Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP3A5 (cytochrome P450 family 3 subfamily A member 5)

Identity

Alias_namescytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
cytochrome P450, family 3, subfamily A, polypeptide 5
Alias_symbol (synonym)PCN3
P450PCN3
CP35
Other aliasCYPIIIA5
HGNC (Hugo) CYP3A5
LocusID (NCBI) 1577
Atlas_Id 40251
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 99648189 and ends at 99680026 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYH3 (17p13.1) / CYP3A5 (7q22.1)MYH3 17p13.1 / CYP3A5 7q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP3A5   2638
Cards
Entrez_Gene (NCBI)CYP3A5  1577  cytochrome P450 family 3 subfamily A member 5
AliasesCP35; CYPIIIA5; P450PCN3; PCN3
GeneCards (Weizmann)CYP3A5
Ensembl hg19 (Hinxton)ENSG00000106258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106258 [Gene_View]  chr7:99648189-99680026 [Contig_View]  CYP3A5 [Vega]
ICGC DataPortalENSG00000106258
TCGA cBioPortalCYP3A5
AceView (NCBI)CYP3A5
Genatlas (Paris)CYP3A5
WikiGenes1577
SOURCE (Princeton)CYP3A5
Genetics Home Reference (NIH)CYP3A5
Genomic and cartography
GoldenPath hg38 (UCSC)CYP3A5  -     chr7:99648189-99680026 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP3A5  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblCYP3A5 - 7q22.1 [CytoView hg19]  CYP3A5 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBICYP3A5 [Mapview hg19]  CYP3A5 [Mapview hg38]
OMIM145500   605325   
Gene and transcription
Genbank (Entrez)AA076026 AF355801 AF355802 AF355804 AK055879
RefSeq transcript (Entrez)NM_000777 NM_001190484 NM_001291829 NM_001291830
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP3A5
Cluster EST : UnigeneHs.571258 [ NCBI ]
CGAP (NCI)Hs.571258
Alternative Splicing GalleryENSG00000106258
Gene ExpressionCYP3A5 [ NCBI-GEO ]   CYP3A5 [ EBI - ARRAY_EXPRESS ]   CYP3A5 [ SEEK ]   CYP3A5 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP3A5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1577
GTEX Portal (Tissue expression)CYP3A5
Human Protein AtlasENSG00000106258-CYP3A5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20815   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20815  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20815
Splice isoforms : SwissVarP20815
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
PhosPhoSitePlusP20815
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_CYP3A    Cyt_P450_E_grp-II   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP3A5
DMDM Disease mutations1577
Blocks (Seattle)CYP3A5
SuperfamilyP20815
Human Protein Atlas [tissue]ENSG00000106258-CYP3A5 [tissue]
Peptide AtlasP20815
HPRD05617
IPIIPI00854876   
Protein Interaction databases
DIP (DOE-UCLA)P20815
IntAct (EBI)P20815
FunCoupENSG00000106258
BioGRIDCYP3A5
STRING (EMBL)CYP3A5
ZODIACCYP3A5
Ontologies - Pathways
QuickGOP20815
Ontology : AmiGOlipid hydroxylation  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  alkaloid catabolic process  oxidoreductase activity  oxygen binding  heme binding  organelle membrane  drug catabolic process  intracellular membrane-bounded organelle  aromatase activity  oxidative demethylation  estrogen 16-alpha-hydroxylase activity  
Ontology : EGO-EBIlipid hydroxylation  monooxygenase activity  iron ion binding  endoplasmic reticulum membrane  xenobiotic metabolic process  steroid metabolic process  alkaloid catabolic process  oxidoreductase activity  oxygen binding  heme binding  organelle membrane  drug catabolic process  intracellular membrane-bounded organelle  aromatase activity  oxidative demethylation  estrogen 16-alpha-hydroxylase activity  
Pathways : KEGGSteroid hormone biosynthesis    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkCYP3A5
Atlas of Cancer Signalling NetworkCYP3A5
Wikipedia pathwaysCYP3A5
Orthology - Evolution
OrthoDB1577
GeneTree (enSembl)ENSG00000106258
Phylogenetic Trees/Animal Genes : TreeFamCYP3A5
HOVERGENP20815
HOGENOMP20815
Homologs : HomoloGeneCYP3A5
Homology/Alignments : Family Browser (UCSC)CYP3A5
Gene fusions - Rearrangements
Fusion : MitelmanMYH3/CYP3A5 [17p13.1/7q22.1]  [t(7;17)(q22;p13)]  
Fusion: TCGA_MDACCMYH3 17p13.1 CYP3A5 7q22.1 PRAD
Tumor Fusion PortalCYP3A5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP3A5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP3A5
dbVarCYP3A5
ClinVarCYP3A5
1000_GenomesCYP3A5 
Exome Variant ServerCYP3A5
ExAC (Exome Aggregation Consortium)ENSG00000106258
GNOMAD BrowserENSG00000106258
Genetic variants : HAPMAP1577
Genomic Variants (DGV)CYP3A5 [DGVbeta]
DECIPHERCYP3A5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP3A5 
Mutations
ICGC Data PortalCYP3A5 
TCGA Data PortalCYP3A5 
Broad Tumor PortalCYP3A5
OASIS PortalCYP3A5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP3A5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP3A5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch CYP3A5
DgiDB (Drug Gene Interaction Database)CYP3A5
DoCM (Curated mutations)CYP3A5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP3A5 (select a term)
intoGenCYP3A5
Cancer3DCYP3A5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM145500    605325   
Orphanet19448   
DisGeNETCYP3A5
MedgenCYP3A5
Genetic Testing Registry CYP3A5
NextProtP20815 [Medical]
TSGene1577
GENETestsCYP3A5
Target ValidationCYP3A5
Huge Navigator CYP3A5 [HugePedia]
snp3D : Map Gene to Disease1577
BioCentury BCIQCYP3A5
ClinGenCYP3A5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1577
Chemical/Pharm GKB GenePA131
Clinical trialCYP3A5
Miscellaneous
canSAR (ICR)CYP3A5 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP3A5
EVEXCYP3A5
GoPubMedCYP3A5
iHOPCYP3A5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:09:50 CET 2017

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