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DBF4 (DBF4 zinc finger)

Identity

Alias (NCBI)ASK
CHIF
DBF4A
ZDBF1
HGNC (Hugo) DBF4
HGNC Alias symbASK
chif
ZDBF1
DBF4A
HGNC Alias nameactivator of S phase kinase
 chiffon homolog (Drosophila)
 zinc finger, DBF-type containing 1
 DBF4 zinc finger A
HGNC Previous nameDBF4 homolog (S. cerevisiae)
LocusID (NCBI) 10926
Atlas_Id 50062
Location 7q21.12  [Link to chromosome band 7q21]
Location_base_pair Starts at 87876493 and ends at 87909552 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DBF4   17364
Cards
Entrez_Gene (NCBI)DBF4    DBF4 zinc finger
AliasesASK; CHIF; DBF4A; ZDBF1
GeneCards (Weizmann)DBF4
Ensembl hg19 (Hinxton)ENSG00000006634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006634 [Gene_View]  ENSG00000006634 [Sequence]  chr7:87876493-87909552 [Contig_View]  DBF4 [Vega]
ICGC DataPortalENSG00000006634
TCGA cBioPortalDBF4
AceView (NCBI)DBF4
Genatlas (Paris)DBF4
SOURCE (Princeton)DBF4
Genetics Home Reference (NIH)DBF4
Genomic and cartography
GoldenPath hg38 (UCSC)DBF4  -     chr7:87876493-87909552 +  7q21.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DBF4  -     7q21.12   [Description]    (hg19-Feb_2009)
GoldenPathDBF4 - 7q21.12 [CytoView hg19]  DBF4 - 7q21.12 [CytoView hg38]
ImmunoBaseENSG00000006634
Genome Data Viewer NCBIDBF4 [Mapview hg19]  
OMIM604281   
Gene and transcription
Genbank (Entrez)AB028069 AB028070 AF160249 AF160876 AK022969
RefSeq transcript (Entrez)NM_001318060 NM_001318061 NM_001318062 NM_006716
Consensus coding sequences : CCDS (NCBI)DBF4
Gene ExpressionDBF4 [ NCBI-GEO ]   DBF4 [ EBI - ARRAY_EXPRESS ]   DBF4 [ SEEK ]   DBF4 [ MEM ]
Gene Expression Viewer (FireBrowse)DBF4 [ Firebrowse - Broad ]
GenevisibleExpression of DBF4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10926
GTEX Portal (Tissue expression)DBF4
Human Protein AtlasENSG00000006634-DBF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBU7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBU7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBU7
PhosPhoSitePlusQ9UBU7
Domaine pattern : Prosite (Expaxy)ZF_DBF4 (PS51265)   
Domains : Interpro (EBI)Znf_DBF    Znf_DBF_sf   
Domain families : Pfam (Sanger)zf-DBF (PF07535)   
Domain families : Pfam (NCBI)pfam07535   
Domain families : Smart (EMBL)ZnF_DBF (SM00586)  
Conserved Domain (NCBI)DBF4
PDB (RSDB)4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
PDB Europe4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
PDB (PDBSum)4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
PDB (IMB)4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
Structural Biology KnowledgeBase4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
SCOP (Structural Classification of Proteins)4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
CATH (Classification of proteins structures)4F99    4F9A    4F9B    4F9C    6YA6    6YA7    6YA8   
SuperfamilyQ9UBU7
AlphaFold pdb e-kbQ9UBU7   
Human Protein Atlas [tissue]ENSG00000006634-DBF4 [tissue]
HPRD10371
Protein Interaction databases
DIP (DOE-UCLA)Q9UBU7
IntAct (EBI)Q9UBU7
BioGRIDDBF4
STRING (EMBL)DBF4
ZODIACDBF4
Ontologies - Pathways
QuickGOQ9UBU7
Ontology : AmiGOG1/S transition of mitotic cell cycle  nucleic acid binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication initiation  enzyme activator activity  zinc ion binding  positive regulation of nuclear cell cycle DNA replication  nuclear body  Dbf4-dependent protein kinase complex  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  regulation of cell cycle phase transition  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nucleic acid binding  protein binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication initiation  enzyme activator activity  zinc ion binding  positive regulation of nuclear cell cycle DNA replication  nuclear body  Dbf4-dependent protein kinase complex  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  regulation of cell cycle phase transition  
Pathways : KEGGCell cycle   
NDEx NetworkDBF4
Atlas of Cancer Signalling NetworkDBF4
Wikipedia pathwaysDBF4
Orthology - Evolution
OrthoDB10926
GeneTree (enSembl)ENSG00000006634
Phylogenetic Trees/Animal Genes : TreeFamDBF4
Homologs : HomoloGeneDBF4
Homology/Alignments : Family Browser (UCSC)DBF4
Gene fusions - Rearrangements
Fusion : QuiverDBF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDBF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DBF4
dbVarDBF4
ClinVarDBF4
MonarchDBF4
1000_GenomesDBF4 
Exome Variant ServerDBF4
GNOMAD BrowserENSG00000006634
Varsome BrowserDBF4
ACMGDBF4 variants
VarityQ9UBU7
Genomic Variants (DGV)DBF4 [DGVbeta]
DECIPHERDBF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDBF4 
Mutations
ICGC Data PortalDBF4 
TCGA Data PortalDBF4 
Broad Tumor PortalDBF4
OASIS PortalDBF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDBF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDBF4
Mutations and Diseases : HGMDDBF4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDBF4
DgiDB (Drug Gene Interaction Database)DBF4
DoCM (Curated mutations)DBF4
CIViC (Clinical Interpretations of Variants in Cancer)DBF4
Cancer3DDBF4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604281   
Orphanet
DisGeNETDBF4
MedgenDBF4
Genetic Testing Registry DBF4
NextProtQ9UBU7 [Medical]
GENETestsDBF4
Target ValidationDBF4
Huge Navigator DBF4 [HugePedia]
ClinGenDBF4
Clinical trials, drugs, therapy
MyCancerGenomeDBF4
Protein Interactions : CTDDBF4
Pharm GKB GenePA142672016
PharosQ9UBU7
Clinical trialDBF4
Miscellaneous
canSAR (ICR)DBF4
HarmonizomeDBF4
ARCHS4DBF4
DataMed IndexDBF4
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDBF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:21:15 CET 2022

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