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DCTN2 (dynactin subunit 2)

Identity

Alias_namesdynactin 2 (p50)
Alias_symbol (synonym)RBP50
DCTN-50
Other aliasDCTN50
DYNAMITIN
HEL-S-77
HGNC (Hugo) DCTN2
LocusID (NCBI) 10540
Atlas_Id 43939
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57530050 and ends at 57547331 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DCTN2 (12q13.3) / AVIL (12q14.1)DCTN2 (12q13.3) / DDX23 (12q13.12)DCTN2 (12q13.3) / HNRNPUL2 (11q12.3)
LSM14A (19q13.11) / DCTN2 (12q13.3)DCTN2 12q13.3 / DDX23 12q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCTN2   2712
Cards
Entrez_Gene (NCBI)DCTN2  10540  dynactin subunit 2
AliasesDCTN50; DYNAMITIN; HEL-S-77; RBP50
GeneCards (Weizmann)DCTN2
Ensembl hg19 (Hinxton)ENSG00000175203 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175203 [Gene_View]  chr12:57530050-57547331 [Contig_View]  DCTN2 [Vega]
ICGC DataPortalENSG00000175203
TCGA cBioPortalDCTN2
AceView (NCBI)DCTN2
Genatlas (Paris)DCTN2
WikiGenes10540
SOURCE (Princeton)DCTN2
Genetics Home Reference (NIH)DCTN2
Genomic and cartography
GoldenPath hg38 (UCSC)DCTN2  -     chr12:57530050-57547331 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCTN2  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblDCTN2 - 12q13.3 [CytoView hg19]  DCTN2 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBIDCTN2 [Mapview hg19]  DCTN2 [Mapview hg38]
OMIM607376   
Gene and transcription
Genbank (Entrez)AK055682 AK096242 AK098794 AK222693 AK292364
RefSeq transcript (Entrez)NM_001261412 NM_001261413 NM_001348065 NM_001348066 NM_001348067 NM_001348068 NM_006400
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCTN2
Cluster EST : UnigeneHs.289123 [ NCBI ]
CGAP (NCI)Hs.289123
Alternative Splicing GalleryENSG00000175203
Gene ExpressionDCTN2 [ NCBI-GEO ]   DCTN2 [ EBI - ARRAY_EXPRESS ]   DCTN2 [ SEEK ]   DCTN2 [ MEM ]
Gene Expression Viewer (FireBrowse)DCTN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10540
GTEX Portal (Tissue expression)DCTN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13561   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13561  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13561
Splice isoforms : SwissVarQ13561
PhosPhoSitePlusQ13561
Domains : Interpro (EBI)Dynamitin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DCTN2
DMDM Disease mutations10540
Blocks (Seattle)DCTN2
SuperfamilyQ13561
Human Protein AtlasENSG00000175203
Peptide AtlasQ13561
HPRD09568
IPIIPI00973457   IPI00220503   IPI00973500   IPI00789792   IPI01018647   IPI01015908   IPI01021277   IPI01022555   IPI01022737   IPI01022874   IPI01023056   IPI01020777   IPI01021097   IPI01021112   IPI01021260   IPI01026290   
Protein Interaction databases
DIP (DOE-UCLA)Q13561
IntAct (EBI)Q13561
FunCoupENSG00000175203
BioGRIDDCTN2
STRING (EMBL)DCTN2
ZODIACDCTN2
Ontologies - Pathways
QuickGOQ13561
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  motor activity  protein binding  cytoplasm  centrosome  cytosol  cytosol  dynactin complex  microtubule  ER to Golgi vesicle-mediated transport  mitotic spindle organization  cell proliferation  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  growth cone  spectrin binding  vesicle  melanosome transport  identical protein binding  extracellular exosome  protein localization to centrosome  ciliary basal body docking  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  motor activity  protein binding  cytoplasm  centrosome  cytosol  cytosol  dynactin complex  microtubule  ER to Golgi vesicle-mediated transport  mitotic spindle organization  cell proliferation  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  dynein complex  growth cone  spectrin binding  vesicle  melanosome transport  identical protein binding  extracellular exosome  protein localization to centrosome  ciliary basal body docking  
Pathways : KEGGVasopressin-regulated water reabsorption    Huntington's disease   
NDEx NetworkDCTN2
Atlas of Cancer Signalling NetworkDCTN2
Wikipedia pathwaysDCTN2
Orthology - Evolution
OrthoDB10540
GeneTree (enSembl)ENSG00000175203
Phylogenetic Trees/Animal Genes : TreeFamDCTN2
HOVERGENQ13561
HOGENOMQ13561
Homologs : HomoloGeneDCTN2
Homology/Alignments : Family Browser (UCSC)DCTN2
Gene fusions - Rearrangements
Fusion : MitelmanDCTN2/DDX23 [12q13.3/12q13.12]  
Fusion: TCGADCTN2 12q13.3 DDX23 12q13.12 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCTN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCTN2
dbVarDCTN2
ClinVarDCTN2
1000_GenomesDCTN2 
Exome Variant ServerDCTN2
ExAC (Exome Aggregation Consortium)DCTN2 (select the gene name)
Genetic variants : HAPMAP10540
Genomic Variants (DGV)DCTN2 [DGVbeta]
DECIPHERDCTN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCTN2 
Mutations
ICGC Data PortalDCTN2 
TCGA Data PortalDCTN2 
Broad Tumor PortalDCTN2
OASIS PortalDCTN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCTN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCTN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCTN2
DgiDB (Drug Gene Interaction Database)DCTN2
DoCM (Curated mutations)DCTN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCTN2 (select a term)
intoGenDCTN2
Cancer3DDCTN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607376   
Orphanet
MedgenDCTN2
Genetic Testing Registry DCTN2
NextProtQ13561 [Medical]
TSGene10540
GENETestsDCTN2
Huge Navigator DCTN2 [HugePedia]
snp3D : Map Gene to Disease10540
BioCentury BCIQDCTN2
ClinGenDCTN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10540
Chemical/Pharm GKB GenePA27181
Clinical trialDCTN2
Miscellaneous
canSAR (ICR)DCTN2 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCTN2
EVEXDCTN2
GoPubMedDCTN2
iHOPDCTN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:12:51 CEST 2017

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