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DACT2 (dishevelled binding antagonist of beta catenin 2)

Identity

Alias_namesC6orf116
chromosome 6 open reading frame 116
dapper homolog 2, antagonist of beta-catenin (xenopus)
dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
Alias_symbol (synonym)bA503C24.7
DAPPER2
Other aliasDPR2
HGNC (Hugo) DACT2
LocusID (NCBI) 168002
Atlas_Id 50106
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 168306904 and ends at 168319754 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DACT2   21231
Cards
Entrez_Gene (NCBI)DACT2  168002  dishevelled binding antagonist of beta catenin 2
AliasesC6orf116; DAPPER2; DPR2; bA503C24.7
GeneCards (Weizmann)DACT2
Ensembl hg19 (Hinxton)ENSG00000164488 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164488 [Gene_View]  ENSG00000164488 [Sequence]  chr6:168306904-168319754 [Contig_View]  DACT2 [Vega]
ICGC DataPortalENSG00000164488
TCGA cBioPortalDACT2
AceView (NCBI)DACT2
Genatlas (Paris)DACT2
WikiGenes168002
SOURCE (Princeton)DACT2
Genetics Home Reference (NIH)DACT2
Genomic and cartography
GoldenPath hg38 (UCSC)DACT2  -     chr6:168306904-168319754 -  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DACT2  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblDACT2 - 6q27 [CytoView hg19]  DACT2 - 6q27 [CytoView hg38]
Mapping of homologs : NCBIDACT2 [Mapview hg19]  DACT2 [Mapview hg38]
OMIM608966   
Gene and transcription
Genbank (Entrez)AF318336 BC092498 BC111764 BC111790 BX329974
RefSeq transcript (Entrez)NM_001286350 NM_001286351 NM_214462
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DACT2
Cluster EST : UnigeneHs.673059 [ NCBI ]
CGAP (NCI)Hs.673059
Alternative Splicing GalleryENSG00000164488
Gene ExpressionDACT2 [ NCBI-GEO ]   DACT2 [ EBI - ARRAY_EXPRESS ]   DACT2 [ SEEK ]   DACT2 [ MEM ]
Gene Expression Viewer (FireBrowse)DACT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)168002
GTEX Portal (Tissue expression)DACT2
Human Protein AtlasENSG00000164488-DACT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5SW24   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5SW24  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5SW24
Splice isoforms : SwissVarQ5SW24
PhosPhoSitePlusQ5SW24
Domains : Interpro (EBI)Dact2    Dapper   
Domain families : Pfam (Sanger)Dapper (PF15268)   
Domain families : Pfam (NCBI)pfam15268   
Conserved Domain (NCBI)DACT2
DMDM Disease mutations168002
Blocks (Seattle)DACT2
SuperfamilyQ5SW24
Human Protein Atlas [tissue]ENSG00000164488-DACT2 [tissue]
Peptide AtlasQ5SW24
HPRD12345
IPIIPI00292470   IPI00888924   IPI00888696   IPI00844552   
Protein Interaction databases
DIP (DOE-UCLA)Q5SW24
IntAct (EBI)Q5SW24
FunCoupENSG00000164488
BioGRIDDACT2
STRING (EMBL)DACT2
ZODIACDACT2
Ontologies - Pathways
QuickGOQ5SW24
Ontology : AmiGOhematopoietic progenitor cell differentiation  epithelial cell morphogenesis  protein kinase C binding  protein kinase C binding  cytoplasm  negative regulation of cell adhesion  beta-catenin binding  beta-catenin binding  transcription factor binding  regulation of Wnt signaling pathway  skin development  protein kinase A binding  protein kinase A binding  delta-catenin binding  delta-catenin binding  inner medullary collecting duct development  negative regulation of nodal signaling pathway  
Ontology : EGO-EBIhematopoietic progenitor cell differentiation  epithelial cell morphogenesis  protein kinase C binding  protein kinase C binding  cytoplasm  negative regulation of cell adhesion  beta-catenin binding  beta-catenin binding  transcription factor binding  regulation of Wnt signaling pathway  skin development  protein kinase A binding  protein kinase A binding  delta-catenin binding  delta-catenin binding  inner medullary collecting duct development  negative regulation of nodal signaling pathway  
NDEx NetworkDACT2
Atlas of Cancer Signalling NetworkDACT2
Wikipedia pathwaysDACT2
Orthology - Evolution
OrthoDB168002
GeneTree (enSembl)ENSG00000164488
Phylogenetic Trees/Animal Genes : TreeFamDACT2
HOVERGENQ5SW24
HOGENOMQ5SW24
Homologs : HomoloGeneDACT2
Homology/Alignments : Family Browser (UCSC)DACT2
Gene fusions - Rearrangements
Fusion : QuiverDACT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDACT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DACT2
dbVarDACT2
ClinVarDACT2
1000_GenomesDACT2 
Exome Variant ServerDACT2
ExAC (Exome Aggregation Consortium)ENSG00000164488
GNOMAD BrowserENSG00000164488
Varsome BrowserDACT2
Genetic variants : HAPMAP168002
Genomic Variants (DGV)DACT2 [DGVbeta]
DECIPHERDACT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDACT2 
Mutations
ICGC Data PortalDACT2 
TCGA Data PortalDACT2 
Broad Tumor PortalDACT2
OASIS PortalDACT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDACT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDACT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DACT2
DgiDB (Drug Gene Interaction Database)DACT2
DoCM (Curated mutations)DACT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DACT2 (select a term)
intoGenDACT2
Cancer3DDACT2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608966   
Orphanet
DisGeNETDACT2
MedgenDACT2
Genetic Testing Registry DACT2
NextProtQ5SW24 [Medical]
TSGene168002
GENETestsDACT2
Target ValidationDACT2
Huge Navigator DACT2 [HugePedia]
snp3D : Map Gene to Disease168002
BioCentury BCIQDACT2
ClinGenDACT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD168002
Chemical/Pharm GKB GenePA134934623
Clinical trialDACT2
Miscellaneous
canSAR (ICR)DACT2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDACT2
EVEXDACT2
GoPubMedDACT2
iHOPDACT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:18:22 CEST 2018

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