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CYP3A4 (cytochrome P450 family 3 subfamily A member 4)

Identity

Alias_namesCYP3A3
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
cytochrome P450, family 3, subfamily A, polypeptide 4
Other aliasCP33
CP34
CYP3A
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
HGNC (Hugo) CYP3A4
LocusID (NCBI) 1576
Atlas_Id 40250
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 99354583 and ends at 99381811 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACSM2B (16p12.3) / CYP3A4 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP3A4   2637
Cards
Entrez_Gene (NCBI)CYP3A4  1576  cytochrome P450 family 3 subfamily A member 4
AliasesCP33; CP34; CYP3A; CYP3A3; 
CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1
GeneCards (Weizmann)CYP3A4
Ensembl hg19 (Hinxton)ENSG00000160868 [Gene_View]  chr7:99354583-99381811 [Contig_View]  CYP3A4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160868 [Gene_View]  chr7:99354583-99381811 [Contig_View]  CYP3A4 [Vega]
ICGC DataPortalENSG00000160868
TCGA cBioPortalCYP3A4
AceView (NCBI)CYP3A4
Genatlas (Paris)CYP3A4
WikiGenes1576
SOURCE (Princeton)CYP3A4
Genetics Home Reference (NIH)CYP3A4
Genomic and cartography
GoldenPath hg19 (UCSC)CYP3A4  -     chr7:99354583-99381811 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP3A4  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblCYP3A4 - 7q22.1 [CytoView hg19]  CYP3A4 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBICYP3A4 [Mapview hg19]  CYP3A4 [Mapview hg38]
OMIM124010   
Gene and transcription
Genbank (Entrez)AF182273 AK298451 AK298462 AK312967 AY606313
RefSeq transcript (Entrez)NM_001202855 NM_001202856 NM_001202857 NM_017460
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_008421 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)CYP3A4
Cluster EST : UnigeneHs.728751 [ NCBI ]
CGAP (NCI)Hs.728751
Alternative Splicing GalleryENSG00000160868
Gene ExpressionCYP3A4 [ NCBI-GEO ]   CYP3A4 [ EBI - ARRAY_EXPRESS ]   CYP3A4 [ SEEK ]   CYP3A4 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP3A4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1576
GTEX Portal (Tissue expression)CYP3A4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08684
Splice isoforms : SwissVarP08684
Catalytic activity : Enzyme1.14.13.- [ Enzyme-Expasy ]   1.14.13.-1.14.13.- [ IntEnz-EBI ]   1.14.13.- [ BRENDA ]   1.14.13.- [ KEGG ]   
PhosPhoSitePlusP08684
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_CYP3A    Cyt_P450_E_grp-II   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP3A4
DMDM Disease mutations1576
Blocks (Seattle)CYP3A4
PDB (SRS)1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
PDB (PDBSum)1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
PDB (IMB)1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
PDB (RSDB)1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
Structural Biology KnowledgeBase1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
SCOP (Structural Classification of Proteins)1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
CATH (Classification of proteins structures)1TQN    1W0E    1W0F    1W0G    2J0D    2V0M    3NXU    3TJS    3UA1    4D6Z    4D75    4D78    4D7D    4I3Q    4I4G    4I4H    4K9T    4K9U    4K9V    4K9W    4K9X    4NY4    5A1P    5A1R   
SuperfamilyP08684
Human Protein AtlasENSG00000160868
Peptide AtlasP08684
HPRD00484
IPIIPI00465138   IPI00940515   IPI01010095   IPI00984151   IPI00925391   
Protein Interaction databases
DIP (DOE-UCLA)P08684
IntAct (EBI)P08684
FunCoupENSG00000160868
BioGRIDCYP3A4
STRING (EMBL)CYP3A4
ZODIACCYP3A4
Ontologies - Pathways
QuickGOP08684
Ontology : AmiGOmonooxygenase activity  monooxygenase activity  steroid binding  iron ion binding  cytoplasm  endoplasmic reticulum membrane  lipid metabolic process  steroid catabolic process  xenobiotic metabolic process  steroid metabolic process  androgen metabolic process  steroid hydroxylase activity  alkaloid catabolic process  integral component of membrane  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  oxygen binding  enzyme binding  heme binding  vitamin D3 25-hydroxylase activity  taurochenodeoxycholate 6alpha-hydroxylase activity  caffeine oxidase activity  calcitriol biosynthetic process from calciol  vitamin D metabolic process  drug catabolic process  drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  heterocycle metabolic process  albendazole monooxygenase activity  quinine 3-monooxygenase activity  testosterone 6-beta-hydroxylase activity  oxidation-reduction process  aromatase activity  vitamin D 24-hydroxylase activity  oxidative demethylation  
Ontology : EGO-EBImonooxygenase activity  monooxygenase activity  steroid binding  iron ion binding  cytoplasm  endoplasmic reticulum membrane  lipid metabolic process  steroid catabolic process  xenobiotic metabolic process  steroid metabolic process  androgen metabolic process  steroid hydroxylase activity  alkaloid catabolic process  integral component of membrane  monoterpenoid metabolic process  oxidoreductase activity  drug metabolic process  oxygen binding  enzyme binding  heme binding  vitamin D3 25-hydroxylase activity  taurochenodeoxycholate 6alpha-hydroxylase activity  caffeine oxidase activity  calcitriol biosynthetic process from calciol  vitamin D metabolic process  drug catabolic process  drug catabolic process  exogenous drug catabolic process  intracellular membrane-bounded organelle  heterocycle metabolic process  albendazole monooxygenase activity  quinine 3-monooxygenase activity  testosterone 6-beta-hydroxylase activity  oxidation-reduction process  aromatase activity  vitamin D 24-hydroxylase activity  oxidative demethylation  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGSteroid hormone biosynthesis    Linoleic acid metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Drug metabolism - other enzymes    Bile secretion    Chemical carcinogenesis   
NDEx NetworkCYP3A4
Atlas of Cancer Signalling NetworkCYP3A4
Wikipedia pathwaysCYP3A4
Orthology - Evolution
OrthoDB1576
GeneTree (enSembl)ENSG00000160868
Phylogenetic Trees/Animal Genes : TreeFamCYP3A4
HOVERGENP08684
HOGENOMP08684
Homologs : HomoloGeneCYP3A4
Homology/Alignments : Family Browser (UCSC)CYP3A4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP3A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP3A4
dbVarCYP3A4
ClinVarCYP3A4
1000_GenomesCYP3A4 
Exome Variant ServerCYP3A4
ExAC (Exome Aggregation Consortium)CYP3A4 (select the gene name)
Genetic variants : HAPMAP1576
Genomic Variants (DGV)CYP3A4 [DGVbeta]
DECIPHER (Syndromes)7:99354583-99381811  ENSG00000160868
CONAN: Copy Number AnalysisCYP3A4 
Mutations
ICGC Data PortalCYP3A4 
TCGA Data PortalCYP3A4 
Broad Tumor PortalCYP3A4
OASIS PortalCYP3A4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP3A4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP3A4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP3A4
DgiDB (Drug Gene Interaction Database)CYP3A4
DoCM (Curated mutations)CYP3A4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP3A4 (select a term)
intoGenCYP3A4
Cancer3DCYP3A4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124010   
Orphanet19448   
MedgenCYP3A4
Genetic Testing Registry CYP3A4
NextProtP08684 [Medical]
TSGene1576
GENETestsCYP3A4
Huge Navigator CYP3A4 [HugePedia]
snp3D : Map Gene to Disease1576
BioCentury BCIQCYP3A4
ClinGenCYP3A4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1576
Chemical/Pharm GKB GenePA130
Clinical trialCYP3A4
Miscellaneous
canSAR (ICR)CYP3A4 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP3A4
EVEXCYP3A4
GoPubMedCYP3A4
iHOPCYP3A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:58:17 CEST 2017

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