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DCLK2 (doublecortin like kinase 2)

Identity

Alias_namesDCAMKL2
doublecortin and CaM kinase-like 2
doublecortin-like kinase 2
Alias_symbol (synonym)MGC45428
DCDC3
DCDC3B
DCK2
Other aliasCL2
CLICK-II
CLICK2
CLIK2
HGNC (Hugo) DCLK2
LocusID (NCBI) 166614
Atlas_Id 43224
Location 4q31.23  [Link to chromosome band 4q31]
Location_base_pair Starts at 150078274 and ends at 150257456 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MACROD2 (20p12.1) / DCLK2 (4q31.23)MACROD2 20p12.1 / DCLK2 4q31.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCLK2   19002
Cards
Entrez_Gene (NCBI)DCLK2  166614  doublecortin like kinase 2
AliasesCL2; CLICK-II; CLICK2; CLIK2; 
DCAMKL2; DCDC3; DCDC3B; DCK2
GeneCards (Weizmann)DCLK2
Ensembl hg19 (Hinxton)ENSG00000170390 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170390 [Gene_View]  chr4:150078274-150257456 [Contig_View]  DCLK2 [Vega]
ICGC DataPortalENSG00000170390
TCGA cBioPortalDCLK2
AceView (NCBI)DCLK2
Genatlas (Paris)DCLK2
WikiGenes166614
SOURCE (Princeton)DCLK2
Genetics Home Reference (NIH)DCLK2
Genomic and cartography
GoldenPath hg38 (UCSC)DCLK2  -     chr4:150078274-150257456 +  4q31.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCLK2  -     4q31.23   [Description]    (hg19-Feb_2009)
EnsemblDCLK2 - 4q31.23 [CytoView hg19]  DCLK2 - 4q31.23 [CytoView hg38]
Mapping of homologs : NCBIDCLK2 [Mapview hg19]  DCLK2 [Mapview hg38]
OMIM613166   
Gene and transcription
Genbank (Entrez)AB209181 AI419589 AL834498 BC019831 BC032726
RefSeq transcript (Entrez)NM_001040260 NM_001040261 NM_152619
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCLK2
Cluster EST : UnigeneHs.591683 [ NCBI ]
CGAP (NCI)Hs.591683
Alternative Splicing GalleryENSG00000170390
Gene ExpressionDCLK2 [ NCBI-GEO ]   DCLK2 [ EBI - ARRAY_EXPRESS ]   DCLK2 [ SEEK ]   DCLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)DCLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)166614
GTEX Portal (Tissue expression)DCLK2
Human Protein AtlasENSG00000170390-DCLK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N568   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N568  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N568
Splice isoforms : SwissVarQ8N568
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8N568
Domaine pattern : Prosite (Expaxy)DC (PS50309)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Doublecortin_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DCX (PF03607)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam03607    pfam00069   
Domain families : Smart (EMBL)DCX (SM00537)  S_TKc (SM00220)  
Conserved Domain (NCBI)DCLK2
DMDM Disease mutations166614
Blocks (Seattle)DCLK2
SuperfamilyQ8N568
Human Protein Atlas [tissue]ENSG00000170390-DCLK2 [tissue]
Peptide AtlasQ8N568
HPRD13122
IPIIPI00552471   IPI00552604   IPI00296360   IPI00942030   IPI00884053   
Protein Interaction databases
DIP (DOE-UCLA)Q8N568
IntAct (EBI)Q8N568
FunCoupENSG00000170390
BioGRIDDCLK2
STRING (EMBL)DCLK2
ZODIACDCLK2
Ontologies - Pathways
QuickGOQ8N568
Ontology : AmiGOmicrotubule cytoskeleton organization  protein serine/threonine kinase activity  ATP binding  cytoplasm  microtubule  microtubule cytoskeleton  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  hippocampus development  pyramidal neuron development  neuron differentiation  intracellular signal transduction  negative regulation of protein localization to nucleus  
Ontology : EGO-EBImicrotubule cytoskeleton organization  protein serine/threonine kinase activity  ATP binding  cytoplasm  microtubule  microtubule cytoskeleton  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  hippocampus development  pyramidal neuron development  neuron differentiation  intracellular signal transduction  negative regulation of protein localization to nucleus  
NDEx NetworkDCLK2
Atlas of Cancer Signalling NetworkDCLK2
Wikipedia pathwaysDCLK2
Orthology - Evolution
OrthoDB166614
GeneTree (enSembl)ENSG00000170390
Phylogenetic Trees/Animal Genes : TreeFamDCLK2
HOVERGENQ8N568
HOGENOMQ8N568
Homologs : HomoloGeneDCLK2
Homology/Alignments : Family Browser (UCSC)DCLK2
Gene fusions - Rearrangements
Fusion : MitelmanMACROD2/DCLK2 [20p12.1/4q31.23]  [t(4;20)(q31;p12)]  
Fusion: TCGA_MDACCMACROD2 20p12.1 DCLK2 4q31.23 BRCA
Tumor Fusion PortalDCLK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCLK2
dbVarDCLK2
ClinVarDCLK2
1000_GenomesDCLK2 
Exome Variant ServerDCLK2
ExAC (Exome Aggregation Consortium)ENSG00000170390
GNOMAD BrowserENSG00000170390
Genetic variants : HAPMAP166614
Genomic Variants (DGV)DCLK2 [DGVbeta]
DECIPHERDCLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCLK2 
Mutations
ICGC Data PortalDCLK2 
TCGA Data PortalDCLK2 
Broad Tumor PortalDCLK2
OASIS PortalDCLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCLK2
DgiDB (Drug Gene Interaction Database)DCLK2
DoCM (Curated mutations)DCLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCLK2 (select a term)
intoGenDCLK2
Cancer3DDCLK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613166   
Orphanet
DisGeNETDCLK2
MedgenDCLK2
Genetic Testing Registry DCLK2
NextProtQ8N568 [Medical]
TSGene166614
GENETestsDCLK2
Target ValidationDCLK2
Huge Navigator DCLK2 [HugePedia]
snp3D : Map Gene to Disease166614
BioCentury BCIQDCLK2
ClinGenDCLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD166614
Chemical/Pharm GKB GenePA162383366
Clinical trialDCLK2
Miscellaneous
canSAR (ICR)DCLK2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCLK2
EVEXDCLK2
GoPubMedDCLK2
iHOPDCLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:05 CET 2017

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