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DCUN1D1 (defective in cullin neddylation 1 domain containing 1)

Identity

Alias_namesDCN1
Alias_symbol (synonym)RP42
SCRO
DCUN1L1
Tes3
SCCRO
Other aliasDCNL1
HGNC (Hugo) DCUN1D1
LocusID (NCBI) 54165
Atlas_Id 42991
Location 3q26.33  [Link to chromosome band 3q26]
Location_base_pair Starts at 182655946 and ends at 182703741 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DCUN1D1 (3q26.33) / ATP11B (3q26.33)DCUN1D1 (3q26.33) / CCDC50 (3q28)DCUN1D1 (3q26.33) / QTRT1 (19p13.2)
DCUN1D1 (3q26.33) / UTP6 (17q11.2)DCUN1D1 (3q26.33) / WWC3 (Xp22.2)MBNL1 (3q25.1) / DCUN1D1 (3q26.33)
DCUN1D1 3q26.33 / CCDC50 3q28MBNL1 3q25.1 / DCUN1D1 3q26.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Head and Neck: Oral squamous cell carcinoma
Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)DCUN1D1   18184
Cards
Entrez_Gene (NCBI)DCUN1D1  54165  defective in cullin neddylation 1 domain containing 1
AliasesDCNL1; DCUN1L1; RP42; SCCRO; 
SCRO; Tes3
GeneCards (Weizmann)DCUN1D1
Ensembl hg19 (Hinxton)ENSG00000043093 [Gene_View]  chr3:182655946-182703741 [Contig_View]  DCUN1D1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000043093 [Gene_View]  chr3:182655946-182703741 [Contig_View]  DCUN1D1 [Vega]
ICGC DataPortalENSG00000043093
TCGA cBioPortalDCUN1D1
AceView (NCBI)DCUN1D1
Genatlas (Paris)DCUN1D1
WikiGenes54165
SOURCE (Princeton)DCUN1D1
Genetics Home Reference (NIH)DCUN1D1
Genomic and cartography
GoldenPath hg19 (UCSC)DCUN1D1  -     chr3:182655946-182703741 -  3q26.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DCUN1D1  -     3q26.33   [Description]    (hg38-Dec_2013)
EnsemblDCUN1D1 - 3q26.33 [CytoView hg19]  DCUN1D1 - 3q26.33 [CytoView hg38]
Mapping of homologs : NCBIDCUN1D1 [Mapview hg19]  DCUN1D1 [Mapview hg38]
OMIM605905   
Gene and transcription
Genbank (Entrez)AF292100 AF456425 AF456426 AK025764 AK056335
RefSeq transcript (Entrez)NM_001308101 NM_020640
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)DCUN1D1
Cluster EST : UnigeneHs.744153 [ NCBI ]
CGAP (NCI)Hs.744153
Alternative Splicing GalleryENSG00000043093
Gene ExpressionDCUN1D1 [ NCBI-GEO ]   DCUN1D1 [ EBI - ARRAY_EXPRESS ]   DCUN1D1 [ SEEK ]   DCUN1D1 [ MEM ]
Gene Expression Viewer (FireBrowse)DCUN1D1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54165
GTEX Portal (Tissue expression)DCUN1D1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GG9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GG9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GG9
Splice isoforms : SwissVarQ96GG9
PhosPhoSitePlusQ96GG9
Domaine pattern : Prosite (Expaxy)DCUN1 (PS51229)   
Domains : Interpro (EBI)DCN-prot    PONY_dom    UBA-like   
Domain families : Pfam (Sanger)Cullin_binding (PF03556)   
Domain families : Pfam (NCBI)pfam03556   
Conserved Domain (NCBI)DCUN1D1
DMDM Disease mutations54165
Blocks (Seattle)DCUN1D1
PDB (SRS)3TDU    3TDZ    4P5O   
PDB (PDBSum)3TDU    3TDZ    4P5O   
PDB (IMB)3TDU    3TDZ    4P5O   
PDB (RSDB)3TDU    3TDZ    4P5O   
Structural Biology KnowledgeBase3TDU    3TDZ    4P5O   
SCOP (Structural Classification of Proteins)3TDU    3TDZ    4P5O   
CATH (Classification of proteins structures)3TDU    3TDZ    4P5O   
SuperfamilyQ96GG9
Human Protein AtlasENSG00000043093
Peptide AtlasQ96GG9
HPRD12067
IPIIPI00291893   IPI00910838   IPI00749447   IPI00945023   IPI00945359   IPI00947521   IPI00945526   IPI00945207   
Protein Interaction databases
DIP (DOE-UCLA)Q96GG9
IntAct (EBI)Q96GG9
FunCoupENSG00000043093
BioGRIDDCUN1D1
STRING (EMBL)DCUN1D1
ZODIACDCUN1D1
Ontologies - Pathways
QuickGOQ96GG9
Ontology : AmiGOubiquitin ligase complex  protein binding  nucleus  biological_process  ubiquitin conjugating enzyme binding  ubiquitin-like protein binding  protein neddylation  positive regulation of ubiquitin-protein transferase activity  cullin family protein binding  
Ontology : EGO-EBIubiquitin ligase complex  protein binding  nucleus  biological_process  ubiquitin conjugating enzyme binding  ubiquitin-like protein binding  protein neddylation  positive regulation of ubiquitin-protein transferase activity  cullin family protein binding  
NDEx NetworkDCUN1D1
Atlas of Cancer Signalling NetworkDCUN1D1
Wikipedia pathwaysDCUN1D1
Orthology - Evolution
OrthoDB54165
GeneTree (enSembl)ENSG00000043093
Phylogenetic Trees/Animal Genes : TreeFamDCUN1D1
HOVERGENQ96GG9
HOGENOMQ96GG9
Homologs : HomoloGeneDCUN1D1
Homology/Alignments : Family Browser (UCSC)DCUN1D1
Gene fusions - Rearrangements
Fusion : MitelmanDCUN1D1/ATP11B [3q26.33/3q26.33]  
Fusion : MitelmanMBNL1/DCUN1D1 [3q25.1/3q26.33]  [t(3;3)(q25;q27)]  
Fusion: TCGADCUN1D1 3q26.33 CCDC50 3q28 BRCA
Fusion: TCGAMBNL1 3q25.1 DCUN1D1 3q26.33 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCUN1D1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCUN1D1
dbVarDCUN1D1
ClinVarDCUN1D1
1000_GenomesDCUN1D1 
Exome Variant ServerDCUN1D1
ExAC (Exome Aggregation Consortium)DCUN1D1 (select the gene name)
Genetic variants : HAPMAP54165
Genomic Variants (DGV)DCUN1D1 [DGVbeta]
DECIPHER (Syndromes)3:182655946-182703741  ENSG00000043093
CONAN: Copy Number AnalysisDCUN1D1 
Mutations
ICGC Data PortalDCUN1D1 
TCGA Data PortalDCUN1D1 
Broad Tumor PortalDCUN1D1
OASIS PortalDCUN1D1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCUN1D1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDCUN1D1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCUN1D1
DgiDB (Drug Gene Interaction Database)DCUN1D1
DoCM (Curated mutations)DCUN1D1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCUN1D1 (select a term)
intoGenDCUN1D1
Cancer3DDCUN1D1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605905   
Orphanet
MedgenDCUN1D1
Genetic Testing Registry DCUN1D1
NextProtQ96GG9 [Medical]
TSGene54165
GENETestsDCUN1D1
Huge Navigator DCUN1D1 [HugePedia]
snp3D : Map Gene to Disease54165
BioCentury BCIQDCUN1D1
ClinGenDCUN1D1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54165
Chemical/Pharm GKB GenePA142672008
Clinical trialDCUN1D1
Miscellaneous
canSAR (ICR)DCUN1D1 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCUN1D1
EVEXDCUN1D1
GoPubMedDCUN1D1
iHOPDCUN1D1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:02:51 CET 2017

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