| Nomenclature |
|---|
| HGNC (Hugo) | CYP2E1 2631 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CYP2E1 1571 cytochrome P450 family 2 subfamily E member 1 |
| Aliases | CPE1; CYP2E; P450-J; P450C2E |
| GeneCards (Weizmann) | CYP2E1 |
| Ensembl hg19 (Hinxton) | ENSG00000130649 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000130649 [Gene_View] ENSG00000130649 [Sequence] chr10:133527363-133539116 [Contig_View] CYP2E1 [Vega] |
| ICGC DataPortal | ENSG00000130649 |
| TCGA cBioPortal | CYP2E1 |
| AceView (NCBI) | CYP2E1 |
| Genatlas (Paris) | CYP2E1 |
| WikiGenes | 1571 |
| SOURCE (Princeton) | CYP2E1 |
| Genetics Home Reference (NIH) | CYP2E1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CYP2E1 - chr10:133527363-133539116 + 10q26.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CYP2E1 - 10q26.3 [Description] (hg19-Feb_2009) |
CYP2E1 - 10q26.3 [CytoView hg19] CYP2E1 - 10q26.3 [CytoView hg38] |
| Mapping of homologs : NCBI | CYP2E1 [Mapview hg19] CYP2E1 [Mapview hg38] |
| OMIM | 124040 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF084225 AF182276 AJ853939 AJ853940 AJ877238 |
| RefSeq transcript (Entrez) | NM_000773 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CYP2E1 |
| Cluster EST : Unigene | Hs.12907 [ NCBI ] |
| CGAP (NCI) | Hs.12907 |
| Alternative Splicing Gallery | ENSG00000130649 |
| Gene Expression | CYP2E1 [ NCBI-GEO ] CYP2E1 [ EBI - ARRAY_EXPRESS ]
CYP2E1 [ SEEK ] CYP2E1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CYP2E1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1571 |
| GTEX Portal (Tissue expression) | CYP2E1 |
| Human Protein Atlas | ENSG00000130649-CYP2E1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P05181 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P05181 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P05181 |
| Splice isoforms : SwissVar | P05181 |
| Catalytic activity : Enzyme | 1.14.13.- [ Enzyme-Expasy ] 1.14.13.-1.14.13.- [ IntEnz-EBI ] 1.14.13.- [ BRENDA ] 1.14.13.- [ KEGG ] |
| PhosPhoSitePlus | P05181 |
| Domaine pattern : Prosite (Expaxy) | CYTOCHROME_P450 (PS00086) |
| Domains : Interpro (EBI) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_E_grp-I_CYP2E-like Cyt_P450_sf |
| Domain families : Pfam (Sanger) | p450 (PF00067) |
| Domain families : Pfam (NCBI) | pfam00067 |
| Conserved Domain (NCBI) | CYP2E1 |
| DMDM Disease mutations | 1571 |
| Blocks (Seattle) | CYP2E1 |
| PDB (RSDB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB Europe | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (PDBSum) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (IMB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| Structural Biology KnowledgeBase | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| SCOP (Structural Classification of Proteins) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| CATH (Classification of proteins structures) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| Superfamily | P05181 |
| Human Protein Atlas [tissue] | ENSG00000130649-CYP2E1 [tissue] |
| Peptide Atlas | P05181 |
| HPRD | 11813 |
| IPI | IPI00007282 IPI01011893 IPI00816414 IPI00555724 IPI01009826 IPI00816043 IPI01011560 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P05181 |
| IntAct (EBI) | P05181 |
| FunCoup | ENSG00000130649 |
| BioGRID | CYP2E1 |
| STRING (EMBL) | CYP2E1 |
| ZODIAC | CYP2E1 |
| Ontologies - Pathways |
|---|
| QuickGO | P05181 |
| Ontology : AmiGO | Golgi membrane monooxygenase activity monooxygenase activity iron ion binding cytoplasm mitochondrion endoplasmic reticulum membrane organic acid metabolic process triglyceride metabolic process xenobiotic metabolic process xenobiotic metabolic process steroid metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity response to bacterium response to ozone response to organonitrogen compound monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process drug metabolic process carbon tetrachloride metabolic process benzene metabolic process epoxygenase P450 pathway oxygen binding enzyme binding heme binding heme binding intrinsic component of endoplasmic reticulum membrane halogenated hydrocarbon metabolic process exogenous drug catabolic process long-chain fatty acid biosynthetic process intracellular membrane-bounded organelle response to ethanol heterocycle metabolic process oxidation-reduction process oxidation-reduction process |
| Ontology : EGO-EBI | Golgi membrane monooxygenase activity monooxygenase activity iron ion binding cytoplasm mitochondrion endoplasmic reticulum membrane organic acid metabolic process triglyceride metabolic process xenobiotic metabolic process xenobiotic metabolic process steroid metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity response to bacterium response to ozone response to organonitrogen compound monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process drug metabolic process carbon tetrachloride metabolic process benzene metabolic process epoxygenase P450 pathway oxygen binding enzyme binding heme binding heme binding intrinsic component of endoplasmic reticulum membrane halogenated hydrocarbon metabolic process exogenous drug catabolic process long-chain fatty acid biosynthetic process intracellular membrane-bounded organelle response to ethanol heterocycle metabolic process oxidation-reduction process oxidation-reduction process |
| Pathways : KEGG | Steroid hormone biosynthesis Arachidonic acid metabolism Linoleic acid metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Non-alcoholic fatty liver disease (NAFLD) Chemical carcinogenesis |
| NDEx Network | CYP2E1 |
| Atlas of Cancer Signalling Network | CYP2E1 |
| Wikipedia pathways | CYP2E1 |
| Orthology - Evolution |
|---|
| OrthoDB | 1571 |
| GeneTree (enSembl) | ENSG00000130649 |
| Phylogenetic Trees/Animal Genes : TreeFam | CYP2E1 |
| HOGENOM | P05181 |
| Homologs : HomoloGene | CYP2E1 |
| Homology/Alignments : Family Browser (UCSC) | CYP2E1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | CYP2E1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CYP2E1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CYP2E1 |
| dbVar | CYP2E1 |
| ClinVar | CYP2E1 |
| 1000_Genomes | CYP2E1 |
| Exome Variant Server | CYP2E1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000130649 |
| GNOMAD Browser | ENSG00000130649 |
| Varsome Browser | CYP2E1 |
| Genetic variants : HAPMAP | 1571 |
| Genomic Variants (DGV) | CYP2E1 [DGVbeta] |
| DECIPHER | CYP2E1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CYP2E1 |
| Mutations |
|---|
| ICGC Data Portal | CYP2E1 |
| TCGA Data Portal | CYP2E1 |
| Broad Tumor Portal | CYP2E1 |
| OASIS Portal | CYP2E1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CYP2E1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CYP2E1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | Pharmacogenomics of Infectious Diseases (PGx_IfD ) |
| BioMuta | search CYP2E1 |
| DgiDB (Drug Gene Interaction Database) | CYP2E1 |
| DoCM (Curated mutations) | CYP2E1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CYP2E1 (select a term) |
| intoGen | CYP2E1 |
| Cancer3D | CYP2E1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 124040 |
| Orphanet | |
| DisGeNET | CYP2E1 |
| Medgen | CYP2E1 |
| Genetic Testing Registry | CYP2E1
|
| NextProt | P05181 [Medical] |
| TSGene | 1571 |
| GENETests | CYP2E1 |
| Target Validation | CYP2E1 |
| Huge Navigator |
CYP2E1 [HugePedia] |
| snp3D : Map Gene to Disease | 1571 |
| BioCentury BCIQ | CYP2E1 |
| ClinGen | CYP2E1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1571 |
| Chemical/Pharm GKB Gene | PA129 |
| Clinical trial | CYP2E1 |
| Miscellaneous |
|---|
| canSAR (ICR) | CYP2E1 (select the gene name) |
| DataMed Index | CYP2E1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CYP2E1 |
| EVEX | CYP2E1 |
| GoPubMed | CYP2E1 |
| iHOP | CYP2E1 |
