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DCDC2 (doublecortin domain containing 2)

Identity

Alias_symbol (synonym)RU2
KIAA1154
DCDC2A
NPHP19
Other aliasDFNB66
NSC
RU2S
HGNC (Hugo) DCDC2
LocusID (NCBI) 51473
Atlas_Id 40269
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 24171755 and ends at 24383292 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PC (11q13.2) / DCDC2 (6p22.3)PCMTD1 (8q11.23) / DCDC2 (6p22.3)PC 11q13.2 / DCDC2 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCDC2   18141
Cards
Entrez_Gene (NCBI)DCDC2  51473  doublecortin domain containing 2
AliasesDCDC2A; DFNB66; NPHP19; NSC; 
RU2; RU2S
GeneCards (Weizmann)DCDC2
Ensembl hg19 (Hinxton)ENSG00000146038 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146038 [Gene_View]  chr6:24171755-24383292 [Contig_View]  DCDC2 [Vega]
ICGC DataPortalENSG00000146038
TCGA cBioPortalDCDC2
AceView (NCBI)DCDC2
Genatlas (Paris)DCDC2
WikiGenes51473
SOURCE (Princeton)DCDC2
Genetics Home Reference (NIH)DCDC2
Genomic and cartography
GoldenPath hg38 (UCSC)DCDC2  -     chr6:24171755-24383292 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCDC2  -     6p22.3   [Description]    (hg19-Feb_2009)
EnsemblDCDC2 - 6p22.3 [CytoView hg19]  DCDC2 - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIDCDC2 [Mapview hg19]  DCDC2 [Mapview hg38]
OMIM605755   610212   616217   617394   
Gene and transcription
Genbank (Entrez)AB032980 AF181721 AI858903 AK027036 AL133043
RefSeq transcript (Entrez)NM_001195610 NM_016356
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCDC2
Cluster EST : UnigeneHs.61345 [ NCBI ]
CGAP (NCI)Hs.61345
Alternative Splicing GalleryENSG00000146038
Gene ExpressionDCDC2 [ NCBI-GEO ]   DCDC2 [ EBI - ARRAY_EXPRESS ]   DCDC2 [ SEEK ]   DCDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)DCDC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51473
GTEX Portal (Tissue expression)DCDC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHG0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHG0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHG0
Splice isoforms : SwissVarQ9UHG0
PhosPhoSitePlusQ9UHG0
Domaine pattern : Prosite (Expaxy)DC (PS50309)   
Domains : Interpro (EBI)DCDC2    Doublecortin_dom   
Domain families : Pfam (Sanger)DCX (PF03607)   
Domain families : Pfam (NCBI)pfam03607   
Domain families : Smart (EMBL)DCX (SM00537)  
Conserved Domain (NCBI)DCDC2
DMDM Disease mutations51473
Blocks (Seattle)DCDC2
PDB (SRS)2DNF   
PDB (PDBSum)2DNF   
PDB (IMB)2DNF   
PDB (RSDB)2DNF   
Structural Biology KnowledgeBase2DNF   
SCOP (Structural Classification of Proteins)2DNF   
CATH (Classification of proteins structures)2DNF   
SuperfamilyQ9UHG0
Human Protein AtlasENSG00000146038
Peptide AtlasQ9UHG0
HPRD09308
IPIIPI00008917   IPI00383816   IPI00641566   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHG0
IntAct (EBI)Q9UHG0
FunCoupENSG00000146038
BioGRIDDCDC2
STRING (EMBL)DCDC2
ZODIACDCDC2
Ontologies - Pathways
QuickGOQ9UHG0
Ontology : AmiGOneuron migration  neuron migration  protein binding  nucleus  cytoplasm  cytosol  cilium  axoneme  cellular defense response  sensory perception of sound  regulation of Wnt signaling pathway  intracellular signal transduction  positive regulation of smoothened signaling pathway  kinocilium  cilium assembly  regulation of cilium assembly  
Ontology : EGO-EBIneuron migration  neuron migration  protein binding  nucleus  cytoplasm  cytosol  cilium  axoneme  cellular defense response  sensory perception of sound  regulation of Wnt signaling pathway  intracellular signal transduction  positive regulation of smoothened signaling pathway  kinocilium  cilium assembly  regulation of cilium assembly  
NDEx NetworkDCDC2
Atlas of Cancer Signalling NetworkDCDC2
Wikipedia pathwaysDCDC2
Orthology - Evolution
OrthoDB51473
GeneTree (enSembl)ENSG00000146038
Phylogenetic Trees/Animal Genes : TreeFamDCDC2
HOVERGENQ9UHG0
HOGENOMQ9UHG0
Homologs : HomoloGeneDCDC2
Homology/Alignments : Family Browser (UCSC)DCDC2
Gene fusions - Rearrangements
Fusion : MitelmanPC/DCDC2 [11q13.2/6p22.3]  [t(6;11)(p22;q13)]  
Fusion: TCGAPC 11q13.2 DCDC2 6p22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCDC2
dbVarDCDC2
ClinVarDCDC2
1000_GenomesDCDC2 
Exome Variant ServerDCDC2
ExAC (Exome Aggregation Consortium)DCDC2 (select the gene name)
Genetic variants : HAPMAP51473
Genomic Variants (DGV)DCDC2 [DGVbeta]
DECIPHERDCDC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCDC2 
Mutations
ICGC Data PortalDCDC2 
TCGA Data PortalDCDC2 
Broad Tumor PortalDCDC2
OASIS PortalDCDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCDC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCDC2
DgiDB (Drug Gene Interaction Database)DCDC2
DoCM (Curated mutations)DCDC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCDC2 (select a term)
intoGenDCDC2
Cancer3DDCDC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605755    610212    616217    617394   
Orphanet12047    11612   
MedgenDCDC2
Genetic Testing Registry DCDC2
NextProtQ9UHG0 [Medical]
TSGene51473
GENETestsDCDC2
Target ValidationDCDC2
Huge Navigator DCDC2 [HugePedia]
snp3D : Map Gene to Disease51473
BioCentury BCIQDCDC2
ClinGenDCDC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51473
Chemical/Pharm GKB GenePA134978716
Clinical trialDCDC2
Miscellaneous
canSAR (ICR)DCDC2 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCDC2
EVEXDCDC2
GoPubMedDCDC2
iHOPDCDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:04:50 CEST 2017

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