Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DAPK3 (death associated protein kinase 3)

Identity

Alias_symbol (synonym)ZIP
ZIPK
Other aliasDLK
HGNC (Hugo) DAPK3
LocusID (NCBI) 1613
Atlas_Id 40264
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 3958453 and ends at 3971123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DAPK3 (19p13.3) / NFATC1 (18q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DAPK3   2676
Cards
Entrez_Gene (NCBI)DAPK3  1613  death associated protein kinase 3
AliasesDLK; ZIP; ZIPK
GeneCards (Weizmann)DAPK3
Ensembl hg19 (Hinxton)ENSG00000167657 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167657 [Gene_View]  ENSG00000167657 [Sequence]  chr19:3958453-3971123 [Contig_View]  DAPK3 [Vega]
ICGC DataPortalENSG00000167657
TCGA cBioPortalDAPK3
AceView (NCBI)DAPK3
Genatlas (Paris)DAPK3
WikiGenes1613
SOURCE (Princeton)DAPK3
Genetics Home Reference (NIH)DAPK3
Genomic and cartography
GoldenPath hg38 (UCSC)DAPK3  -     chr19:3958453-3971123 -  15q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DAPK3  -     15q22.31   [Description]    (hg19-Feb_2009)
EnsemblDAPK3 - 15q22.31 [CytoView hg19]  DAPK3 - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIDAPK3 [Mapview hg19]  DAPK3 [Mapview hg38]
OMIM603289   
Gene and transcription
Genbank (Entrez)AB007144 AB022341 AB265224 AI654829 AK027590
RefSeq transcript (Entrez)NM_001348
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DAPK3
Cluster EST : UnigeneHs.631844 [ NCBI ]
CGAP (NCI)Hs.631844
Alternative Splicing GalleryENSG00000167657
Gene ExpressionDAPK3 [ NCBI-GEO ]   DAPK3 [ EBI - ARRAY_EXPRESS ]   DAPK3 [ SEEK ]   DAPK3 [ MEM ]
Gene Expression Viewer (FireBrowse)DAPK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1613
GTEX Portal (Tissue expression)DAPK3
Human Protein AtlasENSG00000167657-DAPK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43293   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43293  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43293
Splice isoforms : SwissVarO43293
PhosPhoSitePlusO43293
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)DAPK3
DMDM Disease mutations1613
Blocks (Seattle)DAPK3
PDB (SRS)1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
PDB (PDBSum)1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
PDB (IMB)1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
PDB (RSDB)1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
Structural Biology KnowledgeBase1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
SCOP (Structural Classification of Proteins)1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
CATH (Classification of proteins structures)1YRP    2J90    3BHY    3BQR    5A6N    5A6O   
SuperfamilyO43293
Human Protein Atlas [tissue]ENSG00000167657-DAPK3 [tissue]
Peptide AtlasO43293
HPRD04478
IPIIPI00015213   IPI00807379   
Protein Interaction databases
DIP (DOE-UCLA)O43293
IntAct (EBI)O43293
FunCoupENSG00000167657
BioGRIDDAPK3
STRING (EMBL)DAPK3
ZODIACDAPK3
Ontologies - Pathways
QuickGOO43293
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  nucleus  nucleus  cytoplasm  actin filament  chromatin organization  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  apoptotic process  regulation of smooth muscle contraction  regulation of mitotic nuclear division  regulation of mitotic cell cycle  protein C-terminus binding  cAMP response element binding protein binding  regulation of cell shape  regulation of autophagy  PML body  Rho GTPase binding  negative regulation of translation  neuron differentiation  positive regulation of cell migration  intracellular signal transduction  identical protein binding  protein homodimerization activity  regulation of apoptotic process  regulation of apoptotic process  positive regulation of apoptotic process  regulation of myosin II filament organization  leucine zipper domain binding  membrane raft  protein autophosphorylation  protein autophosphorylation  regulation of focal adhesion assembly  cellular response to interferon-gamma  positive regulation of canonical Wnt signaling pathway  apoptotic signaling pathway  regulation of cell motility  regulation of actin cytoskeleton reorganization  regulation of actin cytoskeleton reorganization  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  nucleus  nucleus  cytoplasm  actin filament  chromatin organization  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  apoptotic process  regulation of smooth muscle contraction  regulation of mitotic nuclear division  regulation of mitotic cell cycle  protein C-terminus binding  cAMP response element binding protein binding  regulation of cell shape  regulation of autophagy  PML body  Rho GTPase binding  negative regulation of translation  neuron differentiation  positive regulation of cell migration  intracellular signal transduction  identical protein binding  protein homodimerization activity  regulation of apoptotic process  regulation of apoptotic process  positive regulation of apoptotic process  regulation of myosin II filament organization  leucine zipper domain binding  membrane raft  protein autophosphorylation  protein autophosphorylation  regulation of focal adhesion assembly  cellular response to interferon-gamma  positive regulation of canonical Wnt signaling pathway  apoptotic signaling pathway  regulation of cell motility  regulation of actin cytoskeleton reorganization  regulation of actin cytoskeleton reorganization  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGPathways in cancer    Bladder cancer   
NDEx NetworkDAPK3
Atlas of Cancer Signalling NetworkDAPK3
Wikipedia pathwaysDAPK3
Orthology - Evolution
OrthoDB1613
GeneTree (enSembl)ENSG00000167657
Phylogenetic Trees/Animal Genes : TreeFamDAPK3
HOVERGENO43293
HOGENOMO43293
Homologs : HomoloGeneDAPK3
Homology/Alignments : Family Browser (UCSC)DAPK3
Gene fusions - Rearrangements
Fusion : QuiverDAPK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDAPK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DAPK3
dbVarDAPK3
ClinVarDAPK3
1000_GenomesDAPK3 
Exome Variant ServerDAPK3
ExAC (Exome Aggregation Consortium)ENSG00000167657
GNOMAD BrowserENSG00000167657
Varsome BrowserDAPK3
Genetic variants : HAPMAP1613
Genomic Variants (DGV)DAPK3 [DGVbeta]
DECIPHERDAPK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDAPK3 
Mutations
ICGC Data PortalDAPK3 
TCGA Data PortalDAPK3 
Broad Tumor PortalDAPK3
OASIS PortalDAPK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDAPK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDAPK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DAPK3
DgiDB (Drug Gene Interaction Database)DAPK3
DoCM (Curated mutations)DAPK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DAPK3 (select a term)
intoGenDAPK3
Cancer3DDAPK3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603289   
Orphanet
DisGeNETDAPK3
MedgenDAPK3
Genetic Testing Registry DAPK3
NextProtO43293 [Medical]
TSGene1613
GENETestsDAPK3
Target ValidationDAPK3
Huge Navigator DAPK3 [HugePedia]
snp3D : Map Gene to Disease1613
BioCentury BCIQDAPK3
ClinGenDAPK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1613
Chemical/Pharm GKB GenePA27144
Clinical trialDAPK3
Miscellaneous
canSAR (ICR)DAPK3 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDAPK3
EVEXDAPK3
GoPubMedDAPK3
iHOPDAPK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 10:57:04 CEST 2018
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