CYP2B6 (cytochrome P450 family 2 subfamily B member 6)

2003-06-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CPB6,CYP2B,CYP2B7,CYP2B7P,CYPIIB6,EFVM,IIB1,P450

Other Information

Locus ID:

NCBI: 1555
MIM: 123930
HGNC: 2615
Ensembl: ENSG00000197408

Variants:

dbSNP: 1555
ClinVar: 1555
TCGA: ENSG00000197408
COSMIC: CYP2B6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197408ENST00000324071P20813
ENSG00000197408ENST00000593831M0QZJ2
ENSG00000197408ENST00000598834A0A2R8YFA4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Arachidonic acid metabolismKEGGhsa00590
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999
Fatty acidsREACTOMER-HSA-211935

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10804imatinibChemicalClinicalAnnotationassociatedPD24293093
PA1318870083,4-methylenedioxymethamphetamineChemicalClinicalAnnotation, VipGeneassociatedPK17638512, 11470993, 28117133
PA134850491TransplantationDiseaseClinicalAnnotationassociatedPKPD19005482
PA154410481prasugrelChemicalLabelAnnotation, Literature, MultilinkAnnotationassociated21828263
PA164712505Antivirals for treatment of HIV infections, combinationsChemicalClinicalAnnotationassociatedPD22162992
PA164712708Drugs For Treatment Of TuberculosisChemicalClinicalAnnotationassociatedPD22162992
PA164746157mitotaneChemicalClinicalAnnotationassociatedPK23524664
PA164781343vareniclineChemicalMultilinkAnnotation, VariantAnnotationambiguousPD26153084, 31402421
PA164784021ethambutolChemicalClinicalAnnotation, VariantAnnotationassociatedPD28389387
PA164925725Toxic liver diseaseDiseaseClinicalAnnotation, VariantAnnotationassociatedPD21824325, 23774940, 24359841, 28689274
PA165111696artemisininChemicalPathway, VipGeneassociated17638512, 11470993
PA165111698artemetherChemicalClinicalAnnotationassociatedPK
PA165260403arteetherChemicalPathwayassociated
PA165818750CYP2B6*1HaplotypeLabelAnnotationassociated
PA165818757CYP2B6*4HaplotypeVipGeneassociated16272958, 16495778, 17235330, 12642465
PA165818762CYP2B6*6HaplotypeGuidelineAnnotation, LabelAnnotation, VipGeneassociated12629583, 12642465, 14551287, 15194512, 15622315, 15825040, 16272958, 16495778, 16912956, 16912957, 17235330, 17502835, 17918089, 18171905, 18839779, 19474465, 19531981, 11470993
PA165818765CYP2B6*7HaplotypeVipGeneassociated16272958, 16495778, 17235330, 12642465
PA165818780CYP2B6*16HaplotypeVipGeneassociated16272958, 16495778, 17235330, 15469410
PA165818808CYP2B6*18HaplotypeGuidelineAnnotation, VipGeneassociated16272958, 16495778, 17235330, 15469410
PA166048714PregnancyDiseaseVariantAnnotationassociatedPK
PA166114414cotinineChemicalClinicalAnnotationassociatedPK18004205
PA166119041drug-induced liver injuryDiseaseVariantAnnotationassociatedPD28389387
PA166120927drug reaction with eosinophilia and systemic symptomsDiseaseClinicalAnnotationassociatedPD21824325, 23774940, 28689274
PA166123507discontinuationDiseaseVariantAnnotationassociatedPD
PA166124406platelet reactivityDiseaseVariantAnnotationnot associatedPD27380588
PA166153431flibanserinChemicalLabelAnnotationassociated
PA166155393rs2279343VariantVipGeneassociated16272958, 16495778, 17235330, 12642465
PA166155405rs3211371VariantVipGeneassociated12439223, 12814665, 14515060, 14551287, 15083067, 17638512, 11470993
PA166155409rs3745274VariantLabelAnnotation, VipGeneassociated14551287, 15622315, 15825040, 16912956, 16912957, 17918089, 18171905, 18839779, 19474465, 19531981, 11470993
PA166155478rs28399499VariantVipGeneassociated16272958, 16495778, 17235330, 15469410
PA166176033efavirenz / emtricitabine / tenofovir disoproxilChemicalLabelAnnotationassociated
PA166178554(S)-methadoneChemicalVariantAnnotationassociatedPK17178267
PA166182883ospemifeneChemicalLabelAnnotationassociated
PA378NR1I2GenePathwayassociated21738081
PA391NR1I3GenePathwayassociated21738081
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPD18024866, 20179710, 24682508, 29938344
PA443636Carotid Artery DiseasesDiseaseVariantAnnotationnot associatedPD26526111
PA443657Central Nervous System DiseasesDiseaseVariantAnnotationassociatedPD17686225
PA443833CystitisDiseaseClinicalAnnotationassociatedPKPD19005482
PA443842DeathDiseaseVariantAnnotationnot associatedPD
PA443937Drug ToxicityDiseaseVariantAnnotationambiguousPD24128861
PA444059Epidermal Necrolysis, ToxicDiseaseClinicalAnnotationassociatedPD23774940, 28689274
PA444434Hepatic Veno-Occlusive DiseaseDiseaseClinicalAnnotationassociatedPKPD19005482
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPKPD16338275, 17178267, 17329992, 17502774, 21790905, 21902500, 25556837, 27289271, 30907440
PA444807Long QT SyndromeDiseaseVariantAnnotationassociatedPD
PA444819Lupus erythematosusDiseaseClinicalAnnotationassociatedPKPD
PA444845Lymphoma, Non-HodgkinDiseaseVariantAnnotationassociatedPK28181240
PA445019Myocardial InfarctionDiseaseVariantAnnotationnot associatedPD
PA445043Opioid-Related DisordersDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD16338275, 17178267, 17329992, 17502774, 27286724, 27289271
PA445062NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPK
PA445208PainDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD27289271
PA445506RecurrenceDiseaseVariantAnnotationnot associatedPD18024866, 24682508
PA445738Stevens-Johnson SyndromeDiseaseClinicalAnnotationassociatedPD21824325, 23774940, 28689274
PA445876Tobacco Use DisorderDiseaseClinicalAnnotation, VariantAnnotation, VipGeneambiguousPKPD12439223, 17015050, 17223085, 18004205, 26153084, 31402421
PA445941TuberculosisDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD22162992, 24293076, 24477223, 27045425, 28389387
PA446169Leukemia, Lymphocytic, Chronic, B-CellDiseaseClinicalAnnotation, VariantAnnotationambiguousPD24128861
PA446171Leukemia, Myelogenous, Chronic, BCR-ABL PositiveDiseaseClinicalAnnotationassociatedPD24293093
PA446304Lymphoma, B-CellDiseaseClinicalAnnotation, VariantAnnotationassociatedPK26773420
PA446644Adrenocortical CarcinomaDiseaseClinicalAnnotationassociatedPK23524664
PA446975Neurotoxicity SyndromesDiseaseVariantAnnotationambiguousPD23640958
PA447230HIV InfectionsDiseaseClinicalAnnotation, VariantAnnotation, VipGeneambiguousPKPD15194512, 15622315, 15864119, 16267764, 16272958, 16495778, 17235330, 17559344, 17686225, 17918089, 17968817, 19228205, 20017669, 20441246, 20625352, 20860463, 20881953, 20952418, 21505298, 21715435, 21814190, 21821736, 21824325, 21860339, 21862974, 22057858, 22162992, 22354160, 23089673, 23172109, 23399569, 23640958, 23774940, 23778320, 23859571, 23970651, 23996099, 24080498, 24293076, 24316028, 24359841, 24477223, 24517233, 24831655, 24956253, 25303294, 25669165, 26196596, 26774523, 26779253, 27045425, 28622951, 28689274, 28886044, 29624706, 31628422
PA447278DepressionDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD22926595
PA447321Depressive Disorder, MajorDiseaseVariantAnnotationassociatedPK26830411
PA448687bupropionChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD17638512, 11470993, 12439223, 14515060, 15083067, 15722458, 17223085, 26153084, 26580670, 28181240, 29756345
PA448691busulfanChemicalVariantAnnotationassociatedPD24165757
PA448785carbamazepineChemicalPathway, VipGeneassociated17638512, 21738081
PA448926chlorambucilChemicalVariantAnnotationnot associatedPD24128861
PA449053clopidogrelChemicalClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPD17638512, 20938371, 21828263, 21831410, 26526111, 27380588, 28135763
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD17638512, 11470993, 19005482, 20179710, 21821736, 24128861, 26773420, 28181240, 29938344
PA449283diazepamChemicalVipGeneassociated17638512, 11470993
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD20179710, 29938344
PA449441efavirenzChemicalClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD17638512, 11470993, 15194512, 15622315, 15864119, 16267764, 16495778, 17235330, 17559344, 17686225, 17918089, 17968817, 20441246, 20625352, 20860463, 20881953, 20952418, 21715435, 21814190, 21821736, 21862974, 22057858, 23089673, 23172109, 23399569, 23640958, 23778320, 23859571, 23970651, 23990572, 23996099, 24080498, 24293076, 24316028, 24359841, 24477223, 24497997, 24517233, 24729586, 24831655, 24956253, 25303294, 25669165, 26196596, 26604812, 26622191, 26774523, 26779253, 26831894, 26991336, 27045425, 28622951, 28886044, 29624706, 31628422
PA449527ethinyl estradiolChemicalVipGeneassociated17638512
PA449655fludarabineChemicalVariantAnnotationambiguousPD24128861
PA449964ifosfamideChemicalVipGeneassociated17638512, 11470993
PA450112isoniazidChemicalClinicalAnnotation, VariantAnnotationassociatedPD28389387
PA450144ketamineChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneassociatedPK17638512, 11470993, 25702819
PA450163lamivudineChemicalVariantAnnotationassociatedPK23089673
PA450369meperidineChemicalVipGeneassociated17638512, 11470993
PA450373mephenytoinChemicalVipGeneassociated17638512, 11470993
PA450401methadoneChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneassociatedPKPD17638512, 11470993, 16338275, 17178267, 17329992, 17502774, 21790905, 21902500, 23249875, 25556837, 27286724, 27289271, 30907440
PA450496midazolamChemicalVipGeneassociated17638512, 11470993
PA450522mirtazapineChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD22926595
PA450616nevirapineChemicalClinicalAnnotation, Pathway, VariantAnnotation, VipGeneassociatedPKPD17638512, 11470993, 15864119, 16272958, 16495778, 19228205, 20017669, 20625352, 21505298, 21824325, 21860339, 22354160, 23774940, 28689274
PA450626nicotineChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneassociatedPKPD17638512, 11470993, 17015050, 18004205, 25652250
PA450911phenobarbitalChemicalVipGeneassociated17638512
PA450947phenytoinChemicalVipGeneassociated17638512
PA451141propofolChemicalClinicalAnnotation, VariantAnnotation, VipGeneambiguousPKPD17638512, 11470993, 22006347, 26141406, 28154789
PA451182pyrazinamideChemicalClinicalAnnotation, VariantAnnotationassociatedPD28389387
PA451250rifampinChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneassociatedPD17638512, 27053325, 28389387
PA451316selegilineChemicalVipGeneassociated17638512, 11470993
PA451333sertralineChemicalVariantAnnotationassociatedPK26830411
PA451344sibutramineChemicalVariantAnnotationnot associatedPK23381968
PA451494stavudineChemicalVariantAnnotationassociatedPK23089673
PA451581tamoxifenChemicalPathway, VariantAnnotation, VipGeneambiguousPD17638512, 11470993, 18024866, 23962908, 24682508
PA451668thiotepaChemicalVipGeneassociated17638512
PA451686ticlopidineChemicalVipGeneassociated17638512
PA451735tramadolChemicalPathwayassociated24849324
PA451954zidovudineChemicalVariantAnnotationassociatedPK23089673
PA452609aflatoxin b1ChemicalVipGeneassociated17638512, 11470993
PA452621antineoplastic agentsChemicalVariantAnnotationnot associatedPD24682508
PA7000sorafenibChemicalPathwayassociated28362716

References

Pubmed IDYearTitleCitations
191060842009Cytochrome p-450 polymorphisms and response to clopidogrel.391
204188882010Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.368
156223152004Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.175
167726082006Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.155
179002752007Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.133
158641192005Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients.114
158641192005Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients.114
114709932001Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.113
165381762006Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.112
180248662007Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.109

Citation

Dessen P

CYP2B6 (cytochrome P450 family 2 subfamily B member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40241/cyp2b6