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DCTN4 (dynactin subunit 4)

Identity

Alias (NCBI)DYN4
P62
HGNC (Hugo) DCTN4
HGNC Previous namedynactin 4 (p62)
LocusID (NCBI) 51164
Atlas_Id 62338
Location 5q33.1  [Link to chromosome band 5q33]
Location_base_pair Starts at 150708747 and ends at 150759095 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP3B1 (5q14.1) / DCTN4 (5q33.1)DCTN4 (5q33.1) / DCTN4 (5q33.1)DCTN4 (5q33.1) / PSMB7 (9q33.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)DCTN4   15518
Cards
Entrez_Gene (NCBI)DCTN4    dynactin subunit 4
AliasesDYN4; P62
GeneCards (Weizmann)DCTN4
Ensembl hg19 (Hinxton)ENSG00000132912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132912 [Gene_View]  ENSG00000132912 [Sequence]  chr5:150708747-150759095 [Contig_View]  DCTN4 [Vega]
ICGC DataPortalENSG00000132912
TCGA cBioPortalDCTN4
AceView (NCBI)DCTN4
Genatlas (Paris)DCTN4
SOURCE (Princeton)DCTN4
Genetics Home Reference (NIH)DCTN4
Genomic and cartography
GoldenPath hg38 (UCSC)DCTN4  -     chr5:150708747-150759095 -  5q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCTN4  -     5q33.1   [Description]    (hg19-Feb_2009)
GoldenPathDCTN4 - 5q33.1 [CytoView hg19]  DCTN4 - 5q33.1 [CytoView hg38]
ImmunoBaseENSG00000132912
Genome Data Viewer NCBIDCTN4 [Mapview hg19]  
OMIM614758   
Gene and transcription
Genbank (Entrez)AF156165 AF195120 AK000299 AK125973 AK296787
RefSeq transcript (Entrez)NM_001135643 NM_001135644 NM_016221
Consensus coding sequences : CCDS (NCBI)DCTN4
Gene ExpressionDCTN4 [ NCBI-GEO ]   DCTN4 [ EBI - ARRAY_EXPRESS ]   DCTN4 [ SEEK ]   DCTN4 [ MEM ]
Gene Expression Viewer (FireBrowse)DCTN4 [ Firebrowse - Broad ]
GenevisibleExpression of DCTN4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51164
GTEX Portal (Tissue expression)DCTN4
Human Protein AtlasENSG00000132912-DCTN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJW0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJW0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJW0
PhosPhoSitePlusQ9UJW0
Domains : Interpro (EBI)DCTN4   
Domain families : Pfam (Sanger)Dynactin_p62 (PF05502)   
Domain families : Pfam (NCBI)pfam05502   
Conserved Domain (NCBI)DCTN4
SuperfamilyQ9UJW0
AlphaFold pdb e-kbQ9UJW0   
Human Protein Atlas [tissue]ENSG00000132912-DCTN4 [tissue]
HPRD13126
Protein Interaction databases
DIP (DOE-UCLA)Q9UJW0
IntAct (EBI)Q9UJW0
BioGRIDDCTN4
STRING (EMBL)DCTN4
ZODIACDCTN4
Ontologies - Pathways
QuickGOQ9UJW0
Ontology : AmiGOkinetochore  spindle pole  stress fiber  protein binding  nucleus  cytoplasm  centrosome  cytosol  cytoplasmic dynein complex  dynactin complex  focal adhesion  cell cortex  endoplasmic reticulum to Golgi vesicle-mediated transport  antigen processing and presentation of exogenous peptide antigen via MHC class II  sarcomere  protein N-terminus binding  
Ontology : EGO-EBIkinetochore  spindle pole  stress fiber  protein binding  nucleus  cytoplasm  centrosome  cytosol  cytoplasmic dynein complex  dynactin complex  focal adhesion  cell cortex  endoplasmic reticulum to Golgi vesicle-mediated transport  antigen processing and presentation of exogenous peptide antigen via MHC class II  sarcomere  protein N-terminus binding  
NDEx NetworkDCTN4
Atlas of Cancer Signalling NetworkDCTN4
Wikipedia pathwaysDCTN4
Orthology - Evolution
OrthoDB51164
GeneTree (enSembl)ENSG00000132912
Phylogenetic Trees/Animal Genes : TreeFamDCTN4
Homologs : HomoloGeneDCTN4
Homology/Alignments : Family Browser (UCSC)DCTN4
Gene fusions - Rearrangements
Fusion : QuiverDCTN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCTN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCTN4
dbVarDCTN4
ClinVarDCTN4
MonarchDCTN4
1000_GenomesDCTN4 
Exome Variant ServerDCTN4
GNOMAD BrowserENSG00000132912
Varsome BrowserDCTN4
ACMGDCTN4 variants
VarityQ9UJW0
Genomic Variants (DGV)DCTN4 [DGVbeta]
DECIPHERDCTN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCTN4 
Mutations
ICGC Data PortalDCTN4 
TCGA Data PortalDCTN4 
Broad Tumor PortalDCTN4
OASIS PortalDCTN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCTN4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCTN4
Mutations and Diseases : HGMDDCTN4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaDCTN4
DgiDB (Drug Gene Interaction Database)DCTN4
DoCM (Curated mutations)DCTN4
CIViC (Clinical Interpretations of Variants in Cancer)DCTN4
Cancer3DDCTN4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614758   
Orphanet49   
DisGeNETDCTN4
MedgenDCTN4
Genetic Testing Registry DCTN4
NextProtQ9UJW0 [Medical]
GENETestsDCTN4
Target ValidationDCTN4
Huge Navigator DCTN4 [HugePedia]
ClinGenDCTN4
Clinical trials, drugs, therapy
MyCancerGenomeDCTN4
Protein Interactions : CTDDCTN4
Pharm GKB GenePA27183
PharosQ9UJW0
Clinical trialDCTN4
Miscellaneous
canSAR (ICR)DCTN4
HarmonizomeDCTN4
DataMed IndexDCTN4
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXDCTN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:47:29 CEST 2021

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