Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DCAF6 (DDB1 and CUL4 associated factor 6)

Identity

Alias_namesIQWD1
IQ motif and WD repeats 1
Alias_symbol (synonym)PC326
Other alias1200006M05Rik
ARCAP
MSTP055
NRIP
HGNC (Hugo) DCAF6
LocusID (NCBI) 55827
Atlas_Id 51028
Location 1q24.2  [Link to chromosome band 1q24]
Location_base_pair Starts at 167936559 and ends at 168075843 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACSL4 (Xq23) / DCAF6 (1q24.2)DCAF6 (1q24.2) / MPZL1 (1q24.2)FAF1 (1p32.3) / DCAF6 (1q24.2)
SLC19A2 (1q24.2) / DCAF6 (1q24.2)DCAF6 1q24.2 / MPZL1 1q24.2FAF1 1p32.3 / DCAF6 1q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Adenocarcinoma
t(1;1)(p32;q24) FAF1/DCAF6
t(1;1)(q24;q24) DCAF6/MPZL1
t(1;1)(q24;q24) DCAF6/MPZL1
t(X;1)(q23;q24) ACSL4/DCAF6

External links

Nomenclature
HGNC (Hugo)DCAF6   30002
Cards
Entrez_Gene (NCBI)DCAF6  55827  DDB1 and CUL4 associated factor 6
Aliases1200006M05Rik; ARCAP; IQWD1; MSTP055; 
NRIP; PC326
GeneCards (Weizmann)DCAF6
Ensembl hg19 (Hinxton)ENSG00000143164 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143164 [Gene_View]  ENSG00000143164 [Sequence]  chr1:167936559-168075843 [Contig_View]  DCAF6 [Vega]
ICGC DataPortalENSG00000143164
TCGA cBioPortalDCAF6
AceView (NCBI)DCAF6
Genatlas (Paris)DCAF6
WikiGenes55827
SOURCE (Princeton)DCAF6
Genetics Home Reference (NIH)DCAF6
Genomic and cartography
GoldenPath hg38 (UCSC)DCAF6  -     chr1:167936559-168075843 +  1q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCAF6  -     1q24.2   [Description]    (hg19-Feb_2009)
EnsemblDCAF6 - 1q24.2 [CytoView hg19]  DCAF6 - 1q24.2 [CytoView hg38]
Mapping of homologs : NCBIDCAF6 [Mapview hg19]  DCAF6 [Mapview hg38]
OMIM610494   
Gene and transcription
Genbank (Entrez)AF116725 AF124434 AF150734 AK000984 AK093970
RefSeq transcript (Entrez)NM_001017977 NM_001198956 NM_001198957 NM_001349773 NM_001349774 NM_001349775 NM_001349776 NM_001349777 NM_001349778 NM_001349779 NM_001349780 NM_018442
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCAF6
Cluster EST : UnigeneHs.435741 [ NCBI ]
CGAP (NCI)Hs.435741
Alternative Splicing GalleryENSG00000143164
Gene ExpressionDCAF6 [ NCBI-GEO ]   DCAF6 [ EBI - ARRAY_EXPRESS ]   DCAF6 [ SEEK ]   DCAF6 [ MEM ]
Gene Expression Viewer (FireBrowse)DCAF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55827
GTEX Portal (Tissue expression)DCAF6
Human Protein AtlasENSG00000143164-DCAF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ58WW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ58WW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ58WW2
Splice isoforms : SwissVarQ58WW2
PhosPhoSitePlusQ58WW2
Domaine pattern : Prosite (Expaxy)IQ (PS50096)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)IQ_motif_EF-hand-BS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DCAF6
DMDM Disease mutations55827
Blocks (Seattle)DCAF6
PDB (SRS)3I7O   
PDB (PDBSum)3I7O   
PDB (IMB)3I7O   
PDB (RSDB)3I7O   
Structural Biology KnowledgeBase3I7O   
SCOP (Structural Classification of Proteins)3I7O   
CATH (Classification of proteins structures)3I7O   
SuperfamilyQ58WW2
Human Protein Atlas [tissue]ENSG00000143164-DCAF6 [tissue]
Peptide AtlasQ58WW2
HPRD17156
IPIIPI00290516   IPI00157836   IPI00164246   IPI00910205   IPI00985476   
Protein Interaction databases
DIP (DOE-UCLA)Q58WW2
IntAct (EBI)Q58WW2
FunCoupENSG00000143164
BioGRIDDCAF6
STRING (EMBL)DCAF6
ZODIACDCAF6
Ontologies - Pathways
QuickGOQ58WW2
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytosol  focal adhesion  protein ubiquitination  ligand-dependent nuclear receptor transcription coactivator activity  post-translational protein modification  positive regulation of transcription by RNA polymerase II  Cul4-RING E3 ubiquitin ligase complex  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytosol  focal adhesion  protein ubiquitination  ligand-dependent nuclear receptor transcription coactivator activity  post-translational protein modification  positive regulation of transcription by RNA polymerase II  Cul4-RING E3 ubiquitin ligase complex  
NDEx NetworkDCAF6
Atlas of Cancer Signalling NetworkDCAF6
Wikipedia pathwaysDCAF6
Orthology - Evolution
OrthoDB55827
GeneTree (enSembl)ENSG00000143164
Phylogenetic Trees/Animal Genes : TreeFamDCAF6
HOVERGENQ58WW2
HOGENOMQ58WW2
Homologs : HomoloGeneDCAF6
Homology/Alignments : Family Browser (UCSC)DCAF6
Gene fusions - Rearrangements
Fusion : MitelmanACSL4/DCAF6 [Xq23/1q24.2]  [t(X;1)(q23;q24)]  
Fusion : MitelmanDCAF6/MPZL1 [1q24.2/1q24.2]  [t(1;1)(q24;q24)]  
Fusion : MitelmanFAF1/DCAF6 [1p32.3/1q24.2]  [t(1;1)(p32;q24)]  
Fusion PortalDCAF6 1q24.2 MPZL1 1q24.2 BRCA
Fusion PortalFAF1 1p32.3 DCAF6 1q24.2 LUAD
Fusion : QuiverDCAF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCAF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCAF6
dbVarDCAF6
ClinVarDCAF6
1000_GenomesDCAF6 
Exome Variant ServerDCAF6
ExAC (Exome Aggregation Consortium)ENSG00000143164
GNOMAD BrowserENSG00000143164
Genetic variants : HAPMAP55827
Genomic Variants (DGV)DCAF6 [DGVbeta]
DECIPHERDCAF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCAF6 
Mutations
ICGC Data PortalDCAF6 
TCGA Data PortalDCAF6 
Broad Tumor PortalDCAF6
OASIS PortalDCAF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCAF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCAF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCAF6
DgiDB (Drug Gene Interaction Database)DCAF6
DoCM (Curated mutations)DCAF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCAF6 (select a term)
intoGenDCAF6
Cancer3DDCAF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610494   
Orphanet
DisGeNETDCAF6
MedgenDCAF6
Genetic Testing Registry DCAF6
NextProtQ58WW2 [Medical]
TSGene55827
GENETestsDCAF6
Target ValidationDCAF6
Huge Navigator DCAF6 [HugePedia]
snp3D : Map Gene to Disease55827
BioCentury BCIQDCAF6
ClinGenDCAF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55827
Chemical/Pharm GKB GenePA165751150
Clinical trialDCAF6
Miscellaneous
canSAR (ICR)DCAF6 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCAF6
EVEXDCAF6
GoPubMedDCAF6
iHOPDCAF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:22:01 CEST 2018
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