Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DCAF5 (DDB1 and CUL4 associated factor 5)

Identity

Alias_namesWDR22
WD repeat domain 22
Alias_symbol (synonym)BCRP2
D14S1461E
BCRG2
KIAA1824
Other alias
HGNC (Hugo) DCAF5
LocusID (NCBI) 8816
Atlas_Id 42805
Location 14q24.1  [Link to chromosome band 14q24]
Location_base_pair Starts at 69050920 and ends at 69153197 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCG2 (4q22.1) / DCAF5 (14q24.1)ARF1 (1q42.13) / DCAF5 (14q24.1)DCAF5 (14q24.1) / ABCG2 (4q22.1)
DCAF5 (14q24.1) / ARF1 (1q42.13)DCAF5 (14q24.1) / C14orf39 (14q23.1)DCAF5 (14q24.1) / DCAF5 (14q24.1)
DCAF5 (14q24.1) / FAM122B (Xq26.3)DCAF5 (14q24.1) / NOXRED1 (14q24.3)DCAF5 (14q24.1) / RAB5B (12q13.2)
DCAF5 (14q24.1) / RAD51B (14q24.1)PLEKHA6 (1q32.1) / DCAF5 (14q24.1)RAD51B (14q24.1) / DCAF5 (14q24.1)
TTYH2 (17q25.1) / DCAF5 (14q24.1)DCAF5 14q24.1 C14orf148DCAF5 14q24.1 / C14orf39 14q23.1
DCAF5 14q24.1 / RAB5B 12q13.2PLEKHA6 1q32.1 / DCAF5 14q24.1RAD51B 14q24.1 / DCAF5 14q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(1;14)(q32;q24) PLEKHA6/DCAF5
t(12;14)(q13;q24) DCAF5/RAB5B
t(14;14)(q23;q24) DCAF5/C14orf39
DCAF5/NOXRED1 (14q24)
RAD51B/DCAF5 (14q24)

External links

Nomenclature
HGNC (Hugo)DCAF5   20224
Cards
Entrez_Gene (NCBI)DCAF5  8816  DDB1 and CUL4 associated factor 5
AliasesBCRG2; BCRP2; D14S1461E; WDR22
GeneCards (Weizmann)DCAF5
Ensembl hg19 (Hinxton)ENSG00000139990 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139990 [Gene_View]  ENSG00000139990 [Sequence]  chr14:69050920-69153197 [Contig_View]  DCAF5 [Vega]
ICGC DataPortalENSG00000139990
TCGA cBioPortalDCAF5
AceView (NCBI)DCAF5
Genatlas (Paris)DCAF5
WikiGenes8816
SOURCE (Princeton)DCAF5
Genetics Home Reference (NIH)DCAF5
Genomic and cartography
GoldenPath hg38 (UCSC)DCAF5  -     chr14:69050920-69153197 -  14q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCAF5  -     14q24.1   [Description]    (hg19-Feb_2009)
GoldenPathDCAF5 - 14q24.1 [CytoView hg19]  DCAF5 - 14q24.1 [CytoView hg38]
ImmunoBaseENSG00000139990
Mapping of homologs : NCBIDCAF5 [Mapview hg19]  DCAF5 [Mapview hg38]
OMIM603812   
Gene and transcription
Genbank (Entrez)AB058727 AF044774 AK054692 AL831823 AL831932
RefSeq transcript (Entrez)NM_001284206 NM_001284207 NM_001284208 NM_003861
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCAF5
Cluster EST : UnigeneHs.509780 [ NCBI ]
CGAP (NCI)Hs.509780
Alternative Splicing GalleryENSG00000139990
Gene ExpressionDCAF5 [ NCBI-GEO ]   DCAF5 [ EBI - ARRAY_EXPRESS ]   DCAF5 [ SEEK ]   DCAF5 [ MEM ]
Gene Expression Viewer (FireBrowse)DCAF5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8816
GTEX Portal (Tissue expression)DCAF5
Human Protein AtlasENSG00000139990-DCAF5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JK2
Splice isoforms : SwissVarQ96JK2
PhosPhoSitePlusQ96JK2
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DCAF5
DMDM Disease mutations8816
Blocks (Seattle)DCAF5
PDB (RSDB)3I89   
PDB Europe3I89   
PDB (PDBSum)3I89   
PDB (IMB)3I89   
Structural Biology KnowledgeBase3I89   
SCOP (Structural Classification of Proteins)3I89   
CATH (Classification of proteins structures)3I89   
SuperfamilyQ96JK2
Human Protein Atlas [tissue]ENSG00000139990-DCAF5 [tissue]
Peptide AtlasQ96JK2
HPRD16032
IPIIPI00783277   IPI00382979   IPI00411906   IPI01025647   IPI01024870   IPI01025085   
Protein Interaction databases
DIP (DOE-UCLA)Q96JK2
IntAct (EBI)Q96JK2
FunCoupENSG00000139990
BioGRIDDCAF5
STRING (EMBL)DCAF5
ZODIACDCAF5
Ontologies - Pathways
QuickGOQ96JK2
Ontology : AmiGOprotein binding  nucleoplasm  protein ubiquitination  post-translational protein modification  Cul4-RING E3 ubiquitin ligase complex  
Ontology : EGO-EBIprotein binding  nucleoplasm  protein ubiquitination  post-translational protein modification  Cul4-RING E3 ubiquitin ligase complex  
NDEx NetworkDCAF5
Atlas of Cancer Signalling NetworkDCAF5
Wikipedia pathwaysDCAF5
Orthology - Evolution
OrthoDB8816
GeneTree (enSembl)ENSG00000139990
Phylogenetic Trees/Animal Genes : TreeFamDCAF5
HOGENOMQ96JK2
Homologs : HomoloGeneDCAF5
Homology/Alignments : Family Browser (UCSC)DCAF5
Gene fusions - Rearrangements
Fusion : MitelmanDCAF5/C14orf39 [14q24.1/14q23.1]  
Fusion : MitelmanDCAF5/NOXRED1 [14q24.1/14q24.3]  [t(14;14)(q24;q24)]  
Fusion : MitelmanDCAF5/RAB5B [14q24.1/12q13.2]  [t(12;14)(q13;q24)]  
Fusion : MitelmanPLEKHA6/DCAF5 [1q32.1/14q24.1]  [t(1;14)(q32;q24)]  
Fusion : MitelmanRAD51B/DCAF5 [14q24.1/14q24.1]  [t(14;14)(q24;q24)]  
Fusion PortalDCAF5 14q24.1 C14orf148 OV
Fusion PortalDCAF5 14q24.1 C14orf39 14q23.1 LUAD
Fusion PortalDCAF5 14q24.1 RAB5B 12q13.2 BRCA
Fusion PortalPLEKHA6 1q32.1 DCAF5 14q24.1 LGG
Fusion PortalRAD51B 14q24.1 DCAF5 14q24.1 BRCA
Fusion : QuiverDCAF5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCAF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCAF5
dbVarDCAF5
ClinVarDCAF5
1000_GenomesDCAF5 
Exome Variant ServerDCAF5
ExAC (Exome Aggregation Consortium)ENSG00000139990
GNOMAD BrowserENSG00000139990
Varsome BrowserDCAF5
Genetic variants : HAPMAP8816
Genomic Variants (DGV)DCAF5 [DGVbeta]
DECIPHERDCAF5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCAF5 
Mutations
ICGC Data PortalDCAF5 
TCGA Data PortalDCAF5 
Broad Tumor PortalDCAF5
OASIS PortalDCAF5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCAF5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCAF5
Mutations and Diseases : HGMDDCAF5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCAF5
DgiDB (Drug Gene Interaction Database)DCAF5
DoCM (Curated mutations)DCAF5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCAF5 (select a term)
intoGenDCAF5
Cancer3DDCAF5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603812   
Orphanet
DisGeNETDCAF5
MedgenDCAF5
Genetic Testing Registry DCAF5
NextProtQ96JK2 [Medical]
TSGene8816
GENETestsDCAF5
Target ValidationDCAF5
Huge Navigator DCAF5 [HugePedia]
snp3D : Map Gene to Disease8816
BioCentury BCIQDCAF5
ClinGenDCAF5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8816
Chemical/Pharm GKB GenePA165478844
Clinical trialDCAF5
Miscellaneous
canSAR (ICR)DCAF5 (select the gene name)
DataMed IndexDCAF5
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCAF5
EVEXDCAF5
GoPubMedDCAF5
iHOPDCAF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:39:49 CET 2019
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