Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1)

Identity

Alias_namescytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1
cytochrome P450, family 8, subfamily B, polypeptide 1
Alias_symbol (synonym)CYP12
Other aliasCP8B
HGNC (Hugo) CYP8B1
LocusID (NCBI) 1582
Atlas_Id 62272
Location 3p22.1  [Link to chromosome band 3p22]
Location_base_pair Starts at 42913684 and ends at 42917633 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP8B1   2653
Cards
Entrez_Gene (NCBI)CYP8B1  1582  cytochrome P450, family 8, subfamily B, polypeptide 1
AliasesCP8B; CYP12
GeneCards (Weizmann)CYP8B1
Ensembl hg19 (Hinxton)ENSG00000180432 [Gene_View]  chr3:42913684-42917633 [Contig_View]  CYP8B1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000180432 [Gene_View]  chr3:42913684-42917633 [Contig_View]  CYP8B1 [Vega]
ICGC DataPortalENSG00000180432
TCGA cBioPortalCYP8B1
AceView (NCBI)CYP8B1
Genatlas (Paris)CYP8B1
WikiGenes1582
SOURCE (Princeton)CYP8B1
Genetics Home Reference (NIH)CYP8B1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP8B1  -     chr3:42913684-42917633 -  3p22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP8B1  -     3p22.1   [Description]    (hg38-Dec_2013)
EnsemblCYP8B1 - 3p22.1 [CytoView hg19]  CYP8B1 - 3p22.1 [CytoView hg38]
Mapping of homologs : NCBICYP8B1 [Mapview hg19]  CYP8B1 [Mapview hg38]
OMIM602172   
Gene and transcription
Genbank (Entrez)AF090318 AK310784 AK315330 BC067434 BC067441
RefSeq transcript (Entrez)NM_004391
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_007970 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)CYP8B1
Cluster EST : UnigeneHs.722743 [ NCBI ]
CGAP (NCI)Hs.722743
Alternative Splicing GalleryENSG00000180432
Gene ExpressionCYP8B1 [ NCBI-GEO ]   CYP8B1 [ EBI - ARRAY_EXPRESS ]   CYP8B1 [ SEEK ]   CYP8B1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP8B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1582
GTEX Portal (Tissue expression)CYP8B1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNU6
Splice isoforms : SwissVarQ9UNU6
Catalytic activity : Enzyme1.14.13.95 [ Enzyme-Expasy ]   1.14.13.951.14.13.95 [ IntEnz-EBI ]   1.14.13.95 [ BRENDA ]   1.14.13.95 [ KEGG ]   
PhosPhoSitePlusQ9UNU6
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CYP7A1-type    Cyt_P450_E_grp-IV    Cytochrome_CYP8B1   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP8B1
DMDM Disease mutations1582
Blocks (Seattle)CYP8B1
SuperfamilyQ9UNU6
Human Protein AtlasENSG00000180432
Peptide AtlasQ9UNU6
HPRD03705
IPIIPI00009440   IPI00924774   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNU6
IntAct (EBI)Q9UNU6
FunCoupENSG00000180432
BioGRIDCYP8B1
STRING (EMBL)CYP8B1
ZODIACCYP8B1
Ontologies - Pathways
QuickGOQ9UNU6
Ontology : AmiGOiron ion binding  endoplasmic reticulum  endoplasmic reticulum membrane  lipid metabolic process  bile acid biosynthetic process  xenobiotic metabolic process  bile acid metabolic process  sterol 12-alpha-hydroxylase activity  integral component of membrane  sterol metabolic process  oxygen binding  heme binding  7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity  small molecule metabolic process  oxidation-reduction process  
Ontology : EGO-EBIiron ion binding  endoplasmic reticulum  endoplasmic reticulum membrane  lipid metabolic process  bile acid biosynthetic process  xenobiotic metabolic process  bile acid metabolic process  sterol 12-alpha-hydroxylase activity  integral component of membrane  sterol metabolic process  oxygen binding  heme binding  7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity  small molecule metabolic process  oxidation-reduction process  
Pathways : BIOCARTANuclear Receptors in Lipid Metabolism and Toxicity [Genes]   
Pathways : KEGGPrimary bile acid biosynthesis    PPAR signaling pathway   
NDEx NetworkCYP8B1
Atlas of Cancer Signalling NetworkCYP8B1
Wikipedia pathwaysCYP8B1
Orthology - Evolution
OrthoDB1582
GeneTree (enSembl)ENSG00000180432
Phylogenetic Trees/Animal Genes : TreeFamCYP8B1
HOVERGENQ9UNU6
HOGENOMQ9UNU6
Homologs : HomoloGeneCYP8B1
Homology/Alignments : Family Browser (UCSC)CYP8B1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP8B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP8B1
dbVarCYP8B1
ClinVarCYP8B1
1000_GenomesCYP8B1 
Exome Variant ServerCYP8B1
ExAC (Exome Aggregation Consortium)CYP8B1 (select the gene name)
Genetic variants : HAPMAP1582
Genomic Variants (DGV)CYP8B1 [DGVbeta]
DECIPHER (Syndromes)3:42913684-42917633  ENSG00000180432
CONAN: Copy Number AnalysisCYP8B1 
Mutations
ICGC Data PortalCYP8B1 
TCGA Data PortalCYP8B1 
Broad Tumor PortalCYP8B1
OASIS PortalCYP8B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP8B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP8B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP8B1
DgiDB (Drug Gene Interaction Database)CYP8B1
DoCM (Curated mutations)CYP8B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP8B1 (select a term)
intoGenCYP8B1
Cancer3DCYP8B1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602172   
Orphanet
MedgenCYP8B1
Genetic Testing Registry CYP8B1
NextProtQ9UNU6 [Medical]
TSGene1582
GENETestsCYP8B1
Huge Navigator CYP8B1 [HugePedia]
snp3D : Map Gene to Disease1582
BioCentury BCIQCYP8B1
ClinGenCYP8B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1582
Chemical/Pharm GKB GenePA27125
Clinical trialCYP8B1
Miscellaneous
canSAR (ICR)CYP8B1 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP8B1
EVEXCYP8B1
GoPubMedCYP8B1
iHOPCYP8B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:00:57 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.