DCN (decorin)

2003-02-01 Affiliation

Identity

HGNC

DCN

LOCATION

12q21.33

LOCUSID

1634

ALIAS

CSCD,DSPG2,PG40,PGII,PGS2,SLRR1B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1634
MIM: 125255
HGNC: 2705
Ensembl: ENSG00000011465

Variants:

dbSNP: 1634
ClinVar: 1634
TCGA: ENSG00000011465
COSMIC: DCN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000011465	ENST00000052754	P07585
ENSG00000011465	ENST00000052754	Q6FH10
ENSG00000011465	ENST00000393155	P07585
ENSG00000011465	ENST00000393155	Q6FH10
ENSG00000011465	ENST00000420120	P07585
ENSG00000011465	ENST00000425043	P07585
ENSG00000011465	ENST00000425043	A0A024RBG6
ENSG00000011465	ENST00000441303	P07585
ENSG00000011465	ENST00000456569	P07585
ENSG00000011465	ENST00000546370	F8VNW0
ENSG00000011465	ENST00000546391	F8VNV6
ENSG00000011465	ENST00000546745	F8VU58
ENSG00000011465	ENST00000547568	P07585
ENSG00000011465	ENST00000547568	A0A024RBG6
ENSG00000011465	ENST00000547937	F8VWU0
ENSG00000011465	ENST00000548218	H0YI87
ENSG00000011465	ENST00000549513	F8VX58
ENSG00000011465	ENST00000550099	F8VU58
ENSG00000011465	ENST00000550563	F8VXZ8
ENSG00000011465	ENST00000550758	H0YIH3
ENSG00000011465	ENST00000551354	F8VSI3
ENSG00000011465	ENST00000552145	F8VUF6
ENSG00000011465	ENST00000552962	P07585
ENSG00000011465	ENST00000552962	Q6FH10

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
TGF-beta signaling pathway	KEGG	ko04350
TGF-beta signaling pathway	KEGG	hsa04350
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Disease	REACTOME	R-HSA-1643685
Diseases of glycosylation	REACTOME	R-HSA-3781865
Diseases associated with glycosaminoglycan metabolism	REACTOME	R-HSA-3560782
Defective B4GALT7 causes EDS, progeroid type	REACTOME	R-HSA-3560783
Defective B3GAT3 causes JDSSDHD	REACTOME	R-HSA-3560801
Defective CHSY1 causes TPBS	REACTOME	R-HSA-3595177
Defective CHST3 causes SEDCJD	REACTOME	R-HSA-3595172
Defective CHST14 causes EDS, musculocontractural type	REACTOME	R-HSA-3595174
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME	R-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesis	REACTOME	R-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolism	REACTOME	R-HSA-1793185
Chondroitin sulfate biosynthesis	REACTOME	R-HSA-2022870
Dermatan sulfate biosynthesis	REACTOME	R-HSA-2022923
CS/DS degradation	REACTOME	R-HSA-2024101
Extracellular matrix organization	REACTOME	R-HSA-1474244
ECM proteoglycans	REACTOME	R-HSA-3000178
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Defective B3GALT6 causes EDSP2 and SEMDJL1	REACTOME	R-HSA-4420332

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19433454	2009	Decorin is a novel antagonistic ligand of the Met receptor.	101
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16835231	2006	Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation.	84
15994311	2005	Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.	74
23798385	2013	Decorin causes autophagy in endothelial cells via Peg3.	70
12105206	2002	Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope.	64
21840990	2011	Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.	64
20974860	2010	Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.	59
15016081	2004	Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries.	57
17651433	2007	The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis.	52

Citation

Dessen P

DCN (decorin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40274/dcn