| Nomenclature | | HGNC (Hugo) | CYP2E1 2631 |
| Entrez_Gene (NCBI) | CYP2E1 1571 cytochrome P450, family 2, subfamily E, polypeptide 1 |
| Cards | | GeneCards (Weizmann) | CYP2E1 |
| Ensembl (Hinxton) | ENSG00000130649 [Gene_View] chr10:135340867-135352620 [Contig_View] CYP2E1 [Vega] |
| AceView (NCBI) | CYP2E1 |
| Genatlas (Paris) | CYP2E1 |
| SOURCE (Stanford) | NM_000773 |
| Genomic and cartography | | GoldenPath (UCSC) | CYP2E1 - 10q26.3 chr10:135340867-135352620 + 10q26.3 [Description] (hg19-Feb_2009) |
| Ensembl | CYP2E1 - 10q26.3 [CytoView] |
| Mapping of homologs : NCBI | CYP2E1 [Mapview] |
| OMIM | 124040 |
| Gene and transcription |
| Genbank (Entrez) | AF084225 AF182276 AJ853939 AJ853940 AJ877238 |
| RefSeq transcript (SRS) | NM_000773 |
| RefSeq transcript (Entrez) | NM_000773 |
| RefSeq genomic (SRS) | AC_000142 NC_000010 NC_018921 NG_008383 NT_008818 NW_001838014 NW_004078069 |
| RefSeq genomic (Entrez) | AC_000142 NC_000010 NC_018921 NG_008383 NT_008818 NW_001838014 NW_004078069 |
| Consensus coding sequences : CCDS (NCBI) | CYP2E1 |
| Cluster EST : Unigene | Hs.12907 [ SRS ] Hs.12907 [ NCBI ] |
| CGAP (NCI) | Hs.12907 |
| Alternative Splicing : Fast-db (Paris) | GSHG0003809 |
| Alternative Splicing Gallery | ENSG00000130649 |
| Gene Expression | CYP2E1 [ NCBI-GEO ] CYP2E1 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P05181 (SRS) P05181 (Uniprot) |
| NextProt | P05181 |
| With graphics : InterPro | P05181 |
| Splice isoforms : SwissVar | P05181(Swissvar) |
| Domaine pattern : Prosite (SRS) | CYTOCHROME_P450 (PS00086) |
| Domaine pattern : Prosite (Expaxy) | CYTOCHROME_P450 (PS00086) |
| Domains : Interpro (SRS) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_E_grp-I_CYP2E-like |
| Domains : Interpro (EBI) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_E_grp-I_CYP2E-like |
| Related proteins : CluSTr | P05181 |
| Domain families : Pfam (SRS) | p450 (PF00067) |
| Domain families : Pfam (Sanger) | p450 (PF00067) |
| Domain families : Pfam (NCBI) | pfam00067 |
| DMDM | 1571 |
| Blocks (Seattle) | P05181 |
| PDB (SRS) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (PDBSum) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (IMB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (RSDB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| Human Protein Atlas | ENSG00000130649 |
| HPRD | 11813 |
| IPI | IPI00007282 IPI01011893 IPI00816414 IPI00555724 IPI01009826 IPI00816043 IPI01011560 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P05181 |
| IntAct (EBI) | P05181 |
| FunCoup | ENSG00000130649 |
| REACTOME | CYP2E1 |
| Protein Interaction Database | 1571 |
| BioGRID | CYP2E1 |
| InParanoid | P05181 |
| Interologous Interaction database | P05181 |
| IntegromeDB | CYP2E1 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | CYP2E1 |
| SNP (GeneSNP Utah) | CYP2E1 |
| SNP : HGBase | CYP2E1 |
| Genetic variants : HAPMAP | CYP2E1 |
| Somatic Mutations in Cancer : COSMIC | CYP2E1 |
| CONAN: Copy Number Analysis | CYP2E1 |
| Mutations and Diseases : HGMD | CYP2E1 |
| OMIM | 124040 |
| GENETests | 124040 |
| Disease Genetic Association | CYP2E1 |
| Huge Navigator |
CYP2E1 [HugePedia] CYP2E1 [HugeCancerGEM] |
| Genomic Variants | CYP2E1 CYP2E1 [DGVbeta] |
| snp3D : Map Gene to Disease | 1571 |
| General knowledge |
|---|
| Homologs : HomoloGene | CYP2E1 |
| Homology/Alignments : Family Browser (UCSC) | CYP2E1 |
| Phylogenetic Trees/Animal Genes : TreeFam | CYP2E1 |
| Catalytic activity : Enzyme | 1.14.13.- [ Enzyme-Expasy ] 1.14.13.- [ Enzyme-SRS ] 1.14.13.- [ IntEnz-EBI ] 1.14.13.- [ BRENDA ] 1.14.13.- [ KEGG ] |
| Chemical/Protein Interactions : CTD | 1571 |
| Chemical/Pharm GKB Gene | PA129 |
| Clinical trial | CYP2E1 |
| Cancer Resource (Charite) | ENSG00000130649 |
| Ontology : AmiGO | Golgi membrane monooxygenase activity iron ion binding mitochondrion endoplasmic reticulum membrane triglyceride metabolic process xenobiotic metabolic process steroid metabolic process electron carrier activity response to ozone response to organic nitrogen monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process oxygen binding enzyme binding heme binding intrinsic to endoplasmic reticulum membrane response to drug small molecule metabolic process response to ethanol heterocycle metabolic process oxidation-reduction process |
| Ontology : EGO-EBI | Golgi membrane monooxygenase activity iron ion binding mitochondrion endoplasmic reticulum membrane triglyceride metabolic process xenobiotic metabolic process steroid metabolic process electron carrier activity response to ozone response to organic nitrogen monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process oxygen binding enzyme binding heme binding intrinsic to endoplasmic reticulum membrane response to drug small molecule metabolic process response to ethanol heterocycle metabolic process oxidation-reduction process |
| Pathways : BIOCARTA | Mechanism of Acetaminophen Activity and Toxicity [Genes] Nuclear Receptors in Lipid Metabolism and Toxicity [Genes] |
| Pathways : KEGG | Arachidonic acid metabolismLinoleic acid metabolismMetabolism of xenobiotics by cytochrome P450 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 497 Pubmed reference(s) in Entrez |
| PubGene | CYP2E1 |
| iHOP | CYP2E1 |
