| Nomenclature |
|---|
| HGNC (Hugo) | CYP2C18 2620 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CYP2C18 1562 cytochrome P450 family 2 subfamily C member 18 |
| Aliases | CPCI; CYP2C; CYP2C17; P450-6B/29C; |
| P450IIC17 |
| GeneCards (Weizmann) | CYP2C18 |
| Ensembl hg19 (Hinxton) | ENSG00000108242 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000108242 [Gene_View] ENSG00000108242 [Sequence] chr10:94683494-94736191 [Contig_View] CYP2C18 [Vega] |
| ICGC DataPortal | ENSG00000108242 |
| TCGA cBioPortal | CYP2C18 |
| AceView (NCBI) | CYP2C18 |
| Genatlas (Paris) | CYP2C18 |
| WikiGenes | 1562 |
| SOURCE (Princeton) | CYP2C18 |
| Genetics Home Reference (NIH) | CYP2C18 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CYP2C18 - chr10:94683494-94736191 + 10q23.33 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CYP2C18 - 10q23.33 [Description] (hg19-Feb_2009) |
| GoldenPath | CYP2C18 - 10q23.33 [CytoView hg19] CYP2C18 - 10q23.33 [CytoView hg38] |
| ImmunoBase | ENSG00000108242 |
| Mapping of homologs : NCBI | CYP2C18 [Mapview hg19] CYP2C18 [Mapview hg38] |
| OMIM | 601131 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK223510 AK308558 AK313403 BC069666 BC096257 |
| RefSeq transcript (Entrez) | NM_000772 NM_001128925 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CYP2C18 |
| Cluster EST : Unigene | Hs.511872 [ NCBI ] |
| CGAP (NCI) | Hs.511872 |
| Alternative Splicing Gallery | ENSG00000108242 |
| Gene Expression | CYP2C18 [ NCBI-GEO ] CYP2C18 [ EBI - ARRAY_EXPRESS ]
CYP2C18 [ SEEK ] CYP2C18 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CYP2C18 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1562 |
| GTEX Portal (Tissue expression) | CYP2C18 |
| Human Protein Atlas | ENSG00000108242-CYP2C18 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P33260 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P33260 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P33260 |
| Splice isoforms : SwissVar | P33260 |
| PhosPhoSitePlus | P33260 |
| Domaine pattern : Prosite (Expaxy) | CYTOCHROME_P450 (PS00086) |
| Domains : Interpro (EBI) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_sf |
| Domain families : Pfam (Sanger) | p450 (PF00067) |
| Domain families : Pfam (NCBI) | pfam00067 |
| Conserved Domain (NCBI) | CYP2C18 |
| DMDM Disease mutations | 1562 |
| Blocks (Seattle) | CYP2C18 |
| PDB (RSDB) | 2CIK 2H6P |
| PDB Europe | 2CIK 2H6P |
| PDB (PDBSum) | 2CIK 2H6P |
| PDB (IMB) | 2CIK 2H6P |
| Structural Biology KnowledgeBase | 2CIK 2H6P |
| SCOP (Structural Classification of Proteins) | 2CIK 2H6P |
| CATH (Classification of proteins structures) | 2CIK 2H6P |
| Superfamily | P33260 |
| Human Protein Atlas [tissue] | ENSG00000108242-CYP2C18 [tissue] |
| Peptide Atlas | P33260 |
| HPRD | 03085 |
| IPI | IPI00289647 IPI00844265 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P33260 |
| IntAct (EBI) | P33260 |
| FunCoup | ENSG00000108242 |
| BioGRID | CYP2C18 |
| STRING (EMBL) | CYP2C18 |
| ZODIAC | CYP2C18 |
| Ontologies - Pathways |
|---|
| QuickGO | P33260 |
| Ontology : AmiGO | monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity retinoic acid 4-hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway oxygen binding heme binding retinoic acid metabolic process exogenous drug catabolic process intracellular membrane-bounded organelle oxidation-reduction process aromatase activity |
| Ontology : EGO-EBI | monooxygenase activity iron ion binding cytoplasm endoplasmic reticulum membrane organic acid metabolic process xenobiotic metabolic process xenobiotic metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity retinoic acid 4-hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen epoxygenase P450 pathway oxygen binding heme binding retinoic acid metabolic process exogenous drug catabolic process intracellular membrane-bounded organelle oxidation-reduction process aromatase activity |
| Pathways : KEGG | Retinol metabolism Serotonergic synapse Chemical carcinogenesis |
| NDEx Network | CYP2C18 |
| Atlas of Cancer Signalling Network | CYP2C18 |
| Wikipedia pathways | CYP2C18 |
| Orthology - Evolution |
|---|
| OrthoDB | 1562 |
| GeneTree (enSembl) | ENSG00000108242 |
| Phylogenetic Trees/Animal Genes : TreeFam | CYP2C18 |
| HOGENOM | P33260 |
| Homologs : HomoloGene | CYP2C18 |
| Homology/Alignments : Family Browser (UCSC) | CYP2C18 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | KRT14/CYP2C18 [17q21.2/10q23.33] [t(10;17)(q23;q21)] |
| Fusion Portal | KRT14 17q21.2 CYP2C18 10q23.33 HNSC |
| Fusion : Quiver | CYP2C18 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CYP2C18 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CYP2C18 |
| dbVar | CYP2C18 |
| ClinVar | CYP2C18 |
| 1000_Genomes | CYP2C18 |
| Exome Variant Server | CYP2C18 |
| ExAC (Exome Aggregation Consortium) | ENSG00000108242 |
| GNOMAD Browser | ENSG00000108242 |
| Varsome Browser | CYP2C18 |
| Genetic variants : HAPMAP | 1562 |
| Genomic Variants (DGV) | CYP2C18 [DGVbeta] |
| DECIPHER | CYP2C18 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CYP2C18 |
| Mutations |
|---|
| ICGC Data Portal | CYP2C18 |
| TCGA Data Portal | CYP2C18 |
| Broad Tumor Portal | CYP2C18 |
| OASIS Portal | CYP2C18 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CYP2C18 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CYP2C18 |
| Mutations and Diseases : HGMD | CYP2C18 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CYP2C18 |
| DgiDB (Drug Gene Interaction Database) | CYP2C18 |
| DoCM (Curated mutations) | CYP2C18 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CYP2C18 (select a term) |
| intoGen | CYP2C18 |
| Cancer3D | CYP2C18(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601131 |
| Orphanet | |
| DisGeNET | CYP2C18 |
| Medgen | CYP2C18 |
| Genetic Testing Registry | CYP2C18
|
| NextProt | P33260 [Medical] |
| TSGene | 1562 |
| GENETests | CYP2C18 |
| Target Validation | CYP2C18 |
| Huge Navigator |
CYP2C18 [HugePedia] |
| snp3D : Map Gene to Disease | 1562 |
| BioCentury BCIQ | CYP2C18 |
| ClinGen | CYP2C18 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1562 |
| Chemical/Pharm GKB Gene | PA127 |
| Clinical trial | CYP2C18 |
| Miscellaneous |
|---|
| canSAR (ICR) | CYP2C18 (select the gene name) |
| DataMed Index | CYP2C18 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 46 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CYP2C18 |
| EVEX | CYP2C18 |
| GoPubMed | CYP2C18 |
| iHOP | CYP2C18 |
