CYP4A11 (cytochrome P450 family 4 subfamily A member 11)

2003-06-01 Affiliation

Identity

HGNC

CYP4A11

LOCATION

1p33

LOCUSID

1579

ALIAS

CP4Y,CYP4A2,CYP4AII,CYPIVA11

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1579
MIM: 601310
HGNC: 2642
Ensembl: ENSG00000187048

Variants:

dbSNP: 1579
ClinVar: 1579
TCGA: ENSG00000187048
COSMIC: CYP4A11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187048	ENST00000310638	Q02928
ENSG00000187048	ENST00000371904	E7EVL8
ENSG00000187048	ENST00000371905	A0A0C4DFV7
ENSG00000187048	ENST00000462347	V9GZ77
ENSG00000187048	ENST00000465874	V9GY41
ENSG00000187048	ENST00000468629	V9GYC6
ENSG00000187048	ENST00000474458	V9GYQ2
ENSG00000187048	ENST00000475477	V9GYK4

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fatty acid degradation	KEGG	ko00071
Arachidonic acid metabolism	KEGG	ko00590
Retinol metabolism	KEGG	ko00830
Fatty acid degradation	KEGG	hsa00071
Arachidonic acid metabolism	KEGG	hsa00590
Retinol metabolism	KEGG	hsa00830
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)	REACTOME	R-HSA-2142691
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	REACTOME	R-HSA-2142816
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Fatty acids	REACTOME	R-HSA-211935
Eicosanoids	REACTOME	R-HSA-211979
Miscellaneous substrates	REACTOME	R-HSA-211958

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA444552	Hypertension	Disease	ClinicalAnnotation	associated	PD
PA448368	amiloride	Chemical	ClinicalAnnotation	associated	PD
PA451483	spironolactone	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
15611369	2005	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	66
15611369	2005	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	66
18391101	2008	A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.	57
18391101	2008	A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.	57
18574070	2008	The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.	44
18227405	2008	The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.	34
18227405	2008	The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.	34
16144986	2005	Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy.	29
16144986	2005	Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy.	29

Citation

Dessen P

CYP4A11 (cytochrome P450 family 4 subfamily A member 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40252/cyp4a11