CYP3A7 (cytochrome P450 family 3 subfamily A member 7)

2011-04-01 Affiliation

Identity

HGNC

CYP3A7

LOCATION

7q22.1

LOCUSID

1551

ALIAS

CP37,CYPIIIA7,P-450(HFL33),P-450111A7,P450-HFLA,P450HLp2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1551
MIM: 605340
HGNC: 2640
Ensembl: ENSG00000160870

Variants:

dbSNP: 1551
ClinVar: 1551
TCGA: ENSG00000160870
COSMIC: CYP3A7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160870	ENST00000336374	P24462
ENSG00000160870	ENST00000620220	A0A087WV96

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164771231	etonogestrel	Chemical	VariantAnnotation	associated	PK	PD	30870275
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK		27966227, 28952408
PA443286	Adrenal Hyperplasia, Congenital	Disease	VariantAnnotation	associated		PD
PA443319	Alzheimer Disease	Disease	VariantAnnotation	not associated	PK
PA447215	Psychotic Disorders	Disease	VariantAnnotation	not associated	PK		23609392
PA449130	cortisone acetate	Chemical	VariantAnnotation	associated		PD
PA449167	cyclosporine	Chemical	VariantAnnotation	associated	PK		28952408
PA449394	donepezil	Chemical	VariantAnnotation	not associated	PK
PA451257	risperidone	Chemical	VariantAnnotation	not associated	PK		23609392
PA451578	tacrolimus	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		27966227

References

Pubmed ID	Year	Title	Citations
18676680	2008	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	32
11940601	2002	Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.	29
19692168	2010	Genetic susceptibility to distinct bladder cancer subphenotypes.	25
17885626	2007	1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation.	23
19801957	2009	The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.	22
19424794	2010	Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.	21
16041241	2005	CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele.	18
18978522	2008	CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.	18
20634891	2010	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	18
19593168	2009	ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.	17

Citation

Dessen P

CYP3A7 (cytochrome P450 family 3 subfamily A member 7)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52170/cyp3a7