Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19)

Identity

Other namesCPCJ
CYP2C
P450C2C
P450IIC19
HGNC (Hugo) CYP2C19
LocusID (NCBI) 1557
Location 10q23.33
Location_base_pair Starts at 96522463 and ends at 96612671 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP2C19   2621
Entrez_Gene (NCBI)CYP2C19  1557  cytochrome P450, family 2, subfamily C, polypeptide 19
Cards
GeneCards (Weizmann)CYP2C19
Ensembl (Hinxton) [Gene_View]  chr10:96522463-96612671 [Contig_View]  CYP2C19 [Vega]
AceView (NCBI)CYP2C19
Genatlas (Paris)CYP2C19
SOURCE (Stanford)NM_000769
Genomic and cartography
GoldenPath (UCSC)CYP2C19  -  10q23.33   chr10:96522463-96612671 +  10q23.33   [Description]    (hg19-Feb_2009)
EnsemblCYP2C19 - 10q23.33 [CytoView]
Mapping of homologs : NCBICYP2C19 [Mapview]
OMIM124020   609535   
Gene and transcription
Genbank (Entrez)BC111846 M61854 X65962
RefSeq transcript (SRS)NM_000769
RefSeq transcript (Entrez)NM_000769
RefSeq genomic (SRS)AC_000142 NC_000010 NC_018921 NG_008384 NT_030059 NW_001838005 NW_004078068
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_008384 NT_030059 NW_001838005 NW_004078068
Consensus coding sequences : CCDS (NCBI)CYP2C19
Cluster EST : UnigeneHs.282409 [ SRS ] Hs.282409 [ NCBI ]
CGAP (NCI)Hs.282409
Alternative Splicing : Fast-db (Paris)GSHG0003578
Gene ExpressionCYP2C19 [ NCBI-GEO ]   CYP2C19 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33261 (SRS) P33261 (Uniprot)
NextProtP33261
With graphics : InterProP33261
Splice isoforms : SwissVarP33261(Swissvar)
Domaine pattern : Prosite (SRS)CYTOCHROME_P450 (PS00086)   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (SRS)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Related proteins : CluSTrP33261
Domain families : Pfam (SRS)p450 (PF00067)   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM1557
Blocks (Seattle)P33261
PDB (SRS)4GQS   
PDB (PDBSum)4GQS   
PDB (IMB)4GQS   
PDB (RSDB)4GQS   
HPRD00486
IPIIPI00013323   IPI00657852   
Protein Interaction databases
DIP (DOE-UCLA)P33261
IntAct (EBI)P33261
REACTOMECYP2C19
Protein Interaction Database1557
BioGRIDCYP2C19
InParanoidP33261
Interologous Interaction database P33261
IntegromeDBCYP2C19
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP2C19
SNP (GeneSNP Utah)CYP2C19
SNP : HGBaseCYP2C19
Genetic variants : HAPMAPCYP2C19
Somatic Mutations in Cancer : COSMICCYP2C19 
CONAN: Copy Number AnalysisCYP2C19 
Mutations and Diseases : HGMDCYP2C19
OMIM124020    609535   
GENETests124020    609535   
Disease Genetic AssociationCYP2C19
Huge Navigator CYP2C19 [HugePedia]  CYP2C19 [HugeCancerGEM]
Genomic VariantsCYP2C19  CYP2C19 [DGVbeta]
ClinVarCYP2C19
snp3D : Map Gene to Disease1557
General knowledge
Homologs : HomoloGeneCYP2C19
Homology/Alignments : Family Browser (UCSC)CYP2C19
Phylogenetic Trees/Animal Genes : TreeFamCYP2C19
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.- [ Enzyme-SRS ]   1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
Chemical/Protein Interactions : CTD1557
Chemical/Pharm GKB GenePA124
Clinical trialCYP2C19
Ontology : AmiGOmonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  steroid hydroxylase activity  electron carrier activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  small molecule metabolic process  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  steroid hydroxylase activity  electron carrier activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  small molecule metabolic process  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Pathways : KEGGLinoleic acid metabolismMonoterpenoid biosynthesisLimonene and pinene degradationMetabolism of xenobiotics by cytochrome P450Arachidonic acid metabolism
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneCYP2C19
iHOPCYP2C19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:29:13 CEST 2013
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