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DACH2 (dachshund family transcription factor 2)

Identity

Alias (NCBI)-
HGNC (Hugo) DACH2
HGNC Previous namedachshund homolog 2 (Drosophila)
LocusID (NCBI) 117154
Atlas_Id 45686
Location Xq21.2  [Link to chromosome band Xq21]
Location_base_pair Starts at 86148451 and ends at 86832602 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGF13 (Xq26.3)::DACH2 (Xq21.2)PAX5 (9p13.2)::DACH2 (Xq21.2)FGF13 Xq26.3::DACH2 Xq21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;9)(q21;p13) PAX5::DACH2


External links

 

Nomenclature
HGNC (Hugo)DACH2   16814
Cards
Entrez_Gene (NCBI)DACH2    dachshund family transcription factor 2
Aliases
GeneCards (Weizmann)DACH2
Ensembl hg19 (Hinxton)ENSG00000126733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126733 [Gene_View]  ENSG00000126733 [Sequence]  chrX:86148451-86832602 [Contig_View]  DACH2 [Vega]
ICGC DataPortalENSG00000126733
TCGA cBioPortalDACH2
AceView (NCBI)DACH2
Genatlas (Paris)DACH2
SOURCE (Princeton)DACH2
Genetics Home Reference (NIH)DACH2
Genomic and cartography
GoldenPath hg38 (UCSC)DACH2  -     chrX:86148451-86832602 +  Xq21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DACH2  -     Xq21.2   [Description]    (hg19-Feb_2009)
GoldenPathDACH2 - Xq21.2 [CytoView hg19]  DACH2 - Xq21.2 [CytoView hg38]
ImmunoBaseENSG00000126733
Genome Data Viewer NCBIDACH2 [Mapview hg19]  
OMIM300608   
Gene and transcription
Genbank (Entrez)AF428101 AK055953 AK091842 AK290596 AK294498
RefSeq transcript (Entrez)NM_001139514 NM_001139515 NM_053281
Consensus coding sequences : CCDS (NCBI)DACH2
Gene ExpressionDACH2 [ NCBI-GEO ]   DACH2 [ EBI - ARRAY_EXPRESS ]   DACH2 [ SEEK ]   DACH2 [ MEM ]
Gene Expression Viewer (FireBrowse)DACH2 [ Firebrowse - Broad ]
GenevisibleExpression of DACH2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117154
GTEX Portal (Tissue expression)DACH2
Human Protein AtlasENSG00000126733-DACH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NX9
PhosPhoSitePlusQ96NX9
Domains : Interpro (EBI)DNA-bd_dom_put_sf    SKI/SNO/DAC    Ski_DNA-bd_sf   
Domain families : Pfam (Sanger)Ski_Sno (PF02437)   
Domain families : Pfam (NCBI)pfam02437   
Conserved Domain (NCBI)DACH2
SuperfamilyQ96NX9
AlphaFold pdb e-kbQ96NX9   
Human Protein Atlas [tissue]ENSG00000126733-DACH2 [tissue]
HPRD06481
Protein Interaction databases
DIP (DOE-UCLA)Q96NX9
IntAct (EBI)Q96NX9
BioGRIDDACH2
STRING (EMBL)DACH2
ZODIACDACH2
Ontologies - Pathways
QuickGOQ96NX9
Ontology : AmiGORNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleus  transcription regulator complex  regulation of transcription by RNA polymerase II  development of primary female sexual characteristics  
Ontology : EGO-EBIRNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  nucleus  transcription regulator complex  regulation of transcription by RNA polymerase II  development of primary female sexual characteristics  
NDEx NetworkDACH2
Atlas of Cancer Signalling NetworkDACH2
Wikipedia pathwaysDACH2
Orthology - Evolution
OrthoDB117154
GeneTree (enSembl)ENSG00000126733
Phylogenetic Trees/Animal Genes : TreeFamDACH2
Homologs : HomoloGeneDACH2
Homology/Alignments : Family Browser (UCSC)DACH2
Gene fusions - Rearrangements
Fusion : MitelmanFGF13::DACH2 [Xq26.3/Xq21.2]  
Fusion : MitelmanPAX5::DACH2 [9p13.2/Xq21.2]  
Fusion : QuiverDACH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDACH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DACH2
dbVarDACH2
ClinVarDACH2
MonarchDACH2
1000_GenomesDACH2 
Exome Variant ServerDACH2
GNOMAD BrowserENSG00000126733
Varsome BrowserDACH2
ACMGDACH2 variants
VarityQ96NX9
Genomic Variants (DGV)DACH2 [DGVbeta]
DECIPHERDACH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDACH2 
Mutations
ICGC Data PortalDACH2 
TCGA Data PortalDACH2 
Broad Tumor PortalDACH2
OASIS PortalDACH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDACH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDACH2
Mutations and Diseases : HGMDDACH2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDACH2
DgiDB (Drug Gene Interaction Database)DACH2
DoCM (Curated mutations)DACH2
CIViC (Clinical Interpretations of Variants in Cancer)DACH2
Cancer3DDACH2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300608   
Orphanet
DisGeNETDACH2
MedgenDACH2
Genetic Testing Registry DACH2
NextProtQ96NX9 [Medical]
GENETestsDACH2
Target ValidationDACH2
Huge Navigator DACH2 [HugePedia]
ClinGenDACH2
Clinical trials, drugs, therapy
MyCancerGenomeDACH2
Protein Interactions : CTDDACH2
Pharm GKB GenePA27135
PharosQ96NX9
Clinical trialDACH2
Miscellaneous
canSAR (ICR)DACH2
HarmonizomeDACH2
ARCHS4DACH2
DataMed IndexDACH2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDACH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:29:53 CET 2022

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