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CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7)

Identity

Alias_namescytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7
cytochrome P450, family 2, subfamily A, polypeptide 7
Alias_symbol (synonym)CYP2A
Other aliasCPA7
CPAD
CYPIIA7
P450-IIA4
HGNC (Hugo) CYP2A7
LocusID (NCBI) 1549
Atlas_Id 62250
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 41381344 and ends at 41388657 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLPTM1 (19q13.32) / CYP2A7 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP2A7   2611
Cards
Entrez_Gene (NCBI)CYP2A7  1549  cytochrome P450, family 2, subfamily A, polypeptide 7
AliasesCPA7; CPAD; CYP2A; CYPIIA7; 
P450-IIA4
GeneCards (Weizmann)CYP2A7
Ensembl hg19 (Hinxton)ENSG00000198077 [Gene_View]  chr19:41381344-41388657 [Contig_View]  CYP2A7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198077 [Gene_View]  chr19:41381344-41388657 [Contig_View]  CYP2A7 [Vega]
ICGC DataPortalENSG00000198077
TCGA cBioPortalCYP2A7
AceView (NCBI)CYP2A7
Genatlas (Paris)CYP2A7
WikiGenes1549
SOURCE (Princeton)CYP2A7
Genetics Home Reference (NIH)CYP2A7
Genomic and cartography
GoldenPath hg19 (UCSC)CYP2A7  -     chr19:41381344-41388657 -  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP2A7  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblCYP2A7 - 19q13.2 [CytoView hg19]  CYP2A7 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBICYP2A7 [Mapview hg19]  CYP2A7 [Mapview hg38]
OMIM608054   
Gene and transcription
Genbank (Entrez)BC117165 BC143325 M33317 U22029
RefSeq transcript (Entrez)NM_000764 NM_030589
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_007960 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)CYP2A7
Cluster EST : UnigeneHs.719890 [ NCBI ]
CGAP (NCI)Hs.719890
Alternative Splicing GalleryENSG00000198077
Gene ExpressionCYP2A7 [ NCBI-GEO ]   CYP2A7 [ EBI - ARRAY_EXPRESS ]   CYP2A7 [ SEEK ]   CYP2A7 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2A7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1549
GTEX Portal (Tissue expression)CYP2A7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20853   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20853  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20853
Splice isoforms : SwissVarP20853
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
PhosPhoSitePlusP20853
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2A-like   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2A7
DMDM Disease mutations1549
Blocks (Seattle)CYP2A7
SuperfamilyP20853
Human Protein AtlasENSG00000198077
Peptide AtlasP20853
HPRD07453
IPIIPI00302839   IPI00940937   IPI00873572   
Protein Interaction databases
DIP (DOE-UCLA)P20853
IntAct (EBI)P20853
FunCoupENSG00000198077
BioGRIDCYP2A7
STRING (EMBL)CYP2A7
ZODIACCYP2A7
Ontologies - Pathways
QuickGOP20853
Ontology : AmiGOiron ion binding  cytoplasm  endoplasmic reticulum membrane  xenobiotic metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  coumarin metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  epoxygenase P450 pathway  oxygen binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  oxidation-reduction process  aromatase activity  
Ontology : EGO-EBIiron ion binding  cytoplasm  endoplasmic reticulum membrane  xenobiotic metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  coumarin metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  epoxygenase P450 pathway  oxygen binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  oxidation-reduction process  aromatase activity  
NDEx NetworkCYP2A7
Atlas of Cancer Signalling NetworkCYP2A7
Wikipedia pathwaysCYP2A7
Orthology - Evolution
OrthoDB1549
GeneTree (enSembl)ENSG00000198077
Phylogenetic Trees/Animal Genes : TreeFamCYP2A7
HOVERGENP20853
HOGENOMP20853
Homologs : HomoloGeneCYP2A7
Homology/Alignments : Family Browser (UCSC)CYP2A7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2A7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2A7
dbVarCYP2A7
ClinVarCYP2A7
1000_GenomesCYP2A7 
Exome Variant ServerCYP2A7
ExAC (Exome Aggregation Consortium)CYP2A7 (select the gene name)
Genetic variants : HAPMAP1549
Genomic Variants (DGV)CYP2A7 [DGVbeta]
DECIPHER (Syndromes)19:41381344-41388657  ENSG00000198077
CONAN: Copy Number AnalysisCYP2A7 
Mutations
ICGC Data PortalCYP2A7 
TCGA Data PortalCYP2A7 
Broad Tumor PortalCYP2A7
OASIS PortalCYP2A7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2A7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP2A7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP2A7
DgiDB (Drug Gene Interaction Database)CYP2A7
DoCM (Curated mutations)CYP2A7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2A7 (select a term)
intoGenCYP2A7
Cancer3DCYP2A7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608054   
Orphanet
MedgenCYP2A7
Genetic Testing Registry CYP2A7
NextProtP20853 [Medical]
TSGene1549
GENETestsCYP2A7
Huge Navigator CYP2A7 [HugePedia]
snp3D : Map Gene to Disease1549
BioCentury BCIQCYP2A7
ClinGenCYP2A7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1549
Chemical/Pharm GKB GenePA27102
Clinical trialCYP2A7
Miscellaneous
canSAR (ICR)CYP2A7 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2A7
EVEXCYP2A7
GoPubMedCYP2A7
iHOPCYP2A7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:00:52 CET 2017

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