Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CYP2C8 (cytochrome P450 family 2 subfamily C member 8)

Identity

Alias_namescytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
cytochrome P450, family 2, subfamily C, polypeptide 8
Alias_symbol (synonym)CPC8
Other aliasCYPIIC8
MP-12/MP-20
HGNC (Hugo) CYP2C8
LocusID (NCBI) 1558
Atlas_Id 40244
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 95036772 and ends at 95069497 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP2C8   2622
Cards
Entrez_Gene (NCBI)CYP2C8  1558  cytochrome P450 family 2 subfamily C member 8
AliasesCPC8; CYPIIC8; MP-12/MP-20
GeneCards (Weizmann)CYP2C8
Ensembl hg19 (Hinxton)ENSG00000138115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138115 [Gene_View]  chr10:95036772-95069497 [Contig_View]  CYP2C8 [Vega]
ICGC DataPortalENSG00000138115
TCGA cBioPortalCYP2C8
AceView (NCBI)CYP2C8
Genatlas (Paris)CYP2C8
WikiGenes1558
SOURCE (Princeton)CYP2C8
Genetics Home Reference (NIH)CYP2C8
Genomic and cartography
GoldenPath hg38 (UCSC)CYP2C8  -     chr10:95036772-95069497 -  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP2C8  -     10q23.33   [Description]    (hg19-Feb_2009)
EnsemblCYP2C8 - 10q23.33 [CytoView hg19]  CYP2C8 - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBICYP2C8 [Mapview hg19]  CYP2C8 [Mapview hg38]
OMIM601129   
Gene and transcription
Genbank (Entrez)AK292753 AK293327 AK293328 AK298401 AK303813
RefSeq transcript (Entrez)NM_000770 NM_001198853 NM_001198854 NM_001198855 NM_030878
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP2C8
Cluster EST : UnigeneHs.709188 [ NCBI ]
CGAP (NCI)Hs.709188
Alternative Splicing GalleryENSG00000138115
Gene ExpressionCYP2C8 [ NCBI-GEO ]   CYP2C8 [ EBI - ARRAY_EXPRESS ]   CYP2C8 [ SEEK ]   CYP2C8 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2C8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1558
GTEX Portal (Tissue expression)CYP2C8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10632   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10632  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10632
Splice isoforms : SwissVarP10632
PhosPhoSitePlusP10632
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2C8
DMDM Disease mutations1558
Blocks (Seattle)CYP2C8
PDB (SRS)1PQ2    2NNH    2NNI    2NNJ    2VN0   
PDB (PDBSum)1PQ2    2NNH    2NNI    2NNJ    2VN0   
PDB (IMB)1PQ2    2NNH    2NNI    2NNJ    2VN0   
PDB (RSDB)1PQ2    2NNH    2NNI    2NNJ    2VN0   
Structural Biology KnowledgeBase1PQ2    2NNH    2NNI    2NNJ    2VN0   
SCOP (Structural Classification of Proteins)1PQ2    2NNH    2NNI    2NNJ    2VN0   
CATH (Classification of proteins structures)1PQ2    2NNH    2NNI    2NNJ    2VN0   
SuperfamilyP10632
Human Protein AtlasENSG00000138115
Peptide AtlasP10632
HPRD03083
IPIIPI00290301   IPI00982751   IPI00921969   IPI00983341   IPI01018126   IPI00982165   IPI00978961   IPI00980447   IPI00981469   
Protein Interaction databases
DIP (DOE-UCLA)P10632
IntAct (EBI)P10632
FunCoupENSG00000138115
BioGRIDCYP2C8
STRING (EMBL)CYP2C8
ZODIACCYP2C8
Ontologies - Pathways
QuickGOP10632
Ontology : AmiGOlipid hydroxylation  monooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  drug metabolic process  epoxygenase P450 pathway  epoxygenase P450 pathway  oxygen binding  heme binding  organelle membrane  caffeine oxidase activity  exogenous drug catabolic process  oxidation-reduction process  aromatase activity  oxidative demethylation  omega-hydroxylase P450 pathway  estrogen 16-alpha-hydroxylase activity  
Ontology : EGO-EBIlipid hydroxylation  monooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  drug metabolic process  epoxygenase P450 pathway  epoxygenase P450 pathway  oxygen binding  heme binding  organelle membrane  caffeine oxidase activity  exogenous drug catabolic process  oxidation-reduction process  aromatase activity  oxidative demethylation  omega-hydroxylase P450 pathway  estrogen 16-alpha-hydroxylase activity  
Pathways : KEGGArachidonic acid metabolism    Linoleic acid metabolism    Retinol metabolism    Drug metabolism - cytochrome P450    Serotonergic synapse    Chemical carcinogenesis   
NDEx NetworkCYP2C8
Atlas of Cancer Signalling NetworkCYP2C8
Wikipedia pathwaysCYP2C8
Orthology - Evolution
OrthoDB1558
GeneTree (enSembl)ENSG00000138115
Phylogenetic Trees/Animal Genes : TreeFamCYP2C8
HOVERGENP10632
HOGENOMP10632
Homologs : HomoloGeneCYP2C8
Homology/Alignments : Family Browser (UCSC)CYP2C8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2C8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2C8
dbVarCYP2C8
ClinVarCYP2C8
1000_GenomesCYP2C8 
Exome Variant ServerCYP2C8
ExAC (Exome Aggregation Consortium)CYP2C8 (select the gene name)
Genetic variants : HAPMAP1558
Genomic Variants (DGV)CYP2C8 [DGVbeta]
DECIPHERCYP2C8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP2C8 
Mutations
ICGC Data PortalCYP2C8 
TCGA Data PortalCYP2C8 
Broad Tumor PortalCYP2C8
OASIS PortalCYP2C8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2C8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP2C8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP2C8
DgiDB (Drug Gene Interaction Database)CYP2C8
DoCM (Curated mutations)CYP2C8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2C8 (select a term)
intoGenCYP2C8
Cancer3DCYP2C8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601129   
Orphanet
MedgenCYP2C8
Genetic Testing Registry CYP2C8
NextProtP10632 [Medical]
TSGene1558
GENETestsCYP2C8
Target ValidationCYP2C8
Huge Navigator CYP2C8 [HugePedia]
snp3D : Map Gene to Disease1558
BioCentury BCIQCYP2C8
ClinGenCYP2C8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1558
Chemical/Pharm GKB GenePA125
Clinical trialCYP2C8
Miscellaneous
canSAR (ICR)CYP2C8 (select the gene name)
Probes
Litterature
PubMed200 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2C8
EVEXCYP2C8
GoPubMedCYP2C8
iHOPCYP2C8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:23 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.