Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19)

Identity

Other namesCPCJ
CYP2C
P450C2C
P450IIC19
HGNC (Hugo) CYP2C19
LocusID (NCBI) 1557
Location 10q23.33
Location_base_pair Starts at 96522463 and ends at 96612671 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP2C19   2621
Cards
Entrez_Gene (NCBI)CYP2C19  1557  cytochrome P450, family 2, subfamily C, polypeptide 19
GeneCards (Weizmann)CYP2C19
Ensembl (Hinxton) [Gene_View]  chr10:96522463-96612671 [Contig_View]  CYP2C19 [Vega]
cBioPortalCYP2C19
AceView (NCBI)CYP2C19
Genatlas (Paris)CYP2C19
WikiGenes1557
SOURCE (Princeton)NM_000769
Genomic and cartography
GoldenPath (UCSC)CYP2C19  -  10q23.33   chr10:96522463-96612671 +  10q23.33   [Description]    (hg19-Feb_2009)
EnsemblCYP2C19 - 10q23.33 [CytoView]
Mapping of homologs : NCBICYP2C19 [Mapview]
OMIM124020   609535   
Gene and transcription
Genbank (Entrez)BC111846 M61854 X65962
RefSeq transcript (Entrez)NM_000769
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_008384 NT_030059 NW_001838005 NW_004929376
Consensus coding sequences : CCDS (NCBI)CYP2C19
Cluster EST : UnigeneHs.282409 [ NCBI ]
CGAP (NCI)Hs.282409
Alternative Splicing : Fast-db (Paris)GSHG0003578
Gene ExpressionCYP2C19 [ NCBI-GEO ]     CYP2C19 [ SEEK ]   CYP2C19 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33261 (Uniprot)
NextProtP33261  [Medical]
With graphics : InterProP33261
Splice isoforms : SwissVarP33261 (Swissvar)
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450 [organisation]   Cyt_P450_CS [organisation]   Cyt_P450_E_grp-I [organisation]  
Related proteins : CluSTrP33261
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1557
Blocks (Seattle)P33261
PDB (SRS)4GQS   
PDB (PDBSum)4GQS   
PDB (IMB)4GQS   
PDB (RSDB)4GQS   
Peptide AtlasP33261
HPRD00486
IPIIPI00013323   IPI00657852   
Protein Interaction databases
DIP (DOE-UCLA)P33261
IntAct (EBI)P33261
BioGRIDCYP2C19
InParanoidP33261
Interologous Interaction database P33261
IntegromeDBCYP2C19
STRING (EMBL)CYP2C19
Ontologies - Pathways
Ontology : AmiGOmonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  small molecule metabolic process  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  exogenous drug catabolic process  intracellular membrane-bounded organelle  small molecule metabolic process  heterocycle metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  omega-hydroxylase P450 pathway  
Pathways : KEGGArachidonic acid metabolism    Linoleic acid metabolism    Drug metabolism - cytochrome P450    Serotonergic synapse    Chemical carcinogenesis   
Protein Interaction DatabaseCYP2C19
Wikipedia pathwaysCYP2C19
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP2C19
snp3D : Map Gene to Disease1557
SNP (GeneSNP Utah)CYP2C19
SNP : HGBaseCYP2C19
Genetic variants : HAPMAPCYP2C19
Exome VariantCYP2C19
1000_GenomesCYP2C19 
Somatic Mutations in Cancer : COSMICCYP2C19 
CONAN: Copy Number AnalysisCYP2C19 
Mutations and Diseases : HGMDCYP2C19
Mutations and Diseases : intOGenCYP2C19
Genomic VariantsCYP2C19  CYP2C19 [DGVbeta]
dbVarCYP2C19
ClinVarCYP2C19
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM124020    609535   
MedgenCYP2C19
GENETestsCYP2C19
Disease Genetic AssociationCYP2C19
Huge Navigator CYP2C19 [HugePedia]  CYP2C19 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCYP2C19
Homology/Alignments : Family Browser (UCSC)CYP2C19
Phylogenetic Trees/Animal Genes : TreeFamCYP2C19
Chemical/Protein Interactions : CTD1557
Chemical/Pharm GKB GenePA124
Clinical trialCYP2C19
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCYP2C19
iHOPCYP2C19
OncoSearchCYP2C19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:43:53 CEST 2014

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