Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYTH3 (cytohesin 3)

Identity

Alias_namesPSCD3
pleckstrin homology
Alias_symbol (synonym)GRP1
ARNO3
cytohesin-3
Other alias
HGNC (Hugo) CYTH3
LocusID (NCBI) 9265
Atlas_Id 43434
Location 7p22.1  [Link to chromosome band 7p22]
Location_base_pair Starts at 6161781 and ends at 6272611 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYTH3 (7p22.1) / GRID1 (10q23.1)CYTH3 (7p22.1) / MAD1L1 (7p22.3)CYTH3 (7p22.1) / SPATA18 (4q12)
CYTH3 7p22.1 / GRID1 10q23.1CYTH3 7p22.1 / MAD1L1 7p22.3CYTH3 7p22.1 / SPATA18 4q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(1;7)(p36;p22) AJAP1/CYTH3
t(4;7)(q12;p22) CYTH3/SPATA18
CYTH3/MAD1L1 (7p22)
t(7;10)(p22;q23) CYTH3/GRID1


External links

Nomenclature
HGNC (Hugo)CYTH3   9504
Cards
Entrez_Gene (NCBI)CYTH3  9265  cytohesin 3
AliasesARNO3; GRP1; PSCD3; cytohesin-3
GeneCards (Weizmann)CYTH3
Ensembl hg19 (Hinxton)ENSG00000008256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008256 [Gene_View]  ENSG00000008256 [Sequence]  chr7:6161781-6272611 [Contig_View]  CYTH3 [Vega]
ICGC DataPortalENSG00000008256
TCGA cBioPortalCYTH3
AceView (NCBI)CYTH3
Genatlas (Paris)CYTH3
WikiGenes9265
SOURCE (Princeton)CYTH3
Genetics Home Reference (NIH)CYTH3
Genomic and cartography
GoldenPath hg38 (UCSC)CYTH3  -     chr7:6161781-6272611 -  7p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYTH3  -     7p22.1   [Description]    (hg19-Feb_2009)
EnsemblCYTH3 - 7p22.1 [CytoView hg19]  CYTH3 - 7p22.1 [CytoView hg38]
Mapping of homologs : NCBICYTH3 [Mapview hg19]  CYTH3 [Mapview hg38]
OMIM605081   
Gene and transcription
Genbank (Entrez)AJ005197 AJ223957 AK023609 AK295163 AK313728
RefSeq transcript (Entrez)NM_004227
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYTH3
Cluster EST : UnigeneHs.487479 [ NCBI ]
CGAP (NCI)Hs.487479
Alternative Splicing GalleryENSG00000008256
Gene ExpressionCYTH3 [ NCBI-GEO ]   CYTH3 [ EBI - ARRAY_EXPRESS ]   CYTH3 [ SEEK ]   CYTH3 [ MEM ]
Gene Expression Viewer (FireBrowse)CYTH3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9265
GTEX Portal (Tissue expression)CYTH3
Human Protein AtlasENSG00000008256-CYTH3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43739   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43739  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43739
Splice isoforms : SwissVarO43739
PhosPhoSitePlusO43739
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SEC7 (PS50190)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    Sec7_C_sf    Sec7_dom    Sec7_dom_sf   
Domain families : Pfam (Sanger)PH (PF00169)    Sec7 (PF01369)   
Domain families : Pfam (NCBI)pfam00169    pfam01369   
Domain families : Smart (EMBL)PH (SM00233)  Sec7 (SM00222)  
Conserved Domain (NCBI)CYTH3
DMDM Disease mutations9265
Blocks (Seattle)CYTH3
PDB (SRS)4KAX   
PDB (PDBSum)4KAX   
PDB (IMB)4KAX   
PDB (RSDB)4KAX   
Structural Biology KnowledgeBase4KAX   
SCOP (Structural Classification of Proteins)4KAX   
CATH (Classification of proteins structures)4KAX   
SuperfamilyO43739
Human Protein Atlas [tissue]ENSG00000008256-CYTH3 [tissue]
Peptide AtlasO43739
HPRD05469
IPIIPI00013892   IPI00216718   IPI01009274   
Protein Interaction databases
DIP (DOE-UCLA)O43739
IntAct (EBI)O43739
FunCoupENSG00000008256
BioGRIDCYTH3
STRING (EMBL)CYTH3
ZODIACCYTH3
Ontologies - Pathways
QuickGOO43739
Ontology : AmiGOGolgi membrane  ruffle  ARF guanyl-nucleotide exchange factor activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  cytosol  cytosol  plasma membrane  adherens junction  bicellular tight junction  extrinsic component of cytoplasmic side of plasma membrane  regulation of ARF protein signal transduction  positive regulation of cell adhesion  Golgi vesicle transport  establishment of epithelial cell polarity  
Ontology : EGO-EBIGolgi membrane  ruffle  ARF guanyl-nucleotide exchange factor activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  cytosol  cytosol  plasma membrane  adherens junction  bicellular tight junction  extrinsic component of cytoplasmic side of plasma membrane  regulation of ARF protein signal transduction  positive regulation of cell adhesion  Golgi vesicle transport  establishment of epithelial cell polarity  
NDEx NetworkCYTH3
Atlas of Cancer Signalling NetworkCYTH3
Wikipedia pathwaysCYTH3
Orthology - Evolution
OrthoDB9265
GeneTree (enSembl)ENSG00000008256
Phylogenetic Trees/Animal Genes : TreeFamCYTH3
HOVERGENO43739
HOGENOMO43739
Homologs : HomoloGeneCYTH3
Homology/Alignments : Family Browser (UCSC)CYTH3
Gene fusions - Rearrangements
Fusion : MitelmanCYTH3/GRID1 [7p22.1/10q23.1]  
Fusion : MitelmanCYTH3/MAD1L1 [7p22.1/7p22.3]  [t(7;7)(p22;p22)]  
Fusion : MitelmanCYTH3/SPATA18 [7p22.1/4q12]  [t(4;7)(q12;p22)]  
Fusion PortalCYTH3 7p22.1 GRID1 10q23.1 SKCM
Fusion PortalCYTH3 7p22.1 MAD1L1 7p22.3 BRCA
Fusion PortalCYTH3 7p22.1 SPATA18 4q12 LUAD
Fusion : QuiverCYTH3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYTH3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYTH3
dbVarCYTH3
ClinVarCYTH3
1000_GenomesCYTH3 
Exome Variant ServerCYTH3
ExAC (Exome Aggregation Consortium)ENSG00000008256
GNOMAD BrowserENSG00000008256
Varsome BrowserCYTH3
Genetic variants : HAPMAP9265
Genomic Variants (DGV)CYTH3 [DGVbeta]
DECIPHERCYTH3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYTH3 
Mutations
ICGC Data PortalCYTH3 
TCGA Data PortalCYTH3 
Broad Tumor PortalCYTH3
OASIS PortalCYTH3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYTH3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYTH3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYTH3
DgiDB (Drug Gene Interaction Database)CYTH3
DoCM (Curated mutations)CYTH3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYTH3 (select a term)
intoGenCYTH3
Cancer3DCYTH3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605081   
Orphanet
DisGeNETCYTH3
MedgenCYTH3
Genetic Testing Registry CYTH3
NextProtO43739 [Medical]
TSGene9265
GENETestsCYTH3
Target ValidationCYTH3
Huge Navigator CYTH3 [HugePedia]
snp3D : Map Gene to Disease9265
BioCentury BCIQCYTH3
ClinGenCYTH3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9265
Chemical/Pharm GKB GenePA164718590
Clinical trialCYTH3
Miscellaneous
canSAR (ICR)CYTH3 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYTH3
EVEXCYTH3
GoPubMedCYTH3
iHOPCYTH3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:01:27 CET 2018

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