DCP2 (decapping mRNA 2)

2014-11-01  

Identity

HGNC
LOCATION
5q22.2
LOCUSID
ALIAS
NUDT20
FUSION GENES

Other Information

Locus ID:

NCBI: 167227
MIM: 609844
HGNC: 24452
Ensembl: ENSG00000172795

Variants:

dbSNP: 167227
ClinVar: 167227
TCGA: ENSG00000172795
COSMIC: DCP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172795ENST00000389063Q8IU60
ENSG00000172795ENST00000512751D6RCL0
ENSG00000172795ENST00000513585H0Y9T5
ENSG00000172795ENST00000515408Q8IU60

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAREACTOMER-HSA-450385
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124860122002Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.209
125153822002The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.181
124177152002Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.173
122181872002The hDcp2 protein is a mammalian mRNA decapping enzyme.158
210709682010Multiple mRNA decapping enzymes in mammalian cells.69
230850782012Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.35
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.33
180398492008Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein.30
231153032013The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation.21
258701042015Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity.11

Citation

Dessen P

DCP2 (decapping mRNA 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62333/dcp2