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DCLK3 (doublecortin like kinase 3)

Identity

Alias_namesDCAMKL3
doublecortin and CaM kinase-like 3
doublecortin-like kinase 3
Alias_symbol (synonym)KIAA1765
DCDC3C
Other aliasCLR
DCK3
HGNC (Hugo) DCLK3
LocusID (NCBI) 85443
Atlas_Id 43225
Location 3p22.2  [Link to chromosome band 3p22]
Location_base_pair Starts at 36712422 and ends at 36739861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCLK3   19005
Cards
Entrez_Gene (NCBI)DCLK3  85443  doublecortin like kinase 3
AliasesCLR; DCAMKL3; DCDC3C; DCK3
GeneCards (Weizmann)DCLK3
Ensembl hg19 (Hinxton)ENSG00000163673 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163673 [Gene_View]  chr3:36712422-36739861 [Contig_View]  DCLK3 [Vega]
ICGC DataPortalENSG00000163673
TCGA cBioPortalDCLK3
AceView (NCBI)DCLK3
Genatlas (Paris)DCLK3
WikiGenes85443
SOURCE (Princeton)DCLK3
Genetics Home Reference (NIH)DCLK3
Genomic and cartography
GoldenPath hg38 (UCSC)DCLK3  -     chr3:36712422-36739861 -  3p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCLK3  -     3p22.2   [Description]    (hg19-Feb_2009)
EnsemblDCLK3 - 3p22.2 [CytoView hg19]  DCLK3 - 3p22.2 [CytoView hg38]
Mapping of homologs : NCBIDCLK3 [Mapview hg19]  DCLK3 [Mapview hg38]
OMIM613167   
Gene and transcription
Genbank (Entrez)AB051552 AK122988 DB075681 DR000236
RefSeq transcript (Entrez)NM_033403
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCLK3
Cluster EST : UnigeneHs.631907 [ NCBI ]
CGAP (NCI)Hs.631907
Alternative Splicing GalleryENSG00000163673
Gene ExpressionDCLK3 [ NCBI-GEO ]   DCLK3 [ EBI - ARRAY_EXPRESS ]   DCLK3 [ SEEK ]   DCLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)DCLK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85443
GTEX Portal (Tissue expression)DCLK3
Human Protein AtlasENSG00000163673-DCLK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C098   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C098  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C098
Splice isoforms : SwissVarQ9C098
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9C098
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Ca/CaM-dep_Ca-dep_prot_Kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)DCLK3
DMDM Disease mutations85443
Blocks (Seattle)DCLK3
SuperfamilyQ9C098
Human Protein Atlas [tissue]ENSG00000163673-DCLK3 [tissue]
Peptide AtlasQ9C098
IPIIPI00852660   
Protein Interaction databases
DIP (DOE-UCLA)Q9C098
IntAct (EBI)Q9C098
FunCoupENSG00000163673
BioGRIDDCLK3
STRING (EMBL)DCLK3
ZODIACDCLK3
Ontologies - Pathways
QuickGOQ9C098
Ontology : AmiGOprotein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  negative regulation of protein localization to nucleus  
Ontology : EGO-EBIprotein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  intracellular signal transduction  negative regulation of protein localization to nucleus  
NDEx NetworkDCLK3
Atlas of Cancer Signalling NetworkDCLK3
Wikipedia pathwaysDCLK3
Orthology - Evolution
OrthoDB85443
GeneTree (enSembl)ENSG00000163673
Phylogenetic Trees/Animal Genes : TreeFamDCLK3
HOVERGENQ9C098
HOGENOMQ9C098
Homologs : HomoloGeneDCLK3
Homology/Alignments : Family Browser (UCSC)DCLK3
Gene fusions - Rearrangements
Tumor Fusion PortalDCLK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCLK3
dbVarDCLK3
ClinVarDCLK3
1000_GenomesDCLK3 
Exome Variant ServerDCLK3
ExAC (Exome Aggregation Consortium)ENSG00000163673
GNOMAD BrowserENSG00000163673
Genetic variants : HAPMAP85443
Genomic Variants (DGV)DCLK3 [DGVbeta]
DECIPHERDCLK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCLK3 
Mutations
ICGC Data PortalDCLK3 
TCGA Data PortalDCLK3 
Broad Tumor PortalDCLK3
OASIS PortalDCLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCLK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCLK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCLK3
DgiDB (Drug Gene Interaction Database)DCLK3
DoCM (Curated mutations)DCLK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCLK3 (select a term)
intoGenDCLK3
Cancer3DDCLK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613167   
Orphanet
DisGeNETDCLK3
MedgenDCLK3
Genetic Testing Registry DCLK3
NextProtQ9C098 [Medical]
TSGene85443
GENETestsDCLK3
Target ValidationDCLK3
Huge Navigator DCLK3 [HugePedia]
snp3D : Map Gene to Disease85443
BioCentury BCIQDCLK3
ClinGenDCLK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85443
Chemical/Pharm GKB GenePA162383403
Clinical trialDCLK3
Miscellaneous
canSAR (ICR)DCLK3 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCLK3
EVEXDCLK3
GoPubMedDCLK3
iHOPDCLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:10:05 CET 2017

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