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CYP2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6)

Identity

Other namesCPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
HGNC (Hugo) CYP2D6
LocusID (NCBI) 1565
Location 22q13.2
Location_base_pair Starts at 42522501 and ends at 42526883 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP2D6   2625
Entrez_Gene (NCBI)CYP2D6  1565  cytochrome P450, family 2, subfamily D, polypeptide 6
Cards
GeneCards (Weizmann)CYP2D6
Ensembl (Hinxton)ENSG00000100197 [Gene_View]  chr22:42522501-42526883 [Contig_View]  CYP2D6 [Vega]
AceView (NCBI)CYP2D6
Genatlas (Paris)CYP2D6
SOURCE (Stanford)NM_000106 NM_001025161
Genomic and cartography
GoldenPath (UCSC)CYP2D6  -  22q13.2   chr22:42522501-42526883 -  22q13.2   [Description]    (hg19-Feb_2009)
EnsemblCYP2D6 - 22q13.2 [CytoView]
Mapping of homologs : NCBICYP2D6 [Mapview]
OMIM124030   608902   
Gene and transcription
Genbank (Entrez)AB209492 AK308211 AK309600 AY663390 BC066877
RefSeq transcript (SRS)NM_000106 NM_001025161
RefSeq transcript (Entrez)NM_000106 NM_001025161
RefSeq genomic (SRS)AC_000154 NC_000022 NC_018933 NG_008376 NT_011520 NW_001838745 NW_004078112
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NG_008376 NT_011520 NW_001838745 NW_004078112
Consensus coding sequences : CCDS (NCBI)CYP2D6
Cluster EST : UnigeneHs.648256 [ SRS ] Hs.648256 [ NCBI ]
CGAP (NCI)Hs.648256
Alternative Splicing : Fast-db (Paris)GSHG0020440
Alternative Splicing GalleryENSG00000100197
Gene ExpressionCYP2D6 [ NCBI-GEO ]   CYP2D6 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10635 (SRS) P10635 (Uniprot)
NextProtP10635
With graphics : InterProP10635
Splice isoforms : SwissVarP10635(Swissvar)
Domaine pattern : Prosite (SRS)CYTOCHROME_P450 (PS00086)   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (SRS)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2D-like   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2D-like   
Related proteins : CluSTrP10635
Domain families : Pfam (SRS)p450 (PF00067)   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM1565
Blocks (Seattle)P10635
PDB (SRS)2F9Q    3QM4    3TBG    3TDA   
PDB (PDBSum)2F9Q    3QM4    3TBG    3TDA   
PDB (IMB)2F9Q    3QM4    3TBG    3TDA   
PDB (RSDB)2F9Q    3QM4    3TBG    3TDA   
Human Protein AtlasENSG00000100197
HPRD00487
IPIIPI00943274   IPI00873166   IPI00973047   IPI00456699   IPI00873251   IPI00477143   IPI01011879   IPI00418408   IPI00868752   IPI00433508   
Protein Interaction databases
DIP (DOE-UCLA)P10635
IntAct (EBI)P10635
FunCoupENSG00000100197
REACTOMECYP2D6
Protein Interaction Database1565
BioGRIDCYP2D6
InParanoidP10635
Interologous Interaction database P10635
IntegromeDBCYP2D6
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP2D6
SNP (GeneSNP Utah)CYP2D6
SNP : HGBaseCYP2D6
Genetic variants : HAPMAPCYP2D6
Somatic Mutations in Cancer : COSMICCYP2D6 
CONAN: Copy Number AnalysisCYP2D6 
Mutations and Diseases : HGMDCYP2D6
OMIM124030    608902   
GENETests124030    608902   
Disease Genetic AssociationCYP2D6
Huge Navigator CYP2D6 [HugePedia]  CYP2D6 [HugeCancerGEM]
Genomic VariantsCYP2D6  CYP2D6 [DGVbeta]
snp3D : Map Gene to Disease1565
General knowledge
Homologs : HomoloGeneCYP2D6
Homology/Alignments : Family Browser (UCSC)CYP2D6
Phylogenetic Trees/Animal Genes : TreeFamCYP2D6
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.1 [ Enzyme-SRS ]   1.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
Chemical/Protein Interactions : CTD1565
Chemical/Pharm GKB GenePA128
Clinical trialCYP2D6
Cancer Resource (Charite)ENSG00000100197
Ontology : AmiGOmonooxygenase activity  steroid 21-monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  xenobiotic metabolic process  drug binding  steroid metabolic process  arachidonic acid monooxygenase activity  electron carrier activity  coumarin metabolic process  alkaloid metabolic process  alkaloid catabolic process  response to organic substance  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  drug metabolic process  arachidonic acid metabolic process  heme binding  isoquinoline alkaloid metabolic process  dopamine metabolic process  drug catabolic process  small molecule metabolic process  heterocycle metabolic process  negative regulation of binding  oxidation-reduction process  aromatase activity  oxidative demethylation  negative regulation of cellular organofluorine metabolic process  
Ontology : EGO-EBImonooxygenase activity  steroid 21-monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  xenobiotic metabolic process  drug binding  steroid metabolic process  arachidonic acid monooxygenase activity  electron carrier activity  coumarin metabolic process  alkaloid metabolic process  alkaloid catabolic process  response to organic substance  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  drug metabolic process  arachidonic acid metabolic process  heme binding  isoquinoline alkaloid metabolic process  dopamine metabolic process  drug catabolic process  small molecule metabolic process  heterocycle metabolic process  negative regulation of binding  oxidation-reduction process  aromatase activity  oxidative demethylation  negative regulation of cellular organofluorine metabolic process  
Pathways : KEGGParkinson's disease
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneCYP2D6
iHOPCYP2D6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:37:32 CEST 2013
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