CYP2C19 (cytochrome P450 family 2 subfamily C member 19)

2003-08-01 Affiliation

Identity

HGNC

CYP2C19

LOCATION

10q23.33

LOCUSID

1557

ALIAS

CPCJ,CYP2C,CYPIIC17,CYPIIC19,P450C2C,P450IIC19

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1557
MIM: 124020
HGNC: 2621
Ensembl: ENSG00000165841

Variants:

dbSNP: 1557
ClinVar: 1557
TCGA: ENSG00000165841
COSMIC: CYP2C19

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165841	ENST00000371321	P33261
ENSG00000165841	ENST00000480405	A0A087X125

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
Drug metabolism - cytochrome P450	KEGG	ko00982
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Serotonergic synapse	KEGG	hsa04726
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	REACTOME	R-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	REACTOME	R-HSA-2142670
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
CYP2E1 reactions	REACTOME	R-HSA-211999

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10066	duloxetine	Chemical	VariantAnnotation	not associated		PD	23545896
PA10074	escitalopram	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	20492469, 7969038, 8195181, 8563772, 11802100, 12222994, 12975335, 15168101, 16413245, 16418702, 16855453, 17625515, 18654768, 19404631, 19593158, 19773541, 19840783, 20350136, 20531370, 21926427, 23545896, 23981149, 24014145, 24257813, 24858822, 25122046, 25154506, 25974703, 28614176, 29325448, 30135031, 30983508, 8451774, 8835706
PA10075	esomeprazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	16338278, 18637061, 18751689, 19166419, 19785625, 21118735, 22324425
PA10233	voriconazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	17625515, 20083681, 8195181, 15179414, 16003289, 16413245, 16890574, 17827141, 18982321, 19033450, 19261446, 19299322, 19933691, 20669013, 21038076, 21192313, 21383338, 21507170, 21831685, 23215888, 23588332, 24510446, 24554646, 25084200, 25155930, 25239277, 25558073, 25986028, 26024717, 26239729, 26616742, 26775563, 26861072, 26982740, 27056297, 27143031, 27284960, 27388292, 27432796, 27937048, 28685218, 28834922, 29285995, 29393850, 29607533
PA10251	atazanavir	Chemical	LabelAnnotation	associated
PA10402	benzodiazepine derivatives	Chemical	VipGene	associated			8148870
PA10888	clobazam	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	12451290, 14729419, 15483195, 15533655, 18466100, 23666564, 24345815, 25323806
PA126	CYP2C9	Gene	DataAnnotation	associated
PA128	CYP2D6	Gene	DataAnnotation	associated
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated		PD
PA131887008	3,4-methylenedioxymethamphetamine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	28117133
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA134308647	rosuvastatin	Chemical	VariantAnnotation	ambiguous	PK		23930675, 24140730
PA134687907	formoterol	Chemical	LabelAnnotation	associated
PA151958426	nebivolol	Chemical	VariantAnnotation	ambiguous	PK		29098786
PA153619833	Peripheral Vascular Diseases	Disease	VariantAnnotation	associated		PD	27464309
PA154410481	prasugrel	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	17900275, 20492467, 23257377, 24402637, 25008027, 26151596, 26556524
PA162316739	Maculopapular Exanthema	Disease	ClinicalAnnotation	associated		PD
PA162370415	Metabolic Syndrome	Disease	VariantAnnotation	associated		PD
PA164713207	Proton pump inhibitors	Chemical	Literature, MultilinkAnnotation, VipGene	associated			15258107, 16772608, 21412232, 8148870, 8195181, 15199661, 25303292
PA164743150	labetalol	Chemical	VariantAnnotation	associated	PK		23090703
PA164746334	cilostazol	Chemical	VariantAnnotation	ambiguous	PK	PD	21345843, 21511217
PA164746757	tolterodine	Chemical	LabelAnnotation	associated
PA164781320	flunitrazepam	Chemical	Pathway	associated
PA164784021	ethambutol	Chemical	ClinicalAnnotation	associated		PD
PA164924493	axitinib	Chemical	LabelAnnotation, VariantAnnotation	ambiguous	PK		22170007
PA164925725	Toxic liver disease	Disease	VariantAnnotation	not associated		PD	27284960
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20083681, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20826260, 20833683, 20845077, 20924183, 20965456, 20979470, 21075428, 21099121, 21163112, 21168310, 21178986, 21527445, 21628721, 21700758, 21716274, 21806387, 21831410, 21918510, 21972404, 22028352, 22045970, 22088980, 22228204, 22285300, 22374717, 22390861, 22462746, 22464343, 22624833, 22704413, 22940005, 22955794, 22974728, 22990067, 23001453, 23150151, 23257377, 23364775, 23429358, 23640828, 23692149, 23726091, 23922007, 24019397, 24080325, 24088578, 24214141, 24418943, 24504666, 24508947, 24535487, 24608794, 24821368, 24856643, 25008027, 25542807, 25712182, 25730082, 25828136, 25860557, 25897911, 26151596, 26265231, 26873108, 27450232, 28589365, 28604225, 28806186, 29723426
PA165290928	drospirenone / ethinyl estradiol	Chemical	LabelAnnotation	associated
PA165374639	suicide	Disease	VariantAnnotation	associated		PD
PA165374673	ticagrelor	Chemical	GuidelineAnnotation, LabelAnnotation, VariantAnnotation	associated		PD	26151596
PA165816522	CYP2C19*6	Haplotype	LabelAnnotation	associated
PA165816523	CYP2C19*7	Haplotype	LabelAnnotation	associated
PA165816524	CYP2C19*8	Haplotype	LabelAnnotation	associated
PA165816533	CYP2C19*17	Haplotype	GuidelineAnnotation, VipGene	associated			11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA165816544	CYP2C9*3	Haplotype	GuidelineAnnotation	associated
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	23175667, 29607533
PA165860521	ambrisentan	Chemical	MultilinkAnnotation, VariantAnnotation	associated	PK		25286744
PA165954769	HLA-B*15:02:01	Haplotype	LabelAnnotation	associated
PA165980634	CYP2C19*1	Haplotype	LabelAnnotation	associated
PA165980635	CYP2C19*2	Haplotype	GuidelineAnnotation, LabelAnnotation, VipGene	associated			11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA165980636	CYP2C19*3	Haplotype	LabelAnnotation, VipGene	associated			11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA165980637	CYP2C19*4	Haplotype	LabelAnnotation	associated
PA165980638	CYP2C19*5	Haplotype	LabelAnnotation	associated
PA166014703	etravirine	Chemical	ClinicalAnnotation	associated	PK		23111422
PA166048740	Helicobacter Infections	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10579481, 11240980, 11446878, 11785712, 12121503, 12544691, 12662378, 12809821, 14638340, 15710002, 15952098, 15976989, 16815316, 16863547, 16912869, 17215846, 18637061, 19166419, 19552744, 20559522, 20633187, 21054464, 21118735, 21361732, 23646118, 27611887, 9867757
PA166048829	Elderly Adult	Disease	VariantAnnotation	not associated	PK		24858822
PA166110255	lafutidine	Chemical	VariantAnnotation	not associated		PD	12662378, 14653835
PA166110257	dexlansoprazole	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PK		22455762
PA166114457	lung transplantation	Disease	VariantAnnotation	ambiguous		PD	21038076, 26982740
PA166114460	icotinib	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation	associated	PK		22585284, 25995169
PA166118565	ginkgo biloba extract	Chemical	Literature, MultilinkAnnotation	not associated			19299322
PA166122590	simeprevir	Chemical	LabelAnnotation	associated
PA166122646	hemopoietic stem cell transplant	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	24165757, 24192117, 26616742
PA166123007	hematopoietic stem cell transplantation	Disease	VariantAnnotation	ambiguous	PK	PD	19933691, 28685218
PA166123203	intragastric ph	Disease	VariantAnnotation	associated	PK	PD	21361732, 24996380
PA166123207	overall survival	Disease	VariantAnnotation	associated		PD	21047200
PA166123366	event-free survival	Disease	VariantAnnotation	associated		PD	23842856
PA166123368	schizoaffective disorder	Disease	VariantAnnotation	associated	PK	PD	28664816
PA166123369	electrocardiogram qt prolonged	Disease	VariantAnnotation	associated		PD
PA166123766	platelet aggregation	Disease	VariantAnnotation	associated		PD	28604225, 30020015
PA166124406	platelet reactivity	Disease	VariantAnnotation	ambiguous		PD	24402637, 24856643, 25175362, 25828136, 25832119, 25850030, 25891840, 25897911, 27380588, 28329746, 28589365
PA166124478	endoxifen	Chemical	VariantAnnotation	not associated	PK
PA166127651	n-desmethyltamoxifen	Chemical	VariantAnnotation	not associated	PK
PA166127652	4-hydroxytamoxifen	Chemical	VariantAnnotation	not associated	PK
PA166127658	Recurrence free survival	Disease	VariantAnnotation	not associated		PD	19156902
PA166128095	treatment failure	Disease	VariantAnnotation	associated		PD	25986028, 29325448
PA166128206	dipyrone	Chemical	ClinicalAnnotation	associated	PK		25241292
PA166128371	platelet aggregation inhibition	Disease	VariantAnnotation	associated		PD	25115434, 28135763
PA166129537	composite endpoints (transient ischemic attack (tia), stroke, myocardial infarction, or death)	Disease	VariantAnnotation	ambiguous		PD
PA166129538	secondary composite endpoints (transient ischemic attack (tia), stroke, or death)	Disease	VariantAnnotation	associated		PD
PA166129560	major adverse cardiac events (mace)	Disease	VariantAnnotation	ambiguous		PD	27653892, 28377187, 29397568
PA166131507	desmethyl clomipramine	Chemical	VariantAnnotation	associated	PK		28470111
PA166151827	adverse events	Disease	VariantAnnotation	associated		PD
PA166152940	tolperisone	Chemical	VariantAnnotation	not associated	PK		25953735
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166153491	brivaracetam	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	associated	PK		24717838
PA166154053	rs4244285	Variant	VipGene	associated			11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA166154070	rs4986893	Variant	VipGene	associated			11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA166154147	rs12248560	Variant	VipGene	associated			11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA166160048	lacosamide	Chemical	LabelAnnotation	associated
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166163563	high on-treatment platelet reactivity	Disease	VariantAnnotation	ambiguous		PD	29397568
PA166163659	n-desmethylclozapine	Chemical	VariantAnnotation	associated	PK		28664816
PA166163794	composite endpoints (stroke, myocardial infarction, or vascular death)	Disease	VariantAnnotation	associated		PD	27806998
PA166165020	adverse cardiovascular events	Disease	VariantAnnotation	ambiguous		PD	28329746, 28589365
PA166180939	phenazepam	Chemical	ClinicalAnnotation	associated		PD	30325732
PA193	HTR2A	Gene	DataAnnotation	associated
PA27093	CYP1A2	Gene	DataAnnotation	associated
PA312	SLC6A4	Gene	DataAnnotation	associated
PA443309	Alcoholism	Disease	ClinicalAnnotation	associated		PD	30325732
PA443362	Angina Pectoris	Disease	VariantAnnotation	ambiguous		PD	23993903, 24019397
PA443423	Arterial Occlusive Diseases	Disease	VariantAnnotation	associated		PD
PA443450	Asthma	Disease	VariantAnnotation	associated			23623526
PA443459	Atrial Fibrillation	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	27356304
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	19156902, 20179710, 21047200, 21480951, 21830868, 21961651, 23842856, 24682508, 26799162, 29938344, 30022682
PA443626	Carcinoma, Squamous Cell	Disease	VariantAnnotation	associated		PD	26982740
PA443635	Cardiovascular Diseases	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20833683, 20845077, 20924183, 20965456, 20979470, 21075428, 21099121, 21163112, 21168310, 21178986, 21527445, 21628721, 21700758, 21806387, 21831410, 21918510, 21972404, 22028352, 22088980, 22228204, 22285300, 22390861, 22462746, 22624833, 22940005, 22990067, 23364775, 23993903, 24782221, 25712182, 25730082, 25851472, 25860557, 25897911, 26265231, 28589365, 28806186, 29723426, 30983508
PA443636	Carotid Artery Diseases	Disease	VariantAnnotation	ambiguous		PD	26526111
PA443672	Ischemic Attack, Transient	Disease	VariantAnnotation	ambiguous		PD	26265231, 27806998
PA443678	Cerebrovascular Disorders	Disease	VariantAnnotation	associated		PD
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	18323861, 18346178, 18532997, 19106083, 19106084, 19463375, 19576320, 20083681, 20492469, 20650435, 20724801, 20801498, 20826260, 21075428, 21168310, 21178986, 21716274, 22028352, 22045970, 22123356, 22228204, 22374717, 22462746, 22704413, 22955794, 22974728, 22990067, 23001453, 23150151, 23364775, 23402725, 23428009, 23429358, 23640828, 23692149, 23726091, 23922007, 24019397, 24080325, 24088578, 24214141, 24402637, 24504666, 24508947, 24535487, 24576527, 24608794, 24781308, 24821368, 24996381, 25008027, 25877345, 26071277, 26311225, 27450232, 28589365, 29397568
PA443797	Coronary Disease	Disease	VariantAnnotation	associated		PD	24535487, 24608794, 25891840
PA443829	Cystic Fibrosis	Disease	VariantAnnotation	ambiguous		PD	21038076
PA443842	Death	Disease	VariantAnnotation	ambiguous		PD	19106084, 22527345, 25877345, 26265231
PA443886	Diabetes Mellitus	Disease	VariantAnnotation	associated		PD	28664816
PA443937	Drug Toxicity	Disease	VariantAnnotation	ambiguous		PD	15590749, 18466100, 21038076, 21831685, 28685218
PA444065	Epilepsy	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	12451290, 14729419, 15483195, 15533655, 18466100, 23666564, 24345815, 25162219, 25323806, 26223287
PA444086	Erythema Nodosum	Disease	VariantAnnotation	associated		PD	31124417
PA444104	Esophagitis	Disease	ClinicalAnnotation	associated	PK	PD	10340921, 10982760, 11069321, 14653835, 15447734, 17112810, 21361732, 24996380
PA444255	Gastroesophageal Reflux	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10340921, 10982760, 11012469, 11069321, 11380317, 11446878, 11785712, 11929404, 12121503, 12386647, 12544691, 12656699, 14638340, 14653835, 14687173, 15447734, 15470328, 15903128, 15932363, 15963082, 16338278, 16815316, 16863547, 16911688, 17112810, 17295875, 17725594, 17934830, 19166419, 19259653, 20633187, 21054464, 21361732, 22324425, 24996380, 29377228
PA444327	Granulomatous Disease, Chronic	Disease	VariantAnnotation	associated	PK		23215888
PA444339	Hallucinations	Disease	VariantAnnotation	associated		PD
PA444395	Hematologic Diseases	Disease	VariantAnnotation	ambiguous	PK	PD
PA444417	Hemorrhage	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	22123356, 27348249, 27806998, 28329746, 29260275
PA444445	Hepatitis C	Disease	VariantAnnotation	associated	PK		25155930
PA444516	Hypercholesterolemia	Disease	VariantAnnotation	not associated	PK		23930675
PA444545	Hyperprolactinemia	Disease	VariantAnnotation	associated	PK		25025989
PA444614	Infection	Disease	VariantAnnotation	not associated	PK
PA444620	Inflammation	Disease	VariantAnnotation	not associated		PD	26311225
PA444745	Leprosy	Disease	VariantAnnotation	associated		PD	31124417
PA444773	Leukopenia	Disease	VariantAnnotation	not associated		PD	26894931
PA444822	Lupus Erythematosus, Systemic	Disease	ClinicalAnnotation	associated	PK	PD	20358205
PA444840	Lymphoma	Disease	VariantAnnotation	associated	PK		25155930
PA444845	Lymphoma, Non-Hodgkin	Disease	VariantAnnotation	associated	PK	PD	28181240
PA444859	Malaria	Disease	VariantAnnotation	associated	PK		10471063
PA445009	Mycoses	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	15179414, 16003289, 16890574, 17827141, 18982321, 19033450, 19261446, 19299322, 19933691, 21038076, 21192313, 21383338, 21507170, 21831685, 23215888, 23588332, 24554646, 25155930, 25239277, 25558073, 25986028, 26024717, 26239729, 26616742, 26775563, 26861072, 27056297, 27143031, 27284960, 27388292, 27432796, 27937048, 28685218, 28834922, 29285995, 29393850, 29607533
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	19106083, 19463375, 20083681, 20492469, 20801498, 20826260, 22028352, 22045970, 22228204, 22462746, 22704413, 22955794, 22990067, 23364775, 23726091, 23922007, 24019397, 24080325, 25850030, 25877345, 26265231, 26556524, 27767438, 28604225, 29260275
PA445043	Opioid-Related Disorders	Disease	VariantAnnotation	not associated	PK		17178267
PA445105	Neurologic Manifestations	Disease	VariantAnnotation	associated		PD	25042870
PA445218	Pancreatic Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK		16267764, 25752914
PA445506	Recurrence	Disease	VariantAnnotation	ambiguous		PD	24682508, 27767438, 30022682
PA445526	Respiratory Tract Infections	Disease	VariantAnnotation	associated			23623526
PA445647	Shock, Septic	Disease	VariantAnnotation	associated	PK		25155930
PA445850	Thrombosis	Disease	ClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	ambiguous	PK	PD	16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20833683, 20845077, 20877456, 20924183, 20979470, 21099121, 21163112, 21168310, 21178986, 21527445, 21628721, 21700758, 21806387, 21831410, 21918510, 21972404, 22028352, 22088980, 22228204, 22285300, 22462746, 22624833, 22940005, 22990067, 23364775, 24508947, 25730082, 25860557, 26265231, 28589365, 28806186, 30191759
PA445876	Tobacco Use Disorder	Disease	VariantAnnotation	not associated		PD
PA445941	Tuberculosis	Disease	ClinicalAnnotation	associated		PD
PA445973	Ulcer	Disease	VariantAnnotation	ambiguous		PD	10982760, 17645482, 17934830
PA446023	Vasculitis	Disease	VariantAnnotation	not associated		PD	26894931
PA446065	Wegener Granulomatosis	Disease	VariantAnnotation	not associated		PD	26894931
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	VariantAnnotation	associated		PD	27143031
PA446336	Severe Combined Immunodeficiency	Disease	VariantAnnotation	associated	PK		27056297
PA446459	Myocardial Ischemia	Disease	VariantAnnotation	ambiguous		PD	22955794
PA447054	Stroke	Disease	MultilinkAnnotation, VariantAnnotation	ambiguous		PD	25529343, 25877345, 26019129, 26265231, 26873108, 27233747, 27806998, 29520080
PA447198	Autistic Disorder	Disease	VariantAnnotation	not associated		PD
PA447199	Bipolar Disorder	Disease	VariantAnnotation	not associated		PD	27353638
PA447207	Depressive Disorder	Disease	VariantAnnotation	associated	PK		19773541, 19884907
PA447208	Mental Disorders	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11763000, 12172336, 15205367, 16044105, 16413245, 17625515, 18677622, 20531370
PA447211	Obsessive-Compulsive Disorder	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	23332809, 23357843, 23545896, 27804107
PA447212	Panic Disorder	Disease	VariantAnnotation	associated		PD	28614176
PA447215	Psychotic Disorders	Disease	VariantAnnotation	not associated		PD	27353638
PA447216	Schizophrenia	Disease	VariantAnnotation	associated	PK	PD	28664816
PA447230	HIV	Disease	ClinicalAnnotation	associated	PK		16267764, 21860339, 23111422, 25752914
PA447240	Peptic Ulcer	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	10340921, 10982760, 11069321, 14653835, 15447734, 17112810, 21361732, 23267857, 24996380
PA447278	Depression	Disease	ClinicalAnnotation, DataAnnotation, VariantAnnotation	ambiguous	PK	PD	20468063, 23332809, 23357843, 23545896, 23799451, 27800629, 28480819, 30983508
PA447300	Acquired Long QT Syndrome (aLQTS)	Disease	VariantAnnotation	not associated		PD	30983508
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation, DataAnnotation, VariantAnnotation	ambiguous	PK	PD	10510155, 11452243, 11802100, 12975335, 15168101, 15590749, 16236141, 16418702, 16855453, 17625515, 17667959, 18654768, 18677622, 19404631, 19593158, 19773541, 19840783, 1988236, 19884907, 20350136, 20531370, 21926427, 23545896, 23981149, 24014145, 24257813, 24858822, 25122046, 25154506, 26343256, 26830411, 30135031, 7965806, 8451774, 8835703, 8835706, 9316174
PA447325	Coronary Restenosis	Disease	VariantAnnotation	associated		PD	27464309
PA448385	amitriptyline	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 12012142, 12172336, 15168101, 15205367, 15590749, 16024198, 16044105, 20531370, 23486447
PA448497	aspirin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	20833683, 20965456, 21075428, 21345843, 21511217, 22390861, 23993903, 24336898, 24576527, 25712182, 26311225, 27348249, 28589365, 28604225, 29520080, 29723426, 30020015, 30191759
PA448500	atorvastatin	Chemical	Pathway, VariantAnnotation	associated			24140730
PA448687	bupropion	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotation	ambiguous	PK	PD	25187485
PA448691	busulfan	Chemical	ClinicalAnnotation	associated	PK		24165757, 24192117
PA448785	carbamazepine	Chemical	VipGene	associated
PA448809	carisoprodol	Chemical	ClinicalAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	16021435, 22527345
PA448817	carvedilol	Chemical	VariantAnnotation	not associated	PK		21599570
PA448871	celecoxib	Chemical	VariantAnnotation	not associated	PK		21692664
PA448927	chloramphenicol	Chemical	VipGene	associated
PA449001	cimetidine	Chemical	VipGene	associated
PA449015	citalopram	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 11802100, 12975335, 15168101, 16418702, 16855453, 17625515, 18654768, 19404631, 19593158, 19773541, 19840783, 20350136, 20531370, 21546862, 21926427, 23545896, 23981149, 24014145, 24257813, 24858822, 25122046, 25154506, 26343256, 27804107, 30135031, 30983508, 8451774, 8835706
PA449048	clomipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 11763000, 20531370, 23486447, 23545896, 27800629, 28470111
PA449053	clopidogrel	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	15199661, 15258107, 16132042, 16413245, 16772608, 17625515, 17900275, 18004210, 18781853, 19106083, 19106084, 19108880, 19496924, 20083681, 20351750, 20492469, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 7969038, 8148870, 8195181, 8563772, 12222994, 16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20083681, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20826260, 20833683, 20845077, 20877456, 20924183, 20938371, 20965456, 20979470, 21075428, 21099121, 21163112, 21168310, 21178986, 21345843, 21352268, 21511217, 21527445, 21628721, 21700758, 21716271, 21716274, 21806387, 21831410, 21918510, 21972404, 22028352, 22045970, 22088980, 22123356, 22228204, 22285300, 22374717, 22390861, 22462746, 22464343, 22624833, 22704413, 22940005, 22955794, 22974728, 22990067, 23001453, 23150151, 23364775, 23402725, 23428009, 23429358, 23470885, 23517020, 23556336, 23640828, 23692149, 23698643, 23726091, 23895809, 23922007, 23993903, 24019397, 24080325, 24088578, 24140730, 24214141, 24262617, 24336898, 24402637, 24418943, 24479687, 24504666, 24508947, 24535487, 24576527, 24608794, 24624918, 24632932, 24781308, 24782221, 24821368, 24856643, 24945780, 24951432, 24996381, 25001882, 25008027, 25115434, 25175362, 25258374, 25329996, 25529343, 25542807, 25712182, 25730082, 25828136, 25832119, 25850030, 25851472, 25860557, 25877345, 25891840, 25897911, 26071277, 26151596, 26265231, 26311225, 26362473, 26369612, 26526111, 26556524, 26873108, 27023676, 27233747, 27348249, 27380588, 27450232, 27464309, 27653892, 27767438, 27806998, 28135763, 28329746, 28377187, 28589365, 28604225, 28806186, 29260275, 29397568, 29520080, 29723426, 30020015, 30191759
PA449061	clozapine	Chemical	VariantAnnotation	associated		PD	28664816
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	20179710, 20358205, 26894931, 28181240, 29938344
PA449233	desipramine	Chemical	Pathway, VariantAnnotation	ambiguous	PK		17667959
PA449283	diazepam	Chemical	ClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, Pathway, VariantAnnotation	ambiguous	PK		16338280, 27099220
PA449409	doxepin	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation	associated	PK		12360109, 23486447
PA449412	doxorubicin	Chemical	ClinicalAnnotation	associated		PD	20179710, 29938344
PA449441	efavirenz	Chemical	VariantAnnotation	associated	PK
PA449586	famotidine	Chemical	VariantAnnotation	ambiguous	PK	PD	11929404, 15710002, 15903128, 15963082, 17112810
PA449590	felbamate	Chemical	VipGene	associated
PA449653	fluconazole	Chemical	VariantAnnotation	not associated	PK		21692664
PA449673	fluoxetine	Chemical	Pathway, VariantAnnotation	ambiguous	PK	PD	16236141, 21692664, 23545896, 28494448
PA449688	fluvastatin	Chemical	Pathway	associated
PA449690	fluvoxamine	Chemical	GuidelineAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	21692664, 23545896
PA449918	hydromorphone	Chemical	VariantAnnotation	not associated	PK
PA449957	ibuprofen	Chemical	Pathway	associated			25502615
PA449969	imipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 17667959, 1988236, 19884907, 23486447, 7965806, 8835703, 9316174
PA449982	indomethacin	Chemical	VipGene	associated
PA450112	isoniazid	Chemical	ClinicalAnnotation, VipGene	associated		PD
PA450146	ketoconazole	Chemical	VariantAnnotation	not associated	PK		21692664
PA450180	lansoprazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	11240980, 12222994, 16413245, 16912869, 16961157, 17625515, 17645482, 18654768, 19166419, 19621685, 20083681, 20376628, 20492469, 7969038, 8195181, 8563772, 9867757, 10340921, 11012469, 11240980, 11474773, 11929404, 12121503, 12386647, 12544691, 12656699, 12662378, 14638340, 15710002, 15952098, 15963082, 16815316, 16863547, 17215846, 17295875, 19166419, 19259653, 22076562, 23623526, 24996380, 9164419, 9272410
PA450272	lovastatin	Chemical	Pathway	associated
PA450373	mephenytoin	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	15258107, 16772608, 21412232, 8148870, 8195181, 10022751, 10411572, 12464799, 15199661, 16413245, 17455109, 19661214, 21325430, 25001882, 26153442, 27578295, 7969038, 8195181, 8747407, 8988068, 9103550, 9435198, 9732415
PA450374	methylphenobarbital	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		15499191
PA450401	methadone	Chemical	VariantAnnotation	ambiguous	PK		17178267, 27199033
PA450480	metoprolol	Chemical	VariantAnnotation	not associated	PK		15467211
PA450522	mirtazapine	Chemical	GuidelineAnnotation, VariantAnnotation	ambiguous		PD	23545896
PA450530	modafinil	Chemical	VipGene	associated
PA450606	nelfinavir	Chemical	ClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation	associated	PK		16267764, 25752914
PA450616	nevirapine	Chemical	ClinicalAnnotation	associated	PK		21860339
PA450651	norethindrone	Chemical	VipGene	associated
PA450657	nortriptyline	Chemical	VariantAnnotation	ambiguous	PK		12012142, 15205367, 20531370
PA450704	omeprazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	11240980, 12222994, 16413245, 16912869, 16961157, 17625515, 17645482, 18654768, 19166419, 19621685, 20083681, 20376628, 20492469, 7969038, 8195181, 8563772, 9867757, 10206083, 10340921, 10511062, 10579481, 10626755, 10982760, 11046127, 11069321, 11240980, 11446878, 11474773, 11785712, 12121503, 12809821, 14638340, 14653835, 1505152, 15447734, 15932363, 15976989, 16815316, 16863547, 17112810, 17934830, 18312490, 18637061, 18751689, 19166419, 19661214, 20633187, 21054464, 21118735, 21325430, 21352268, 21361732, 21692664, 24945780, 24996380, 25495411, 26153442, 26244421, 27578295, 29377228, 7648764, 8675169, 8681489, 8747407, 8823231, 9014204, 9284848, 9357389, 9797796, 9829356, 9867757
PA450731	oxazepam	Chemical	Pathway	associated
PA450774	pantoprazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	11240974, 15976989, 16912869, 17645482, 18637061, 18664620, 19166419, 19785625, 25495411, 27611887, 9433390
PA450801	paroxetine	Chemical	Pathway, VariantAnnotation	ambiguous		PD	23545896
PA450911	phenobarbital	Chemical	VariantAnnotation	associated		PD	23551241
PA450921	phenprocoumon	Chemical	VariantAnnotation	associated		PD	21636598
PA450947	phenytoin	Chemical	ClinicalAnnotation, DataAnnotation, LabelAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	22569204, 23551241, 25162219, 25597548, 28391407
PA451100	prednisone	Chemical	VipGene	associated
PA451123	progesterone	Chemical	ClinicalAnnotation	associated	PK		31482508
PA451124	proguanil	Chemical	VariantAnnotation	associated	PK		10471063
PA451182	pyrazinamide	Chemical	ClinicalAnnotation	associated		PD
PA451201	quetiapine	Chemical	VariantAnnotation	associated	PK		25025989
PA451216	rabeprazole	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation	ambiguous	PK	PD	11012469, 11380317, 11446878, 11474773, 11785712, 12121503, 12544691, 14638340, 14687173, 15470328, 15903128, 16815316, 16863547, 16911688, 17725594, 17934830, 19166419, 19552744, 20559522, 20633187, 21054464, 21118735, 22324425, 23646118, 24996380, 25495411, 7648764
PA451250	rifampin	Chemical	ClinicalAnnotation, VipGene	associated		PD
PA451257	risperidone	Chemical	VariantAnnotation	associated		PD	25042870
PA451333	sertraline	Chemical	ClinicalAnnotation, GuidelineAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 10510155, 11452243, 15168101, 18677622, 21692664, 23545896, 25974703, 26830411, 30983508
PA451363	simvastatin	Chemical	Pathway	associated
PA451578	tacrolimus	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	23175667
PA451581	tamoxifen	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	19156902, 21047200, 21480951, 21830868, 21961651, 23842856, 23962908, 24682508, 26799162, 30022682
PA451608	temazepam	Chemical	Pathway	associated
PA451644	thalidomide	Chemical	VariantAnnotation	associated		PD	31124417
PA451686	ticlopidine	Chemical	VariantAnnotation, VipGene	ambiguous	PK		21692664
PA451718	tolbutamide	Chemical	VariantAnnotation	associated	PK		10022751, 10411572
PA451728	topiramate	Chemical	VipGene	associated
PA451741	tranylcypromine	Chemical	VariantAnnotation	not associated	PK		21692664
PA451791	trimipramine	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	associated	PK		12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 10774635, 11452243, 14520122, 23486447
PA451799	troglitazone	Chemical	VariantAnnotation	not associated	PK		21692664
PA451846	valproic acid	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	26223287, 27353638
PA451866	venlafaxine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	23332809, 23357843, 23545896, 23799451, 28480819
PA451906	warfarin	Chemical	ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation	associated	PK	PD	18574025, 19752777, 21692828, 23941071, 25652102, 27356304, 8723744
PA452229	antidepressants	Chemical	GuidelineAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	associated	PK		15258107, 16772608, 21412232, 8148870, 8195181, 15168101, 15199661, 27023676
PA452615	moclobemide	Chemical	GuidelineAnnotation, LabelAnnotation	associated
PA452621	antineoplastic agents	Chemical	VariantAnnotation	ambiguous		PD	19156902, 23842856, 24682508
PA452632	acenocoumarol	Chemical	VariantAnnotation	ambiguous		PD	21636598, 23651023

References

Pubmed ID	Year	Title	Citations
37543868	2024	Clinical application of a real-time polymerase chain reaction test for CYP2C19 genotyping based on genotype distribution in a healthy Korean population.	0
37875597	2024	Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.	0
38092392	2024	Utility of the ACD-GENE-CLI Score in Asian Patients with Critical Limb Ischemia Undergoing Endovascular Interventions.	0
38114408	2024	Net clinical benefit of clopidogrel versus ticagrelor in elderly patients carrying CYP2C19 loss-of-function variants with acute coronary syndrome after percutaneous coronary intervention.	1
38503672	2024	Aiming for precision: CYP2C19 gene polymorphism and clopidogrel resistance in patients with peripheral artery disease.	0
38581109	2024	The association of CYP2C19 LoF alleles with adverse clinical outcomes in stroke patients taking clopidogrel: An updated meta-analysis.	1
38671468	2024	Genetic variability in stroke patients: CYP2C19 polymorphisms unraveled.	0
38874073	2024	CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention.	0
39025838	2024	Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis.	0
37543868	2024	Clinical application of a real-time polymerase chain reaction test for CYP2C19 genotyping based on genotype distribution in a healthy Korean population.	0
37875597	2024	Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.	0
38092392	2024	Utility of the ACD-GENE-CLI Score in Asian Patients with Critical Limb Ischemia Undergoing Endovascular Interventions.	0
38114408	2024	Net clinical benefit of clopidogrel versus ticagrelor in elderly patients carrying CYP2C19 loss-of-function variants with acute coronary syndrome after percutaneous coronary intervention.	1
38503672	2024	Aiming for precision: CYP2C19 gene polymorphism and clopidogrel resistance in patients with peripheral artery disease.	0
38581109	2024	The association of CYP2C19 LoF alleles with adverse clinical outcomes in stroke patients taking clopidogrel: An updated meta-analysis.	1

Citation

Dessen P

CYP2C19 (cytochrome P450 family 2 subfamily C member 19)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40243/cyp2c19

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