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DCAF8 (DDB1 and CUL4 associated factor 8)

Identity

Alias_namesWDR42A
WD repeat domain 42A
Alias_symbol (synonym)H326
FLJ35857
Other aliasGAN2
HGNC (Hugo) DCAF8
LocusID (NCBI) 50717
Atlas_Id 54249
Location 1q23.2  [Link to chromosome band 1q23]
Location_base_pair Starts at 160215715 and ends at 160262560 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APOOL (Xq21.1) / DCAF8 (1q23.2)CHEK1 (11q24.2) / DCAF8 (1q23.2)CMBL (5p15.2) / DCAF8 (1q23.2)
DCAF8 (1q23.2) / DCAF8 (1q23.2)DCAF8 (1q23.2) / EIF2D (1q32.1)DCAF8 (1q23.2) / NME7 (1q24.2)
DCAF8 (1q23.2) / PWP1 (12q23.3)MGAT1 (5q35.3) / DCAF8 (1q23.2)RPS19 (19q13.2) / DCAF8 (1q23.2)
TAF15 (17q12) / DCAF8 (1q23.2)DCAF8 1q23.2 / NME7 1q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCAF8   24891
Cards
Entrez_Gene (NCBI)DCAF8  50717  DDB1 and CUL4 associated factor 8
AliasesGAN2; H326; WDR42A
GeneCards (Weizmann)DCAF8
Ensembl hg19 (Hinxton)ENSG00000132716 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132716 [Gene_View]  chr1:160215715-160262560 [Contig_View]  DCAF8 [Vega]
ICGC DataPortalENSG00000132716
TCGA cBioPortalDCAF8
AceView (NCBI)DCAF8
Genatlas (Paris)DCAF8
WikiGenes50717
SOURCE (Princeton)DCAF8
Genetics Home Reference (NIH)DCAF8
Genomic and cartography
GoldenPath hg38 (UCSC)DCAF8  -     chr1:160215715-160262560 -  1q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCAF8  -     1q23.2   [Description]    (hg19-Feb_2009)
EnsemblDCAF8 - 1q23.2 [CytoView hg19]  DCAF8 - 1q23.2 [CytoView hg38]
Mapping of homologs : NCBIDCAF8 [Mapview hg19]  DCAF8 [Mapview hg38]
OMIM610100   615820   
Gene and transcription
Genbank (Entrez)AI352273 AK022091 AK026213 AK026481 AK093176
RefSeq transcript (Entrez)NM_015726
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCAF8
Cluster EST : UnigeneHs.632447 [ NCBI ]
CGAP (NCI)Hs.632447
Alternative Splicing GalleryENSG00000132716
Gene ExpressionDCAF8 [ NCBI-GEO ]   DCAF8 [ EBI - ARRAY_EXPRESS ]   DCAF8 [ SEEK ]   DCAF8 [ MEM ]
Gene Expression Viewer (FireBrowse)DCAF8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50717
GTEX Portal (Tissue expression)DCAF8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TAQ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TAQ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TAQ9
Splice isoforms : SwissVarQ5TAQ9
PhosPhoSitePlusQ5TAQ9
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)DCAF8
DMDM Disease mutations50717
Blocks (Seattle)DCAF8
PDB (SRS)3I8E   
PDB (PDBSum)3I8E   
PDB (IMB)3I8E   
PDB (RSDB)3I8E   
Structural Biology KnowledgeBase3I8E   
SCOP (Structural Classification of Proteins)3I8E   
CATH (Classification of proteins structures)3I8E   
SuperfamilyQ5TAQ9
Human Protein AtlasENSG00000132716
Peptide AtlasQ5TAQ9
HPRD18300
IPIIPI00290071   IPI00854775   IPI00646221   IPI01025455   IPI00929484   IPI00641656   IPI00640954   IPI00646776   
Protein Interaction databases
DIP (DOE-UCLA)Q5TAQ9
IntAct (EBI)Q5TAQ9
FunCoupENSG00000132716
BioGRIDDCAF8
STRING (EMBL)DCAF8
ZODIACDCAF8
Ontologies - Pathways
QuickGOQ5TAQ9
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  protein ubiquitination  protein ubiquitination  Cul4-RING E3 ubiquitin ligase complex  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  protein ubiquitination  protein ubiquitination  Cul4-RING E3 ubiquitin ligase complex  
NDEx NetworkDCAF8
Atlas of Cancer Signalling NetworkDCAF8
Wikipedia pathwaysDCAF8
Orthology - Evolution
OrthoDB50717
GeneTree (enSembl)ENSG00000132716
Phylogenetic Trees/Animal Genes : TreeFamDCAF8
HOVERGENQ5TAQ9
HOGENOMQ5TAQ9
Homologs : HomoloGeneDCAF8
Homology/Alignments : Family Browser (UCSC)DCAF8
Gene fusions - Rearrangements
Fusion : MitelmanAPOOL/DCAF8 [Xq21.1/1q23.2]  [t(X;1)(q21;q23)]  
Fusion : MitelmanDCAF8/NME7 [1q23.2/1q24.2]  [t(1;1)(q23;q24)]  
Fusion: TCGADCAF8 1q23.2 NME7 1q24.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCAF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCAF8
dbVarDCAF8
ClinVarDCAF8
1000_GenomesDCAF8 
Exome Variant ServerDCAF8
ExAC (Exome Aggregation Consortium)DCAF8 (select the gene name)
Genetic variants : HAPMAP50717
Genomic Variants (DGV)DCAF8 [DGVbeta]
DECIPHERDCAF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCAF8 
Mutations
ICGC Data PortalDCAF8 
TCGA Data PortalDCAF8 
Broad Tumor PortalDCAF8
OASIS PortalDCAF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCAF8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCAF8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCAF8
DgiDB (Drug Gene Interaction Database)DCAF8
DoCM (Curated mutations)DCAF8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCAF8 (select a term)
intoGenDCAF8
Cancer3DDCAF8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610100    615820   
Orphanet22860   
MedgenDCAF8
Genetic Testing Registry DCAF8
NextProtQ5TAQ9 [Medical]
TSGene50717
GENETestsDCAF8
Huge Navigator DCAF8 [HugePedia]
snp3D : Map Gene to Disease50717
BioCentury BCIQDCAF8
ClinGenDCAF8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50717
Chemical/Pharm GKB GenePA165751195
Clinical trialDCAF8
Miscellaneous
canSAR (ICR)DCAF8 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCAF8
EVEXDCAF8
GoPubMedDCAF8
iHOPDCAF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:12:47 CEST 2017

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