Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2C19 (cytochrome P450 family 2 subfamily C member 19)

Identity

Alias (NCBI)CPCJ
CYP2C
CYPIIC17
CYPIIC19
P450C2C
P450IIC19
HGNC (Hugo) CYP2C19
HGNC Alias symbP450IIC19
CPCJ
HGNC Previous nameCYP2C
HGNC Previous namecytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19
 cytochrome P450, family 2, subfamily C, polypeptide 19
LocusID (NCBI) 1557
Atlas_Id 40243
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 94762681 and ends at 94855547 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C10orf11 (10q22.2) / CYP2C19 (10q23.33)CCSER2 (10q23.1) / CYP2C19 (10q23.33)PLCE1 (10q23.33) / CYP2C19 (10q23.33)
SNX9 (6q25.3) / CYP2C19 (10q23.33)C10orf11 10q22.2 / CYP2C19 10q23.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CYP2C19   2621
Cards
Entrez_Gene (NCBI)CYP2C19    cytochrome P450 family 2 subfamily C member 19
AliasesCPCJ; CYP2C; CYPIIC17; CYPIIC19; 
P450C2C; P450IIC19
GeneCards (Weizmann)CYP2C19
Ensembl hg19 (Hinxton)ENSG00000165841 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165841 [Gene_View]  ENSG00000165841 [Sequence]  chr10:94762681-94855547 [Contig_View]  CYP2C19 [Vega]
ICGC DataPortalENSG00000165841
TCGA cBioPortalCYP2C19
AceView (NCBI)CYP2C19
Genatlas (Paris)CYP2C19
SOURCE (Princeton)CYP2C19
Genetics Home Reference (NIH)CYP2C19
Genomic and cartography
GoldenPath hg38 (UCSC)CYP2C19  -     chr10:94762681-94855547 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP2C19  -     10q23.33   [Description]    (hg19-Feb_2009)
GoldenPathCYP2C19 - 10q23.33 [CytoView hg19]  CYP2C19 - 10q23.33 [CytoView hg38]
ImmunoBaseENSG00000165841
Genome Data Viewer NCBICYP2C19 [Mapview hg19]  
OMIM124020   609535   
Gene and transcription
Genbank (Entrez)CB158473 CB161988 M61854 X65962
RefSeq transcript (Entrez)NM_000769
Consensus coding sequences : CCDS (NCBI)CYP2C19
Gene ExpressionCYP2C19 [ NCBI-GEO ]   CYP2C19 [ EBI - ARRAY_EXPRESS ]   CYP2C19 [ SEEK ]   CYP2C19 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2C19 [ Firebrowse - Broad ]
GenevisibleExpression of CYP2C19 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1557
GTEX Portal (Tissue expression)CYP2C19
Human Protein AtlasENSG00000165841-CYP2C19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33261   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33261  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33261
PhosPhoSitePlusP33261
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_sf   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2C19
PDB (RSDB)4GQS   
PDB Europe4GQS   
PDB (PDBSum)4GQS   
PDB (IMB)4GQS   
Structural Biology KnowledgeBase4GQS   
SCOP (Structural Classification of Proteins)4GQS   
CATH (Classification of proteins structures)4GQS   
SuperfamilyP33261
AlphaFold pdb e-kbP33261   
Human Protein Atlas [tissue]ENSG00000165841-CYP2C19 [tissue]
HPRD00486
Protein Interaction databases
DIP (DOE-UCLA)P33261
IntAct (EBI)P33261
BioGRIDCYP2C19
STRING (EMBL)CYP2C19
ZODIACCYP2C19
Ontologies - Pathways
QuickGOP33261
Ontology : AmiGOmonooxygenase activity  iron ion binding  cytoplasm  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  epoxygenase P450 pathway  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  heme binding  exogenous drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  aromatase activity  omega-hydroxylase P450 pathway  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  cytoplasm  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  epoxygenase P450 pathway  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  heme binding  exogenous drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  aromatase activity  omega-hydroxylase P450 pathway  
Pathways : KEGGArachidonic acid metabolism    Linoleic acid metabolism    Drug metabolism - cytochrome P450    Serotonergic synapse    Chemical carcinogenesis   
NDEx NetworkCYP2C19
Atlas of Cancer Signalling NetworkCYP2C19
Wikipedia pathwaysCYP2C19
Orthology - Evolution
OrthoDB1557
GeneTree (enSembl)ENSG00000165841
Phylogenetic Trees/Animal Genes : TreeFamCYP2C19
Homologs : HomoloGeneCYP2C19
Homology/Alignments : Family Browser (UCSC)CYP2C19
Gene fusions - Rearrangements
Fusion : MitelmanC10orf11/CYP2C19 [10q22.2/10q23.33]  
Fusion : MitelmanCCSER2/CYP2C19 [10q23.1/10q23.33]  
Fusion : MitelmanPLCE1/CYP2C19 [10q23.33/10q23.33]  
Fusion : QuiverCYP2C19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2C19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2C19
dbVarCYP2C19
ClinVarCYP2C19
MonarchCYP2C19
1000_GenomesCYP2C19 
Exome Variant ServerCYP2C19
GNOMAD BrowserENSG00000165841
Varsome BrowserCYP2C19
ACMGCYP2C19 variants
VarityP33261
Genomic Variants (DGV)CYP2C19 [DGVbeta]
DECIPHERCYP2C19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP2C19 
Mutations
ICGC Data PortalCYP2C19 
TCGA Data PortalCYP2C19 
Broad Tumor PortalCYP2C19
OASIS PortalCYP2C19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2C19  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYP2C19
Mutations and Diseases : HGMDCYP2C19
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCYP2C19
DgiDB (Drug Gene Interaction Database)CYP2C19
DoCM (Curated mutations)CYP2C19
CIViC (Clinical Interpretations of Variants in Cancer)CYP2C19
Cancer3DCYP2C19
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124020    609535   
Orphanet19387    19394    23059   
DisGeNETCYP2C19
MedgenCYP2C19
Genetic Testing Registry CYP2C19
NextProtP33261 [Medical]
GENETestsCYP2C19
Target ValidationCYP2C19
Huge Navigator CYP2C19 [HugePedia]
ClinGenCYP2C19
Clinical trials, drugs, therapy
MyCancerGenomeCYP2C19
Protein Interactions : CTDCYP2C19
Pharm GKB GenePA124
Pharm GKB PathwaysPA145011108   PA145011109   PA145011111   PA145011113   PA145011115   PA145011119   PA152325160   PA152530846   PA154424674   PA154444041   PA161749012   PA162359940   PA164713427   PA164713429   PA165111375   PA165817070   PA165960076   PA165981686   PA166014758   PA166041114   PA166121347   PA2034   
PharosP33261
Clinical trialCYP2C19
Miscellaneous
canSAR (ICR)CYP2C19
HarmonizomeCYP2C19
DataMed IndexCYP2C19
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCYP2C19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:56 CEST 2021

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