CYP2A7 (cytochrome P450 family 2 subfamily A member 7)

2017-10-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CPA7,CPAD,CYP2A,CYPIIA7,P450-IIA4
FUSION GENES

Other Information

Locus ID:

NCBI: 1549
MIM: 608054
HGNC: 2611
Ensembl: ENSG00000198077

Variants:

dbSNP: 1549
ClinVar: 1549
TCGA: ENSG00000198077
COSMIC: CYP2A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198077ENST00000291764F8W816
ENSG00000198077ENST00000301146P20853
ENSG00000198077ENST00000594332M0R020

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999
Fatty acidsREACTOMER-HSA-211935

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
123250232002Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.15
257109392015CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.13
119609142002CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.12
166366852006CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.7
281454232017Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers.7
297677742019Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.2

Citation

Dessen P

CYP2A7 (cytochrome P450 family 2 subfamily A member 7)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57197/cyp2a7