1 [HugePedia]  CYP1B1 [HugeCancerGEM]
snp3D : Map Gene to Disease1545
BioCentury BCIQCYP1B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1545
Chemical/Pharm GKB GenePA27094
Clinical trialCYP1B1
Miscellaneous
canSAR (ICR)CYP1B1 (select the gene name)
Probes
Litterature
PubMed462 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP1B1
GoPubMedCYP1B1
iHOPCYP1B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:41:49 CEST 2016

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