Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DAG1 (dystroglycan 1)

Identity

Alias_namesdystroglycan 1 (dystrophin-associated glycoprotein 1)
Alias_symbol (synonym)A3a
156DAG
AGRNR
DAG
Other aliasMDDGA9
MDDGC7
MDDGC9
HGNC (Hugo) DAG1
LocusID (NCBI) 1605
Atlas_Id 46013
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49470132 and ends at 49535618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DAG1 (3p21.31) / APP (21q21.3)DAG1 (3p21.31) / DAG1 (3p21.31)DAG1 (3p21.31) / NEAT1 (11q13.1)
DAG1 (3p21.31) / SLC35F2 (11q22.3)DAG1 (3p21.31) / ZNF589 (3p21.31)SERPINE1 (7q22.1) / DAG1 (3p21.31)
SLCO2A1 (3q22.1) / DAG1 (3p21.31)TGM2 (20q11.23) / DAG1 (3p21.31)DAG1 3p21.31 / ZNF589 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DAG1   2666
LRG (Locus Reference Genomic)LRG_854
Cards
Entrez_Gene (NCBI)DAG1  1605  dystroglycan 1
Aliases156DAG; A3a; AGRNR; DAG; 
MDDGA9; MDDGC7; MDDGC9
GeneCards (Weizmann)DAG1
Ensembl hg19 (Hinxton)ENSG00000173402 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173402 [Gene_View]  chr3:49470132-49535618 [Contig_View]  DAG1 [Vega]
ICGC DataPortalENSG00000173402
TCGA cBioPortalDAG1
AceView (NCBI)DAG1
Genatlas (Paris)DAG1
WikiGenes1605
SOURCE (Princeton)DAG1
Genetics Home Reference (NIH)DAG1
Genomic and cartography
GoldenPath hg38 (UCSC)DAG1  -     chr3:49470132-49535618 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DAG1  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblDAG1 - 3p21.31 [CytoView hg19]  DAG1 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIDAG1 [Mapview hg19]  DAG1 [Mapview hg38]
OMIM128239   613818   616538   
Gene and transcription
Genbank (Entrez)AK291692 AK297802 AU140753 AW204012 BC012740
RefSeq transcript (Entrez)NM_001165928 NM_001177634 NM_001177635 NM_001177636 NM_001177637 NM_001177638 NM_001177639 NM_001177640 NM_001177641 NM_001177642 NM_001177643 NM_001177644 NM_004393
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DAG1
Cluster EST : UnigeneHs.76111 [ NCBI ]
CGAP (NCI)Hs.76111
Alternative Splicing GalleryENSG00000173402
Gene ExpressionDAG1 [ NCBI-GEO ]   DAG1 [ EBI - ARRAY_EXPRESS ]   DAG1 [ SEEK ]   DAG1 [ MEM ]
Gene Expression Viewer (FireBrowse)DAG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1605
GTEX Portal (Tissue expression)DAG1
Human Protein AtlasENSG00000173402-DAG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14118   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14118  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14118
Splice isoforms : SwissVarQ14118
PhosPhoSitePlusQ14118
Domaine pattern : Prosite (Expaxy)SEA_DG (PS51699)   
Domains : Interpro (EBI)Alpha-dystroglycan_domain_2    Cadg    Cadherin-like    DAG1    Ig-like_fold    SEA_DG_dom   
Domain families : Pfam (Sanger)DAG1 (PF05454)   
Domain families : Pfam (NCBI)pfam05454   
Domain families : Smart (EMBL)CADG (SM00736)  
Conserved Domain (NCBI)DAG1
DMDM Disease mutations1605
Blocks (Seattle)DAG1
PDB (SRS)1EG4    2MK7    5GGP   
PDB (PDBSum)1EG4    2MK7    5GGP   
PDB (IMB)1EG4    2MK7    5GGP   
PDB (RSDB)1EG4    2MK7    5GGP   
Structural Biology KnowledgeBase1EG4    2MK7    5GGP   
SCOP (Structural Classification of Proteins)1EG4    2MK7    5GGP   
CATH (Classification of proteins structures)1EG4    2MK7    5GGP   
SuperfamilyQ14118
Human Protein Atlas [tissue]ENSG00000173402-DAG1 [tissue]
Peptide AtlasQ14118
HPRD00546
IPIIPI00028911   IPI00910536   IPI00926257   IPI00926069   IPI00925763   IPI00925548   IPI00925319   IPI00925141   IPI00925042   IPI00924621   IPI00927942   
Protein Interaction databases
DIP (DOE-UCLA)Q14118
IntAct (EBI)Q14118
FunCoupENSG00000173402
BioGRIDDAG1
STRING (EMBL)DAG1
ZODIACDAG1
Ontologies - Pathways
QuickGOQ14118
Ontology : AmiGOvirus receptor activity  positive regulation of cell-matrix adhesion  morphogenesis of an epithelial sheet  dystroglycan binding  actin binding  calcium ion binding  protein binding  extracellular region  basement membrane  extracellular space  nucleoplasm  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  cytosol  cytoskeleton  plasma membrane  plasma membrane  cell-cell adherens junction  focal adhesion  focal adhesion  protein O-linked glycosylation  membrane protein ectodomain proteolysis  NLS-bearing protein import into nucleus  cytoskeletal anchoring at plasma membrane  aging  structural constituent of muscle  external side of plasma membrane  regulation of gastrulation  regulation of epithelial to mesenchymal transition  response to denervation involved in regulation of muscle adaptation  tubulin binding  dystrophin-associated glycoprotein complex  dystroglycan complex  integral component of membrane  basolateral plasma membrane  calcium-dependent cell-matrix adhesion  regulation of embryonic cell shape  vinculin binding  modulation by virus of host morphology or physiology  nerve maturation  myelination in peripheral nervous system  lamellipodium  filopodium  extracellular matrix organization  negative regulation of cell migration  axon regeneration  positive regulation of myelination  node of Ranvier  microtubule anchoring  SH2 domain binding  sarcolemma  costamere  laminin-1 binding  skeletal muscle tissue regeneration  negative regulation of MAPK cascade  response to peptide hormone  plasma membrane raft  postsynaptic membrane  positive regulation of protein kinase activity  viral entry into host cell  positive regulation of oligodendrocyte differentiation  alpha-actinin binding  negative regulation of protein kinase B signaling  epithelial tube branching involved in lung morphogenesis  branching involved in salivary gland morphogenesis  extracellular exosome  contractile ring  cellular response to mechanical stimulus  cellular response to cholesterol  commissural neuron axon guidance  basement membrane organization  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
Ontology : EGO-EBIvirus receptor activity  positive regulation of cell-matrix adhesion  morphogenesis of an epithelial sheet  dystroglycan binding  actin binding  calcium ion binding  protein binding  extracellular region  basement membrane  extracellular space  nucleoplasm  cytoplasm  endoplasmic reticulum lumen  Golgi lumen  cytosol  cytoskeleton  plasma membrane  plasma membrane  cell-cell adherens junction  focal adhesion  focal adhesion  protein O-linked glycosylation  membrane protein ectodomain proteolysis  NLS-bearing protein import into nucleus  cytoskeletal anchoring at plasma membrane  aging  structural constituent of muscle  external side of plasma membrane  regulation of gastrulation  regulation of epithelial to mesenchymal transition  response to denervation involved in regulation of muscle adaptation  tubulin binding  dystrophin-associated glycoprotein complex  dystroglycan complex  integral component of membrane  basolateral plasma membrane  calcium-dependent cell-matrix adhesion  regulation of embryonic cell shape  vinculin binding  modulation by virus of host morphology or physiology  nerve maturation  myelination in peripheral nervous system  lamellipodium  filopodium  extracellular matrix organization  negative regulation of cell migration  axon regeneration  positive regulation of myelination  node of Ranvier  microtubule anchoring  SH2 domain binding  sarcolemma  costamere  laminin-1 binding  skeletal muscle tissue regeneration  negative regulation of MAPK cascade  response to peptide hormone  plasma membrane raft  postsynaptic membrane  positive regulation of protein kinase activity  viral entry into host cell  positive regulation of oligodendrocyte differentiation  alpha-actinin binding  negative regulation of protein kinase B signaling  epithelial tube branching involved in lung morphogenesis  branching involved in salivary gland morphogenesis  extracellular exosome  contractile ring  cellular response to mechanical stimulus  cellular response to cholesterol  commissural neuron axon guidance  basement membrane organization  positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGECM-receptor interaction    Hypertrophic cardiomyopathy (HCM)    Arrhythmogenic right ventricular cardiomyopathy (ARVC)    Dilated cardiomyopathy    Viral myocarditis   
NDEx NetworkDAG1
Atlas of Cancer Signalling NetworkDAG1
Wikipedia pathwaysDAG1
Orthology - Evolution
OrthoDB1605
GeneTree (enSembl)ENSG00000173402
Phylogenetic Trees/Animal Genes : TreeFamDAG1
HOVERGENQ14118
HOGENOMQ14118
Homologs : HomoloGeneDAG1
Homology/Alignments : Family Browser (UCSC)DAG1
Gene fusions - Rearrangements
Fusion : MitelmanDAG1/ZNF589 [3p21.31/3p21.31]  
Fusion: TCGA_MDACCDAG1 3p21.31 ZNF589 3p21.31 BRCA
Tumor Fusion PortalDAG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDAG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DAG1
dbVarDAG1
ClinVarDAG1
1000_GenomesDAG1 
Exome Variant ServerDAG1
ExAC (Exome Aggregation Consortium)ENSG00000173402
GNOMAD BrowserENSG00000173402
Genetic variants : HAPMAP1605
Genomic Variants (DGV)DAG1 [DGVbeta]
DECIPHERDAG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDAG1 
Mutations
ICGC Data PortalDAG1 
TCGA Data PortalDAG1 
Broad Tumor PortalDAG1
OASIS PortalDAG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDAG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDAG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DAG1
DgiDB (Drug Gene Interaction Database)DAG1
DoCM (Curated mutations)DAG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DAG1 (select a term)
intoGenDAG1
Cancer3DDAG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM128239    613818    616538   
Orphanet20455    22512    8725   
DisGeNETDAG1
MedgenDAG1
Genetic Testing Registry DAG1
NextProtQ14118 [Medical]
TSGene1605
GENETestsDAG1
Target ValidationDAG1
Huge Navigator DAG1 [HugePedia]
snp3D : Map Gene to Disease1605
BioCentury BCIQDAG1
ClinGenDAG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1605
Chemical/Pharm GKB GenePA27138
Clinical trialDAG1
Miscellaneous
canSAR (ICR)DAG1 (select the gene name)
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDAG1
EVEXDAG1
GoPubMedDAG1
iHOPDAG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:09:56 CET 2017

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