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DAND5 (DAN domain BMP antagonist family member 5)

Identity

Alias_namesDAN domain family member 5
Alias_symbol (synonym)FLJ38607
CKTSF1B3
DANTE
GREM3
CER2
DTE
Coco
Other aliasCERL2
COCO
CRL2
SP1
HGNC (Hugo) DAND5
LocusID (NCBI) 199699
Atlas_Id 50397
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12969618 and ends at 12974753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FKBP8 (19p13.11) / DAND5 (19p13.2)NFIX (19p13.2) / DAND5 (19p13.2)ZNF20 (19p13.2) / DAND5 (19p13.2)
FKBP8 19p13.11 / DAND5 19p13.2NFIX 19p13.2 / DAND5 19p13.2ZNF20 19p13.2 / DAND5 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  FKBP8/DAND5 (19p13)
NFIX/DAND5 (19p13)
ZNF20/DAND5 (19p13)

External links

Nomenclature
HGNC (Hugo)DAND5   26780
Cards
Entrez_Gene (NCBI)DAND5  199699  DAN domain BMP antagonist family member 5
AliasesCER2; CERL2; CKTSF1B3; COCO; 
CRL2; DANTE; GREM3; SP1
GeneCards (Weizmann)DAND5
Ensembl hg19 (Hinxton)ENSG00000179284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179284 [Gene_View]  ENSG00000179284 [Sequence]  chr19:12969618-12974753 [Contig_View]  DAND5 [Vega]
ICGC DataPortalENSG00000179284
TCGA cBioPortalDAND5
AceView (NCBI)DAND5
Genatlas (Paris)DAND5
WikiGenes199699
SOURCE (Princeton)DAND5
Genetics Home Reference (NIH)DAND5
Genomic and cartography
GoldenPath hg38 (UCSC)DAND5  -     chr19:12969618-12974753 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DAND5  -     19p13.13   [Description]    (hg19-Feb_2009)
EnsemblDAND5 - 19p13.13 [CytoView hg19]  DAND5 - 19p13.13 [CytoView hg38]
Mapping of homologs : NCBIDAND5 [Mapview hg19]  DAND5 [Mapview hg38]
OMIM609068   
Gene and transcription
Genbank (Entrez)AB070695 AK095926 BC025333 BC101800 BC113476
RefSeq transcript (Entrez)NM_152654
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DAND5
Cluster EST : UnigeneHs.331981 [ NCBI ]
CGAP (NCI)Hs.331981
Alternative Splicing GalleryENSG00000179284
Gene ExpressionDAND5 [ NCBI-GEO ]   DAND5 [ EBI - ARRAY_EXPRESS ]   DAND5 [ SEEK ]   DAND5 [ MEM ]
Gene Expression Viewer (FireBrowse)DAND5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)199699
GTEX Portal (Tissue expression)DAND5
Human Protein AtlasENSG00000179284-DAND5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N907   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N907  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N907
Splice isoforms : SwissVarQ8N907
PhosPhoSitePlusQ8N907
Domains : Interpro (EBI)Cerberus    Cystine-knot_cytokine    DAN   
Domain families : Pfam (Sanger)DAN (PF03045)   
Domain families : Pfam (NCBI)pfam03045   
Conserved Domain (NCBI)DAND5
DMDM Disease mutations199699
Blocks (Seattle)DAND5
SuperfamilyQ8N907
Human Protein Atlas [tissue]ENSG00000179284-DAND5 [tissue]
Peptide AtlasQ8N907
HPRD08788
IPIIPI00167536   
Protein Interaction databases
DIP (DOE-UCLA)Q8N907
IntAct (EBI)Q8N907
FunCoupENSG00000179284
BioGRIDDAND5
STRING (EMBL)DAND5
ZODIACDAND5
Ontologies - Pathways
QuickGOQ8N907
Ontology : AmiGOdetermination of left/right asymmetry in lateral mesoderm  ventricular septum development  atrial septum development  extracellular region  extracellular space  regulation of signaling receptor activity  morphogen activity  morphogen activity  signal transduction involved in regulation of gene expression  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  sequestering of BMP in extracellular matrix  sequestering of nodal from receptor via nodal binding  determination of heart left/right asymmetry  determination of heart left/right asymmetry  negative regulation of nodal signaling pathway  negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  
Ontology : EGO-EBIdetermination of left/right asymmetry in lateral mesoderm  ventricular septum development  atrial septum development  extracellular region  extracellular space  regulation of signaling receptor activity  morphogen activity  morphogen activity  signal transduction involved in regulation of gene expression  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  sequestering of BMP in extracellular matrix  sequestering of nodal from receptor via nodal binding  determination of heart left/right asymmetry  determination of heart left/right asymmetry  negative regulation of nodal signaling pathway  negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  
NDEx NetworkDAND5
Atlas of Cancer Signalling NetworkDAND5
Wikipedia pathwaysDAND5
Orthology - Evolution
OrthoDB199699
GeneTree (enSembl)ENSG00000179284
Phylogenetic Trees/Animal Genes : TreeFamDAND5
HOGENOMQ8N907
Homologs : HomoloGeneDAND5
Homology/Alignments : Family Browser (UCSC)DAND5
Gene fusions - Rearrangements
Fusion : MitelmanFKBP8/DAND5 [19p13.11/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIX/DAND5 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanZNF20/DAND5 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion PortalFKBP8 19p13.11 DAND5 19p13.2 OV
Fusion PortalNFIX 19p13.2 DAND5 19p13.2 BRCA LUAD
Fusion PortalZNF20 19p13.2 DAND5 19p13.2 OV
Fusion : QuiverDAND5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDAND5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DAND5
dbVarDAND5
ClinVarDAND5
1000_GenomesDAND5 
Exome Variant ServerDAND5
ExAC (Exome Aggregation Consortium)ENSG00000179284
GNOMAD BrowserENSG00000179284
Varsome BrowserDAND5
Genetic variants : HAPMAP199699
Genomic Variants (DGV)DAND5 [DGVbeta]
DECIPHERDAND5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDAND5 
Mutations
ICGC Data PortalDAND5 
TCGA Data PortalDAND5 
Broad Tumor PortalDAND5
OASIS PortalDAND5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDAND5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDAND5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DAND5
DgiDB (Drug Gene Interaction Database)DAND5
DoCM (Curated mutations)DAND5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DAND5 (select a term)
intoGenDAND5
Cancer3DDAND5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609068   
Orphanet
DisGeNETDAND5
MedgenDAND5
Genetic Testing Registry DAND5
NextProtQ8N907 [Medical]
TSGene199699
GENETestsDAND5
Target ValidationDAND5
Huge Navigator DAND5 [HugePedia]
snp3D : Map Gene to Disease199699
BioCentury BCIQDAND5
ClinGenDAND5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD199699
Chemical/Pharm GKB GenePA134875268
Clinical trialDAND5
Miscellaneous
canSAR (ICR)DAND5 (select the gene name)
DataMed IndexDAND5
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDAND5
EVEXDAND5
GoPubMedDAND5
iHOPDAND5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:08:55 CET 2019
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