Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYP2C18 (cytochrome P450 family 2 subfamily C member 18)

Identity

Alias_namesCYP2C17
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18
cytochrome P450, family 2, subfamily C, polypeptide 18
Alias_symbol (synonym)P450IIC17
CPCI
CYP2C
Other aliasP450-6B/29C
HGNC (Hugo) CYP2C18
LocusID (NCBI) 1562
Atlas_Id 40242
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 94683494 and ends at 94736191 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KRT14 (17q21.2) / CYP2C18 (10q23.33)KRT14 17q21.2 / CYP2C18 10q23.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;17)(q23;q21) KRT14/CYP2C18

External links

Nomenclature
HGNC (Hugo)CYP2C18   2620
Cards
Entrez_Gene (NCBI)CYP2C18  1562  cytochrome P450 family 2 subfamily C member 18
AliasesCPCI; CYP2C; CYP2C17; P450-6B/29C; 
P450IIC17
GeneCards (Weizmann)CYP2C18
Ensembl hg19 (Hinxton)ENSG00000108242 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108242 [Gene_View]  ENSG00000108242 [Sequence]  chr10:94683494-94736191 [Contig_View]  CYP2C18 [Vega]
ICGC DataPortalENSG00000108242
TCGA cBioPortalCYP2C18
AceView (NCBI)CYP2C18
Genatlas (Paris)CYP2C18
WikiGenes1562
SOURCE (Princeton)CYP2C18
Genetics Home Reference (NIH)CYP2C18
Genomic and cartography
GoldenPath hg38 (UCSC)CYP2C18  -     chr10:94683494-94736191 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP2C18  -     10q23.33   [Description]    (hg19-Feb_2009)
EnsemblCYP2C18 - 10q23.33 [CytoView hg19]  CYP2C18 - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBICYP2C18 [Mapview hg19]  CYP2C18 [Mapview hg38]
OMIM601131   
Gene and transcription
Genbank (Entrez)AK223510 AK308558 AK313403 BC069666 BC096257
RefSeq transcript (Entrez)NM_000772 NM_001128925
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP2C18
Cluster EST : UnigeneHs.511872 [ NCBI ]
CGAP (NCI)Hs.511872
Alternative Splicing GalleryENSG00000108242
Gene ExpressionCYP2C18 [ NCBI-GEO ]   CYP2C18 [ EBI - ARRAY_EXPRESS ]   CYP2C18 [ SEEK ]   CYP2C18 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2C18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1562
GTEX Portal (Tissue expression)CYP2C18
Human Protein AtlasENSG00000108242-CYP2C18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33260   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33260  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33260
Splice isoforms : SwissVarP33260
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
PhosPhoSitePlusP33260
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_sf   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2C18
DMDM Disease mutations1562
Blocks (Seattle)CYP2C18
PDB (SRS)2CIK    2H6P   
PDB (PDBSum)2CIK    2H6P   
PDB (IMB)2CIK    2H6P   
PDB (RSDB)2CIK    2H6P   
Structural Biology KnowledgeBase2CIK    2H6P   
SCOP (Structural Classification of Proteins)2CIK    2H6P   
CATH (Classification of proteins structures)2CIK    2H6P   
SuperfamilyP33260
Human Protein Atlas [tissue]ENSG00000108242-CYP2C18 [tissue]
Peptide AtlasP33260
HPRD03085
IPIIPI00289647   IPI00844265   
Protein Interaction databases
DIP (DOE-UCLA)P33260
IntAct (EBI)P33260
FunCoupENSG00000108242
BioGRIDCYP2C18
STRING (EMBL)CYP2C18
ZODIACCYP2C18
Ontologies - Pathways
QuickGOP33260
Ontology : AmiGOmonooxygenase activity  iron ion binding  cytoplasm  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  oxygen binding  heme binding  heme binding  organelle membrane  exogenous drug catabolic process  intracellular membrane-bounded organelle  oxidation-reduction process  oxidation-reduction process  aromatase activity  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  cytoplasm  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  oxygen binding  heme binding  heme binding  organelle membrane  exogenous drug catabolic process  intracellular membrane-bounded organelle  oxidation-reduction process  oxidation-reduction process  aromatase activity  
Pathways : KEGGRetinol metabolism    Serotonergic synapse    Chemical carcinogenesis   
NDEx NetworkCYP2C18
Atlas of Cancer Signalling NetworkCYP2C18
Wikipedia pathwaysCYP2C18
Orthology - Evolution
OrthoDB1562
GeneTree (enSembl)ENSG00000108242
Phylogenetic Trees/Animal Genes : TreeFamCYP2C18
HOVERGENP33260
HOGENOMP33260
Homologs : HomoloGeneCYP2C18
Homology/Alignments : Family Browser (UCSC)CYP2C18
Gene fusions - Rearrangements
Fusion : MitelmanKRT14/CYP2C18 [17q21.2/10q23.33]  [t(10;17)(q23;q21)]  
Fusion PortalKRT14 17q21.2 CYP2C18 10q23.33 HNSC
Fusion : QuiverCYP2C18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2C18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2C18
dbVarCYP2C18
ClinVarCYP2C18
1000_GenomesCYP2C18 
Exome Variant ServerCYP2C18
ExAC (Exome Aggregation Consortium)ENSG00000108242
GNOMAD BrowserENSG00000108242
Varsome BrowserCYP2C18
Genetic variants : HAPMAP1562
Genomic Variants (DGV)CYP2C18 [DGVbeta]
DECIPHERCYP2C18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP2C18 
Mutations
ICGC Data PortalCYP2C18 
TCGA Data PortalCYP2C18 
Broad Tumor PortalCYP2C18
OASIS PortalCYP2C18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2C18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP2C18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP2C18
DgiDB (Drug Gene Interaction Database)CYP2C18
DoCM (Curated mutations)CYP2C18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2C18 (select a term)
intoGenCYP2C18
Cancer3DCYP2C18(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601131   
Orphanet
DisGeNETCYP2C18
MedgenCYP2C18
Genetic Testing Registry CYP2C18
NextProtP33260 [Medical]
TSGene1562
GENETestsCYP2C18
Target ValidationCYP2C18
Huge Navigator CYP2C18 [HugePedia]
snp3D : Map Gene to Disease1562
BioCentury BCIQCYP2C18
ClinGenCYP2C18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1562
Chemical/Pharm GKB GenePA127
Clinical trialCYP2C18
Miscellaneous
canSAR (ICR)CYP2C18 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2C18
EVEXCYP2C18
GoPubMedCYP2C18
iHOPCYP2C18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:18:11 CEST 2018
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