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DACH2 (dachshund family transcription factor 2)

Identity

Alias_namesdachshund homolog 2 (Drosophila)
Other alias-
HGNC (Hugo) DACH2
LocusID (NCBI) 117154
Atlas_Id 45686
Location Xq21.2  [Link to chromosome band Xq21]
Location_base_pair Starts at 86148451 and ends at 86832602 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FGF13 (Xq26.3) / DACH2 (Xq21.2)PAX5 (9p13.2) / DACH2 (Xq21.2)FGF13 Xq26.3 / DACH2 Xq21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;9)(q21;p13) PAX5/DACH2


External links

Nomenclature
HGNC (Hugo)DACH2   16814
Cards
Entrez_Gene (NCBI)DACH2  117154  dachshund family transcription factor 2
Aliases
GeneCards (Weizmann)DACH2
Ensembl hg19 (Hinxton)ENSG00000126733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126733 [Gene_View]  chrX:86148451-86832602 [Contig_View]  DACH2 [Vega]
ICGC DataPortalENSG00000126733
TCGA cBioPortalDACH2
AceView (NCBI)DACH2
Genatlas (Paris)DACH2
WikiGenes117154
SOURCE (Princeton)DACH2
Genetics Home Reference (NIH)DACH2
Genomic and cartography
GoldenPath hg38 (UCSC)DACH2  -     chrX:86148451-86832602 +  Xq21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DACH2  -     Xq21.2   [Description]    (hg19-Feb_2009)
EnsemblDACH2 - Xq21.2 [CytoView hg19]  DACH2 - Xq21.2 [CytoView hg38]
Mapping of homologs : NCBIDACH2 [Mapview hg19]  DACH2 [Mapview hg38]
OMIM300608   
Gene and transcription
Genbank (Entrez)AF428101 AK055953 AK091842 AK290596 AK294498
RefSeq transcript (Entrez)NM_001139514 NM_001139515 NM_053281
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DACH2
Cluster EST : UnigeneHs.86603 [ NCBI ]
CGAP (NCI)Hs.86603
Alternative Splicing GalleryENSG00000126733
Gene ExpressionDACH2 [ NCBI-GEO ]   DACH2 [ EBI - ARRAY_EXPRESS ]   DACH2 [ SEEK ]   DACH2 [ MEM ]
Gene Expression Viewer (FireBrowse)DACH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117154
GTEX Portal (Tissue expression)DACH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NX9
Splice isoforms : SwissVarQ96NX9
PhosPhoSitePlusQ96NX9
Domains : Interpro (EBI)DNA-bd_dom_put    Transform_Ski   
Domain families : Pfam (Sanger)Ski_Sno (PF02437)   
Domain families : Pfam (NCBI)pfam02437   
Conserved Domain (NCBI)DACH2
DMDM Disease mutations117154
Blocks (Seattle)DACH2
SuperfamilyQ96NX9
Human Protein AtlasENSG00000126733
Peptide AtlasQ96NX9
HPRD06481
IPIIPI00065787   IPI00402352   IPI00984015   IPI01011992   IPI00085091   IPI01018735   IPI00966411   IPI00967337   
Protein Interaction databases
DIP (DOE-UCLA)Q96NX9
IntAct (EBI)Q96NX9
FunCoupENSG00000126733
BioGRIDDACH2
STRING (EMBL)DACH2
ZODIACDACH2
Ontologies - Pathways
QuickGOQ96NX9
Ontology : AmiGOtranscription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly  DNA binding  nucleus  transcription factor complex  regulation of transcription, DNA-templated  multicellular organism development  development of primary female sexual characteristics  RNA polymerase II transcriptional preinitiation complex assembly  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly  DNA binding  nucleus  transcription factor complex  regulation of transcription, DNA-templated  multicellular organism development  development of primary female sexual characteristics  RNA polymerase II transcriptional preinitiation complex assembly  
NDEx NetworkDACH2
Atlas of Cancer Signalling NetworkDACH2
Wikipedia pathwaysDACH2
Orthology - Evolution
OrthoDB117154
GeneTree (enSembl)ENSG00000126733
Phylogenetic Trees/Animal Genes : TreeFamDACH2
HOVERGENQ96NX9
HOGENOMQ96NX9
Homologs : HomoloGeneDACH2
Homology/Alignments : Family Browser (UCSC)DACH2
Gene fusions - Rearrangements
Fusion : MitelmanFGF13/DACH2 [Xq26.3/Xq21.2]  [t(X;X)(q21;q27)]  
Fusion : MitelmanPAX5/DACH2 [9p13.2/Xq21.2]  [t(X;9)(q21;p13)]  
Fusion: TCGAFGF13 Xq26.3 DACH2 Xq21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDACH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DACH2
dbVarDACH2
ClinVarDACH2
1000_GenomesDACH2 
Exome Variant ServerDACH2
ExAC (Exome Aggregation Consortium)DACH2 (select the gene name)
Genetic variants : HAPMAP117154
Genomic Variants (DGV)DACH2 [DGVbeta]
DECIPHERDACH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDACH2 
Mutations
ICGC Data PortalDACH2 
TCGA Data PortalDACH2 
Broad Tumor PortalDACH2
OASIS PortalDACH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDACH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDACH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch DACH2
DgiDB (Drug Gene Interaction Database)DACH2
DoCM (Curated mutations)DACH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DACH2 (select a term)
intoGenDACH2
Cancer3DDACH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300608   
Orphanet
MedgenDACH2
Genetic Testing Registry DACH2
NextProtQ96NX9 [Medical]
TSGene117154
GENETestsDACH2
Target ValidationDACH2
Huge Navigator DACH2 [HugePedia]
snp3D : Map Gene to Disease117154
BioCentury BCIQDACH2
ClinGenDACH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD117154
Chemical/Pharm GKB GenePA27135
Clinical trialDACH2
Miscellaneous
canSAR (ICR)DACH2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDACH2
EVEXDACH2
GoPubMedDACH2
iHOPDACH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:09 CEST 2017

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