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DCTN4 (dynactin subunit 4)

Identity

Alias_namesdynactin 4 (p62)
Other aliasDYN4
P62
HGNC (Hugo) DCTN4
LocusID (NCBI) 51164
Atlas_Id 62338
Location 5q33.1  [Link to chromosome band 5q33]
Location_base_pair Starts at 150708747 and ends at 150759095 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP3B1 (5q14.1) / DCTN4 (5q33.1)DCTN4 (5q33.1) / DCTN4 (5q33.1)DCTN4 (5q33.1) / PSMB7 (9q33.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)DCTN4   15518
Cards
Entrez_Gene (NCBI)DCTN4  51164  dynactin subunit 4
AliasesDYN4; P62
GeneCards (Weizmann)DCTN4
Ensembl hg19 (Hinxton)ENSG00000132912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132912 [Gene_View]  chr5:150708747-150759095 [Contig_View]  DCTN4 [Vega]
ICGC DataPortalENSG00000132912
TCGA cBioPortalDCTN4
AceView (NCBI)DCTN4
Genatlas (Paris)DCTN4
WikiGenes51164
SOURCE (Princeton)DCTN4
Genetics Home Reference (NIH)DCTN4
Genomic and cartography
GoldenPath hg38 (UCSC)DCTN4  -     chr5:150708747-150759095 -  5q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCTN4  -     5q33.1   [Description]    (hg19-Feb_2009)
EnsemblDCTN4 - 5q33.1 [CytoView hg19]  DCTN4 - 5q33.1 [CytoView hg38]
Mapping of homologs : NCBIDCTN4 [Mapview hg19]  DCTN4 [Mapview hg38]
OMIM614758   
Gene and transcription
Genbank (Entrez)AF156165 AF195120 AK000299 AK125973 AK296787
RefSeq transcript (Entrez)NM_001135643 NM_001135644 NM_016221
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCTN4
Cluster EST : UnigeneHs.675564 [ NCBI ]
CGAP (NCI)Hs.675564
Alternative Splicing GalleryENSG00000132912
Gene ExpressionDCTN4 [ NCBI-GEO ]   DCTN4 [ EBI - ARRAY_EXPRESS ]   DCTN4 [ SEEK ]   DCTN4 [ MEM ]
Gene Expression Viewer (FireBrowse)DCTN4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51164
GTEX Portal (Tissue expression)DCTN4
Human Protein AtlasENSG00000132912-DCTN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJW0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJW0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJW0
Splice isoforms : SwissVarQ9UJW0
PhosPhoSitePlusQ9UJW0
Domains : Interpro (EBI)DCTN4   
Domain families : Pfam (Sanger)Dynactin_p62 (PF05502)   
Domain families : Pfam (NCBI)pfam05502   
Conserved Domain (NCBI)DCTN4
DMDM Disease mutations51164
Blocks (Seattle)DCTN4
SuperfamilyQ9UJW0
Human Protein Atlas [tissue]ENSG00000132912-DCTN4 [tissue]
Peptide AtlasQ9UJW0
HPRD13126
IPIIPI00550852   IPI01010751   IPI00914016   IPI00910858   IPI00983232   IPI00974130   IPI00976086   IPI00985127   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJW0
IntAct (EBI)Q9UJW0
FunCoupENSG00000132912
BioGRIDDCTN4
STRING (EMBL)DCTN4
ZODIACDCTN4
Ontologies - Pathways
QuickGOQ9UJW0
Ontology : AmiGOprotein binding  nucleus  cytoplasm  centrosome  cytosol  cytoplasmic dynein complex  dynactin complex  ER to Golgi vesicle-mediated transport  nuclear migration  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein N-terminus binding  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  centrosome  cytosol  cytoplasmic dynein complex  dynactin complex  ER to Golgi vesicle-mediated transport  nuclear migration  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein N-terminus binding  
Pathways : KEGGVasopressin-regulated water reabsorption    Huntington's disease   
NDEx NetworkDCTN4
Atlas of Cancer Signalling NetworkDCTN4
Wikipedia pathwaysDCTN4
Orthology - Evolution
OrthoDB51164
GeneTree (enSembl)ENSG00000132912
Phylogenetic Trees/Animal Genes : TreeFamDCTN4
HOVERGENQ9UJW0
HOGENOMQ9UJW0
Homologs : HomoloGeneDCTN4
Homology/Alignments : Family Browser (UCSC)DCTN4
Gene fusions - Rearrangements
Fusion: Tumor Portal DCTN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCTN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCTN4
dbVarDCTN4
ClinVarDCTN4
1000_GenomesDCTN4 
Exome Variant ServerDCTN4
ExAC (Exome Aggregation Consortium)ENSG00000132912
GNOMAD BrowserENSG00000132912
Genetic variants : HAPMAP51164
Genomic Variants (DGV)DCTN4 [DGVbeta]
DECIPHERDCTN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCTN4 
Mutations
ICGC Data PortalDCTN4 
TCGA Data PortalDCTN4 
Broad Tumor PortalDCTN4
OASIS PortalDCTN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCTN4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCTN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCTN4
DgiDB (Drug Gene Interaction Database)DCTN4
DoCM (Curated mutations)DCTN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCTN4 (select a term)
intoGenDCTN4
Cancer3DDCTN4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614758   
Orphanet49   
MedgenDCTN4
Genetic Testing Registry DCTN4
NextProtQ9UJW0 [Medical]
TSGene51164
GENETestsDCTN4
Target ValidationDCTN4
Huge Navigator DCTN4 [HugePedia]
snp3D : Map Gene to Disease51164
BioCentury BCIQDCTN4
ClinGenDCTN4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51164
Chemical/Pharm GKB GenePA27183
Clinical trialDCTN4
Miscellaneous
canSAR (ICR)DCTN4 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCTN4
EVEXDCTN4
GoPubMedDCTN4
iHOPDCTN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:44:08 CET 2017

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