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DCAF1 (DDB1 and CUL4 associated factor 1)

Identity

Alias_namesVPRBP
Vpr (HIV-1) binding protein
Alias_symbol (synonym)KIAA0800
MGC102804
Other aliasRIP
HGNC (Hugo) DCAF1
LocusID (NCBI) 9730
Atlas_Id 47561
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 51395867 and ends at 51500002 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
VPRBP 3p21.2 / POC1A 3p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCAF1   30911
Cards
Entrez_Gene (NCBI)DCAF1  9730  DDB1 and CUL4 associated factor 1
AliasesRIP; VPRBP
GeneCards (Weizmann)DCAF1
Ensembl hg19 (Hinxton)ENSG00000145041 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145041 [Gene_View]  chr3:51395867-51500002 [Contig_View]  DCAF1 [Vega]
ICGC DataPortalENSG00000145041
TCGA cBioPortalDCAF1
AceView (NCBI)DCAF1
Genatlas (Paris)DCAF1
WikiGenes9730
SOURCE (Princeton)DCAF1
Genetics Home Reference (NIH)DCAF1
Genomic and cartography
GoldenPath hg38 (UCSC)DCAF1  -     chr3:51395867-51500002 -  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCAF1  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblDCAF1 - 3p21.2 [CytoView hg19]  DCAF1 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIDCAF1 [Mapview hg19]  DCAF1 [Mapview hg38]
OMIM617259   
Gene and transcription
Genbank (Entrez)AB018343 AF061935 AF086402 AK023239 AL080145
RefSeq transcript (Entrez)NM_001171904 NM_001349168 NM_001349169 NM_001349170 NM_001349171 NM_014703
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCAF1
Cluster EST : UnigeneHs.716623 [ NCBI ]
CGAP (NCI)Hs.716623
Alternative Splicing GalleryENSG00000145041
Gene ExpressionDCAF1 [ NCBI-GEO ]   DCAF1 [ EBI - ARRAY_EXPRESS ]   DCAF1 [ SEEK ]   DCAF1 [ MEM ]
Gene Expression Viewer (FireBrowse)DCAF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9730
GTEX Portal (Tissue expression)DCAF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4B6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4B6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4B6
Splice isoforms : SwissVarQ9Y4B6
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9Y4B6
Domaine pattern : Prosite (Expaxy)LISH (PS50896)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    LisH    VPRBP/DCAF1    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)LisH (SM00667)  
Conserved Domain (NCBI)DCAF1
DMDM Disease mutations9730
Blocks (Seattle)DCAF1
PDB (SRS)3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
PDB (PDBSum)3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
PDB (IMB)3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
PDB (RSDB)3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
Structural Biology KnowledgeBase3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
SCOP (Structural Classification of Proteins)3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
CATH (Classification of proteins structures)3WA0    4CC9    4P7I    4PXW    4Z8L    5AJA    5JK7   
SuperfamilyQ9Y4B6
Human Protein AtlasENSG00000145041
Peptide AtlasQ9Y4B6
HPRD11674
IPIIPI00329528   IPI00794498   IPI00181396   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4B6
IntAct (EBI)Q9Y4B6
FunCoupENSG00000145041
BioGRIDDCAF1
STRING (EMBL)DCAF1
ZODIACDCAF1
Ontologies - Pathways
QuickGOQ9Y4B6
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  fibrillar center  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  COP9 signalosome  viral process  protein ubiquitination  B cell differentiation  estrogen receptor binding  V(D)J recombination  cell competition in a multicellular organism  histone kinase activity (H2A-T120 specific)  histone H2A-T120 phosphorylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  fibrillar center  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  COP9 signalosome  viral process  protein ubiquitination  B cell differentiation  estrogen receptor binding  V(D)J recombination  cell competition in a multicellular organism  histone kinase activity (H2A-T120 specific)  histone H2A-T120 phosphorylation  
NDEx NetworkDCAF1
Atlas of Cancer Signalling NetworkDCAF1
Wikipedia pathwaysDCAF1
Orthology - Evolution
OrthoDB9730
GeneTree (enSembl)ENSG00000145041
Phylogenetic Trees/Animal Genes : TreeFamDCAF1
HOVERGENQ9Y4B6
HOGENOMQ9Y4B6
Homologs : HomoloGeneDCAF1
Homology/Alignments : Family Browser (UCSC)DCAF1
Gene fusions - Rearrangements
Fusion : MitelmanRAD54L2/VPRBP [3p21.2/3p21.2]  [t(3;3)(p21;p21)]  
Fusion : MitelmanVPRBP/POC1A [3p21.2/3p21.2]  [t(3;3)(p21;p21)]  
Fusion: TCGAVPRBP 3p21.2 POC1A 3p21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCAF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCAF1
dbVarDCAF1
ClinVarDCAF1
1000_GenomesDCAF1 
Exome Variant ServerDCAF1
ExAC (Exome Aggregation Consortium)DCAF1 (select the gene name)
Genetic variants : HAPMAP9730
Genomic Variants (DGV)DCAF1 [DGVbeta]
DECIPHERDCAF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCAF1 
Mutations
ICGC Data PortalDCAF1 
TCGA Data PortalDCAF1 
Broad Tumor PortalDCAF1
OASIS PortalDCAF1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDCAF1
BioMutasearch DCAF1
DgiDB (Drug Gene Interaction Database)DCAF1
DoCM (Curated mutations)DCAF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCAF1 (select a term)
intoGenDCAF1
Cancer3DDCAF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617259   
Orphanet
MedgenDCAF1
Genetic Testing Registry DCAF1
NextProtQ9Y4B6 [Medical]
TSGene9730
GENETestsDCAF1
Target ValidationDCAF1
Huge Navigator DCAF1 [HugePedia]
snp3D : Map Gene to Disease9730
BioCentury BCIQDCAF1
ClinGenDCAF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9730
Chemical/Pharm GKB GenePA142670621
Clinical trialDCAF1
Miscellaneous
canSAR (ICR)DCAF1 (select the gene name)
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCAF1
EVEXDCAF1
GoPubMedDCAF1
iHOPDCAF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:30:39 CEST 2017

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