Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1)

Identity

Other namesCPE1
CYP2E
P450-J
P450C2E
HGNC (Hugo) CYP2E1
LocusID (NCBI) 1571
Location 10q26.3
Location_base_pair Starts at 135340867 and ends at 135352620 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP2E1   2631
Cards
Entrez_Gene (NCBI)CYP2E1  1571  cytochrome P450, family 2, subfamily E, polypeptide 1
GeneCards (Weizmann)CYP2E1
Ensembl hg19 (Hinxton)ENSG00000130649 [Gene_View]  chr10:135340867-135352620 [Contig_View]  CYP2E1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130649 [Gene_View]  chr10:135340867-135352620 [Contig_View]  CYP2E1 [Vega]
ICGC DataPortalENSG00000130649
cBioPortalCYP2E1
AceView (NCBI)CYP2E1
Genatlas (Paris)CYP2E1
WikiGenes1571
SOURCE (Princeton)CYP2E1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP2E1  -     chr10:135340867-135352620 +  10q26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP2E1  -     10q26.3   [Description]    (hg38-Dec_2013)
EnsemblCYP2E1 - 10q26.3 [CytoView hg19]  CYP2E1 - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBICYP2E1 [Mapview hg19]  CYP2E1 [Mapview hg38]
OMIM124040   
Gene and transcription
Genbank (Entrez)AF084225 AF182276 AJ853939 AJ853940 AJ877238
RefSeq transcript (Entrez)NM_000773
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_008383 NT_030059 NW_001838014 NW_004929377
Consensus coding sequences : CCDS (NCBI)CYP2E1
Cluster EST : UnigeneHs.12907 [ NCBI ]
CGAP (NCI)Hs.12907
Alternative Splicing : Fast-db (Paris)GSHG0003809
Alternative Splicing GalleryENSG00000130649
Gene ExpressionCYP2E1 [ NCBI-GEO ]     CYP2E1 [ SEEK ]   CYP2E1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05181 (Uniprot)
NextProtP05181  [Medical]
With graphics : InterProP05181
Splice isoforms : SwissVarP05181 (Swissvar)
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP2E-like   
Related proteins : CluSTrP05181
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1571
Blocks (Seattle)P05181
PDB (SRS)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (PDBSum)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (IMB)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
PDB (RSDB)3E4E    3E6I    3GPH    3KOH    3LC4    3T3Z   
Human Protein AtlasENSG00000130649
Peptide AtlasP05181
HPRD11813
IPIIPI00007282   IPI01011893   IPI00816414   IPI00555724   IPI01009826   IPI00816043   IPI01011560   
Protein Interaction databases
DIP (DOE-UCLA)P05181
IntAct (EBI)P05181
FunCoupENSG00000130649
BioGRIDCYP2E1
IntegromeDBCYP2E1
STRING (EMBL)CYP2E1
Ontologies - Pathways
QuickGOP05181
Ontology : AmiGOGolgi membrane  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  triglyceride metabolic process  xenobiotic metabolic process  steroid metabolic process  response to ozone  response to organonitrogen compound  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  oxygen binding  enzyme binding  heme binding  intrinsic component of endoplasmic reticulum membrane  response to drug  small molecule metabolic process  response to ethanol  heterocycle metabolic process  oxidation-reduction process  
Ontology : EGO-EBIGolgi membrane  monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum membrane  triglyceride metabolic process  xenobiotic metabolic process  steroid metabolic process  response to ozone  response to organonitrogen compound  monoterpenoid metabolic process  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  drug metabolic process  drug metabolic process  oxygen binding  enzyme binding  heme binding  intrinsic component of endoplasmic reticulum membrane  response to drug  small molecule metabolic process  response to ethanol  heterocycle metabolic process  oxidation-reduction process  
Pathways : BIOCARTAMechanism of Acetaminophen Activity and Toxicity [Genes]    Nuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGSteroid hormone biosynthesis    Arachidonic acid metabolism    Linoleic acid metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Non-alcoholic fatty liver disease (NAFLD)    Chemical carcinogenesis   
Protein Interaction DatabaseCYP2E1
DoCM (Curated mutations)CYP2E1
Wikipedia pathwaysCYP2E1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCYP2E1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP2E1
dbVarCYP2E1
ClinVarCYP2E1
1000_GenomesCYP2E1 
Exome Variant ServerCYP2E1
SNP (GeneSNP Utah)CYP2E1
SNP : HGBaseCYP2E1
Genetic variants : HAPMAPCYP2E1
Genomic VariantsCYP2E1  CYP2E1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000130649 
Somatic Mutations in Cancer : COSMICCYP2E1 
CONAN: Copy Number AnalysisCYP2E1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:135340867-135352620
Mutations and Diseases : HGMDCYP2E1
OMIM124040   
MedgenCYP2E1
NextProtP05181 [Medical]
GENETestsCYP2E1
Disease Genetic AssociationCYP2E1
Huge Navigator CYP2E1 [HugePedia]  CYP2E1 [HugeCancerGEM]
snp3D : Map Gene to Disease1571
DGIdb (Drug Gene Interaction db)CYP2E1
General knowledge
Homologs : HomoloGeneCYP2E1
Homology/Alignments : Family Browser (UCSC)CYP2E1
Phylogenetic Trees/Animal Genes : TreeFamCYP2E1
Chemical/Protein Interactions : CTD1571
Chemical/Pharm GKB GenePA129
Clinical trialCYP2E1
Cancer Resource (Charite)ENSG00000130649
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCYP2E1
GoPubMedCYP2E1
iHOPCYP2E1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:06:15 CET 2014

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