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CYP51A1 (cytochrome P450, family 51, subfamily A, polypeptide 1)

Identity

Alias_namesCYP51
cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
cytochrome P450, family 51, subfamily A, polypeptide 1
Alias_symbol (synonym)CP51
CYPL1
P450L1
LDM
P450-14DM
Other alias
HGNC (Hugo) CYP51A1
LocusID (NCBI) 1595
Atlas_Id 62270
Location 7q21.2  [Link to chromosome band 7q21]
Location_base_pair Starts at 91741463 and ends at 91763840 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP51A1   2649
Cards
Entrez_Gene (NCBI)CYP51A1  1595  cytochrome P450, family 51, subfamily A, polypeptide 1
AliasesCP51; CYP51; CYPL1; LDM; 
P450-14DM; P450L1
GeneCards (Weizmann)CYP51A1
Ensembl hg19 (Hinxton)ENSG00000001630 [Gene_View]  chr7:91741463-91763840 [Contig_View]  CYP51A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000001630 [Gene_View]  chr7:91741463-91763840 [Contig_View]  CYP51A1 [Vega]
ICGC DataPortalENSG00000001630
TCGA cBioPortalCYP51A1
AceView (NCBI)CYP51A1
Genatlas (Paris)CYP51A1
WikiGenes1595
SOURCE (Princeton)CYP51A1
Genetics Home Reference (NIH)CYP51A1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP51A1  -     chr7:91741463-91763840 -  7q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP51A1  -     7q21.2   [Description]    (hg38-Dec_2013)
EnsemblCYP51A1 - 7q21.2 [CytoView hg19]  CYP51A1 - 7q21.2 [CytoView hg38]
Mapping of homologs : NCBICYP51A1 [Mapview hg19]  CYP51A1 [Mapview hg38]
OMIM601637   
Gene and transcription
Genbank (Entrez)AK295932 AK314205 BC018429 BC032322 D55653
RefSeq transcript (Entrez)NM_000786 NM_001146152
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007968 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)CYP51A1
Cluster EST : UnigeneHs.417077 [ NCBI ]
CGAP (NCI)Hs.417077
Alternative Splicing GalleryENSG00000001630
Gene ExpressionCYP51A1 [ NCBI-GEO ]   CYP51A1 [ EBI - ARRAY_EXPRESS ]   CYP51A1 [ SEEK ]   CYP51A1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP51A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1595
GTEX Portal (Tissue expression)CYP51A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16850   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16850  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16850
Splice isoforms : SwissVarQ16850
Catalytic activity : Enzyme1.14.13.70 [ Enzyme-Expasy ]   1.14.13.701.14.13.70 [ IntEnz-EBI ]   1.14.13.70 [ BRENDA ]   1.14.13.70 [ KEGG ]   
PhosPhoSitePlusQ16850
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-IV   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP51A1
DMDM Disease mutations1595
Blocks (Seattle)CYP51A1
PDB (SRS)3JUS    3JUV    3LD6   
PDB (PDBSum)3JUS    3JUV    3LD6   
PDB (IMB)3JUS    3JUV    3LD6   
PDB (RSDB)3JUS    3JUV    3LD6   
Structural Biology KnowledgeBase3JUS    3JUV    3LD6   
SCOP (Structural Classification of Proteins)3JUS    3JUV    3LD6   
CATH (Classification of proteins structures)3JUS    3JUV    3LD6   
SuperfamilyQ16850
Human Protein AtlasENSG00000001630
Peptide AtlasQ16850
HPRD03381
IPIIPI00926839   IPI01013163   IPI00295772   IPI00926468   IPI00926620   
Protein Interaction databases
DIP (DOE-UCLA)Q16850
IntAct (EBI)Q16850
FunCoupENSG00000001630
BioGRIDCYP51A1
STRING (EMBL)CYP51A1
ZODIACCYP51A1
Ontologies - Pathways
QuickGOQ16850
Ontology : AmiGOiron ion binding  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  cholesterol biosynthetic process  xenobiotic metabolic process  sterol 14-demethylase activity  membrane  integral component of membrane  sterol metabolic process  heme binding  cholesterol biosynthetic process via 24,25-dihydrolanosterol  small molecule metabolic process  oxidation-reduction process  demethylation  demethylation  
Ontology : EGO-EBIiron ion binding  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  cholesterol biosynthetic process  xenobiotic metabolic process  sterol 14-demethylase activity  membrane  integral component of membrane  sterol metabolic process  heme binding  cholesterol biosynthetic process via 24,25-dihydrolanosterol  small molecule metabolic process  oxidation-reduction process  demethylation  demethylation  
Pathways : KEGGSteroid biosynthesis   
NDEx NetworkCYP51A1
Atlas of Cancer Signalling NetworkCYP51A1
Wikipedia pathwaysCYP51A1
Orthology - Evolution
OrthoDB1595
GeneTree (enSembl)ENSG00000001630
Phylogenetic Trees/Animal Genes : TreeFamCYP51A1
HOVERGENQ16850
HOGENOMQ16850
Homologs : HomoloGeneCYP51A1
Homology/Alignments : Family Browser (UCSC)CYP51A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP51A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP51A1
dbVarCYP51A1
ClinVarCYP51A1
1000_GenomesCYP51A1 
Exome Variant ServerCYP51A1
ExAC (Exome Aggregation Consortium)CYP51A1 (select the gene name)
Genetic variants : HAPMAP1595
Genomic Variants (DGV)CYP51A1 [DGVbeta]
DECIPHER (Syndromes)7:91741463-91763840  ENSG00000001630
CONAN: Copy Number AnalysisCYP51A1 
Mutations
ICGC Data PortalCYP51A1 
TCGA Data PortalCYP51A1 
Broad Tumor PortalCYP51A1
OASIS PortalCYP51A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP51A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP51A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP51A1
DgiDB (Drug Gene Interaction Database)CYP51A1
DoCM (Curated mutations)CYP51A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP51A1 (select a term)
intoGenCYP51A1
Cancer3DCYP51A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601637   
Orphanet
MedgenCYP51A1
Genetic Testing Registry CYP51A1
NextProtQ16850 [Medical]
TSGene1595
GENETestsCYP51A1
Huge Navigator CYP51A1 [HugePedia]
snp3D : Map Gene to Disease1595
BioCentury BCIQCYP51A1
ClinGenCYP51A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1595
Chemical/Pharm GKB GenePA27123
Clinical trialCYP51A1
Miscellaneous
canSAR (ICR)CYP51A1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP51A1
EVEXCYP51A1
GoPubMedCYP51A1
iHOPCYP51A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:00:56 CET 2017

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