Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2E1 (cytochrome P450 family 2 subfamily E member 1)

Identity

Other namesCPE1
CYP2E
P450-J
P450C2E
HGNC (Hugo) CYP2E1
LocusID (NCBI) 1571
Atlas_Id 40248
Location 10q26.3
Location_base_pair Starts at 135340867 and ends at 135352620 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP2E1   2631
Cards
Entrez_Gene (NCBI)CYP2E1  1571  cytochrome P450 family 2 subfamily E member 1
AliasesCPE1; CYP2E; P450-J; P450C2E
GeneCards (Weizmann)CYP2E1
Ensembl hg19 (Hinxton)ENSG00000130649 [Gene_View]  chr10:135340867-135352620 [Contig_View]  CYP2E1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130649 [Gene_View]  chr10:135340867-135352620 [Contig_View]  CYP2E1 [Vega]
ICGC DataPortalENSG00000130649
TCGA cBioPortalCYP2E1
AceView (NCBI)CYP2E1
Genatlas (Paris)CYP2E1
WikiGenes1571
SOURCE (Princeton)CYP2E1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP2E1  -     chr10:135340867-135352620 +  10q26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP2E1  -     10q26.3   [Description]    (hg38-Dec_2013)
EnsemblCYP2E1 - 10q26.3 [CytoView hg19]  CYP2E1 - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBICYP2E1 [Mapview hg19]  CYP2E1 [Mapview hg38]
OMIM124040   
Gene and transcription
Genbank (Entrez)AF084225 AF182276 AJ853939 AJ853940 AJ877238
RefSeq transcript (Entrez)NM_000773
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_008383 NT_030059 NW_004929377
Consensus coding sequences : CCDS (NCBI)CYP2E1
Cluster EST : UnigeneHs.12907 [ NCBI ]
CGAP (NCI)Hs.12907
Alternative Splicing GalleryENSG00000130649
Gene ExpressionCYP2E1 [ NCBI-GEO ]   CYP2E1 [ EBI - ARRAY_EXPRESS ]   CYP2E1 [ SEEK ]   CYP2E1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2E1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1571
GTEX Portal (Tissue expression)CYP2E1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05181 (Uniprot)
NextProtP05181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05181
Splice isoforms : SwissVarP05181 (Swissvar)
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
PhosPhoSitePlusP05181
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2E-like   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1571
Blocks (Seattle)CYP2E1
PDB (SRS)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (PDBSum)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (IMB)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (RSDB)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
Structural Biology KnowledgeBase3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
SCOP (Structural Classification of Proteins)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
CATH (Classification of proteins structures)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
SuperfamilyP05181
Human Protein AtlasENSG00000130649
Peptide AtlasP05181
HPRD11813
IPIIPI00007282   IPI01011893   IPI00816414   IPI00555724   IPI01009826   IPI00816043   IPI01011560   
Protein Interaction databases
DIP (DOE-UCLA)P05181
IntAct (EBI)P05181
FunCoupENSG00000130649
BioGRIDCYP2E1
STRING (EMBL)CYP2E1
ZODIACCYP2E1
Ontologies - Pathways
QuickGOP05181
Ontology : AmiGOGolgi membrane  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  triglyceride metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  response to ozone  response to organonitrogen compound  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  drug metabolic process  carbon tetrachloride metabolic process  benzene metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  intrinsic component of endoplasmic reticulum membrane  halogenated hydrocarbon metabolic process  response to drug  response to ethanol  heterocycle metabolic process  oxidation-reduction process  
Ontology : EGO-EBIGolgi membrane  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  triglyceride metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  response to ozone  response to organonitrogen compound  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  drug metabolic process  carbon tetrachloride metabolic process  benzene metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  intrinsic component of endoplasmic reticulum membrane  halogenated hydrocarbon metabolic process  response to drug  response to ethanol  heterocycle metabolic process  oxidation-reduction process  
Pathways : BIOCARTAMechanism of Acetaminophen Activity and Toxicity [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGSteroid hormone biosynthesis    Arachidonic acid metabolism    Linoleic acid metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Non-alcoholic fatty liver disease (NAFLD)    Chemical carcinogenesis   
NDEx Network
Atlas of Cancer Signalling NetworkCYP2E1
Wikipedia pathwaysCYP2E1
Orthology - Evolution
OrthoDB1571
GeneTree (enSembl)ENSG00000130649
Phylogenetic Trees/Animal Genes : TreeFamCYP2E1
Homologs : HomoloGeneCYP2E1
Homology/Alignments : Family Browser (UCSC)CYP2E1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCYP2E1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2E1
dbVarCYP2E1
ClinVarCYP2E1
1000_GenomesCYP2E1 
Exome Variant ServerCYP2E1
ExAC (Exome Aggregation Consortium)CYP2E1 (select the gene name)
Genetic variants : HAPMAP1571
Genomic Variants (DGV)CYP2E1 [DGVbeta]
Mutations
ICGC Data PortalCYP2E1 
TCGA Data PortalCYP2E1 
Broad Tumor PortalCYP2E1
OASIS PortalCYP2E1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2E1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP2E1
DgiDB (Drug Gene Interaction Database)CYP2E1
DoCM (Curated mutations)CYP2E1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP2E1 (select a term)
intoGenCYP2E1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:135340867-135352620  ENSG00000130649
CONAN: Copy Number AnalysisCYP2E1 
Mutations and Diseases : HGMDCYP2E1
OMIM124040   
MedgenCYP2E1
Genetic Testing Registry CYP2E1
NextProtP05181 [Medical]
TSGene1571
GENETestsCYP2E1
Huge Navigator CYP2E1 [HugePedia]
snp3D : Map Gene to Disease1571
BioCentury BCIQCYP2E1
ClinGenCYP2E1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1571
Chemical/Pharm GKB GenePA129
Clinical trialCYP2E1
Miscellaneous
canSAR (ICR)CYP2E1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP2E1
EVEXCYP2E1
GoPubMedCYP2E1
iHOPCYP2E1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 10:59:39 CEST 2016

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