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DCT (dopachrome tautomerase)

Identity

Alias (NCBI)OCA8
TRP-2
TYRP2
HGNC (Hugo) DCT
HGNC Alias namedopachrome delta-isomerase
 L-dopachrome isomerase
HGNC Previous nameTYRP2
HGNC Previous nametyrosine-related protein 2
LocusID (NCBI) 1638
Atlas_Id 43594
Location 13q32.1  [Link to chromosome band 13q32]
Location_base_pair Starts at 94436811 and ends at 94479682 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)DCT   2709
Cards
Entrez_Gene (NCBI)DCT    dopachrome tautomerase
AliasesOCA8; TRP-2; TYRP2
GeneCards (Weizmann)DCT
Ensembl hg19 (Hinxton)ENSG00000080166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080166 [Gene_View]  ENSG00000080166 [Sequence]  chr13:94436811-94479682 [Contig_View]  DCT [Vega]
ICGC DataPortalENSG00000080166
TCGA cBioPortalDCT
AceView (NCBI)DCT
Genatlas (Paris)DCT
SOURCE (Princeton)DCT
Genetics Home Reference (NIH)DCT
Genomic and cartography
GoldenPath hg38 (UCSC)DCT  -     chr13:94436811-94479682 -  13q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCT  -     13q32.1   [Description]    (hg19-Feb_2009)
GoldenPathDCT - 13q32.1 [CytoView hg19]  DCT - 13q32.1 [CytoView hg38]
ImmunoBaseENSG00000080166
Genome Data Viewer NCBIDCT [Mapview hg19]  
OMIM191275   619165   
Gene and transcription
Genbank (Entrez)AF339808 AJ000503 AJ132932 AJ132933 AK293115
RefSeq transcript (Entrez)NM_001129889 NM_001322182 NM_001322183 NM_001322184 NM_001322185 NM_001322186 NM_001922
Consensus coding sequences : CCDS (NCBI)DCT
Gene ExpressionDCT [ NCBI-GEO ]   DCT [ EBI - ARRAY_EXPRESS ]   DCT [ SEEK ]   DCT [ MEM ]
Gene Expression Viewer (FireBrowse)DCT [ Firebrowse - Broad ]
GenevisibleExpression of DCT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1638
GTEX Portal (Tissue expression)DCT
Human Protein AtlasENSG00000080166-DCT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40126   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40126  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40126
Catalytic activity : Enzyme5.3.3.12 [ Enzyme-Expasy ]   5.3.3.125.3.3.12 [ IntEnz-EBI ]   5.3.3.12 [ BRENDA ]   5.3.3.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP40126
Domaine pattern : Prosite (Expaxy)TYROSINASE_1 (PS00497)    TYROSINASE_2 (PS00498)   
Domains : Interpro (EBI)Tyrosinase_Cu-bd    Unchr_di-copper_centre   
Domain families : Pfam (Sanger)Tyrosinase (PF00264)   
Domain families : Pfam (NCBI)pfam00264   
Conserved Domain (NCBI)DCT
PDB (RSDB)4HX1   
PDB Europe4HX1   
PDB (PDBSum)4HX1   
PDB (IMB)4HX1   
Structural Biology KnowledgeBase4HX1   
SCOP (Structural Classification of Proteins)4HX1   
CATH (Classification of proteins structures)4HX1   
SuperfamilyP40126
AlphaFold pdb e-kbP40126   
Human Protein Atlas [tissue]ENSG00000080166-DCT [tissue]
HPRD01864
Protein Interaction databases
DIP (DOE-UCLA)P40126
IntAct (EBI)P40126
BioGRIDDCT
STRING (EMBL)DCT
ZODIACDCT
Ontologies - Pathways
QuickGOP40126
Ontology : AmiGOpositive regulation of neuroblast proliferation  dopachrome isomerase activity  dopachrome isomerase activity  copper ion binding  protein binding  cytosol  plasma membrane  melanin biosynthetic process from tyrosine  melanin biosynthetic process from tyrosine  epidermis development  response to blue light  integral component of membrane  oxidoreductase activity  ventricular zone neuroblast division  melanosome membrane  melanin biosynthetic process  melanosome  melanosome  intracellular membrane-bounded organelle  developmental pigmentation  cell development  
Ontology : EGO-EBIpositive regulation of neuroblast proliferation  dopachrome isomerase activity  dopachrome isomerase activity  copper ion binding  protein binding  cytosol  plasma membrane  melanin biosynthetic process from tyrosine  melanin biosynthetic process from tyrosine  epidermis development  response to blue light  integral component of membrane  oxidoreductase activity  ventricular zone neuroblast division  melanosome membrane  melanin biosynthetic process  melanosome  melanosome  intracellular membrane-bounded organelle  developmental pigmentation  cell development  
Pathways : KEGGTyrosine metabolism    Melanogenesis   
NDEx NetworkDCT
Atlas of Cancer Signalling NetworkDCT
Wikipedia pathwaysDCT
Orthology - Evolution
OrthoDB1638
GeneTree (enSembl)ENSG00000080166
Phylogenetic Trees/Animal Genes : TreeFamDCT
Homologs : HomoloGeneDCT
Homology/Alignments : Family Browser (UCSC)DCT
Gene fusions - Rearrangements
Fusion : QuiverDCT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCT
dbVarDCT
ClinVarDCT
MonarchDCT
1000_GenomesDCT 
Exome Variant ServerDCT
GNOMAD BrowserENSG00000080166
Varsome BrowserDCT
ACMGDCT variants
VarityP40126
Genomic Variants (DGV)DCT [DGVbeta]
DECIPHERDCT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCT 
Mutations
ICGC Data PortalDCT 
TCGA Data PortalDCT 
Broad Tumor PortalDCT
OASIS PortalDCT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCT
Mutations and Diseases : HGMDDCT
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDCT
DgiDB (Drug Gene Interaction Database)DCT
DoCM (Curated mutations)DCT
CIViC (Clinical Interpretations of Variants in Cancer)DCT
Cancer3DDCT
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191275    619165   
Orphanet
DisGeNETDCT
MedgenDCT
Genetic Testing Registry DCT
NextProtP40126 [Medical]
GENETestsDCT
Target ValidationDCT
Huge Navigator DCT [HugePedia]
ClinGenDCT
Clinical trials, drugs, therapy
MyCancerGenomeDCT
Protein Interactions : CTDDCT
Pharm GKB GenePA27179
PharosP40126
Clinical trialDCT
Miscellaneous
canSAR (ICR)DCT
HarmonizomeDCT
DataMed IndexDCT
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDCT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:06:16 CEST 2021
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