Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1633
MIM: 125450
HGNC: 2704
Ensembl: ENSG00000156136
Variants:
dbSNP: 1633
ClinVar: 1633
TCGA: ENSG00000156136
COSMIC: DCK
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444760 | Leukemia, Myeloid, Acute | Disease | ClinicalAnnotation | associated | PK | PD | 15564883 |
| PA445218 | Pancreatic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 20665488 | |
| PA449177 | cytarabine | Chemical | ClinicalAnnotation | associated | PK | PD | 15564883 |
| PA449212 | daunorubicin | Chemical | MultilinkAnnotation | associated | 25119182 | ||
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway | associated | PK | PD | 12477049, 20665488, 22705007, 23230131, 25162786 |
| PA449961 | idarubicin | Chemical | ClinicalAnnotation | associated | PK | PD | 15564883 |
| PA450163 | lamivudine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38346958 | 2024 | Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer. | 1 |
| 38346958 | 2024 | Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer. | 1 |
| 34825941 | 2022 | Drug resistance to nelarabine in leukemia cell lines might be caused by reduced expression of deoxycytidine kinase through epigenetic mechanisms. | 1 |
| 34825941 | 2022 | Drug resistance to nelarabine in leukemia cell lines might be caused by reduced expression of deoxycytidine kinase through epigenetic mechanisms. | 1 |
| 33626530 | 2021 | Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine. | 4 |
| 34571370 | 2021 | Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase. | 3 |
| 33626530 | 2021 | Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine. | 4 |
| 34571370 | 2021 | Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase. | 3 |
| 32588770 | 2020 | DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer. | 2 |
| 32671914 | 2020 | Human equilibrative nucleoside transporter-1 and deoxycytidine kinase can predict gemcitabine effectiveness in Egyptian patients with Hepatocellular carcinoma. | 3 |
| 32588770 | 2020 | DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer. | 2 |
| 32671914 | 2020 | Human equilibrative nucleoside transporter-1 and deoxycytidine kinase can predict gemcitabine effectiveness in Egyptian patients with Hepatocellular carcinoma. | 3 |
| 28820179 | 2017 | Effects of DCK knockdown on proliferation, apoptosis and tumorigenicity in vivo of cervical cancer HeLa cells. | 5 |
| 28820179 | 2017 | Effects of DCK knockdown on proliferation, apoptosis and tumorigenicity in vivo of cervical cancer HeLa cells. | 5 |
| 26362587 | 2016 | Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer. | 7 |
Citation
Dessen P
DCK (deoxycytidine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40270/dck
