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CYP2D6 (cytochrome P450 family 2 subfamily D member 6)

Identity

Alias (NCBI)CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
HGNC (Hugo) CYP2D6
HGNC Alias symbCPD6
P450-DB1
CYP2D
P450C2D
HGNC Previous nameCYP2DL1
 CYP2D7P2
 CYP2D7BP
 CYP2D8P2
 CYP2D7AP
HGNC Previous namecytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
 cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2
 cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2
 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2
 cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2
 cytochrome P450, family 2, subfamily D, polypeptide 6
LocusID (NCBI) 1565
Atlas_Id 40246
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 42126499 and ends at 42130810 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CYP2D6   2625
LRG (Locus Reference Genomic)LRG_303
Cards
Entrez_Gene (NCBI)CYP2D6    cytochrome P450 family 2 subfamily D member 6
AliasesCPD6; CYP2D; CYP2D7AP; CYP2D7BP; 
CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1
GeneCards (Weizmann)CYP2D6
Ensembl hg19 (Hinxton)ENSG00000100197 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100197 [Gene_View]  ENSG00000100197 [Sequence]  chr22:42126499-42130810 [Contig_View]  CYP2D6 [Vega]
ICGC DataPortalENSG00000100197
TCGA cBioPortalCYP2D6
AceView (NCBI)CYP2D6
Genatlas (Paris)CYP2D6
SOURCE (Princeton)CYP2D6
Genetics Home Reference (NIH)CYP2D6
Genomic and cartography
GoldenPath hg38 (UCSC)CYP2D6  -     chr22:42126499-42130810 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP2D6  -     22q13.2   [Description]    (hg19-Feb_2009)
GoldenPathCYP2D6 - 22q13.2 [CytoView hg19]  CYP2D6 - 22q13.2 [CytoView hg38]
ImmunoBaseENSG00000100197
Genome Data Viewer NCBICYP2D6 [Mapview hg19]  
OMIM124030   608902   
Gene and transcription
Genbank (Entrez)AK309600 AW297258 AY663390 BC066877 BC067432
RefSeq transcript (Entrez)NM_000106 NM_001025161
Consensus coding sequences : CCDS (NCBI)CYP2D6
Gene ExpressionCYP2D6 [ NCBI-GEO ]   CYP2D6 [ EBI - ARRAY_EXPRESS ]   CYP2D6 [ SEEK ]   CYP2D6 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2D6 [ Firebrowse - Broad ]
GenevisibleExpression of CYP2D6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1565
GTEX Portal (Tissue expression)CYP2D6
Human Protein AtlasENSG00000100197-CYP2D6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10635   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10635  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10635
PhosPhoSitePlusP10635
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2D-like    Cyt_P450_sf   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2D6
PDB (RSDB)2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
PDB Europe2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
PDB (PDBSum)2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
PDB (IMB)2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
Structural Biology KnowledgeBase2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
SCOP (Structural Classification of Proteins)2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
CATH (Classification of proteins structures)2F9Q    3QM4    3TBG    3TDA    4WNT    4WNU    4WNV    4WNW    4XRY    4XRZ    5TFT    5TFU    6CSB    6CSD   
SuperfamilyP10635
AlphaFold pdb e-kbP10635   
Human Protein Atlas [tissue]ENSG00000100197-CYP2D6 [tissue]
HPRD00487
Protein Interaction databases
DIP (DOE-UCLA)P10635
IntAct (EBI)P10635
BioGRIDCYP2D6
STRING (EMBL)CYP2D6
ZODIACCYP2D6
Ontologies - Pathways
QuickGOP10635
Ontology : AmiGOmonooxygenase activity  iron ion binding  cytoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  cholesterol metabolic process  estrogen metabolic process  steroid hydroxylase activity  coumarin metabolic process  alkaloid metabolic process  alkaloid catabolic process  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  arachidonic acid metabolic process  heme binding  heme binding  isoquinoline alkaloid metabolic process  retinol metabolic process  retinol metabolic process  drug catabolic process  exogenous drug catabolic process  long-chain fatty acid biosynthetic process  intracellular membrane-bounded organelle  heterocycle metabolic process  negative regulation of binding  anandamide 8,9 epoxidase activity  anandamide 11,12 epoxidase activity  anandamide 14,15 epoxidase activity  oxidative demethylation  negative regulation of cellular organofluorine metabolic process  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  cytoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  organic acid metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  cholesterol metabolic process  estrogen metabolic process  steroid hydroxylase activity  coumarin metabolic process  alkaloid metabolic process  alkaloid catabolic process  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  arachidonic acid metabolic process  heme binding  heme binding  isoquinoline alkaloid metabolic process  retinol metabolic process  retinol metabolic process  drug catabolic process  exogenous drug catabolic process  long-chain fatty acid biosynthetic process  intracellular membrane-bounded organelle  heterocycle metabolic process  negative regulation of binding  anandamide 8,9 epoxidase activity  anandamide 11,12 epoxidase activity  anandamide 14,15 epoxidase activity  oxidative demethylation  negative regulation of cellular organofluorine metabolic process  
Pathways : KEGGMetabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Serotonergic synapse   
NDEx NetworkCYP2D6
Atlas of Cancer Signalling NetworkCYP2D6
Wikipedia pathwaysCYP2D6
Orthology - Evolution
OrthoDB1565
GeneTree (enSembl)ENSG00000100197
Phylogenetic Trees/Animal Genes : TreeFamCYP2D6
Homologs : HomoloGeneCYP2D6
Homology/Alignments : Family Browser (UCSC)CYP2D6
Gene fusions - Rearrangements
Fusion : QuiverCYP2D6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2D6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2D6
dbVarCYP2D6
ClinVarCYP2D6
MonarchCYP2D6
1000_GenomesCYP2D6 
Exome Variant ServerCYP2D6
GNOMAD BrowserENSG00000100197
Varsome BrowserCYP2D6
ACMGCYP2D6 variants
VarityP10635
Genomic Variants (DGV)CYP2D6 [DGVbeta]
DECIPHERCYP2D6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP2D6 
Mutations
ICGC Data PortalCYP2D6 
TCGA Data PortalCYP2D6 
Broad Tumor PortalCYP2D6
OASIS PortalCYP2D6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2D6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYP2D6
Mutations and Diseases : HGMDCYP2D6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCYP2D6
DgiDB (Drug Gene Interaction Database)CYP2D6
DoCM (Curated mutations)CYP2D6
CIViC (Clinical Interpretations of Variants in Cancer)CYP2D6
Cancer3DCYP2D6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124030    608902   
Orphanet19360    19400    23059   
DisGeNETCYP2D6
MedgenCYP2D6
Genetic Testing Registry CYP2D6
NextProtP10635 [Medical]
GENETestsCYP2D6
Target ValidationCYP2D6
Huge Navigator CYP2D6 [HugePedia]
ClinGenCYP2D6
Clinical trials, drugs, therapy
MyCancerGenomeCYP2D6
Protein Interactions : CTDCYP2D6
Pharm GKB GenePA128
Pharm GKB PathwaysPA145011108   PA145011109   PA145011111   PA145011115   PA145011119   PA146123006   PA152325160   PA161749012   PA162359940   PA164713427   PA164713429   PA165111375   PA165816736   PA165946349   PA165950411   PA165960076   PA165981686   PA165986279   PA166014758   PA166117881   PA166121347   
PharosP10635
Clinical trialCYP2D6
Miscellaneous
canSAR (ICR)CYP2D6
HarmonizomeCYP2D6
DataMed IndexCYP2D6
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCYP2D6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:57 CEST 2021

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