Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19)

Identity

Other namesCPCJ
CYP2C
P450C2C
P450IIC19
HGNC (Hugo) CYP2C19
LocusID (NCBI) 1557
Location 10q23.33
Location_base_pair Starts at 96522463 and ends at 96612671 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP2C19   2621
Cards
Entrez_Gene (NCBI)CYP2C19  1557  cytochrome P450, family 2, subfamily C, polypeptide 19
GeneCards (Weizmann)CYP2C19
Ensembl (Hinxton) [Gene_View]  chr10:96522463-96612671 [Contig_View]  CYP2C19 [Vega]
AceView (NCBI)CYP2C19
Genatlas (Paris)CYP2C19
WikiGenes1557
SOURCE (Princeton)NM_000769
Genomic and cartography
GoldenPath (UCSC)CYP2C19  -  10q23.33   chr10:96522463-96612671 +  10q23.33   [Description]    (hg19-Feb_2009)
EnsemblCYP2C19 - 10q23.33 [CytoView]
Mapping of homologs : NCBICYP2C19 [Mapview]
OMIM124020   609535   
Gene and transcription
Genbank (Entrez)BC111846 M61854 X65962
RefSeq transcript (Entrez)NM_000769
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_008384 NT_030059 NW_001838005 NW_004929376
Consensus coding sequences : CCDS (NCBI)CYP2C19
Cluster EST : UnigeneHs.282409 [ NCBI ]
CGAP (NCI)Hs.282409
Alternative Splicing : Fast-db (Paris)GSHG0003578
Gene ExpressionCYP2C19 [ NCBI-GEO ]     CYP2C19 [ SEEK ]   CYP2C19 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33261 (Uniprot)
NextProtP33261  [Medical]
With graphics : InterProP33261
Splice isoforms : SwissVarP33261 (Swissvar)
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Related proteins : CluSTrP33261
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1557
Blocks (Seattle)P33261
PDB (SRS)4GQS   
PDB (PDBSum)4GQS   
PDB (IMB)4GQS   
PDB (RSDB)4GQS   
Peptide AtlasP33261
HPRD00486
IPIIPI00013323   IPI00657852   
Protein Interaction databases
DIP (DOE-UCLA)P33261
IntAct (EBI)P33261
BioGRIDCYP2C19
IntegromeDBCYP2C19
STRING (EMBL)CYP2C19
Ontologies - Pathways
QuickGOP33261
Ontology : AmiGOmonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  small molecule metabolic process  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  small molecule metabolic process  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Pathways : KEGGArachidonic acid metabolism    Linoleic acid metabolism    Drug metabolism - cytochrome P450    Serotonergic synapse    Chemical carcinogenesis   
Protein Interaction DatabaseCYP2C19
Wikipedia pathwaysCYP2C19
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP2C19
SNP (GeneSNP Utah)CYP2C19
SNP : HGBaseCYP2C19
Genetic variants : HAPMAPCYP2C19
1000_GenomesCYP2C19 
CONAN: Copy Number AnalysisCYP2C19 
Somatic Mutations in Cancer : COSMICCYP2C19 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
DECIPHER (Syndromes)10:96522463-96612671
Mutations and Diseases : HGMDCYP2C19
OMIM124020    609535   
MedgenCYP2C19
GENETestsCYP2C19
Disease Genetic AssociationCYP2C19
Huge Navigator CYP2C19 [HugePedia]  CYP2C19 [HugeCancerGEM]
Genomic VariantsCYP2C19  CYP2C19 [DGVbeta]
Exome VariantCYP2C19
dbVarCYP2C19
ClinVarCYP2C19
snp3D : Map Gene to Disease1557
General knowledge
Homologs : HomoloGeneCYP2C19
Homology/Alignments : Family Browser (UCSC)CYP2C19
Phylogenetic Trees/Animal Genes : TreeFamCYP2C19
Chemical/Protein Interactions : CTD1557
Chemical/Pharm GKB GenePA124
Clinical trialCYP2C19
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCYP2C19
GoPubMedCYP2C19
iHOPCYP2C19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:21:05 CET 2014

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