DAO (D-amino acid oxidase)

2013-02-01  

Identity

HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
DAAO,DAMOX,OXDA
FUSION GENES

Other Information

Locus ID:

NCBI: 1610
MIM: 124050
HGNC: 2671
Ensembl: ENSG00000110887

Variants:

dbSNP: 1610
ClinVar: 1610
TCGA: ENSG00000110887
COSMIC: DAO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110887ENST00000228476P14920
ENSG00000110887ENST00000228476A0A024RBI1
ENSG00000110887ENST00000547122A0A0B4J257
ENSG00000110887ENST00000547166F8W152
ENSG00000110887ENST00000547768F8VV35
ENSG00000110887ENST00000549215F8VVT2
ENSG00000110887ENST00000551281A0A0B4J250

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Arginine and proline metabolismKEGGko00330
D-Arginine and D-ornithine metabolismKEGGko00472
Glycine, serine and threonine metabolismKEGGhsa00260
Arginine and proline metabolismKEGGhsa00330
D-Arginine and D-ornithine metabolismKEGGhsa00472
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
123645862002Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.163
163809052005Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.131
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
187157572008Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.62
203684212010Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.61
149664792004Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder.59
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
185445342008pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility.45
173369462007Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level.43

Citation

Dessen P

DAO (D-amino acid oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53173/dao