CYP26A1 (cytochrome P450 family 26 subfamily A member 1)

2008-09-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
CP26,CYP26,P450RAI,P450RAI1
FUSION GENES

Other Information

Locus ID:

NCBI: 1592
MIM: 602239
HGNC: 2603
Ensembl: ENSG00000095596

Variants:

dbSNP: 1592
ClinVar: 1592
TCGA: ENSG00000095596
COSMIC: CYP26A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095596ENST00000224356O43174
ENSG00000095596ENST00000371531O43174
ENSG00000095596ENST00000624589A0A096LNN2

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
VitaminsREACTOMER-HSA-211916

References

Pubmed IDYearTitleCitations
195192822009The role of CYP26 enzymes in retinoic acid clearance.70
189927172009Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.54
160534442005Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility.53
220201192012Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.48
240437862013Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling.42
205133612010The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.36
254928132015Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.26
206824642010Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liver.25
219755122011Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma.24
215217702011Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase.21

Citation

Dessen P

CYP26A1 (cytochrome P450 family 26 subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50342/cyp26a1