| Nomenclature |
|---|
| HGNC (Hugo) | CYP2E1 2631 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CYP2E1 cytochrome P450 family 2 subfamily E member 1 |
| Aliases | CPE1; CYP2E; P450-J; P450C2E |
| GeneCards (Weizmann) | CYP2E1 |
| Ensembl hg19 (Hinxton) | ENSG00000130649 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000130649 [Gene_View] ENSG00000130649 [Sequence] chr10:133527363-133539123 [Contig_View] CYP2E1 [Vega] |
| ICGC DataPortal | ENSG00000130649 |
| TCGA cBioPortal | CYP2E1 |
| AceView (NCBI) | CYP2E1 |
| Genatlas (Paris) | CYP2E1 |
| SOURCE (Princeton) | CYP2E1 |
| Genetics Home Reference (NIH) | CYP2E1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CYP2E1 - chr10:133527363-133539123 + 10q26.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CYP2E1 - 10q26.3 [Description] (hg19-Feb_2009) |
| GoldenPath | CYP2E1 - 10q26.3 [CytoView hg19] CYP2E1 - 10q26.3 [CytoView hg38] |
| ImmunoBase | ENSG00000130649 |
| Genome Data Viewer NCBI | CYP2E1 [Mapview hg19] |
| OMIM | 124040 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF084225 AF182276 AJ853939 AJ853940 AJ877238 |
| RefSeq transcript (Entrez) | NM_000773 |
| Consensus coding sequences : CCDS (NCBI) | CYP2E1 |
| Gene Expression | CYP2E1 [ NCBI-GEO ] CYP2E1 [ EBI - ARRAY_EXPRESS ]
CYP2E1 [ SEEK ] CYP2E1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CYP2E1 [ Firebrowse - Broad ] |
| Genevisible | Expression of CYP2E1 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1571 |
| GTEX Portal (Tissue expression) | CYP2E1 |
| Human Protein Atlas | ENSG00000130649-CYP2E1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P05181 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P05181 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P05181 |
| PhosPhoSitePlus | P05181 |
| Domaine pattern : Prosite (Expaxy) | CYTOCHROME_P450 (PS00086) |
| Domains : Interpro (EBI) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_E_grp-I_CYP2E-like Cyt_P450_sf |
| Domain families : Pfam (Sanger) | p450 (PF00067) |
| Domain families : Pfam (NCBI) | pfam00067 |
| Conserved Domain (NCBI) | CYP2E1 |
| PDB (RSDB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB Europe | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (PDBSum) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| PDB (IMB) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| Structural Biology KnowledgeBase | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| SCOP (Structural Classification of Proteins) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| CATH (Classification of proteins structures) | 3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z |
| Superfamily | P05181 |
| AlphaFold pdb e-kb | P05181 |
| Human Protein Atlas [tissue] | ENSG00000130649-CYP2E1 [tissue] |
| HPRD | 11813 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P05181 |
| IntAct (EBI) | P05181 |
| BioGRID | CYP2E1 |
| STRING (EMBL) | CYP2E1 |
| ZODIAC | CYP2E1 |
| Ontologies - Pathways |
|---|
| QuickGO | P05181 |
| Ontology : AmiGO | Golgi membrane lipid hydroxylation monooxygenase activity iron ion binding cytoplasm mitochondrial inner membrane endoplasmic reticulum membrane organic acid metabolic process triglyceride metabolic process xenobiotic metabolic process xenobiotic metabolic process steroid metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity response to bacterium response to ozone response to organonitrogen compound monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process drug metabolic process 4-nitrophenol 2-monooxygenase activity carbon tetrachloride metabolic process benzene metabolic process 4-nitrophenol metabolic process epoxygenase P450 pathway oxygen binding enzyme binding heme binding heme binding Hsp70 protein binding intrinsic component of endoplasmic reticulum membrane halogenated hydrocarbon metabolic process exogenous drug catabolic process long-chain fatty acid biosynthetic process intracellular membrane-bounded organelle response to ethanol heterocycle metabolic process Hsp90 protein binding aromatase activity |
| Ontology : EGO-EBI | Golgi membrane lipid hydroxylation monooxygenase activity iron ion binding cytoplasm mitochondrial inner membrane endoplasmic reticulum membrane organic acid metabolic process triglyceride metabolic process xenobiotic metabolic process xenobiotic metabolic process steroid metabolic process arachidonic acid epoxygenase activity steroid hydroxylase activity response to bacterium response to ozone response to organonitrogen compound monoterpenoid metabolic process oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen drug metabolic process drug metabolic process drug metabolic process 4-nitrophenol 2-monooxygenase activity carbon tetrachloride metabolic process benzene metabolic process 4-nitrophenol metabolic process epoxygenase P450 pathway oxygen binding enzyme binding heme binding heme binding Hsp70 protein binding intrinsic component of endoplasmic reticulum membrane halogenated hydrocarbon metabolic process exogenous drug catabolic process long-chain fatty acid biosynthetic process intracellular membrane-bounded organelle response to ethanol heterocycle metabolic process Hsp90 protein binding aromatase activity |
| Pathways : BIOCARTA | Mechanism of Acetaminophen Activity and Toxicity [Genes] Nuclear Receptors in Lipid Metabolism and Toxicity [Genes] |
| Pathways : KEGG | Steroid hormone biosynthesis Arachidonic acid metabolism Linoleic acid metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Non-alcoholic fatty liver disease (NAFLD) Chemical carcinogenesis |
| NDEx Network | CYP2E1 |
| Atlas of Cancer Signalling Network | CYP2E1 |
| Wikipedia pathways | CYP2E1 |
| Orthology - Evolution |
|---|
| OrthoDB | 1571 |
| GeneTree (enSembl) | ENSG00000130649 |
| Phylogenetic Trees/Animal Genes : TreeFam | CYP2E1 |
| Homologs : HomoloGene | CYP2E1 |
| Homology/Alignments : Family Browser (UCSC) | CYP2E1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | CYP2E1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CYP2E1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CYP2E1 |
| dbVar | CYP2E1 |
| ClinVar | CYP2E1 |
| Monarch | CYP2E1 |
| 1000_Genomes | CYP2E1 |
| Exome Variant Server | CYP2E1 |
| GNOMAD Browser | ENSG00000130649 |
| Varsome Browser | CYP2E1 |
| ACMG | CYP2E1 variants |
| Varity | P05181 |
| Genomic Variants (DGV) | CYP2E1 [DGVbeta] |
| DECIPHER | CYP2E1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CYP2E1 |
| Mutations |
|---|
| ICGC Data Portal | CYP2E1 |
| TCGA Data Portal | CYP2E1 |
| Broad Tumor Portal | CYP2E1 |
| OASIS Portal | CYP2E1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CYP2E1 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CYP2E1 |
| Mutations and Diseases : HGMD | CYP2E1 |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | CYP2E1 |
| DgiDB (Drug Gene Interaction Database) | CYP2E1 |
| DoCM (Curated mutations) | CYP2E1 |
| CIViC (Clinical Interpretations of Variants in Cancer) | CYP2E1 |
| Cancer3D | CYP2E1 |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 124040 |
| Orphanet | |
| DisGeNET | CYP2E1 |
| Medgen | CYP2E1 |
| Genetic Testing Registry | CYP2E1
|
| NextProt | P05181 [Medical] |
| GENETests | CYP2E1 |
| Target Validation | CYP2E1 |
| Huge Navigator |
CYP2E1 [HugePedia] |
| ClinGen | CYP2E1 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | CYP2E1 |
| Protein Interactions : CTD | CYP2E1 |
| Pharm GKB Gene | PA129 |
| Pharm GKB Pathways | PA145011115 PA165817070 PA165859361 PA165884757 PA165958541 PA165986279 PA166117881 |
| Pharos | P05181 |
| Clinical trial | CYP2E1 |
| Miscellaneous |
|---|
| canSAR (ICR) | CYP2E1 |
| Harmonizome | CYP2E1 |
| DataMed Index | CYP2E1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | CYP2E1 |
