Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64858
MIM: 609683
HGNC: 17641
Ensembl: ENSG00000118655
Variants:
dbSNP: 64858
ClinVar: 64858
TCGA: ENSG00000118655
COSMIC: DCLRE1B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000118655 | ENST00000466480 | A0A3B3IT16 |
| ENSG00000118655 | ENST00000648795 | A0A3B3IT16 |
| ENSG00000118655 | ENST00000650450 | Q9H816 |
| ENSG00000118655 | ENST00000650596 | A0A3B3ITQ0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| Fanconi Anemia Pathway | REACTOME | R-HSA-6783310 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38407308 | 2024 | DNA-PK controls Apollo's access to leading-end telomeres. | 1 |
| 38430974 | 2024 | DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection. | 1 |
| 38407308 | 2024 | DNA-PK controls Apollo's access to leading-end telomeres. | 1 |
| 38430974 | 2024 | DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection. | 1 |
| 37936074 | 2023 | DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer. | 0 |
| 37936074 | 2023 | DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer. | 0 |
| 34387694 | 2021 | A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. | 4 |
| 34387696 | 2021 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. | 15 |
| 34387694 | 2021 | A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. | 4 |
| 34387696 | 2021 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. | 15 |
| 26582912 | 2015 | The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. | 25 |
| 26582912 | 2015 | The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. | 25 |
| 23863462 | 2013 | The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability. | 14 |
| 23863462 | 2013 | The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability. | 14 |
| 22692201 | 2012 | Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. | 36 |
Citation
Dessen P
DCLRE1B (DNA cross-link repair 1B)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/40272/dclre1b
