| Nomenclature |
|---|
| HGNC (Hugo) | CYP2R1 20580 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CYP2R1 cytochrome P450 family 2 subfamily R member 1 |
| Aliases | |
| GeneCards (Weizmann) | CYP2R1 |
| Ensembl hg19 (Hinxton) | ENSG00000186104 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186104 [Gene_View] ENSG00000186104 [Sequence] chr11:14877440-14892231 [Contig_View] CYP2R1 [Vega] |
| ICGC DataPortal | ENSG00000186104 |
| TCGA cBioPortal | CYP2R1 |
| AceView (NCBI) | CYP2R1 |
| Genatlas (Paris) | CYP2R1 |
| SOURCE (Princeton) | CYP2R1 |
| Genetics Home Reference (NIH) | CYP2R1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CYP2R1 - chr11:14877440-14892231 - 11p15.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CYP2R1 - 11p15.2 [Description] (hg19-Feb_2009) |
| GoldenPath | CYP2R1 - 11p15.2 [CytoView hg19] CYP2R1 - 11p15.2 [CytoView hg38] |
| ImmunoBase | ENSG00000186104 |
| genome Data Viewer NCBI | CYP2R1 [Mapview hg19] |
| OMIM | 600081 608713 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK092584 AK312019 AW138676 AY323817 BC052580 |
| RefSeq transcript (Entrez) | NM_001377214 NM_001377215 NM_001377216 NM_001377217 NM_001377227 NM_024514 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CYP2R1 |
| Alternative Splicing Gallery | ENSG00000186104 |
| Gene Expression | CYP2R1 [ NCBI-GEO ] CYP2R1 [ EBI - ARRAY_EXPRESS ]
CYP2R1 [ SEEK ] CYP2R1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CYP2R1 [ Firebrowse - Broad ] |
| Genevisible | Expression of CYP2R1 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 120227 |
| GTEX Portal (Tissue expression) | CYP2R1 |
| Human Protein Atlas | ENSG00000186104-CYP2R1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q6VVX0 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q6VVX0 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q6VVX0 |
| Splice isoforms : SwissVar | Q6VVX0 |
| PhosPhoSitePlus | Q6VVX0 |
| Domaine pattern : Prosite (Expaxy) | CYTOCHROME_P450 (PS00086) |
| Domains : Interpro (EBI) | Cyt_P450 Cyt_P450_CS Cyt_P450_E_grp-I Cyt_P450_sf |
| Domain families : Pfam (Sanger) | p450 (PF00067) |
| Domain families : Pfam (NCBI) | pfam00067 |
| Conserved Domain (NCBI) | CYP2R1 |
| Blocks (Seattle) | CYP2R1 |
| PDB (RSDB) | 3C6G 3CZH 3DL9 |
| PDB Europe | 3C6G 3CZH 3DL9 |
| PDB (PDBSum) | 3C6G 3CZH 3DL9 |
| PDB (IMB) | 3C6G 3CZH 3DL9 |
| Structural Biology KnowledgeBase | 3C6G 3CZH 3DL9 |
| SCOP (Structural Classification of Proteins) | 3C6G 3CZH 3DL9 |
| CATH (Classification of proteins structures) | 3C6G 3CZH 3DL9 |
| Superfamily | Q6VVX0 |
| Human Protein Atlas [tissue] | ENSG00000186104-CYP2R1 [tissue] |
| Peptide Atlas | Q6VVX0 |
| HPRD | 10569 |
| IPI | IPI00409700 IPI00984511 IPI00983845 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q6VVX0 |
| IntAct (EBI) | Q6VVX0 |
| BioGRID | CYP2R1 |
| STRING (EMBL) | CYP2R1 |
| ZODIAC | CYP2R1 |
| Ontologies - Pathways |
|---|
| QuickGO | Q6VVX0 |
| Ontology : AmiGO | iron ion binding cytoplasm endoplasmic reticulum membrane organic acid metabolic process vitamin metabolic process xenobiotic metabolic process steroid hydroxylase activity response to cesium ion response to ionizing radiation oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding heme binding vitamin D3 25-hydroxylase activity vitamin D3 25-hydroxylase activity calcitriol biosynthetic process from calciol vitamin D metabolic process exogenous drug catabolic process protein homodimerization activity intracellular membrane-bounded organelle D3 vitamins binding |
| Ontology : EGO-EBI | iron ion binding cytoplasm endoplasmic reticulum membrane organic acid metabolic process vitamin metabolic process xenobiotic metabolic process steroid hydroxylase activity response to cesium ion response to ionizing radiation oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen heme binding heme binding vitamin D3 25-hydroxylase activity vitamin D3 25-hydroxylase activity calcitriol biosynthetic process from calciol vitamin D metabolic process exogenous drug catabolic process protein homodimerization activity intracellular membrane-bounded organelle D3 vitamins binding |
| Pathways : KEGG | Steroid biosynthesis |
| NDEx Network | CYP2R1 |
| Atlas of Cancer Signalling Network | CYP2R1 |
| Wikipedia pathways | CYP2R1 |
| Orthology - Evolution |
|---|
| OrthoDB | 120227 |
| GeneTree (enSembl) | ENSG00000186104 |
| Phylogenetic Trees/Animal Genes : TreeFam | CYP2R1 |
| HOGENOM | Q6VVX0 |
| Homologs : HomoloGene | CYP2R1 |
| Homology/Alignments : Family Browser (UCSC) | CYP2R1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | ANO1/CYP2R1 [11q13.3/11p15.2] |
| Fusion Portal | ANO1 11q13.3 CYP2R1 11p15.2 BRCA |
| Fusion : Quiver | CYP2R1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CYP2R1 [hg38] |
| dbVar | CYP2R1 |
| ClinVar | CYP2R1 |
| Monarch | CYP2R1 |
| 1000_Genomes | CYP2R1 |
| Exome Variant Server | CYP2R1 |
| GNOMAD Browser | ENSG00000186104 |
| Varsome Browser | CYP2R1 |
| Genomic Variants (DGV) | CYP2R1 [DGVbeta] |
| DECIPHER | CYP2R1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CYP2R1 |
| Mutations |
|---|
| ICGC Data Portal | CYP2R1 |
| TCGA Data Portal | CYP2R1 |
| Broad Tumor Portal | CYP2R1 |
| OASIS Portal | CYP2R1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CYP2R1 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CYP2R1 |
| Mutations and Diseases : HGMD | CYP2R1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CYP2R1 |
| DgiDB (Drug Gene Interaction Database) | CYP2R1 |
| DoCM (Curated mutations) | CYP2R1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CYP2R1 (select a term) |
| intoGen | CYP2R1 |
| Cancer3D | CYP2R1(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600081 608713 |
| Orphanet | 20702 |
| DisGeNET | CYP2R1 |
| Medgen | CYP2R1 |
| Genetic Testing Registry | CYP2R1
|
| NextProt | Q6VVX0 [Medical] |
| GENETests | CYP2R1 |
| Target Validation | CYP2R1 |
| Huge Navigator |
CYP2R1 [HugePedia] |
| ClinGen | CYP2R1 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | CYP2R1 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA134986407 |
| Pharos | Q6VVX0 |
| Clinical trial | CYP2R1 |
| Miscellaneous |
|---|
| canSAR (ICR) | CYP2R1 (select the gene name) |
| Harmonizome | CYP2R1 |
| DataMed Index | CYP2R1 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 91 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | CYP2R1 |
