DCAF1 (DDB1 and CUL4 associated factor 1)

2016-06-01  

Identity

HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
RIP,VPRBP
FUSION GENES

Other Information

Locus ID:

NCBI: 9730
MIM: 617259
HGNC: 30911
Ensembl: ENSG00000145041

Variants:

dbSNP: 9730
ClinVar: 9730
TCGA: ENSG00000145041
COSMIC: DCAF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145041ENST00000335891Q9Y4B6
ENSG00000145041ENST00000423656Q9Y4B6
ENSG00000145041ENST00000504652Q9Y4B6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173145152007HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.141
201787412010Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.138
176093812007Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.125
176203342007The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.91
250262112014Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.88
230635252012EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.84
208707152010HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.59
243361982014Structural basis of lentiviral subversion of a cellular protein degradation pathway.47
186067812008Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.44
183328682008VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.38

Citation

Dessen P

DCAF1 (DDB1 and CUL4 associated factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-06-01

Online version: http://atlasgeneticsoncology.org/gene/47561/dcaf1