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DACH1 (dachshund family transcription factor 1)

Identity

Alias_namesDACH
dachshund homolog (Drosophila)
dachshund homolog 1 (Drosophila)
Other alias
HGNC (Hugo) DACH1
LocusID (NCBI) 1602
Atlas_Id 50251
Location 13q21.33  [Link to chromosome band 13q21]
Location_base_pair Starts at 71437966 and ends at 71867192 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DACH1 (13q21.33) / SMAD4 (18q21.2)PAX5 (9p13.2) / DACH1 (13q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(9;13)(p12;q21) PAX5/DACH1
t(X;9)(q21;p13) PAX5/DACH2


External links

Nomenclature
HGNC (Hugo)DACH1   2663
Cards
Entrez_Gene (NCBI)DACH1  1602  dachshund family transcription factor 1
AliasesDACH
GeneCards (Weizmann)DACH1
Ensembl hg19 (Hinxton)ENSG00000276644 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000276644 [Gene_View]  chr13:71437966-71867192 [Contig_View]  DACH1 [Vega]
ICGC DataPortalENSG00000276644
TCGA cBioPortalDACH1
AceView (NCBI)DACH1
Genatlas (Paris)DACH1
WikiGenes1602
SOURCE (Princeton)DACH1
Genetics Home Reference (NIH)DACH1
Genomic and cartography
GoldenPath hg38 (UCSC)DACH1  -     chr13:71437966-71867192 -  13q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DACH1  -     13q21.33   [Description]    (hg19-Feb_2009)
EnsemblDACH1 - 13q21.33 [CytoView hg19]  DACH1 - 13q21.33 [CytoView hg38]
Mapping of homologs : NCBIDACH1 [Mapview hg19]  DACH1 [Mapview hg38]
OMIM603803   
Gene and transcription
Genbank (Entrez)AA007235 AF069509 AF102546 AF356492 AJ005670
RefSeq transcript (Entrez)NM_004392 NM_080759 NM_080760
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DACH1
Cluster EST : UnigeneHs.129452 [ NCBI ]
CGAP (NCI)Hs.129452
Alternative Splicing GalleryENSG00000276644
Gene ExpressionDACH1 [ NCBI-GEO ]   DACH1 [ EBI - ARRAY_EXPRESS ]   DACH1 [ SEEK ]   DACH1 [ MEM ]
Gene Expression Viewer (FireBrowse)DACH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1602
GTEX Portal (Tissue expression)DACH1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI36   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UI36  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI36
Splice isoforms : SwissVarQ9UI36
PhosPhoSitePlusQ9UI36
Domains : Interpro (EBI)DNA-bd_dom_put    Transform_Ski   
Domain families : Pfam (Sanger)Ski_Sno (PF02437)   
Domain families : Pfam (NCBI)pfam02437   
Conserved Domain (NCBI)DACH1
DMDM Disease mutations1602
Blocks (Seattle)DACH1
PDB (SRS)1L8R   
PDB (PDBSum)1L8R   
PDB (IMB)1L8R   
PDB (RSDB)1L8R   
Structural Biology KnowledgeBase1L8R   
SCOP (Structural Classification of Proteins)1L8R   
CATH (Classification of proteins structures)1L8R   
SuperfamilyQ9UI36
Human Protein AtlasENSG00000276644
Peptide AtlasQ9UI36
HPRD16031
IPIIPI00854705   IPI00953918   IPI00953943   IPI00039808   IPI00084569   IPI00936290   IPI00400774   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI36
IntAct (EBI)Q9UI36
FunCoupENSG00000276644
BioGRIDDACH1
STRING (EMBL)DACH1
ZODIACDACH1
Ontologies - Pathways
QuickGOQ9UI36
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  suckling behavior  DNA binding  protein binding  nucleus  transcription factor complex  cytoplasm  multicellular organism development  respiratory gaseous exchange  cell proliferation  negative regulation of transcription by competitive promoter binding  negative regulation of cell migration  regulation of nuclear cell cycle DNA replication  negative regulation of transcription, DNA-templated  development of primary female sexual characteristics  negative regulation of fibroblast proliferation  RNA polymerase II transcriptional preinitiation complex assembly  negative regulation of cell proliferation involved in contact inhibition  negative regulation of DNA biosynthetic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  suckling behavior  DNA binding  protein binding  nucleus  transcription factor complex  cytoplasm  multicellular organism development  respiratory gaseous exchange  cell proliferation  negative regulation of transcription by competitive promoter binding  negative regulation of cell migration  regulation of nuclear cell cycle DNA replication  negative regulation of transcription, DNA-templated  development of primary female sexual characteristics  negative regulation of fibroblast proliferation  RNA polymerase II transcriptional preinitiation complex assembly  negative regulation of cell proliferation involved in contact inhibition  negative regulation of DNA biosynthetic process  
NDEx NetworkDACH1
Atlas of Cancer Signalling NetworkDACH1
Wikipedia pathwaysDACH1
Orthology - Evolution
OrthoDB1602
GeneTree (enSembl)ENSG00000276644
Phylogenetic Trees/Animal Genes : TreeFamDACH1
HOVERGENQ9UI36
HOGENOMQ9UI36
Homologs : HomoloGeneDACH1
Homology/Alignments : Family Browser (UCSC)DACH1
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/DACH1 [9p13.2/13q21.33]  [t(9;13)(p12;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDACH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DACH1
dbVarDACH1
ClinVarDACH1
1000_GenomesDACH1 
Exome Variant ServerDACH1
ExAC (Exome Aggregation Consortium)DACH1 (select the gene name)
Genetic variants : HAPMAP1602
Genomic Variants (DGV)DACH1 [DGVbeta]
DECIPHERDACH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDACH1 
Mutations
ICGC Data PortalDACH1 
TCGA Data PortalDACH1 
Broad Tumor PortalDACH1
OASIS PortalDACH1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDACH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DACH1
DgiDB (Drug Gene Interaction Database)DACH1
DoCM (Curated mutations)DACH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DACH1 (select a term)
intoGenDACH1
Cancer3DDACH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603803   
Orphanet
MedgenDACH1
Genetic Testing Registry DACH1
NextProtQ9UI36 [Medical]
TSGene1602
GENETestsDACH1
Target ValidationDACH1
Huge Navigator DACH1 [HugePedia]
snp3D : Map Gene to Disease1602
BioCentury BCIQDACH1
ClinGenDACH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1602
Chemical/Pharm GKB GenePA27134
Clinical trialDACH1
Miscellaneous
canSAR (ICR)DACH1 (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDACH1
EVEXDACH1
GoPubMedDACH1
iHOPDACH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:59:09 CEST 2017

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