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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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CYP24A1 (cytochrome P450, family 24, subfamily A, polypeptide 1)

Identity

Other namesCP24
CYP24
HCAI
P450-CC24
HGNC (Hugo) CYP24A1
LocusID (NCBI) 1591
Location 20q13.2
Location_base_pair Starts at 52769988 and ends at 52790516 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP24A1   2602
Cards
Entrez_Gene (NCBI)CYP24A1  1591  cytochrome P450, family 24, subfamily A, polypeptide 1
GeneCards (Weizmann)CYP24A1
Ensembl hg19 (Hinxton)ENSG00000019186 [Gene_View]  chr20:52769988-52790516 [Contig_View]  CYP24A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000019186 [Gene_View]  chr20:52769988-52790516 [Contig_View]  CYP24A1 [Vega]
ICGC DataPortalENSG00000019186
cBioPortalCYP24A1
AceView (NCBI)CYP24A1
Genatlas (Paris)CYP24A1
WikiGenes1591
SOURCE (Princeton)CYP24A1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP24A1  -     chr20:52769988-52790516 -  20q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP24A1  -     20q13.2   [Description]    (hg38-Dec_2013)
EnsemblCYP24A1 - 20q13.2 [CytoView hg19]  CYP24A1 - 20q13.2 [CytoView hg38]
Mapping of homologs : NCBICYP24A1 [Mapview hg19]  CYP24A1 [Mapview hg38]
OMIM126065   143880   
Gene and transcription
Genbank (Entrez)AI400154 AW022349 AY858838 BC109083 BC109084
RefSeq transcript (Entrez)NM_000782 NM_001128915
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_008334 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)CYP24A1
Cluster EST : UnigeneHs.89663 [ NCBI ]
CGAP (NCI)Hs.89663
Alternative Splicing : Fast-db (Paris)GSHG0019273
Alternative Splicing GalleryENSG00000019186
Gene ExpressionCYP24A1 [ NCBI-GEO ]     CYP24A1 [ SEEK ]   CYP24A1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07973 (Uniprot)
NextProtQ07973  [Medical]
With graphics : InterProQ07973
Splice isoforms : SwissVarQ07973 (Swissvar)
Catalytic activity : Enzyme1.14.13.126 [ Enzyme-Expasy ]   1.14.13.1261.14.13.126 [ IntEnz-EBI ]   1.14.13.126 [ BRENDA ]   1.14.13.126 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Related proteins : CluSTrQ07973
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1591
Blocks (Seattle)Q07973
Human Protein AtlasENSG00000019186
Peptide AtlasQ07973
HPRD00522
IPIIPI00020586   IPI00656023   IPI00796070   
Protein Interaction databases
DIP (DOE-UCLA)Q07973
IntAct (EBI)Q07973
FunCoupENSG00000019186
BioGRIDCYP24A1
IntegromeDBCYP24A1
STRING (EMBL)CYP24A1
Ontologies - Pathways
QuickGOQ07973
Ontology : AmiGOosteoblast differentiation  iron ion binding  mitochondrial inner membrane  vitamin metabolic process  xenobiotic metabolic process  steroid metabolic process  25-hydroxycholecalciferol-24-hydroxylase activity  oxidoreductase activity  heme binding  1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity  response to vitamin D  vitamin D metabolic process  vitamin D catabolic process  small molecule metabolic process  oxidation-reduction process  vitamin D receptor signaling pathway  
Ontology : EGO-EBIosteoblast differentiation  iron ion binding  mitochondrial inner membrane  vitamin metabolic process  xenobiotic metabolic process  steroid metabolic process  25-hydroxycholecalciferol-24-hydroxylase activity  oxidoreductase activity  heme binding  1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity  response to vitamin D  vitamin D metabolic process  vitamin D catabolic process  small molecule metabolic process  oxidation-reduction process  vitamin D receptor signaling pathway  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGSteroid biosynthesis    MicroRNAs in cancer   
Protein Interaction DatabaseCYP24A1
DoCM (Curated mutations)CYP24A1
Wikipedia pathwaysCYP24A1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCYP24A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP24A1
dbVarCYP24A1
ClinVarCYP24A1
1000_GenomesCYP24A1 
Exome Variant ServerCYP24A1
SNP (GeneSNP Utah)CYP24A1
SNP : HGBaseCYP24A1
Genetic variants : HAPMAPCYP24A1
Genomic Variants (DGV)CYP24A1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000019186 
Somatic Mutations in Cancer : COSMICCYP24A1 
CONAN: Copy Number AnalysisCYP24A1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:52769988-52790516
Mutations and Diseases : HGMDCYP24A1
OMIM126065    143880   
MedgenCYP24A1
NextProtQ07973 [Medical]
GENETestsCYP24A1
Disease Genetic AssociationCYP24A1
Huge Navigator CYP24A1 [HugePedia]  CYP24A1 [HugeCancerGEM]
snp3D : Map Gene to Disease1591
DGIdb (Drug Gene Interaction db)CYP24A1
General knowledge
Homologs : HomoloGeneCYP24A1
Homology/Alignments : Family Browser (UCSC)CYP24A1
Phylogenetic Trees/Animal Genes : TreeFamCYP24A1
Chemical/Protein Interactions : CTD1591
Chemical/Pharm GKB GenePA27097
Clinical trialCYP24A1
Cancer Resource (Charite)ENSG00000019186
Other databases
Probes
Litterature
PubMed142 Pubmed reference(s) in Entrez
CoreMineCYP24A1
GoPubMedCYP24A1
iHOPCYP24A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:09:35 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.