Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP4A11 (cytochrome P450 family 4 subfamily A member 11)

Identity

Alias_namesCYP4A2
cytochrome P450, subfamily IVA, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
Alias_symbol (synonym)CYP4AII
Other aliasCP4Y
HGNC (Hugo) CYP4A11
LocusID (NCBI) 1579
Atlas_Id 40252
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 46929174 and ends at 46941484 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYP4A11 (1p33) / SLC4A7 (3p24.1)RERE (1p36.23) / CYP4A11 (1p33)RERE 1p36.23 / CYP4A11 1p33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP4A11   2642
Cards
Entrez_Gene (NCBI)CYP4A11  1579  cytochrome P450 family 4 subfamily A member 11
AliasesCP4Y; CYP4A2; CYP4AII
GeneCards (Weizmann)CYP4A11
Ensembl hg19 (Hinxton)ENSG00000187048 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187048 [Gene_View]  chr1:46929174-46941484 [Contig_View]  CYP4A11 [Vega]
ICGC DataPortalENSG00000187048
TCGA cBioPortalCYP4A11
AceView (NCBI)CYP4A11
Genatlas (Paris)CYP4A11
WikiGenes1579
SOURCE (Princeton)CYP4A11
Genetics Home Reference (NIH)CYP4A11
Genomic and cartography
GoldenPath hg38 (UCSC)CYP4A11  -     chr1:46929174-46941484 -  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP4A11  -     1p33   [Description]    (hg19-Feb_2009)
EnsemblCYP4A11 - 1p33 [CytoView hg19]  CYP4A11 - 1p33 [CytoView hg38]
Mapping of homologs : NCBICYP4A11 [Mapview hg19]  CYP4A11 [Mapview hg38]
OMIM601310   
Gene and transcription
Genbank (Entrez)AK298267 AK298413 BC022851 BC041158 CD013974
RefSeq transcript (Entrez)NM_000778 NM_001319155
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP4A11
Cluster EST : UnigeneHs.726474 [ NCBI ]
CGAP (NCI)Hs.726474
Alternative Splicing GalleryENSG00000187048
Gene ExpressionCYP4A11 [ NCBI-GEO ]   CYP4A11 [ EBI - ARRAY_EXPRESS ]   CYP4A11 [ SEEK ]   CYP4A11 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP4A11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1579
GTEX Portal (Tissue expression)CYP4A11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02928   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02928  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02928
Splice isoforms : SwissVarQ02928
PhosPhoSitePlusQ02928
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP4A11
DMDM Disease mutations1579
Blocks (Seattle)CYP4A11
SuperfamilyQ02928
Human Protein AtlasENSG00000187048
Peptide AtlasQ02928
HPRD03201
IPIIPI00872799   IPI00908917   IPI00829998   IPI00646318   
Protein Interaction databases
DIP (DOE-UCLA)Q02928
IntAct (EBI)Q02928
FunCoupENSG00000187048
BioGRIDCYP4A11
STRING (EMBL)CYP4A11
ZODIACCYP4A11
Ontologies - Pathways
QuickGOQ02928
Ontology : AmiGOlong-chain fatty acid metabolic process  renal water homeostasis  pressure natriuresis  monooxygenase activity  iron ion binding  cytoplasm  endoplasmic reticulum membrane  fatty acid metabolic process  leukotriene metabolic process  arachidonic acid epoxygenase activity  apical plasma membrane  alkane 1-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  organelle membrane  positive regulation of icosanoid secretion  leukotriene B4 catabolic process  intracellular membrane-bounded organelle  leukotriene-B4 20-monooxygenase activity  sodium ion homeostasis  oxidation-reduction process  extracellular exosome  omega-hydroxylase P450 pathway  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  renal water homeostasis  pressure natriuresis  monooxygenase activity  iron ion binding  cytoplasm  endoplasmic reticulum membrane  fatty acid metabolic process  leukotriene metabolic process  arachidonic acid epoxygenase activity  apical plasma membrane  alkane 1-monooxygenase activity  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  heme binding  organelle membrane  positive regulation of icosanoid secretion  leukotriene B4 catabolic process  intracellular membrane-bounded organelle  leukotriene-B4 20-monooxygenase activity  sodium ion homeostasis  oxidation-reduction process  extracellular exosome  omega-hydroxylase P450 pathway  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGFatty acid degradation    Arachidonic acid metabolism    Retinol metabolism    Vascular smooth muscle contraction   
NDEx NetworkCYP4A11
Atlas of Cancer Signalling NetworkCYP4A11
Wikipedia pathwaysCYP4A11
Orthology - Evolution
OrthoDB1579
GeneTree (enSembl)ENSG00000187048
Phylogenetic Trees/Animal Genes : TreeFamCYP4A11
HOVERGENQ02928
HOGENOMQ02928
Homologs : HomoloGeneCYP4A11
Homology/Alignments : Family Browser (UCSC)CYP4A11
Gene fusions - Rearrangements
Fusion : MitelmanRERE/CYP4A11 [1p36.23/1p33]  [t(1;1)(p33;p36)]  
Fusion: TCGARERE 1p36.23 CYP4A11 1p33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP4A11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP4A11
dbVarCYP4A11
ClinVarCYP4A11
1000_GenomesCYP4A11 
Exome Variant ServerCYP4A11
ExAC (Exome Aggregation Consortium)CYP4A11 (select the gene name)
Genetic variants : HAPMAP1579
Genomic Variants (DGV)CYP4A11 [DGVbeta]
DECIPHERCYP4A11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP4A11 
Mutations
ICGC Data PortalCYP4A11 
TCGA Data PortalCYP4A11 
Broad Tumor PortalCYP4A11
OASIS PortalCYP4A11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP4A11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP4A11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP4A11
DgiDB (Drug Gene Interaction Database)CYP4A11
DoCM (Curated mutations)CYP4A11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP4A11 (select a term)
intoGenCYP4A11
Cancer3DCYP4A11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601310   
Orphanet
MedgenCYP4A11
Genetic Testing Registry CYP4A11
NextProtQ02928 [Medical]
TSGene1579
GENETestsCYP4A11
Target ValidationCYP4A11
Huge Navigator CYP4A11 [HugePedia]
snp3D : Map Gene to Disease1579
BioCentury BCIQCYP4A11
ClinGenCYP4A11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1579
Chemical/Pharm GKB GenePA27118
Clinical trialCYP4A11
Miscellaneous
canSAR (ICR)CYP4A11 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP4A11
EVEXCYP4A11
GoPubMedCYP4A11
iHOPCYP4A11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:30:26 CEST 2017

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