CYTH2 (cytohesin 2)

2008-09-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
ARNO,CTS18,CTS18.1,PSCD2,PSCD2L,SEC7L,Sec7p-L,Sec7p-like,cytohesin-2
FUSION GENES

Other Information

Locus ID:

NCBI: 9266
MIM: 602488
HGNC: 9502
Ensembl: ENSG00000105443

Variants:

dbSNP: 9266
ClinVar: 9266
TCGA: ENSG00000105443
COSMIC: CYTH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105443ENST00000325139F8W8E2
ENSG00000105443ENST00000391881G5E9B7
ENSG00000105443ENST00000427476A0A0D9SFG6
ENSG00000105443ENST00000452733Q99418
ENSG00000105443ENST00000460595A0A286YF81
ENSG00000105443ENST00000595765M0R2J0
ENSG00000105443ENST00000620214Q8WYS2
ENSG00000105443ENST00000641098Q99418

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173980952007The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.47
211188132011Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop.43
223414622012Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.33
200160092010GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.26
160271492005Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway.24
129201292003Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.21
205256962010Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.21
176237782007The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.20
213073482011Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.18
152776852004Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2.16

Citation

Dessen P

CYTH2 (cytohesin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50360/cyth2