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CYP2B6 (cytochrome P450 family 2 subfamily B member 6)

Identity

Alias_namesCYP2B
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
cytochrome P450, family 2, subfamily B
cytochrome P450, subfamily IIB (phenobarbital-inducible)
cytochrome P450, family 2, subfamily B, polypeptide 6
Alias_symbol (synonym)CPB6
CYPIIB6
Other aliasCYP2B7
CYP2B7P
EFVM
IIB1
P450
HGNC (Hugo) CYP2B6
LocusID (NCBI) 1555
Atlas_Id 40241
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 41497204 and ends at 41524301 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP2B6   2615
Cards
Entrez_Gene (NCBI)CYP2B6  1555  cytochrome P450 family 2 subfamily B member 6
AliasesCPB6; CYP2B; CYP2B7; CYP2B7P; 
CYPIIB6; EFVM; IIB1; P450
GeneCards (Weizmann)CYP2B6
Ensembl hg19 (Hinxton)ENSG00000197408 [Gene_View]  chr19:41497204-41524301 [Contig_View]  CYP2B6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197408 [Gene_View]  chr19:41497204-41524301 [Contig_View]  CYP2B6 [Vega]
ICGC DataPortalENSG00000197408
TCGA cBioPortalCYP2B6
AceView (NCBI)CYP2B6
Genatlas (Paris)CYP2B6
WikiGenes1555
SOURCE (Princeton)CYP2B6
Genetics Home Reference (NIH)CYP2B6
Genomic and cartography
GoldenPath hg19 (UCSC)CYP2B6  -     chr19:41497204-41524301 +  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP2B6  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblCYP2B6 - 19q13.2 [CytoView hg19]  CYP2B6 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBICYP2B6 [Mapview hg19]  CYP2B6 [Mapview hg38]
OMIM123930   614546   
Gene and transcription
Genbank (Entrez)AF182277 AK301620 BC067430 BC067431 M29874
RefSeq transcript (Entrez)NM_000767
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_007929 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)CYP2B6
Cluster EST : UnigeneHs.1360 [ NCBI ]
CGAP (NCI)Hs.1360
Alternative Splicing GalleryENSG00000197408
Gene ExpressionCYP2B6 [ NCBI-GEO ]   CYP2B6 [ EBI - ARRAY_EXPRESS ]   CYP2B6 [ SEEK ]   CYP2B6 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2B6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1555
GTEX Portal (Tissue expression)CYP2B6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20813   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20813  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20813
Splice isoforms : SwissVarP20813
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
PhosPhoSitePlusP20813
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2B-like   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2B6
DMDM Disease mutations1555
Blocks (Seattle)CYP2B6
PDB (SRS)3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
PDB (PDBSum)3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
PDB (IMB)3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
PDB (RSDB)3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
Structural Biology KnowledgeBase3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
SCOP (Structural Classification of Proteins)3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
CATH (Classification of proteins structures)3IBD    3QOA    3QU8    3UA5    4I91    4RQL    4RRT   
SuperfamilyP20813
Human Protein AtlasENSG00000197408
Peptide AtlasP20813
HPRD00477
IPIIPI00025829   IPI00909440   IPI00066215   
Protein Interaction databases
DIP (DOE-UCLA)P20813
IntAct (EBI)P20813
FunCoupENSG00000197408
BioGRIDCYP2B6
STRING (EMBL)CYP2B6
ZODIACCYP2B6
Ontologies - Pathways
QuickGOP20813
Ontology : AmiGOmonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  cellular ketone metabolic process  exogenous drug catabolic process  oxidation-reduction process  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  cellular ketone metabolic process  exogenous drug catabolic process  oxidation-reduction process  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGArachidonic acid metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450   
NDEx NetworkCYP2B6
Atlas of Cancer Signalling NetworkCYP2B6
Wikipedia pathwaysCYP2B6
Orthology - Evolution
OrthoDB1555
GeneTree (enSembl)ENSG00000197408
Phylogenetic Trees/Animal Genes : TreeFamCYP2B6
HOVERGENP20813
HOGENOMP20813
Homologs : HomoloGeneCYP2B6
Homology/Alignments : Family Browser (UCSC)CYP2B6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2B6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2B6
dbVarCYP2B6
ClinVarCYP2B6
1000_GenomesCYP2B6 
Exome Variant ServerCYP2B6
ExAC (Exome Aggregation Consortium)CYP2B6 (select the gene name)
Genetic variants : HAPMAP1555
Genomic Variants (DGV)CYP2B6 [DGVbeta]
DECIPHER (Syndromes)19:41497204-41524301  ENSG00000197408
CONAN: Copy Number AnalysisCYP2B6 
Mutations
ICGC Data PortalCYP2B6 
TCGA Data PortalCYP2B6 
Broad Tumor PortalCYP2B6
OASIS PortalCYP2B6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2B6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP2B6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP2B6
DgiDB (Drug Gene Interaction Database)CYP2B6
DoCM (Curated mutations)CYP2B6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2B6 (select a term)
intoGenCYP2B6
Cancer3DCYP2B6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123930    614546   
Orphanet19361   
MedgenCYP2B6
Genetic Testing Registry CYP2B6
NextProtP20813 [Medical]
TSGene1555
GENETestsCYP2B6
Huge Navigator CYP2B6 [HugePedia]
snp3D : Map Gene to Disease1555
BioCentury BCIQCYP2B6
ClinGenCYP2B6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1555
Chemical/Pharm GKB GenePA123
Clinical trialCYP2B6
Miscellaneous
canSAR (ICR)CYP2B6 (select the gene name)
Probes
Litterature
PubMed264 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2B6
EVEXCYP2B6
GoPubMedCYP2B6
iHOPCYP2B6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:30 CET 2017

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