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DCT (dopachrome tautomerase)

Identity

Alias_namesTYRP2
tyrosine-related protein 2
Other aliasTRP-2
HGNC (Hugo) DCT
LocusID (NCBI) 1638
Atlas_Id 43594
Location 13q32.1  [Link to chromosome band 13q32]
Location_base_pair Starts at 94437304 and ends at 94479682 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCT   2709
Cards
Entrez_Gene (NCBI)DCT  1638  dopachrome tautomerase
AliasesTRP-2; TYRP2
GeneCards (Weizmann)DCT
Ensembl hg19 (Hinxton)ENSG00000080166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080166 [Gene_View]  chr13:94437304-94479682 [Contig_View]  DCT [Vega]
ICGC DataPortalENSG00000080166
TCGA cBioPortalDCT
AceView (NCBI)DCT
Genatlas (Paris)DCT
WikiGenes1638
SOURCE (Princeton)DCT
Genetics Home Reference (NIH)DCT
Genomic and cartography
GoldenPath hg38 (UCSC)DCT  -     chr13:94437304-94479682 -  13q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCT  -     13q32.1   [Description]    (hg19-Feb_2009)
EnsemblDCT - 13q32.1 [CytoView hg19]  DCT - 13q32.1 [CytoView hg38]
Mapping of homologs : NCBIDCT [Mapview hg19]  DCT [Mapview hg38]
OMIM191275   
Gene and transcription
Genbank (Entrez)AF339808 AJ000503 AJ132932 AJ132933 AK293115
RefSeq transcript (Entrez)NM_001129889 NM_001322182 NM_001322183 NM_001322184 NM_001322185 NM_001322186 NM_001922
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCT
Cluster EST : UnigeneHs.301865 [ NCBI ]
CGAP (NCI)Hs.301865
Alternative Splicing GalleryENSG00000080166
Gene ExpressionDCT [ NCBI-GEO ]   DCT [ EBI - ARRAY_EXPRESS ]   DCT [ SEEK ]   DCT [ MEM ]
Gene Expression Viewer (FireBrowse)DCT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1638
GTEX Portal (Tissue expression)DCT
Human Protein AtlasENSG00000080166-DCT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40126   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40126  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40126
Splice isoforms : SwissVarP40126
Catalytic activity : Enzyme5.3.3.12 [ Enzyme-Expasy ]   5.3.3.125.3.3.12 [ IntEnz-EBI ]   5.3.3.12 [ BRENDA ]   5.3.3.12 [ KEGG ]   
PhosPhoSitePlusP40126
Domaine pattern : Prosite (Expaxy)TYROSINASE_1 (PS00497)    TYROSINASE_2 (PS00498)   
Domains : Interpro (EBI)Tyrosinase_Cu-bd    Unchr_di-copper_centre   
Domain families : Pfam (Sanger)Tyrosinase (PF00264)   
Domain families : Pfam (NCBI)pfam00264   
Conserved Domain (NCBI)DCT
DMDM Disease mutations1638
Blocks (Seattle)DCT
PDB (SRS)4HX1   
PDB (PDBSum)4HX1   
PDB (IMB)4HX1   
PDB (RSDB)4HX1   
Structural Biology KnowledgeBase4HX1   
SCOP (Structural Classification of Proteins)4HX1   
CATH (Classification of proteins structures)4HX1   
SuperfamilyP40126
Human Protein Atlas [tissue]ENSG00000080166-DCT [tissue]
Peptide AtlasP40126
HPRD01864
IPIIPI00027343   IPI01014530   IPI00798153   IPI00844305   
Protein Interaction databases
DIP (DOE-UCLA)P40126
IntAct (EBI)P40126
FunCoupENSG00000080166
BioGRIDDCT
STRING (EMBL)DCT
ZODIACDCT
Ontologies - Pathways
QuickGOP40126
Ontology : AmiGOpositive regulation of neuroblast proliferation  dopachrome isomerase activity  copper ion binding  cytosol  melanin biosynthetic process from tyrosine  epidermis development  integral component of membrane  oxidoreductase activity  ventricular zone neuroblast division  melanosome membrane  melanin biosynthetic process  melanosome  developmental pigmentation  cell development  oxidation-reduction process  
Ontology : EGO-EBIpositive regulation of neuroblast proliferation  dopachrome isomerase activity  copper ion binding  cytosol  melanin biosynthetic process from tyrosine  epidermis development  integral component of membrane  oxidoreductase activity  ventricular zone neuroblast division  melanosome membrane  melanin biosynthetic process  melanosome  developmental pigmentation  cell development  oxidation-reduction process  
Pathways : KEGGTyrosine metabolism    Melanogenesis   
NDEx NetworkDCT
Atlas of Cancer Signalling NetworkDCT
Wikipedia pathwaysDCT
Orthology - Evolution
OrthoDB1638
GeneTree (enSembl)ENSG00000080166
Phylogenetic Trees/Animal Genes : TreeFamDCT
HOVERGENP40126
HOGENOMP40126
Homologs : HomoloGeneDCT
Homology/Alignments : Family Browser (UCSC)DCT
Gene fusions - Rearrangements
Tumor Fusion PortalDCT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCT
dbVarDCT
ClinVarDCT
1000_GenomesDCT 
Exome Variant ServerDCT
ExAC (Exome Aggregation Consortium)ENSG00000080166
GNOMAD BrowserENSG00000080166
Genetic variants : HAPMAP1638
Genomic Variants (DGV)DCT [DGVbeta]
DECIPHERDCT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCT 
Mutations
ICGC Data PortalDCT 
TCGA Data PortalDCT 
Broad Tumor PortalDCT
OASIS PortalDCT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCT
DgiDB (Drug Gene Interaction Database)DCT
DoCM (Curated mutations)DCT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCT (select a term)
intoGenDCT
Cancer3DDCT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191275   
Orphanet
DisGeNETDCT
MedgenDCT
Genetic Testing Registry DCT
NextProtP40126 [Medical]
TSGene1638
GENETestsDCT
Target ValidationDCT
Huge Navigator DCT [HugePedia]
snp3D : Map Gene to Disease1638
BioCentury BCIQDCT
ClinGenDCT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1638
Chemical/Pharm GKB GenePA27179
Clinical trialDCT
Miscellaneous
canSAR (ICR)DCT (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCT
EVEXDCT
GoPubMedDCT
iHOPDCT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:10:07 CET 2017

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