Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DCTN1 (dynactin 1)

Identity

Other namesDAP-150
DP-150
P135
HGNC (Hugo) DCTN1
LocusID (NCBI) 1639
Location 2p13.1
Location_base_pair Starts at 74588281 and ends at 74607482 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DCTN1   2711
Cards
Entrez_Gene (NCBI)DCTN1  1639  dynactin 1
GeneCards (Weizmann)DCTN1
Ensembl (Hinxton)ENSG00000204843 [Gene_View]  chr2:74588281-74607482 [Contig_View]  DCTN1 [Vega]
ICGC DataPortalENSG00000204843
cBioPortalDCTN1
AceView (NCBI)DCTN1
Genatlas (Paris)DCTN1
WikiGenes1639
SOURCE (Princeton)NM_001135040 NM_001135041 NM_001190836 NM_001190837 NM_004082 NM_023019
Genomic and cartography
GoldenPath (UCSC)DCTN1  -  2p13.1   chr2:74588281-74607482 -  2p13.1   [Description]    (hg19-Feb_2009)
EnsemblDCTN1 - 2p13.1 [CytoView]
Mapping of homologs : NCBIDCTN1 [Mapview]
OMIM105400   168605   601143   607641   
Gene and transcription
Genbank (Entrez)AB209625 AJ709213 AK055298 AK297286 AK314352
RefSeq transcript (Entrez)NM_001135040 NM_001135041 NM_001190836 NM_001190837 NM_004082 NM_023019
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008735 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)DCTN1
Cluster EST : UnigeneHs.516111 [ NCBI ]
CGAP (NCI)Hs.516111
Alternative Splicing : Fast-db (Paris)GSHG0017738
Alternative Splicing GalleryENSG00000204843
Gene ExpressionDCTN1 [ NCBI-GEO ]     DCTN1 [ SEEK ]   DCTN1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14203 (Uniprot)
NextProtQ14203  [Medical]
With graphics : InterProQ14203
Splice isoforms : SwissVarQ14203 (Swissvar)
Domaine pattern : Prosite (Expaxy)CAP_GLY_1 (PS00845)    CAP_GLY_2 (PS50245)   
Domains : Interpro (EBI)CAP-Gly_domain [organisation]   Dynactin [organisation]  
Related proteins : CluSTrQ14203
Domain families : Pfam (Sanger)CAP_GLY (PF01302)    Dynactin (PF12455)   
Domain families : Pfam (NCBI)pfam01302    pfam12455   
Domain families : Smart (EMBL)CAP_GLY (SM01052)  
DMDM Disease mutations1639
Blocks (Seattle)Q14203
PDB (SRS)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
PDB (PDBSum)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
PDB (IMB)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
PDB (RSDB)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
Human Protein AtlasENSG00000204843 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ14203
HPRD07206
IPIIPI00872359   IPI00219114   IPI00873712   IPI00917045   IPI00555695   IPI00917681   IPI00935906   IPI00914026   IPI00917166   IPI00916757   IPI00916125   IPI00917189   IPI00465112   IPI00916359   IPI01018648   IPI00917852   
Protein Interaction databases
DIP (DOE-UCLA)Q14203
IntAct (EBI)Q14203
FunCoupENSG00000204843
BioGRIDDCTN1
InParanoidQ14203
Interologous Interaction database Q14203
IntegromeDBDCTN1
STRING (EMBL)DCTN1
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  spindle pole  motor activity  protein binding  cytoplasm  centrosome  cytosol  dynactin complex  microtubule  activation of signaling protein activity involved in unfolded protein response  mitotic nuclear division  nervous system development  cell death  microtubule-based transport  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  endoplasmic reticulum unfolded protein response  cell leading edge  cellular protein metabolic process  dynein binding  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  spindle pole  motor activity  protein binding  cytoplasm  centrosome  cytosol  dynactin complex  microtubule  activation of signaling protein activity involved in unfolded protein response  mitotic nuclear division  nervous system development  cell death  microtubule-based transport  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  endoplasmic reticulum unfolded protein response  cell leading edge  cellular protein metabolic process  dynein binding  
Pathways : BIOCARTALissencephaly gene (LIS1) in neuronal migration and development [Genes]   
Pathways : KEGGVasopressin-regulated water reabsorption    Huntington's disease   
Protein Interaction DatabaseDCTN1
Wikipedia pathwaysDCTN1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)DCTN1
snp3D : Map Gene to Disease1639
SNP (GeneSNP Utah)DCTN1
SNP : HGBaseDCTN1
Genetic variants : HAPMAPDCTN1
Exome VariantDCTN1
1000_GenomesDCTN1 
ICGC programENSG00000204843 
Somatic Mutations in Cancer : COSMICDCTN1 
CONAN: Copy Number AnalysisDCTN1 
Mutations and Diseases : HGMDDCTN1
Mutations and Diseases : intOGenDCTN1
Genomic VariantsDCTN1  DCTN1 [DGVbeta]
dbVarDCTN1
ClinVarDCTN1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM105400    168605    601143    607641   
MedgenDCTN1
GENETestsDCTN1
Disease Genetic AssociationDCTN1
Huge Navigator DCTN1 [HugePedia]  DCTN1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneDCTN1
Homology/Alignments : Family Browser (UCSC)DCTN1
Phylogenetic Trees/Animal Genes : TreeFamDCTN1
Chemical/Protein Interactions : CTD1639
Chemical/Pharm GKB GenePA27180
Clinical trialDCTN1
Cancer Resource (Charite)ENSG00000204843
Other databases
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
CoreMineDCTN1
iHOPDCTN1
OncoSearchDCTN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:44:10 CEST 2014

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