| Nomenclature |
|---|
| HGNC (Hugo) | CYP2E1 2631 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CYP2E1 1571 cytochrome P450, family 2, subfamily E, polypeptide 1 |
| GeneCards (Weizmann) | CYP2E1 |
| Ensembl hg19 (Hinxton) | ENSG00000130649 [Gene_View] chr10:135340867-135352620 [Contig_View] CYP2E1 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000130649 [Gene_View] chr10:135340867-135352620 [Contig_View] CYP2E1 [Vega] |
| ICGC DataPortal | ENSG00000130649 |
| cBioPortal | CYP2E1 |
| AceView (NCBI) | CYP2E1 |
| Genatlas (Paris) | CYP2E1 |
| WikiGenes | 1571 |
| SOURCE (Princeton) | CYP2E1 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | CYP2E1 - chr10:135340867-135352620 + 10q26.3 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | CYP2E1 - 10q26.3 [Description] (hg38-Dec_2013) |
| Ensembl | CYP2E1 - 10q26.3 [CytoView hg19] CYP2E1 - 10q26.3 [CytoView hg38] |
| Mapping of homologs : NCBI | CYP2E1 [Mapview hg19] CYP2E1 [Mapview hg38] |
| OMIM | 124040 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF084225 AF182276 AJ853939 AJ853940 AJ877238 |
| RefSeq transcript (Entrez) | NM_000773 |
| RefSeq genomic (Entrez) | AC_000142 NC_000010 NC_018921 NG_008383 NT_030059 NW_001838014 NW_004929377 |
| Consensus coding sequences : CCDS (NCBI) | CYP2E1 |
| Cluster EST : Unigene | Hs.12907 [ NCBI ] |
| CGAP (NCI) | Hs.12907 |
| Alternative Splicing : Fast-db (Paris) | GSHG0003809 |
| Alternative Splicing Gallery | ENSG00000130649 |
| Gene Expression | CYP2E1 [ NCBI-GEO ] CYP2E1 [ SEEK ] CYP2E1 [ MEM ] |
| SOURCE (Princeton) | Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P05181 (Uniprot) |
| NextProt | P05181 [Medical] |
| With graphics : InterPro | P05181 |
| Splice isoforms : SwissVar | P05181 (Swissvar) |
| Catalytic activity : Enzyme | 1.14.13.- [ Enzyme-Expasy ] 1.14.13.-1.14.13.- [ IntEnz-EBI ] 1.14.13.- [ BRENDA ] 1.14.13.- [ KEGG ] |
| Domaine pattern : Prosite (Expaxy) | CYTOCHROME_P450 (PS00086) |
| Domains : Interpro (EBI) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_E_grp-I_CYP2E-like |
| Related proteins : CluSTr | P05181 |
| Domain families : Pfam (Sanger) | p450 (PF00067) |
| Domain families : Pfam (NCBI) | pfam00067 |
| DMDM Disease mutations | 1571 |
| Blocks (Seattle) | P05181 |
| PDB (SRS) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (PDBSum) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (IMB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (RSDB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| Human Protein Atlas | ENSG00000130649 |
| Peptide Atlas | P05181 |
| HPRD | 11813 |
| IPI | IPI00007282 IPI01011893 IPI00816414 IPI00555724 IPI01009826 IPI00816043 IPI01011560 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P05181 |
| IntAct (EBI) | P05181 |
| FunCoup | ENSG00000130649 |
| BioGRID | CYP2E1 |
| IntegromeDB | CYP2E1 |
| STRING (EMBL) | CYP2E1 |
| Ontologies - Pathways |
|---|
| QuickGO | P05181 |
| Ontology : AmiGO | Golgi membrane monooxygenase activity iron ion binding mitochondrion endoplasmic reticulum membrane triglyceride metabolic process xenobiotic metabolic process steroid metabolic process response to ozone response to organonitrogen compound monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process oxygen binding enzyme binding heme binding intrinsic component of endoplasmic reticulum membrane response to drug small molecule metabolic process response to ethanol heterocycle metabolic process oxidation-reduction process |
| Ontology : EGO-EBI | Golgi membrane monooxygenase activity iron ion binding mitochondrion endoplasmic reticulum membrane triglyceride metabolic process xenobiotic metabolic process steroid metabolic process response to ozone response to organonitrogen compound monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process oxygen binding enzyme binding heme binding intrinsic component of endoplasmic reticulum membrane response to drug small molecule metabolic process response to ethanol heterocycle metabolic process oxidation-reduction process |
| Pathways : BIOCARTA | Mechanism of Acetaminophen Activity and Toxicity [Genes] Nuclear Receptors in Lipid Metabolism and Toxicity [Genes] |
| Pathways : KEGG | Steroid hormone biosynthesis Arachidonic acid metabolism Linoleic acid metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Non-alcoholic fatty liver disease (NAFLD) Chemical carcinogenesis |
| Protein Interaction Database | CYP2E1 |
| DoCM (Curated mutations) | CYP2E1 |
| Wikipedia pathways | CYP2E1 |
| Gene fusion - rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | CYP2E1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CYP2E1 |
| dbVar | CYP2E1 |
| ClinVar | CYP2E1 |
| 1000_Genomes | CYP2E1 |
| Exome Variant Server | CYP2E1 |
| SNP (GeneSNP Utah) | CYP2E1 |
| SNP : HGBase | CYP2E1 |
| Genetic variants : HAPMAP | CYP2E1 |
| Genomic Variants | CYP2E1 CYP2E1 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | ENSG00000130649 |
| Somatic Mutations in Cancer : COSMIC | CYP2E1 |
| CONAN: Copy Number Analysis | CYP2E1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | Pharmacogenomics of Infectious Diseases (PGx_IfD ) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 10:135340867-135352620 |
| Mutations and Diseases : HGMD | CYP2E1 |
| OMIM | 124040 |
| Medgen | CYP2E1 |
| NextProt | P05181 [Medical] |
| GENETests | CYP2E1 |
| Disease Genetic Association | CYP2E1 |
| Huge Navigator |
CYP2E1 [HugePedia] CYP2E1 [HugeCancerGEM] |
| snp3D : Map Gene to Disease | 1571 |
| DGIdb (Drug Gene Interaction db) | CYP2E1 |
| General knowledge |
|---|
| Homologs : HomoloGene | CYP2E1 |
| Homology/Alignments : Family Browser (UCSC) | CYP2E1 |
| Phylogenetic Trees/Animal Genes : TreeFam | CYP2E1 |
| Chemical/Protein Interactions : CTD | 1571 |
| Chemical/Pharm GKB Gene | PA129 |
| Clinical trial | CYP2E1 |
| Cancer Resource (Charite) | ENSG00000130649 |
| Other databases |
|---|
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| CoreMine | CYP2E1 |
| GoPubMed | CYP2E1 |
| iHOP | CYP2E1 |
