Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2C19 (cytochrome P450 family 2 subfamily C member 19)

Identity

Other namesCPCJ
CYP2C
CYPIIC17
CYPIIC19
P450C2C
P450IIC19
HGNC (Hugo) CYP2C19
LocusID (NCBI) 1557
Atlas_Id 40243
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 96522438 and ends at 96612962 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C10orf11 (10q22.2) / CYP2C19 (10q23.33)CCSER2 (10q23.1) / CYP2C19 (10q23.33)PLCE1 (10q23.33) / CYP2C19 (10q23.33)
SNX9 (6q25.3) / CYP2C19 (10q23.33)C10orf11 10q22.2 / CYP2C19 10q23.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP2C19   2621
Cards
Entrez_Gene (NCBI)CYP2C19  1557  cytochrome P450 family 2 subfamily C member 19
AliasesCPCJ; CYP2C; CYPIIC17; CYPIIC19; 
P450C2C; P450IIC19
GeneCards (Weizmann)CYP2C19
Ensembl hg19 (Hinxton)ENSG00000165841 [Gene_View]  chr10:96522438-96612962 [Contig_View]  CYP2C19 [Vega]
Ensembl hg38 (Hinxton)ENSG00000165841 [Gene_View]  chr10:96522438-96612962 [Contig_View]  CYP2C19 [Vega]
ICGC DataPortalENSG00000165841
TCGA cBioPortalCYP2C19
AceView (NCBI)CYP2C19
Genatlas (Paris)CYP2C19
WikiGenes1557
SOURCE (Princeton)CYP2C19
Genomic and cartography
GoldenPath hg19 (UCSC)CYP2C19  -     chr10:96522438-96612962 +  10q23.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP2C19  -     10q23.33   [Description]    (hg38-Dec_2013)
EnsemblCYP2C19 - 10q23.33 [CytoView hg19]  CYP2C19 - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBICYP2C19 [Mapview hg19]  CYP2C19 [Mapview hg38]
OMIM124020   609535   
Gene and transcription
Genbank (Entrez)BC111846 CB158473 CB161988 M61854 X65962
RefSeq transcript (Entrez)NM_000769
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_008384 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)CYP2C19
Cluster EST : UnigeneHs.282409 [ NCBI ]
CGAP (NCI)Hs.282409
Alternative Splicing GalleryENSG00000165841
Gene ExpressionCYP2C19 [ NCBI-GEO ]   CYP2C19 [ EBI - ARRAY_EXPRESS ]   CYP2C19 [ SEEK ]   CYP2C19 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2C19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1557
GTEX Portal (Tissue expression)CYP2C19
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33261 (Uniprot)
NextProtP33261  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33261
Splice isoforms : SwissVarP33261 (Swissvar)
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
PhosPhoSitePlusP33261
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1557
Blocks (Seattle)CYP2C19
PDB (SRS)4GQS   
PDB (PDBSum)4GQS   
PDB (IMB)4GQS   
PDB (RSDB)4GQS   
Structural Biology KnowledgeBase4GQS   
SCOP (Structural Classification of Proteins)4GQS   
CATH (Classification of proteins structures)4GQS   
SuperfamilyP33261
Human Protein AtlasENSG00000165841
Peptide AtlasP33261
HPRD00486
IPIIPI00013323   IPI00657852   
Protein Interaction databases
DIP (DOE-UCLA)P33261
IntAct (EBI)P33261
FunCoupENSG00000165841
BioGRIDCYP2C19
STRING (EMBL)CYP2C19
ZODIACCYP2C19
Ontologies - Pathways
QuickGOP33261
Ontology : AmiGOmonooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  epoxygenase P450 pathway  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Ontology : EGO-EBImonooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  epoxygenase P450 pathway  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Pathways : KEGGArachidonic acid metabolism    Linoleic acid metabolism    Drug metabolism - cytochrome P450    Serotonergic synapse    Chemical carcinogenesis   
NDEx Network
Atlas of Cancer Signalling NetworkCYP2C19
Wikipedia pathwaysCYP2C19
Orthology - Evolution
OrthoDB1557
GeneTree (enSembl)ENSG00000165841
Phylogenetic Trees/Animal Genes : TreeFamCYP2C19
Homologs : HomoloGeneCYP2C19
Homology/Alignments : Family Browser (UCSC)CYP2C19
Gene fusions - Rearrangements
Fusion: TCGAC10orf11 10q22.2 CYP2C19 10q23.33 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerCYP2C19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2C19
dbVarCYP2C19
ClinVarCYP2C19
1000_GenomesCYP2C19 
Exome Variant ServerCYP2C19
ExAC (Exome Aggregation Consortium)CYP2C19 (select the gene name)
Genetic variants : HAPMAP1557
Genomic Variants (DGV)CYP2C19 [DGVbeta]
Mutations
ICGC Data PortalCYP2C19 
TCGA Data PortalCYP2C19 
Broad Tumor PortalCYP2C19
OASIS PortalCYP2C19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2C19 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP2C19
DgiDB (Drug Gene Interaction Database)CYP2C19
DoCM (Curated mutations)CYP2C19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2C19 (select a term)
intoGenCYP2C19
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:96522438-96612962  ENSG00000165841
CONAN: Copy Number AnalysisCYP2C19 
Mutations and Diseases : HGMDCYP2C19
OMIM124020    609535   
MedgenCYP2C19
Genetic Testing Registry CYP2C19
NextProtP33261 [Medical]
TSGene1557
GENETestsCYP2C19
Huge Navigator CYP2C19 [HugePedia]
snp3D : Map Gene to Disease1557
BioCentury BCIQCYP2C19
ClinGenCYP2C19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1557
Chemical/Pharm GKB GenePA124
Clinical trialCYP2C19
Miscellaneous
canSAR (ICR)CYP2C19 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2C19
EVEXCYP2C19
GoPubMedCYP2C19
iHOPCYP2C19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:01:28 CEST 2016

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