DCUN1D1 (defective in cullin neddylation 1 domain containing 1)

2006-12-01  

Identity

HGNC
LOCATION
3q26.33
LOCUSID
ALIAS
DCNL1,DCUN1L1,RP42,SCCRO,SCRO,Tes3
FUSION GENES

Other Information

Locus ID:

NCBI: 54165
MIM: 605905
HGNC: 18184
Ensembl: ENSG00000043093

Variants:

dbSNP: 54165
ClinVar: 54165
TCGA: ENSG00000043093
COSMIC: DCUN1D1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000043093ENST00000292782Q96GG9
ENSG00000043093ENST00000460412C9JVE2
ENSG00000043093ENST00000466812C9JRU6
ENSG00000043093ENST00000469954C9JVE2
ENSG00000043093ENST00000487822C9J0B2
ENSG00000043093ENST00000492563F8WC32
ENSG00000043093ENST00000497606C9J8R4
ENSG00000043093ENST00000632685C9JVE2

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188269542008SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.45
170185982006Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas.43
232012712013Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.41
218136412011Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1.19
253492112014SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).12
290749782017A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.11
189809712008SCCRO (DCUN1D1) induces extracellular matrix invasion by activating matrix metalloproteinase 2.10
234018592013DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.8
297503062018MicroRNA‑195 inhibits cell proliferation, migration and invasion by targeting defective in cullin neddylation 1 domain containing 1 in cervical cancer.8
287914112017MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1.6

Citation

Dessen P

DCUN1D1 (defective in cullin neddylation 1 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-12-01

Online version: http://atlasgeneticsoncology.org/gene/42991/dcun1d1