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CYP2C9 (cytochrome P450 family 2 subfamily C member 9)

Identity

Alias_namesCYP2C10
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9
cytochrome P450, family 2, subfamily C, polypeptide 9
Alias_symbol (synonym)P450IIC9
Other aliasCPC9
CYP2C
CYPIIC9
HGNC (Hugo) CYP2C9
LocusID (NCBI) 1559
Atlas_Id 40245
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 96698415 and ends at 96749148 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SMG1 (16p12.3) / CYP2C9 (10q23.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP2C9   2623
Cards
Entrez_Gene (NCBI)CYP2C9  1559  cytochrome P450 family 2 subfamily C member 9
AliasesCPC9; CYP2C; CYP2C10; CYPIIC9; 
P450IIC9
GeneCards (Weizmann)CYP2C9
Ensembl hg19 (Hinxton)ENSG00000138109 [Gene_View]  chr10:96698415-96749148 [Contig_View]  CYP2C9 [Vega]
Ensembl hg38 (Hinxton)ENSG00000138109 [Gene_View]  chr10:96698415-96749148 [Contig_View]  CYP2C9 [Vega]
ICGC DataPortalENSG00000138109
TCGA cBioPortalCYP2C9
AceView (NCBI)CYP2C9
Genatlas (Paris)CYP2C9
WikiGenes1559
SOURCE (Princeton)CYP2C9
Genetics Home Reference (NIH)CYP2C9
Genomic and cartography
GoldenPath hg19 (UCSC)CYP2C9  -     chr10:96698415-96749148 +  10q23.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP2C9  -     10q23.33   [Description]    (hg38-Dec_2013)
EnsemblCYP2C9 - 10q23.33 [CytoView hg19]  CYP2C9 - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBICYP2C9 [Mapview hg19]  CYP2C9 [Mapview hg38]
OMIM122700   601130   
Gene and transcription
Genbank (Entrez)AK289420 AK298458 BC020754 BC070317 BC125054
RefSeq transcript (Entrez)NM_000771
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_008385 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)CYP2C9
Cluster EST : UnigeneHs.282624 [ NCBI ]
CGAP (NCI)Hs.282624
Alternative Splicing GalleryENSG00000138109
Gene ExpressionCYP2C9 [ NCBI-GEO ]   CYP2C9 [ EBI - ARRAY_EXPRESS ]   CYP2C9 [ SEEK ]   CYP2C9 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2C9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1559
GTEX Portal (Tissue expression)CYP2C9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11712   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11712  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11712
Splice isoforms : SwissVarP11712
PhosPhoSitePlusP11712
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2C9
DMDM Disease mutations1559
Blocks (Seattle)CYP2C9
PDB (SRS)1OG2    1OG5    1R9O    4NZ2   
PDB (PDBSum)1OG2    1OG5    1R9O    4NZ2   
PDB (IMB)1OG2    1OG5    1R9O    4NZ2   
PDB (RSDB)1OG2    1OG5    1R9O    4NZ2   
Structural Biology KnowledgeBase1OG2    1OG5    1R9O    4NZ2   
SCOP (Structural Classification of Proteins)1OG2    1OG5    1R9O    4NZ2   
CATH (Classification of proteins structures)1OG2    1OG5    1R9O    4NZ2   
SuperfamilyP11712
Human Protein AtlasENSG00000138109
Peptide AtlasP11712
HPRD03084
IPIIPI00007219   IPI01010379   
Protein Interaction databases
DIP (DOE-UCLA)P11712
IntAct (EBI)P11712
FunCoupENSG00000138109
BioGRIDCYP2C9
STRING (EMBL)CYP2C9
ZODIACCYP2C9
Ontologies - Pathways
QuickGOP11712
Ontology : AmiGOcholesterol 25-hydroxylase activity  monooxygenase activity  monooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  drug binding  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  epoxygenase P450 pathway  epoxygenase P450 pathway  urea metabolic process  oxygen binding  heme binding  monocarboxylic acid metabolic process  caffeine oxidase activity  drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  cellular amide metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  oxidative demethylation  omega-hydroxylase P450 pathway  
Ontology : EGO-EBIcholesterol 25-hydroxylase activity  monooxygenase activity  monooxygenase activity  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  drug binding  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  drug metabolic process  (S)-limonene 6-monooxygenase activity  (S)-limonene 7-monooxygenase activity  epoxygenase P450 pathway  epoxygenase P450 pathway  urea metabolic process  oxygen binding  heme binding  monocarboxylic acid metabolic process  caffeine oxidase activity  drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  cellular amide metabolic process  (R)-limonene 6-monooxygenase activity  oxidation-reduction process  oxidative demethylation  omega-hydroxylase P450 pathway  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGArachidonic acid metabolism    Linoleic acid metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Serotonergic synapse    Chemical carcinogenesis   
NDEx NetworkCYP2C9
Atlas of Cancer Signalling NetworkCYP2C9
Wikipedia pathwaysCYP2C9
Orthology - Evolution
OrthoDB1559
GeneTree (enSembl)ENSG00000138109
Phylogenetic Trees/Animal Genes : TreeFamCYP2C9
HOVERGENP11712
HOGENOMP11712
Homologs : HomoloGeneCYP2C9
Homology/Alignments : Family Browser (UCSC)CYP2C9
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2C9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2C9
dbVarCYP2C9
ClinVarCYP2C9
1000_GenomesCYP2C9 
Exome Variant ServerCYP2C9
ExAC (Exome Aggregation Consortium)CYP2C9 (select the gene name)
Genetic variants : HAPMAP1559
Genomic Variants (DGV)CYP2C9 [DGVbeta]
DECIPHER (Syndromes)10:96698415-96749148  ENSG00000138109
CONAN: Copy Number AnalysisCYP2C9 
Mutations
ICGC Data PortalCYP2C9 
TCGA Data PortalCYP2C9 
Broad Tumor PortalCYP2C9
OASIS PortalCYP2C9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2C9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP2C9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP2C9
DgiDB (Drug Gene Interaction Database)CYP2C9
DoCM (Curated mutations)CYP2C9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2C9 (select a term)
intoGenCYP2C9
Cancer3DCYP2C9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM122700    601130   
Orphanet23060    23061   
MedgenCYP2C9
Genetic Testing Registry CYP2C9
NextProtP11712 [Medical]
TSGene1559
GENETestsCYP2C9
Huge Navigator CYP2C9 [HugePedia]
snp3D : Map Gene to Disease1559
BioCentury BCIQCYP2C9
ClinGenCYP2C9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1559
Chemical/Pharm GKB GenePA126
Clinical trialCYP2C9
Miscellaneous
canSAR (ICR)CYP2C9 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2C9
EVEXCYP2C9
GoPubMedCYP2C9
iHOPCYP2C9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:58:15 CEST 2017

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