Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP26A1 (cytochrome P450 family 26 subfamily A member 1)

Identity

Alias_namescytochrome P450, subfamily XXVIA, polypeptide 1
cytochrome P450, family 26, subfamily A, polypeptide 1
Alias_symbol (synonym)P450RAI
CP26
CYP26
P450RAI1
Other alias
HGNC (Hugo) CYP26A1
LocusID (NCBI) 1592
Atlas_Id 50342
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 93073475 and ends at 93077884 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYP26A1 (10q23.33) / DGCR2 (22q11.21)NRBF2 (10q21.3) / CYP26A1 (10q23.33)NRBF2 10q21.3 / CYP26A1 10q23.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q21;q23) NRBF2/CYP26A1


External links

Nomenclature
HGNC (Hugo)CYP26A1   2603
Cards
Entrez_Gene (NCBI)CYP26A1  1592  cytochrome P450 family 26 subfamily A member 1
AliasesCP26; CYP26; P450RAI; P450RAI1
GeneCards (Weizmann)CYP26A1
Ensembl hg19 (Hinxton)ENSG00000095596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095596 [Gene_View]  ENSG00000095596 [Sequence]  chr10:93073475-93077884 [Contig_View]  CYP26A1 [Vega]
ICGC DataPortalENSG00000095596
TCGA cBioPortalCYP26A1
AceView (NCBI)CYP26A1
Genatlas (Paris)CYP26A1
WikiGenes1592
SOURCE (Princeton)CYP26A1
Genetics Home Reference (NIH)CYP26A1
Genomic and cartography
GoldenPath hg38 (UCSC)CYP26A1  -     chr10:93073475-93077884 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP26A1  -     10q23.33   [Description]    (hg19-Feb_2009)
EnsemblCYP26A1 - 10q23.33 [CytoView hg19]  CYP26A1 - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBICYP26A1 [Mapview hg19]  CYP26A1 [Mapview hg38]
OMIM602239   
Gene and transcription
Genbank (Entrez)AF005418 AK027560 AK075374
RefSeq transcript (Entrez)NM_000783 NM_057157
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP26A1
Cluster EST : UnigeneHs.150595 [ NCBI ]
CGAP (NCI)Hs.150595
Alternative Splicing GalleryENSG00000095596
Gene ExpressionCYP26A1 [ NCBI-GEO ]   CYP26A1 [ EBI - ARRAY_EXPRESS ]   CYP26A1 [ SEEK ]   CYP26A1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP26A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1592
GTEX Portal (Tissue expression)CYP26A1
Human Protein AtlasENSG00000095596-CYP26A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43174   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43174  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43174
Splice isoforms : SwissVarO43174
PhosPhoSitePlusO43174
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-IV    Cyt_P450_sf   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP26A1
DMDM Disease mutations1592
Blocks (Seattle)CYP26A1
SuperfamilyO43174
Human Protein Atlas [tissue]ENSG00000095596-CYP26A1 [tissue]
Peptide AtlasO43174
HPRD03759
IPIIPI00304967   IPI00376949   
Protein Interaction databases
DIP (DOE-UCLA)O43174
IntAct (EBI)O43174
FunCoupENSG00000095596
BioGRIDCYP26A1
STRING (EMBL)CYP26A1
ZODIACCYP26A1
Ontologies - Pathways
QuickGOO43174
Ontology : AmiGOkidney development  retinoic acid binding  iron ion binding  endoplasmic reticulum membrane  vitamin metabolic process  xenobiotic metabolic process  retinoic acid 4-hydroxylase activity  retinoic acid 4-hydroxylase activity  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxygen binding  heme binding  organelle membrane  response to retinoic acid  response to vitamin A  retinoic acid catabolic process  retinoic acid metabolic process  negative regulation of retinoic acid receptor signaling pathway  oxidation-reduction process  
Ontology : EGO-EBIkidney development  retinoic acid binding  iron ion binding  endoplasmic reticulum membrane  vitamin metabolic process  xenobiotic metabolic process  retinoic acid 4-hydroxylase activity  retinoic acid 4-hydroxylase activity  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxygen binding  heme binding  organelle membrane  response to retinoic acid  response to vitamin A  retinoic acid catabolic process  retinoic acid metabolic process  negative regulation of retinoic acid receptor signaling pathway  oxidation-reduction process  
Pathways : KEGGRetinol metabolism   
NDEx NetworkCYP26A1
Atlas of Cancer Signalling NetworkCYP26A1
Wikipedia pathwaysCYP26A1
Orthology - Evolution
OrthoDB1592
GeneTree (enSembl)ENSG00000095596
Phylogenetic Trees/Animal Genes : TreeFamCYP26A1
HOVERGENO43174
HOGENOMO43174
Homologs : HomoloGeneCYP26A1
Homology/Alignments : Family Browser (UCSC)CYP26A1
Gene fusions - Rearrangements
Fusion : MitelmanNRBF2/CYP26A1 [10q21.3/10q23.33]  [t(10;10)(q21;q23)]  
Fusion PortalNRBF2 10q21.3 CYP26A1 10q23.33 BRCA
Fusion : QuiverCYP26A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP26A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP26A1
dbVarCYP26A1
ClinVarCYP26A1
1000_GenomesCYP26A1 
Exome Variant ServerCYP26A1
ExAC (Exome Aggregation Consortium)ENSG00000095596
GNOMAD BrowserENSG00000095596
Varsome BrowserCYP26A1
Genetic variants : HAPMAP1592
Genomic Variants (DGV)CYP26A1 [DGVbeta]
DECIPHERCYP26A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP26A1 
Mutations
ICGC Data PortalCYP26A1 
TCGA Data PortalCYP26A1 
Broad Tumor PortalCYP26A1
OASIS PortalCYP26A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP26A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP26A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP26A1
DgiDB (Drug Gene Interaction Database)CYP26A1
DoCM (Curated mutations)CYP26A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP26A1 (select a term)
intoGenCYP26A1
Cancer3DCYP26A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602239   
Orphanet
DisGeNETCYP26A1
MedgenCYP26A1
Genetic Testing Registry CYP26A1
NextProtO43174 [Medical]
TSGene1592
GENETestsCYP26A1
Target ValidationCYP26A1
Huge Navigator CYP26A1 [HugePedia]
snp3D : Map Gene to Disease1592
BioCentury BCIQCYP26A1
ClinGenCYP26A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1592
Chemical/Pharm GKB GenePA27098
Clinical trialCYP26A1
Miscellaneous
canSAR (ICR)CYP26A1 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP26A1
EVEXCYP26A1
GoPubMedCYP26A1
iHOPCYP26A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:01:16 CET 2018

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