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DAB1 (DAB1, reelin adaptor protein)

Identity

Alias_namesdisabled (Drosophila) homolog 1
disabled homolog 1 (Drosophila)
Dab reelin signal transducer 1
Dab, reelin signal transducer, homolog 1 (Drosophila)
Other alias-
HGNC (Hugo) DAB1
LocusID (NCBI) 1600
Atlas_Id 50441
Location 1p32.2  [Link to chromosome band 1p32]
Location_base_pair Starts at 56997906 and ends at 58250539 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DAB1 (1p32.2) / CADM2 (3p12.1)DAB1 (1p32.2) / FAM46C (1p12)DAB1 (1p32.2) / LIMCH1 (4p13)
DAB1 (1p32.2) / NDUFA4 (7p21.3)DAB1 (1p32.2) / PMP22 (17p12)DAB1 (1p32.2) / SSH2 (17q11.2)
IL12RB2 (1p31.3) / DAB1 (1p32.2)MOCS2 (5q11.2) / DAB1 (1p32.2)RYR3 (15q14) / DAB1 (1p32.2)
VAV3 (1p13.3) / DAB1 (1p32.2)XPO7 (8p21.3) / DAB1 (1p32.2)ZNF732 (4p16.3) / DAB1 (1p32.2)
IL12RB2 1p31.3 / DAB1 1p32.2ZNF732 4p16.3 / DAB1 1p32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DAB1   2661
Cards
Entrez_Gene (NCBI)DAB1  1600  DAB1, reelin adaptor protein
Aliases
GeneCards (Weizmann)DAB1
Ensembl hg19 (Hinxton)ENSG00000173406 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173406 [Gene_View]  chr1:56997906-58250539 [Contig_View]  DAB1 [Vega]
ICGC DataPortalENSG00000173406
TCGA cBioPortalDAB1
AceView (NCBI)DAB1
Genatlas (Paris)DAB1
WikiGenes1600
SOURCE (Princeton)DAB1
Genetics Home Reference (NIH)DAB1
Genomic and cartography
GoldenPath hg38 (UCSC)DAB1  -     chr1:56997906-58250539 -  1p32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DAB1  -     1p32.2   [Description]    (hg19-Feb_2009)
EnsemblDAB1 - 1p32.2 [CytoView hg19]  DAB1 - 1p32.2 [CytoView hg38]
Mapping of homologs : NCBIDAB1 [Mapview hg19]  DAB1 [Mapview hg38]
OMIM603448   
Gene and transcription
Genbank (Entrez)AB210012 AF071062 AF525763 AK055341 AK095513
RefSeq transcript (Entrez)NM_021080
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DAB1
Cluster EST : UnigeneHs.477370 [ NCBI ]
CGAP (NCI)Hs.477370
Alternative Splicing GalleryENSG00000173406
Gene ExpressionDAB1 [ NCBI-GEO ]   DAB1 [ EBI - ARRAY_EXPRESS ]   DAB1 [ SEEK ]   DAB1 [ MEM ]
Gene Expression Viewer (FireBrowse)DAB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1600
GTEX Portal (Tissue expression)DAB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75553   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75553  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75553
Splice isoforms : SwissVarO75553
PhosPhoSitePlusO75553
Domaine pattern : Prosite (Expaxy)PID (PS01179)   
Domains : Interpro (EBI)PH_dom-like    PTB/PI_dom   
Domain families : Pfam (Sanger)PID (PF00640)   
Domain families : Pfam (NCBI)pfam00640   
Domain families : Smart (EMBL)PTB (SM00462)  
Conserved Domain (NCBI)DAB1
DMDM Disease mutations1600
Blocks (Seattle)DAB1
SuperfamilyO75553
Human Protein AtlasENSG00000173406
Peptide AtlasO75553
HPRD04582
IPIIPI00514638   IPI00514371   IPI00433142   IPI00847156   IPI00433150   IPI00026889   IPI00848179   
Protein Interaction databases
DIP (DOE-UCLA)O75553
IntAct (EBI)O75553
FunCoupENSG00000173406
BioGRIDDAB1
STRING (EMBL)DAB1
ZODIACDAB1
Ontologies - Pathways
QuickGOO75553
Ontology : AmiGOprotein binding  cytosol  brush border  negative regulation of cell adhesion  small GTPase mediated signal transduction  midgut development  adult walking behavior  postsynaptic density  membrane  dendrite development  ventral spinal cord development  cerebellum structural organization  cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration  radial glia guided migration of Purkinje cell  response to drug  neuron projection  neuronal cell body  intracellular membrane-bounded organelle  phosphatidylinositol 3-kinase binding  apical part of cell  positive regulation of neuron differentiation  positive regulation of protein kinase activity  negative regulation of JAK-STAT cascade  perinuclear region of cytoplasm  negative regulation of astrocyte differentiation  negative regulation of axonogenesis  Golgi localization  lateral motor column neuron migration  
Ontology : EGO-EBIprotein binding  cytosol  brush border  negative regulation of cell adhesion  small GTPase mediated signal transduction  midgut development  adult walking behavior  postsynaptic density  membrane  dendrite development  ventral spinal cord development  cerebellum structural organization  cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration  radial glia guided migration of Purkinje cell  response to drug  neuron projection  neuronal cell body  intracellular membrane-bounded organelle  phosphatidylinositol 3-kinase binding  apical part of cell  positive regulation of neuron differentiation  positive regulation of protein kinase activity  negative regulation of JAK-STAT cascade  perinuclear region of cytoplasm  negative regulation of astrocyte differentiation  negative regulation of axonogenesis  Golgi localization  lateral motor column neuron migration  
Pathways : BIOCARTAReelin Signaling Pathway [Genes]   
NDEx NetworkDAB1
Atlas of Cancer Signalling NetworkDAB1
Wikipedia pathwaysDAB1
Orthology - Evolution
OrthoDB1600
GeneTree (enSembl)ENSG00000173406
Phylogenetic Trees/Animal Genes : TreeFamDAB1
HOVERGENO75553
HOGENOMO75553
Homologs : HomoloGeneDAB1
Homology/Alignments : Family Browser (UCSC)DAB1
Gene fusions - Rearrangements
Fusion : MitelmanDAB1/FAM46C [1p32.2/1p12]  
Fusion : MitelmanIL12RB2/DAB1 [1p31.3/1p32.2]  [t(1;1)(p31;p32)]  
Fusion : MitelmanRYR3/DAB1 [15q14/1p32.2]  [t(1;15)(p32;q14)]  
Fusion : MitelmanVAV3/DAB1 [1p13.3/1p32.2]  [t(1;1)(p13;p32)]  
Fusion : MitelmanZNF732/DAB1 [4p16.3/1p32.2]  [t(1;4)(p32;p16)]  
Fusion: TCGAIL12RB2 1p31.3 DAB1 1p32.2 BRCA
Fusion: TCGAZNF732 4p16.3 DAB1 1p32.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDAB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DAB1
dbVarDAB1
ClinVarDAB1
1000_GenomesDAB1 
Exome Variant ServerDAB1
ExAC (Exome Aggregation Consortium)DAB1 (select the gene name)
Genetic variants : HAPMAP1600
Genomic Variants (DGV)DAB1 [DGVbeta]
DECIPHERDAB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDAB1 
Mutations
ICGC Data PortalDAB1 
TCGA Data PortalDAB1 
Broad Tumor PortalDAB1
OASIS PortalDAB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDAB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDAB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DAB1
DgiDB (Drug Gene Interaction Database)DAB1
DoCM (Curated mutations)DAB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DAB1 (select a term)
intoGenDAB1
Cancer3DDAB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603448   
Orphanet
MedgenDAB1
Genetic Testing Registry DAB1
NextProtO75553 [Medical]
TSGene1600
GENETestsDAB1
Target ValidationDAB1
Huge Navigator DAB1 [HugePedia]
snp3D : Map Gene to Disease1600
BioCentury BCIQDAB1
ClinGenDAB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1600
Chemical/Pharm GKB GenePA27131
Clinical trialDAB1
Miscellaneous
canSAR (ICR)DAB1 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDAB1
EVEXDAB1
GoPubMedDAB1
iHOPDAB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:51:14 CEST 2017

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