Atlas of Genetics and Cytogenetics in Oncology and Haematology


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DCTN1 (dynactin subunit 1)

Identity

Other namesDAP-150
DP-150
P135
HGNC (Hugo) DCTN1
LocusID (NCBI) 1639
Atlas_Id 50680
Location 2p13.1
Location_base_pair Starts at 74588281 and ends at 74607482 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DCTN1 (2p13.1) / ALK (2p23.2)DCTN1 (2p13.1) / OGDH (7p13)DCTN1 (2p13.1) / SLC4A5 (2p13.1)
DPYSL3 (5q32) / DCTN1 (2p13.1)KCNJ10 (1q23.2) / DCTN1 (2p13.1)ZBED4 (22q13.33) / DCTN1 (2p13.1)
DCTN1 2p13.1 / ALK 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCTN1   2711
Cards
Entrez_Gene (NCBI)DCTN1  1639  dynactin subunit 1
GeneCards (Weizmann)DCTN1
Ensembl hg19 (Hinxton)ENSG00000204843 [Gene_View]  chr2:74588281-74607482 [Contig_View]  DCTN1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000204843 [Gene_View]  chr2:74588281-74607482 [Contig_View]  DCTN1 [Vega]
ICGC DataPortalENSG00000204843
TCGA cBioPortalDCTN1
AceView (NCBI)DCTN1
Genatlas (Paris)DCTN1
WikiGenes1639
SOURCE (Princeton)DCTN1
Genomic and cartography
GoldenPath hg19 (UCSC)DCTN1  -     chr2:74588281-74607482 -  2p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DCTN1  -     2p13.1   [Description]    (hg38-Dec_2013)
EnsemblDCTN1 - 2p13.1 [CytoView hg19]  DCTN1 - 2p13.1 [CytoView hg38]
Mapping of homologs : NCBIDCTN1 [Mapview hg19]  DCTN1 [Mapview hg38]
OMIM105400   168605   601143   607641   
Gene and transcription
Genbank (Entrez)AB209625 AJ709213 AK055298 AK297286 AK314352
RefSeq transcript (Entrez)NM_001135040 NM_001135041 NM_001190836 NM_001190837 NM_004082 NM_023019
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_008735 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)DCTN1
Cluster EST : UnigeneHs.516111 [ NCBI ]
CGAP (NCI)Hs.516111
Alternative Splicing GalleryENSG00000204843
Gene ExpressionDCTN1 [ NCBI-GEO ]   DCTN1 [ EBI - ARRAY_EXPRESS ]   DCTN1 [ SEEK ]   DCTN1 [ MEM ]
Gene Expression Viewer (FireBrowse)DCTN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1639
GTEX Portal (Tissue expression)DCTN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14203 (Uniprot)
NextProtQ14203  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14203
Splice isoforms : SwissVarQ14203 (Swissvar)
PhosPhoSitePlusQ14203
Domaine pattern : Prosite (Expaxy)CAP_GLY_1 (PS00845)    CAP_GLY_2 (PS50245)   
Domains : Interpro (EBI)CAP-Gly_domain    DCTN1    Dynactin   
Domain families : Pfam (Sanger)CAP_GLY (PF01302)    Dynactin (PF12455)   
Domain families : Pfam (NCBI)pfam01302    pfam12455   
Domain families : Smart (EMBL)CAP_GLY (SM01052)  
DMDM Disease mutations1639
Blocks (Seattle)DCTN1
PDB (SRS)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
PDB (PDBSum)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
PDB (IMB)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
PDB (RSDB)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
Structural Biology KnowledgeBase1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
SCOP (Structural Classification of Proteins)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
CATH (Classification of proteins structures)1TXQ    2COY    2HKN    2HKQ    2HL3    2HL5    2HQH    3E2U    3TQ7   
SuperfamilyQ14203
Human Protein AtlasENSG00000204843
Peptide AtlasQ14203
HPRD07206
IPIIPI00872359   IPI00219114   IPI00873712   IPI00917045   IPI00555695   IPI00917681   IPI00935906   IPI00914026   IPI00917166   IPI00916757   IPI00916125   IPI00917189   IPI00465112   IPI00916359   IPI01018648   IPI00917852   
Protein Interaction databases
DIP (DOE-UCLA)Q14203
IntAct (EBI)Q14203
FunCoupENSG00000204843
BioGRIDDCTN1
STRING (EMBL)DCTN1
ZODIACDCTN1
Ontologies - Pathways
QuickGOQ14203
Ontology : AmiGOG2/M transition of mitotic cell cycle  kinetochore  spindle pole  motor activity  protein binding  cytoplasm  centrosome  cytosol  dynactin complex  microtubule  ER to Golgi vesicle-mediated transport  mitotic nuclear division  nervous system development  metabolic process  establishment of localization by movement along microtubule  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  retromer complex  cell leading edge  melanosome transport  IRE1-mediated unfolded protein response  retrograde transport, endosome to Golgi  dynein binding  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  kinetochore  spindle pole  motor activity  protein binding  cytoplasm  centrosome  cytosol  dynactin complex  microtubule  ER to Golgi vesicle-mediated transport  mitotic nuclear division  nervous system development  metabolic process  establishment of localization by movement along microtubule  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  retromer complex  cell leading edge  melanosome transport  IRE1-mediated unfolded protein response  retrograde transport, endosome to Golgi  dynein binding  
Pathways : BIOCARTALissencephaly gene (LIS1) in neuronal migration and development [Genes]   
Pathways : KEGGVasopressin-regulated water reabsorption    Huntington's disease   
NDEx Network
Atlas of Cancer Signalling NetworkDCTN1
Wikipedia pathwaysDCTN1
Orthology - Evolution
OrthoDB1639
GeneTree (enSembl)ENSG00000204843
Phylogenetic Trees/Animal Genes : TreeFamDCTN1
Homologs : HomoloGeneDCTN1
Homology/Alignments : Family Browser (UCSC)DCTN1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerDCTN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCTN1
dbVarDCTN1
ClinVarDCTN1
1000_GenomesDCTN1 
Exome Variant ServerDCTN1
ExAC (Exome Aggregation Consortium)DCTN1 (select the gene name)
Genetic variants : HAPMAP1639
Genomic Variants (DGV)DCTN1 [DGVbeta]
Mutations
ICGC Data PortalDCTN1 
TCGA Data PortalDCTN1 
Broad Tumor PortalDCTN1
OASIS PortalDCTN1 [ Somatic mutations - Copy number]
Cancer Gene: CensusDCTN1 
Somatic Mutations in Cancer : COSMICDCTN1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCTN1
DgiDB (Drug Gene Interaction Database)DCTN1
DoCM (Curated mutations)DCTN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCTN1 (select a term)
intoGenDCTN1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:74588281-74607482  ENSG00000204843
CONAN: Copy Number AnalysisDCTN1 
Mutations and Diseases : HGMDDCTN1
OMIM105400    168605    601143    607641   
MedgenDCTN1
Genetic Testing Registry DCTN1
NextProtQ14203 [Medical]
TSGene1639
GENETestsDCTN1
Huge Navigator DCTN1 [HugePedia]
snp3D : Map Gene to Disease1639
BioCentury BCIQDCTN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1639
Chemical/Pharm GKB GenePA27180
Clinical trialDCTN1
Miscellaneous
canSAR (ICR)DCTN1 (select the gene name)
Probes
Litterature
PubMed154 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCTN1
EVEXDCTN1
GoPubMedDCTN1
iHOPDCTN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 8 18:43:27 CEST 2016

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