Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2E1 (cytochrome P450 family 2 subfamily E member 1)

Identity

Alias (NCBI)CPE1
CYP2E
P450-J
P450C2E
HGNC (Hugo) CYP2E1
HGNC Previous nameCYP2E
HGNC Previous namecytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
 cytochrome P450, family 2, subfamily E, polypeptide 1
LocusID (NCBI) 1571
Atlas_Id 40248
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 133527363 and ends at 133539123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CYP2E1   2631
Cards
Entrez_Gene (NCBI)CYP2E1    cytochrome P450 family 2 subfamily E member 1
AliasesCPE1; CYP2E; P450-J; P450C2E
GeneCards (Weizmann)CYP2E1
Ensembl hg19 (Hinxton)ENSG00000130649 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130649 [Gene_View]  ENSG00000130649 [Sequence]  chr10:133527363-133539123 [Contig_View]  CYP2E1 [Vega]
ICGC DataPortalENSG00000130649
TCGA cBioPortalCYP2E1
AceView (NCBI)CYP2E1
Genatlas (Paris)CYP2E1
SOURCE (Princeton)CYP2E1
Genetics Home Reference (NIH)CYP2E1
Genomic and cartography
GoldenPath hg38 (UCSC)CYP2E1  -     chr10:133527363-133539123 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP2E1  -     10q26.3   [Description]    (hg19-Feb_2009)
GoldenPathCYP2E1 - 10q26.3 [CytoView hg19]  CYP2E1 - 10q26.3 [CytoView hg38]
ImmunoBaseENSG00000130649
Genome Data Viewer NCBICYP2E1 [Mapview hg19]  
OMIM124040   
Gene and transcription
Genbank (Entrez)AF084225 AF182276 AJ853939 AJ853940 AJ877238
RefSeq transcript (Entrez)NM_000773
Consensus coding sequences : CCDS (NCBI)CYP2E1
Gene ExpressionCYP2E1 [ NCBI-GEO ]   CYP2E1 [ EBI - ARRAY_EXPRESS ]   CYP2E1 [ SEEK ]   CYP2E1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP2E1 [ Firebrowse - Broad ]
GenevisibleExpression of CYP2E1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1571
GTEX Portal (Tissue expression)CYP2E1
Human Protein AtlasENSG00000130649-CYP2E1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05181   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05181  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05181
PhosPhoSitePlusP05181
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2E-like    Cyt_P450_sf   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP2E1
PDB (RSDB)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB Europe3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (PDBSum)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (IMB)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
Structural Biology KnowledgeBase3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
SCOP (Structural Classification of Proteins)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
CATH (Classification of proteins structures)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
SuperfamilyP05181
AlphaFold pdb e-kbP05181   
Human Protein Atlas [tissue]ENSG00000130649-CYP2E1 [tissue]
HPRD11813
Protein Interaction databases
DIP (DOE-UCLA)P05181
IntAct (EBI)P05181
BioGRIDCYP2E1
STRING (EMBL)CYP2E1
ZODIACCYP2E1
Ontologies - Pathways
QuickGOP05181
Ontology : AmiGOGolgi membrane  lipid hydroxylation  monooxygenase activity  iron ion binding  cytoplasm  mitochondrial inner membrane  endoplasmic reticulum membrane  organic acid metabolic process  triglyceride metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  response to bacterium  response to ozone  response to organonitrogen compound  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  drug metabolic process  4-nitrophenol 2-monooxygenase activity  carbon tetrachloride metabolic process  benzene metabolic process  4-nitrophenol metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  heme binding  Hsp70 protein binding  intrinsic component of endoplasmic reticulum membrane  halogenated hydrocarbon metabolic process  exogenous drug catabolic process  long-chain fatty acid biosynthetic process  intracellular membrane-bounded organelle  response to ethanol  heterocycle metabolic process  Hsp90 protein binding  aromatase activity  
Ontology : EGO-EBIGolgi membrane  lipid hydroxylation  monooxygenase activity  iron ion binding  cytoplasm  mitochondrial inner membrane  endoplasmic reticulum membrane  organic acid metabolic process  triglyceride metabolic process  xenobiotic metabolic process  xenobiotic metabolic process  steroid metabolic process  arachidonic acid epoxygenase activity  steroid hydroxylase activity  response to bacterium  response to ozone  response to organonitrogen compound  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  drug metabolic process  4-nitrophenol 2-monooxygenase activity  carbon tetrachloride metabolic process  benzene metabolic process  4-nitrophenol metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  heme binding  Hsp70 protein binding  intrinsic component of endoplasmic reticulum membrane  halogenated hydrocarbon metabolic process  exogenous drug catabolic process  long-chain fatty acid biosynthetic process  intracellular membrane-bounded organelle  response to ethanol  heterocycle metabolic process  Hsp90 protein binding  aromatase activity  
Pathways : BIOCARTAMechanism of Acetaminophen Activity and Toxicity [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGSteroid hormone biosynthesis    Arachidonic acid metabolism    Linoleic acid metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Non-alcoholic fatty liver disease (NAFLD)    Chemical carcinogenesis   
NDEx NetworkCYP2E1
Atlas of Cancer Signalling NetworkCYP2E1
Wikipedia pathwaysCYP2E1
Orthology - Evolution
OrthoDB1571
GeneTree (enSembl)ENSG00000130649
Phylogenetic Trees/Animal Genes : TreeFamCYP2E1
Homologs : HomoloGeneCYP2E1
Homology/Alignments : Family Browser (UCSC)CYP2E1
Gene fusions - Rearrangements
Fusion : QuiverCYP2E1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP2E1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2E1
dbVarCYP2E1
ClinVarCYP2E1
MonarchCYP2E1
1000_GenomesCYP2E1 
Exome Variant ServerCYP2E1
GNOMAD BrowserENSG00000130649
Varsome BrowserCYP2E1
ACMGCYP2E1 variants
VarityP05181
Genomic Variants (DGV)CYP2E1 [DGVbeta]
DECIPHERCYP2E1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP2E1 
Mutations
ICGC Data PortalCYP2E1 
TCGA Data PortalCYP2E1 
Broad Tumor PortalCYP2E1
OASIS PortalCYP2E1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP2E1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYP2E1
Mutations and Diseases : HGMDCYP2E1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCYP2E1
DgiDB (Drug Gene Interaction Database)CYP2E1
DoCM (Curated mutations)CYP2E1
CIViC (Clinical Interpretations of Variants in Cancer)CYP2E1
Cancer3DCYP2E1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124040   
Orphanet
DisGeNETCYP2E1
MedgenCYP2E1
Genetic Testing Registry CYP2E1
NextProtP05181 [Medical]
GENETestsCYP2E1
Target ValidationCYP2E1
Huge Navigator CYP2E1 [HugePedia]
ClinGenCYP2E1
Clinical trials, drugs, therapy
MyCancerGenomeCYP2E1
Protein Interactions : CTDCYP2E1
Pharm GKB GenePA129
Pharm GKB PathwaysPA145011115   PA165817070   PA165859361   PA165884757   PA165958541   PA165986279   PA166117881   
PharosP05181
Clinical trialCYP2E1
Miscellaneous
canSAR (ICR)CYP2E1
HarmonizomeCYP2E1
DataMed IndexCYP2E1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCYP2E1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:57 CEST 2021

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