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CYP2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6)

Identity

Other namesCPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
HGNC (Hugo) CYP2D6
LocusID (NCBI) 1565
Location 22q13.2
Location_base_pair Starts at 42522501 and ends at 42526883 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP2D6   2625
Cards
Entrez_Gene (NCBI)CYP2D6  1565  cytochrome P450, family 2, subfamily D, polypeptide 6
GeneCards (Weizmann)CYP2D6
Ensembl (Hinxton)ENSG00000100197 [Gene_View]  chr22:42522501-42526883 [Contig_View]  CYP2D6 [Vega]
ICGC DataPortalENSG00000100197
cBioPortalCYP2D6
AceView (NCBI)CYP2D6
Genatlas (Paris)CYP2D6
WikiGenes1565
SOURCE (Princeton)NM_000106 NM_001025161
Genomic and cartography
GoldenPath (UCSC)CYP2D6  -  22q13.2   chr22:42522501-42526883 -  22q13.2   [Description]    (hg19-Feb_2009)
EnsemblCYP2D6 - 22q13.2 [CytoView]
Mapping of homologs : NCBICYP2D6 [Mapview]
OMIM124030   608902   
Gene and transcription
Genbank (Entrez)AB209492 AK308211 AK309600 AY663390 BC066877
RefSeq transcript (Entrez)NM_000106 NM_001025161
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_008376 NT_011520 NW_001838745 NW_004504305 NW_004929430
Consensus coding sequences : CCDS (NCBI)CYP2D6
Cluster EST : UnigeneHs.648256 [ NCBI ]
CGAP (NCI)Hs.648256
Alternative Splicing : Fast-db (Paris)GSHG0020440
Alternative Splicing GalleryENSG00000100197
Gene ExpressionCYP2D6 [ NCBI-GEO ]     CYP2D6 [ SEEK ]   CYP2D6 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10635 (Uniprot)
NextProtP10635  [Medical]
With graphics : InterProP10635
Splice isoforms : SwissVarP10635 (Swissvar)
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450 [organisation]   Cyt_P450_CS [organisation]   Cyt_P450_E_grp-I [organisation]   Cyt_P450_E_grp-I_CYP2D-like [organisation]  
Related proteins : CluSTrP10635
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1565
Blocks (Seattle)P10635
PDB (SRS)2F9Q    3QM4    3TBG    3TDA   
PDB (PDBSum)2F9Q    3QM4    3TBG    3TDA   
PDB (IMB)2F9Q    3QM4    3TBG    3TDA   
PDB (RSDB)2F9Q    3QM4    3TBG    3TDA   
Human Protein AtlasENSG00000100197 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP10635
HPRD00487
IPIIPI00943274   IPI00873166   IPI00973047   IPI00456699   IPI00873251   IPI00477143   IPI01011879   IPI00418408   IPI00868752   IPI00433508   
Protein Interaction databases
DIP (DOE-UCLA)P10635
IntAct (EBI)P10635
FunCoupENSG00000100197
BioGRIDCYP2D6
InParanoidP10635
Interologous Interaction database P10635
IntegromeDBCYP2D6
STRING (EMBL)CYP2D6
Ontologies - Pathways
Ontology : AmiGOmonooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  xenobiotic metabolic process  drug binding  steroid metabolic process  coumarin metabolic process  alkaloid metabolic process  alkaloid catabolic process  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  drug metabolic process  heme binding  isoquinoline alkaloid metabolic process  drug catabolic process  small molecule metabolic process  heterocycle metabolic process  negative regulation of binding  oxidation-reduction process  aromatase activity  oxidative demethylation  negative regulation of cellular organofluorine metabolic process  
Ontology : EGO-EBImonooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  xenobiotic metabolic process  drug binding  steroid metabolic process  coumarin metabolic process  alkaloid metabolic process  alkaloid catabolic process  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  drug metabolic process  heme binding  isoquinoline alkaloid metabolic process  drug catabolic process  small molecule metabolic process  heterocycle metabolic process  negative regulation of binding  oxidation-reduction process  aromatase activity  oxidative demethylation  negative regulation of cellular organofluorine metabolic process  
Pathways : KEGGMetabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Serotonergic synapse   
Protein Interaction DatabaseCYP2D6
Wikipedia pathwaysCYP2D6
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP2D6
snp3D : Map Gene to Disease1565
SNP (GeneSNP Utah)CYP2D6
SNP : HGBaseCYP2D6
Genetic variants : HAPMAPCYP2D6
Exome VariantCYP2D6
1000_GenomesCYP2D6 
ICGC programENSG00000100197 
Somatic Mutations in Cancer : COSMICCYP2D6 
CONAN: Copy Number AnalysisCYP2D6 
Mutations and Diseases : HGMDCYP2D6
Genomic VariantsCYP2D6  CYP2D6 [DGVbeta]
dbVarCYP2D6
ClinVarCYP2D6
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM124030    608902   
MedgenCYP2D6
GENETestsCYP2D6
Disease Genetic AssociationCYP2D6
Huge Navigator CYP2D6 [HugePedia]  CYP2D6 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCYP2D6
Homology/Alignments : Family Browser (UCSC)CYP2D6
Phylogenetic Trees/Animal Genes : TreeFamCYP2D6
Chemical/Protein Interactions : CTD1565
Chemical/Pharm GKB GenePA128
Clinical trialCYP2D6
Cancer Resource (Charite)ENSG00000100197
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCYP2D6
iHOPCYP2D6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:52:12 CEST 2014

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