CYP2C9 (cytochrome P450 family 2 subfamily C member 9)

2003-08-01  

Identity

HGNC
CYP2C9
LOCATION
10q23.33
LOCUSID
1559
ALIAS
CPC9,CYP2C,CYP2C10,CYPIIC9,P450IIC9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1559
MIM: 601130
HGNC: 2623
Ensembl: ENSG00000138109

Variants:

dbSNP: 1559
ClinVar: 1559
TCGA: ENSG00000138109
COSMIC: CYP2C9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138109ENST00000260682P11712
ENSG00000138109ENST00000260682S5RV20
ENSG00000138109ENST00000461906P11712
ENSG00000138109ENST00000643112A0A2R8YF67

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)REACTOMER-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10034bosentanChemicalVariantAnnotationambiguousPKPD24048276, 24842639
PA10075esomeprazoleChemicalLabelAnnotationassociated
PA10233voriconazoleChemicalLabelAnnotation, VariantAnnotationambiguousPK26886310
PA10390sulfonamides, urea derivativesChemicalClinicalAnnotationassociatedPD19794412, 24442125, 29681852
PA10892gliclazideChemicalGuidelineAnnotation, VariantAnnotationassociated24442125
PA124CYP2C19GeneDataAnnotationassociated
PA131301952gefitinibChemicalLiterature, MultilinkAnnotationassociated24433361
PA131890625tenoxicamChemicalClinicalAnnotation, GuidelineAnnotation, VariantAnnotationassociatedPK15229460, 18992346
PA133787052VKORC1GeneDataAnnotation, VipGeneassociated12931134, 14765194, 14765195, 15358623, 15597574, 15865594, 15930419, 15938684, 16888441, 16960144, 16983400, 17124101, 9684798, 11926893
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134308647rosuvastatinChemicalVariantAnnotationnot associatedPK23930675
PA134852920benzbromaroneChemicalMultilinkAnnotation, VariantAnnotationassociatedPK20962433, 25876828
PA143485705antiepilepticsChemicalVariantAnnotationassociatedPD
PA154410481prasugrelChemicalLabelAnnotationassociated
PA162316739Maculopapular ExanthemaDiseaseClinicalAnnotation, VariantAnnotationambiguousPD20941486, 25096692
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD17681167
PA164744895gliquidoneChemicalVariantAnnotationassociated24442125
PA164746757tolterodineChemicalLabelAnnotationassociated
PA164784021ethambutolChemicalClinicalAnnotationassociatedPD20941486
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPKPD17900275, 19463375, 19934793, 20833683, 21831410, 22990067, 27756942
PA165111675Drug ResistanceDiseaseVariantAnnotationassociatedPD
PA165816542CYP2C9*1HaplotypeLabelAnnotationassociated
PA165816543CYP2C9*2HaplotypeGuidelineAnnotation, LabelAnnotation, VipGeneassociated11927841, 14597963, 15469410, 15637526, 16863464, 19151603, 8004131, 9241660, 11337938
PA165816544CYP2C9*3HaplotypeGuidelineAnnotation, LabelAnnotation, VipGeneassociated11927841, 12698304, 14597963, 15289789, 15637526, 19082874, 10761997
PA165816546CYP2C9*5HaplotypeGuidelineAnnotationassociated
PA165816547CYP2C9*6HaplotypeGuidelineAnnotationassociated
PA165816549CYP2C9*8HaplotypeGuidelineAnnotationassociated
PA165816552CYP2C9*11HaplotypeGuidelineAnnotationassociated
PA165954769HLA-B*15:02:01HaplotypeLabelAnnotationassociated
PA165958395lornoxicamChemicalClinicalAnnotation, GuidelineAnnotation, VariantAnnotation, VipGeneassociatedPK15764711, 16182270, 16342679
PA165980614fluindioneChemicalGuidelineAnnotation, VariantAnnotationambiguousPK
PA166119041drug-induced liver injuryDiseaseVariantAnnotationambiguousPD24842639
PA166120927drug reaction with eosinophilia and systemic symptomsDiseaseVariantAnnotationambiguousPD25096692, 29458119
PA166120929severe cutaneous adverse reactionsDiseaseVariantAnnotationassociatedPD25994870
PA166122646hemopoietic stem cell transplantDiseaseClinicalAnnotationassociatedPK24165757
PA166123298over-anticoagulationDiseaseVariantAnnotationambiguousPD11692083, 11926893, 12414349, 12634980, 14614357, 15001971, 15116052, 15128048, 15536456, 16815313, 17226852, 17324110, 17989110, 18690342, 18781852, 19225451, 19794411, 20354686, 21318593, 22252093, 22571356, 22990331, 23016521, 23104259, 23279643, 23602689, 24911077, 24919870, 24956252, 25769357
PA166123431heart valve replacementDiseaseClinicalAnnotation, VariantAnnotationassociatedPD11926893, 17324110, 17955230, 18322281, 18690342, 19077919, 23279643, 24474498, 25504915, 29396738
PA166123766platelet aggregationDiseaseVariantAnnotationambiguousPD28745576
PA166124478endoxifenChemicalVariantAnnotationnot associatedPK15632378, 29436156
PA166127651n-desmethyltamoxifenChemicalVariantAnnotationnot associatedPK29436156
PA1661276524-hydroxytamoxifenChemicalVariantAnnotationambiguousPK29436156
PA166129530time to achieve stable doseDiseaseVariantAnnotationambiguousPD11926893, 15116052, 16815313, 17324110, 17955230, 18690342, 21057703, 23279643, 24956252
PA166129531time in therapeutic rangeDiseaseVariantAnnotationambiguousPD10961881, 12414349, 17226852, 17955230, 18690342, 26469104, 27511999
PA166129532time to therapeutic inrDiseaseVariantAnnotationambiguousPD11926893, 17226852, 19794411, 20339978, 20386359, 20833980, 21148049, 21318593, 22571356, 23279643, 29396738
PA166129534time above therapeutic rangeDiseaseVariantAnnotationassociatedPD26469104
PA166129560major adverse cardiac events (mace)DiseaseVariantAnnotationnot associatedPD28745576
PA166129562time below therapeutic rangeDiseaseVariantAnnotationassociatedPD23016521
PA1661313884-hydroxycyclophosphamideChemicalVipGeneassociated18496131, 12684728
PA166151827adverse eventsDiseaseVariantAnnotationnot associatedPD
PA166153431flibanserinChemicalLabelAnnotationassociated
PA166153491brivaracetamChemicalLabelAnnotationassociated
PA166153959rs1057910VariantVipGeneassociated11927841, 12698304, 14597963, 15289789, 15637526, 19082874, 10761997
PA166153972rs1799853VariantVipGeneassociated11927841, 14597963, 15469410, 15637526, 16863464, 19151603, 8004131, 9241660, 11337938
PA166154157rs12777823VariantGuidelineAnnotationassociated
PA166155091rs9923231VariantGuidelineAnnotation, LabelAnnotationassociated
PA166155096rs9934438VariantGuidelineAnnotationassociated
PA166155381rs2108622VariantGuidelineAnnotationassociated
PA166160006lesinuradChemicalLabelAnnotationassociated
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166179849avatrombopagChemicalLabelAnnotationassociated
PA166182720erdafitinibChemicalLabelAnnotationassociated
PA166182736siponimodChemicalGuidelineAnnotation, LabelAnnotationassociated
PA166182883ospemifeneChemicalLabelAnnotationassociated
PA27121CYP4F2GeneDataAnnotationassociated
PA28660GGCXGeneDataAnnotationassociated
PA443309AlcoholismDiseaseVariantAnnotationassociated
PA443459Atrial FibrillationDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD11926893, 15094935, 15970795, 17324110, 17955230, 18322281, 18690342, 19077919, 19387626, 20072124, 21590310, 21635147, 21981797, 22040439, 22534826, 22676192, 23113310, 23279643, 24108193, 24251363, 24474498, 25089947, 25504915, 25769357, 27121899, 29396738, 29479633, 29986700
PA443460Atrial FlutterDiseaseVariantAnnotationassociatedPD29479633
PA443523Blood Coagulation DisordersDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD11692083, 12414349, 12634980, 14614357, 15116052, 15128048, 16815313, 18781852, 19225451, 22252093, 23651023, 24911077, 24919870, 24956252, 29479633
PA443560Breast NeoplasmsDiseaseVariantAnnotationambiguousPKPD15632378, 18024866, 29436156
PA443635Cardiovascular DiseasesDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD10509530, 11926893, 12496751, 12621390, 14656880, 15001971, 15094935, 15590403, 15841315, 15883587, 15947090, 16493479, 16890578, 17049586, 17391071, 17510308, 17851566, 17989110, 18756910, 18836275, 19031075, 19077919, 19135231, 19177029, 19582440, 19745563, 20421126, 21174619, 21185752, 21326313, 21590310, 21782804, 21981797, 22010099, 22040439, 22075505, 22349464, 22528326, 22534826, 22549502, 22594507, 22676192, 22854539, 22855348, 22892446, 22990331, 23061746, 23104259, 23183958, 23208322, 23279643, 23949431, 24029542, 24474498, 25042728, 25084205, 26517138, 29298995, 31395958, 31653973
PA443636Carotid Artery DiseasesDiseaseVariantAnnotationnot associatedPD26526111
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPKPD17900275, 19463375, 19934793, 20833683, 21831410, 22990067, 27756942
PA443886Diabetes MellitusDiseaseVariantAnnotationassociated24442125
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotationassociatedPD19794412, 24442125, 29681852
PA443937Drug ToxicityDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD22641027, 26658169
PA444059Epidermal Necrolysis, ToxicDiseaseVariantAnnotationassociatedPD25096692, 26928377
PA444065EpilepsyDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD10774639, 10901705, 11434505, 11668218, 11673755, 12707459, 14659971, 15024534, 15385837, 16815679, 19030785, 20390258, 21068649, 21338443, 21532277, 21537551, 22641027, 25096692, 25162219, 25597548, 25994870, 25998968, 26122019, 26928377, 27163851, 9333104, 9860067
PA444250GastritisDiseaseVariantAnnotationassociatedPD26517138
PA444368Heart DiseasesDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD10509530, 11926893, 12496751, 12621390, 14656880, 15001971, 15094935, 15590403, 15841315, 15883587, 15947090, 16493479, 16890578, 17049586, 17391071, 17510308, 17851566, 17989110, 18756910, 18836275, 19031075, 19077919, 19135231, 19177029, 19582440, 19745563, 20421126, 21174619, 21185752, 21326313, 21590310, 21782804, 21981797, 22010099, 22040439, 22075505, 22349464, 22528326, 22534826, 22549502, 22594507, 22676192, 22854539, 22855348, 22892446, 22990331, 23061746, 23104259, 23183958, 23208322, 23279643, 23949431, 24029542, 24474498, 25042728, 25084205, 29298995, 31395958, 31653973
PA444398Hematoma, SubduralDiseaseVariantAnnotationassociatedPD
PA444417HemorrhageDiseaseClinicalAnnotation, MultilinkAnnotation, VariantAnnotationambiguousPD10509530, 11926893, 12414349, 12728288, 12876643, 14676821, 15213846, 15714076, 16699986, 17653141, 17955230, 18570163, 18574025, 18690342, 18752379, 18756910, 18950464, 19297219, 21148049, 22571356, 23104259, 23113310, 23348161, 23602689, 23774101, 23932037, 24474498, 24503627, 24602049, 25001883, 25244877, 25521356, 25585969, 25769357, 25858232, 26777610, 27488176, 27581200, 28033245, 28689179, 29432897, 29577257
PA444516HypercholesterolemiaDiseaseVariantAnnotationnot associatedPK23930675
PA444552HypertensionDiseaseVariantAnnotationambiguousPD18971529
PA444555Hypertension, PulmonaryDiseaseVariantAnnotationnot associatedPD24842639
PA444570HypoglycemiaDiseaseVariantAnnotationassociated24442125
PA444584HypotensionDiseaseClinicalAnnotation, VariantAnnotationassociatedPD23559402
PA444682Kidney DiseasesDiseaseVariantAnnotationassociatedPD
PA444773LeukopeniaDiseaseVariantAnnotationassociatedPD26894931
PA445019Myocardial InfarctionDiseaseVariantAnnotationnot associatedPD
PA445043Opioid-Related DisordersDiseaseVariantAnnotationnot associatedPK17178267
PA445062NeoplasmsDiseaseVariantAnnotationambiguousPD17226852
PA445208PainDiseaseVariantAnnotationassociatedPD
PA445465Pulmonary EmbolismDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD15094935, 15970795, 19387626, 20072124, 21590310, 21635147, 22676192, 27121899, 29986700
PA445506RecurrenceDiseaseVariantAnnotationnot associatedPD18024866
PA445553Rheumatic Heart DiseaseDiseaseVariantAnnotationassociatedPD27335128
PA445676Skin DiseasesDiseaseVariantAnnotationnot associatedPD29458119
PA445738Stevens-Johnson SyndromeDiseaseVariantAnnotationassociatedPD25096692, 26928377
PA445848ThromboembolismDiseaseVariantAnnotationassociatedPKPD22528326
PA445862ThyrotoxicosisDiseaseVariantAnnotationassociatedPD
PA445941TuberculosisDiseaseClinicalAnnotationassociatedPD20941486
PA446023VasculitisDiseaseVariantAnnotationassociatedPD26894931
PA446065Wegener GranulomatosisDiseaseVariantAnnotationassociatedPD26894931
PA446813Gingival OvergrowthDiseaseVariantAnnotationnot associatedPD14659971
PA446969Venous ThrombosisDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD15094935, 15970795, 19387626, 20072124, 21590310, 21635147, 22676192, 27121899, 29479633, 29986700
PA447054StrokeDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD15094935, 15970795, 19387626, 20072124, 21590310, 21635147, 22676192, 25989350, 27121899, 29986700
PA447199Bipolar DisorderDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD27353638
PA447207Depressive DisorderDiseaseVariantAnnotationnot associatedPD24663076
PA447208Mental DisordersDiseaseVariantAnnotationambiguousPK14726986, 18677622
PA447215Psychotic DisordersDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD27353638
PA447216SchizophreniaDiseaseVariantAnnotationnot associatedPK15260906
PA447230HIVDiseaseVariantAnnotationassociatedPD11186133
PA447276Thrombosis of cerebral veinsDiseaseVariantAnnotationassociatedPD24530212
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPKPD16094537, 21842338
PA447298venous thromboembolismDiseaseVariantAnnotationassociatedPD20421126, 24251363, 25089947
PA447321Depressive Disorder, MajorDiseaseVariantAnnotationambiguousPK16236141
PA448497aspirinChemicalVariantAnnotationassociatedPD20833683, 26517138
PA448500atorvastatinChemicalPathwayassociated
PA448691busulfanChemicalClinicalAnnotation, VariantAnnotationassociatedPK24165757
PA448817carvedilolChemicalLabelAnnotation, VariantAnnotationambiguousPK21599570
PA448871celecoxibChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGeneassociatedPKPD11337938, 12893985, 16153401, 16401468, 17681167, 22336956, 23996211, 25585969, 26360837, 27864660
PA449053clopidogrelChemicalClinicalAnnotation, Pathway, VariantAnnotationambiguousPKPD17900275, 19463375, 19934793, 20833683, 20938371, 21831410, 22929815, 22990067, 24262617, 26526111, 27756942, 28745576
PA449165cyclophosphamideChemicalVariantAnnotation, VipGeneassociatedPD18496131, 12684728, 26894931
PA449211dapsoneChemicalVariantAnnotationnot associatedPD29458119
PA449283diazepamChemicalVariantAnnotationassociatedPKPD22641027
PA449293diclofenacChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD17681167, 20814155, 23400009, 23959274, 25994031, 8417277
PA449409doxepinChemicalClinicalAnnotation, Pathway, VariantAnnotationassociatedPKPD12360109
PA449421dronabinolChemicalLabelAnnotationassociated
PA449653fluconazoleChemicalVariantAnnotationassociatedPK26886310
PA449673fluoxetineChemicalPathway, VariantAnnotationambiguousPKPD14726986, 16236141, 24663076
PA449683flurbiprofenChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotationassociatedPK12698304, 25712887, 32423989
PA449688fluvastatinChemicalClinicalAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD12891229, 17289397, 30363031, 7586933
PA449761glimepirideChemicalGuidelineAnnotation, VariantAnnotation, VipGeneassociated16325295, 12235454, 24442125
PA449762glipizideChemicalVariantAnnotation, VipGeneassociated10208645, 24442125
PA449782glibenclamideChemicalGuidelineAnnotation, VariantAnnotation, VipGeneassociated16342679, 24442125
PA449957ibuprofenChemicalClinicalAnnotation, GuidelineAnnotation, Pathway, VariantAnnotationambiguousPKPD12152005, 15289789, 18694831, 19480553, 25502615, 26122864
PA449982indomethacinChemicalClinicalAnnotation, VariantAnnotationassociatedPD12876643
PA450084irbesartanChemicalClinicalAnnotation, MultilinkAnnotationassociatedPKPD12359989, 16094537, 21842338
PA450112isoniazidChemicalClinicalAnnotationassociatedPD20941486
PA450268losartanChemicalClinicalAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD10096267, 11408373, 11823761, 15197523, 15289788, 18971529, 22294058, 22735459, 25303293, 25994031
PA450272lovastatinChemicalPathwayassociated
PA450353meloxicamChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGeneassociatedPK24322170, 24615047, 9493314
PA450401methadoneChemicalVariantAnnotationnot associatedPK17178267
PA450595naproxenChemicalClinicalAnnotation, VariantAnnotation, VipGeneambiguousPK17686967, 19280158, 32423989, 8866821
PA450600nateglinideChemicalPathway, VariantAnnotationassociatedPK22842957
PA450616nevirapineChemicalPathwayassociated
PA450688olanzapineChemicalClinicalAnnotation, VariantAnnotationassociatedPD23559402
PA450921phenprocoumonChemicalClinicalAnnotation, DataAnnotation, GuidelineAnnotation, VariantAnnotationambiguousPKPD12728288, 15128047, 15128048, 15213846, 15536456, 15742978, 16847664, 18629445, 19319511, 20020283, 20376629, 20833980, 21057703, 21063236, 23016521, 23423913, 24224579, 26984978, 30207196
PA450947phenytoinChemicalClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD10208645, 10774639, 10901705, 11434505, 11668218, 11673755, 12707459, 14659971, 15024534, 15385837, 16220110, 16815679, 19030785, 20390258, 21068649, 21338443, 21532277, 21537551, 22569204, 22641027, 25096692, 25099164, 25162219, 25597548, 25994870, 25998968, 26122019, 26658169, 26928377, 27163851, 32423989, 9333104, 9860067
PA450970pioglitazoneChemicalVariantAnnotationassociatedPK28099407
PA450985piroxicamChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotationassociatedPKPD16198655, 17112811
PA451141propofolChemicalVariantAnnotationassociatedPK24891132
PA451182pyrazinamideChemicalClinicalAnnotationassociatedPD20941486
PA451250rifampinChemicalClinicalAnnotationassociatedPD20941486
PA451257risperidoneChemicalVariantAnnotationnot associatedPK15260906
PA451283rosiglitazoneChemicalPathwayassociated
PA451333sertralineChemicalVariantAnnotationnot associatedPK18677622
PA451363simvastatinChemicalClinicalAnnotation, Pathway, VariantAnnotationambiguousPKPD17289397, 22594507
PA451544sulfamethoxazoleChemicalVariantAnnotationassociatedPD11186133
PA451581tamoxifenChemicalPathway, VariantAnnotation, VipGeneambiguousPKPD15632378, 18024866, 23962908, 29436156
PA451718tolbutamideChemicalClinicalAnnotation, GuidelineAnnotation, VariantAnnotation, VipGeneassociatedPK11875364, 15284535, 25994031, 27339126, 8742240
PA451791trimipramineChemicalClinicalAnnotation, VariantAnnotationassociatedPK14520122
PA451846valproic acidChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD14597963, 27353638
PA451906warfarinChemicalClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD8004131, 8747411, 8801057, 10073515, 10509530, 10961881, 11127854, 11926893, 12414349, 12496751, 12621390, 12634980, 12876643, 14521618, 14656880, 14676821, 15001971, 15094935, 15213846, 15590403, 15714076, 1581537, 15841315, 15883587, 15947090, 15970795, 16432637, 16493479, 16699986, 16863464, 16890578, 16983400, 17015052, 17049586, 17111199, 17226852, 17289397, 17324110, 17387222, 17391071, 17510308, 17653141, 17851566, 17955230, 17989110, 18030307, 18183038, 18305455, 18322281, 18466099, 18535201, 18542936, 18570163, 18574025, 18690342, 18698879, 18752379, 18756910, 18836275, 18950464, 19031075, 19074728, 19077919, 19135231, 19177029, 19228618, 19297219, 19300499, 19387626, 19582440, 19745563, 19752777, 19794411, 20072124, 20339191, 20339978, 20354686, 20386359, 20410877, 20421126, 20585834, 20833655, 20833980, 21110192, 21148049, 21174619, 21185752, 21228733, 21318593, 21326313, 21383771, 21590310, 21635147, 21725053, 21782804, 21900891, 21981797, 22010099, 22040439, 22075505, 22130800, 22248286, 22349464, 22528326, 22534826, 22549502, 22571356, 22594507, 22676192, 22854539, 22855348, 22892446, 22990331, 23061746, 23104259, 23113310, 23159229, 23183958, 23208322, 23279643, 23348161, 23582453, 23602689, 23688605, 23774101, 23932037, 23941071, 23949431, 24019055, 24029542, 24088130, 24251363, 24330000, 24474498, 24503627, 24602049, 24728385, 24911077, 25001883, 25026456, 25042728, 25075423, 25084205, 25126975, 25244877, 25312789, 25504915, 25521356, 25594941, 25712185, 25769357, 25858232, 25989350, 25994031, 26010205, 26219158, 26223945, 26257249, 26469104, 26777610, 27121899, 27488176, 27488389, 27511999, 27581200, 27617219, 27661060, 27878474, 28033245, 28049362, 28262345, 28429387, 28550460, 28689179, 28973620, 29054760, 29298995, 29396738, 29432897, 29577257, 29986700, 30821933, 31395958, 31653973, 32423989, 8004131, 9630825
PA451949zafirlukastChemicalClinicalAnnotation, VariantAnnotationassociatedPK27377818
PA451954zidovudineChemicalPathwayassociated22960662
PA452632acenocoumarolChemicalClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotationambiguousPKPD10509530, 11186138, 11557918, 11692083, 11926893, 12010835, 12123234, 12414349, 12634980, 12844136, 12876643, 14521618, 14614357, 14676821, 15116052, 15116053, 15128048, 15213846, 15714076, 15790782, 16699986, 16815313, 16863464, 17653141, 17955230, 18021343, 18570163, 18574025, 18690342, 18756910, 18781852, 18950464, 19018719, 19225451, 19277427, 19297219, 19578179, 20020283, 21148049, 21811894, 22252093, 22486182, 22571356, 22629463, 22911785, 22920394, 23104259, 23113310, 23159639, 23348161, 23473641, 23481074, 23582453, 23602689, 23651023, 23774101, 23774941, 23932037, 24108193, 24474498, 24503627, 24530212, 24602049, 24911077, 24919870, 24956252, 25001883, 25042728, 25089947, 25244877, 25519826, 25521356, 25769357, 25858232, 26777610, 26781925, 27335128, 27488176, 27581200, 28033245, 28689179, 29432897, 29479633, 29577257, 30983536
PA452637hormonal contraceptives for systemic useChemicalClinicalAnnotationassociatedPD28750087
PA55APOEGeneDataAnnotationassociated
PA7000sorafenibChemicalPathwayassociated28362716

References

Pubmed IDYearTitleCitations
377477732024Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.0
378755972024Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.0
382271542024Genetic variation of CYP2C9 gene and its correlation with cardiovascular disease risk factors.0
377477732024Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.0
378755972024Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.0
382271542024Genetic variation of CYP2C9 gene and its correlation with cardiovascular disease risk factors.0
366017112023Dosage exploration of meloxicam according to CYP2C9 genetic polymorphisms based on a population pharmacokinetic-pharmacodynamic model.1
366511852023Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study.4
367189582023Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients.0
367870942023CYP2C9 Polymorphisms and the Risk of Cardiovascular Events in Patients Treated with Clopidogrel: Combined Data from the POPular Genetics and POPular AGE Trials.2
368551702023Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences.10
369422992023The role of CYP2C9*2, CYP2C9*3 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study.3
369605182023Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant.0
370089232023Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects.1
372221582023The frequency of major ABCG2, SLCO1B1 and CYP2C9 variants in Asian, Native Hawaiian and Pacific Islander women subgroups: implications for personalized statins dosing.0

Citation

Dessen P

CYP2C9 (cytochrome P450 family 2 subfamily C member 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40245/cyp2c9