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DARS (aspartyl-tRNA synthetase)

Identity

Other aliasHBSL
aspRS
HGNC (Hugo) DARS
LocusID (NCBI) 1615
Atlas_Id 62291
Location 2q21.3  [Link to chromosome band 2q21]
Location_base_pair Starts at 135905881 and ends at 135985684 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DARS (2q21.3) / C14orf132 (14q32.2)DARS (2q21.3) / DARS (2q21.3)DARS (2q21.3) / THSD7B (2q22.1)
DARS (2q21.3) / ZNF148 (3q21.2)MCM6 (2q21.3) / DARS (2q21.3)THSD7B (2q22.1) / DARS (2q21.3)
WDR33 (2q14.3) / DARS (2q21.3)MCM6 DARSTHSD7B DARS

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DARS   2678
Cards
Entrez_Gene (NCBI)DARS  1615  aspartyl-tRNA synthetase
AliasesHBSL; aspRS
GeneCards (Weizmann)DARS
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr2:135905881-135985684 [Contig_View]  DARS [Vega]
TCGA cBioPortalDARS
AceView (NCBI)DARS
Genatlas (Paris)DARS
WikiGenes1615
SOURCE (Princeton)DARS
Genetics Home Reference (NIH)DARS
Genomic and cartography
GoldenPath hg38 (UCSC)DARS  -     chr2:135905881-135985684 -  2q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DARS  -     2q21.3   [Description]    (hg19-Feb_2009)
EnsemblDARS - 2q21.3 [CytoView hg19]  DARS - 2q21.3 [CytoView hg38]
Mapping of homologs : NCBIDARS [Mapview hg19]  DARS [Mapview hg38]
OMIM603084   615281   
Gene and transcription
Genbank (Entrez)AK129521 AK222476 AK290607 AY762100 BC000629
RefSeq transcript (Entrez)NM_001293312 NM_001349
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DARS
Cluster EST : UnigeneHs.595819 [ NCBI ]
CGAP (NCI)Hs.595819
Gene ExpressionDARS [ NCBI-GEO ]   DARS [ EBI - ARRAY_EXPRESS ]   DARS [ SEEK ]   DARS [ MEM ]
Gene Expression Viewer (FireBrowse)DARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1615
GTEX Portal (Tissue expression)DARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14868   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14868  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14868
Splice isoforms : SwissVarP14868
Catalytic activity : Enzyme6.1.1.12 [ Enzyme-Expasy ]   6.1.1.126.1.1.12 [ IntEnz-EBI ]   6.1.1.12 [ BRENDA ]   6.1.1.12 [ KEGG ]   
PhosPhoSitePlusP14868
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)aa-tRNA-synt_II    aa-tRNA-synth_II    Asp-tRNA_synthase_arc    Asp/Asn-tRNA-synth_IIb    NA-bd_OB-fold    NA-bd_OB_tRNA   
Domain families : Pfam (Sanger)tRNA-synt_2 (PF00152)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam00152    pfam01336   
Conserved Domain (NCBI)DARS
DMDM Disease mutations1615
Blocks (Seattle)DARS
PDB (SRS)4J15   
PDB (PDBSum)4J15   
PDB (IMB)4J15   
PDB (RSDB)4J15   
Structural Biology KnowledgeBase4J15   
SCOP (Structural Classification of Proteins)4J15   
CATH (Classification of proteins structures)4J15   
SuperfamilyP14868
Peptide AtlasP14868
HPRD04361
IPIIPI00216951   IPI01009538   IPI00917399   IPI00917615   IPI00917492   IPI00917920   IPI00917783   
Protein Interaction databases
DIP (DOE-UCLA)P14868
IntAct (EBI)P14868
BioGRIDDARS
STRING (EMBL)DARS
ZODIACDARS
Ontologies - Pathways
QuickGOP14868
Ontology : AmiGORNA binding  aminoacylase activity  aspartate-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  aspartyl-tRNA aminoacylation  protein complex assembly  membrane  aminoacyl-tRNA synthetase multienzyme complex  extracellular exosome  
Ontology : EGO-EBIRNA binding  aminoacylase activity  aspartate-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  aspartyl-tRNA aminoacylation  protein complex assembly  membrane  aminoacyl-tRNA synthetase multienzyme complex  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkDARS
Atlas of Cancer Signalling NetworkDARS
Wikipedia pathwaysDARS
Orthology - Evolution
OrthoDB1615
Phylogenetic Trees/Animal Genes : TreeFamDARS
HOVERGENP14868
HOGENOMP14868
Homologs : HomoloGeneDARS
Homology/Alignments : Family Browser (UCSC)DARS
Gene fusions - Rearrangements
Fusion: TCGAMCM6 DARS
Fusion: TCGATHSD7B DARS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DARS
dbVarDARS
ClinVarDARS
1000_GenomesDARS 
Exome Variant ServerDARS
ExAC (Exome Aggregation Consortium)DARS (select the gene name)
Genetic variants : HAPMAP1615
Genomic Variants (DGV)DARS [DGVbeta]
DECIPHERDARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDARS 
Mutations
ICGC Data PortalDARS 
TCGA Data PortalDARS 
Broad Tumor PortalDARS
OASIS PortalDARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DARS
DgiDB (Drug Gene Interaction Database)DARS
DoCM (Curated mutations)DARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DARS (select a term)
intoGenDARS
Cancer3DDARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603084    615281   
Orphanet22297   
MedgenDARS
Genetic Testing Registry DARS
NextProtP14868 [Medical]
TSGene1615
GENETestsDARS
Target ValidationDARS
Huge Navigator DARS [HugePedia]
snp3D : Map Gene to Disease1615
BioCentury BCIQDARS
ClinGenDARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1615
Chemical/Pharm GKB GenePA27146
Clinical trialDARS
Miscellaneous
canSAR (ICR)DARS (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDARS
EVEXDARS
GoPubMedDARS
iHOPDARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:05:50 CEST 2017

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