CYP2J2 (cytochrome P450 family 2 subfamily J member 2)

2007-09-01  

Identity

HGNC
LOCATION
1p32.1
LOCUSID
ALIAS
CPJ2,CYPIIJ2
FUSION GENES

Other Information

Locus ID:

NCBI: 1573
MIM: 601258
HGNC: 2634
Ensembl: ENSG00000134716

Variants:

dbSNP: 1573
ClinVar: 1573
TCGA: ENSG00000134716
COSMIC: CYP2J2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134716ENST00000371204P51589
ENSG00000134716ENST00000466095A0A3B3IU95
ENSG00000134716ENST00000468257A0A3B3IT99
ENSG00000134716ENST00000469406A0A3B3ITF2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
Fatty acidsREACTOMER-HSA-211935

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164746058albendazoleChemicalVipGeneassociated19923256
PA164749056danazolChemicalVipGeneassociated19923256
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD28316087
PA166153598rs890293VariantVipGeneassociated15861034, 15864120, 16202848, 17126841, 17327508, 17475630, 18496133, 19851119, 11901223
PA443796Coronary Artery DiseaseDiseaseVipGeneassociated
PA444552HypertensionDiseaseVipGeneassociated15864120
PA445019Myocardial InfarctionDiseaseVipGeneassociated17126841
PA448383amiodaroneChemicalVipGeneassociated19923256
PA448498astemizoleChemicalVipGeneassociated15861034
PA449293diclofenacChemicalVipGeneassociated15861034
PA450386mesoridazineChemicalVipGeneassociated19923256
PA450572nabumetoneChemicalVipGeneassociated19923256
PA451578tacrolimusChemicalClinicalAnnotationassociatedPD28316087
PA451619terfenadineChemicalVipGeneassociated15861034
PA451666thioridazineChemicalVipGeneassociated19923256

References

Pubmed IDYearTitleCitations
152564822004Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.103
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
154666382004Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.75
154666382004Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.75
176388762007Cytochrome p450 epoxygenase promotes human cancer metastasis.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
210597502011Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.60
201730832010Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.44
158641202005Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.34
158641202005Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension.34

Citation

Dessen P

CYP2J2 (cytochrome P450 family 2 subfamily J member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49722/cyp2j2