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DARS1 (aspartyl-tRNA synthetase 1)

Identity

Alias (NCBI)DARS
HBSL
aspRS
HGNC (Hugo) DARS1
HGNC Alias nameaspartate tRNA ligase 1, cytoplasmic
LocusID (NCBI) 1615
Atlas_Id 62291
Location 2q21.3  [Link to chromosome band 2q21]
Location_base_pair Starts at 135905881 and ends at 135985626 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCM6 DARSTHSD7B DARS
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)DARS1   2678
Cards
Entrez_Gene (NCBI)DARS1    aspartyl-tRNA synthetase 1
AliasesDARS; HBSL; aspRS
GeneCards (Weizmann)DARS1
Ensembl hg19 (Hinxton)ENSG00000115866 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115866 [Gene_View]  ENSG00000115866 [Sequence]  chr2:135905881-135985626 [Contig_View]  DARS1 [Vega]
ICGC DataPortalENSG00000115866
TCGA cBioPortalDARS1
AceView (NCBI)DARS1
Genatlas (Paris)DARS1
SOURCE (Princeton)DARS1
Genetics Home Reference (NIH)DARS1
Genomic and cartography
GoldenPath hg38 (UCSC)DARS1  -     chr2:135905881-135985626 -  2q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DARS1  -     2q21.3   [Description]    (hg19-Feb_2009)
GoldenPathDARS1 - 2q21.3 [CytoView hg19]  DARS1 - 2q21.3 [CytoView hg38]
ImmunoBaseENSG00000115866
Genome Data Viewer NCBIDARS1 [Mapview hg19]  
OMIM603084   615281   
Gene and transcription
Genbank (Entrez)AK129521 AK222476 AK290607 AY762100 BC000629
RefSeq transcript (Entrez)NM_001293312 NM_001349
Consensus coding sequences : CCDS (NCBI)DARS1
Gene ExpressionDARS1 [ NCBI-GEO ]   DARS1 [ EBI - ARRAY_EXPRESS ]   DARS1 [ SEEK ]   DARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)DARS1 [ Firebrowse - Broad ]
GenevisibleExpression of DARS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1615
GTEX Portal (Tissue expression)DARS1
Human Protein AtlasENSG00000115866-DARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14868   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14868  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14868
PhosPhoSitePlusP14868
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)Aa-tRNA-synt_II    aa-tRNA-synth_II    Asp-tRNA_synthase_2    Asp/Asn-tRNA-synth_IIb    NA-bd_OB-fold    NA-bd_OB_tRNA   
Domain families : Pfam (Sanger)tRNA-synt_2 (PF00152)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam00152    pfam01336   
Conserved Domain (NCBI)DARS1
PDB (RSDB)4J15    5Y6L    6IY6   
PDB Europe4J15    5Y6L    6IY6   
PDB (PDBSum)4J15    5Y6L    6IY6   
PDB (IMB)4J15    5Y6L    6IY6   
Structural Biology KnowledgeBase4J15    5Y6L    6IY6   
SCOP (Structural Classification of Proteins)4J15    5Y6L    6IY6   
CATH (Classification of proteins structures)4J15    5Y6L    6IY6   
SuperfamilyP14868
AlphaFold pdb e-kbP14868   
Human Protein Atlas [tissue]ENSG00000115866-DARS1 [tissue]
HPRD04361
Protein Interaction databases
DIP (DOE-UCLA)P14868
IntAct (EBI)P14868
BioGRIDDARS1
STRING (EMBL)DARS1
ZODIACDARS1
Ontologies - Pathways
QuickGOP14868
Ontology : AmiGORNA binding  RNA binding  aminoacylase activity  aspartate-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  aspartyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  synapse  protein-containing complex assembly  extracellular exosome  
Ontology : EGO-EBIRNA binding  RNA binding  aminoacylase activity  aspartate-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  aspartyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  synapse  protein-containing complex assembly  extracellular exosome  
Pathways : KEGGKEGG_hsa00970 Aminoacyl-tRNA biosynthesis    KEGG_hsa00252 Alanine and aspartate metabolism   
NDEx NetworkDARS1
Atlas of Cancer Signalling NetworkDARS1
Wikipedia pathwaysDARS1
Orthology - Evolution
OrthoDB1615
GeneTree (enSembl)ENSG00000115866
Phylogenetic Trees/Animal Genes : TreeFamDARS1
Homologs : HomoloGeneDARS1
Homology/Alignments : Family Browser (UCSC)DARS1
Gene fusions - Rearrangements
Fusion : QuiverDARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DARS1
dbVarDARS1
ClinVarDARS1
MonarchDARS1
1000_GenomesDARS1 
Exome Variant ServerDARS1
GNOMAD BrowserENSG00000115866
Varsome BrowserDARS1
ACMGDARS1 variants
VarityP14868
Genomic Variants (DGV)DARS1 [DGVbeta]
DECIPHERDARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDARS1 
Mutations
ICGC Data PortalDARS1 
TCGA Data PortalDARS1 
Broad Tumor PortalDARS1
OASIS PortalDARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDARS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDARS1
DgiDB (Drug Gene Interaction Database)DARS1
DoCM (Curated mutations)DARS1
CIViC (Clinical Interpretations of Variants in Cancer)DARS1
Cancer3DDARS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603084    615281   
Orphanet22297   
DisGeNETDARS1
MedgenDARS1
Genetic Testing Registry DARS1
NextProtP14868 [Medical]
GENETestsDARS1
Target ValidationDARS1
Huge Navigator DARS1 [HugePedia]
ClinGenDARS1
Clinical trials, drugs, therapy
MyCancerGenomeDARS1
Protein Interactions : CTDDARS1
Pharm GKB GenePA27146
PharosP14868
Clinical trialDARS1
Miscellaneous
canSAR (ICR)DARS1
HarmonizomeDARS1
ARCHS4DARS1
DataMed IndexDARS1
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:16:09 CET 2022

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