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DCUN1D4 (defective in cullin neddylation 1 domain containing 4)

Identity

Alias (NCBI)-
HGNC (Hugo) DCUN1D4
HGNC Alias symbKIAA0276
HGNC Previous nameDCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
LocusID (NCBI) 23142
Atlas_Id 62344
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 51843000 and ends at 51916837 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTDSP2 (12q14.1) / DCUN1D4 (4q12)DCUN1D4 (4q12) / DCUN1D4 (4q12)DCUN1D4 (4q12) / EML4 (2p21)
DCUN1D4 (4q12) / N4BP2L2 (13q13.1)NEK10 (3p24.1) / DCUN1D4 (4q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;12)(q12;q14) CTDSP2/DCUN1D4

External links

Nomenclature
HGNC (Hugo)DCUN1D4   28998
Cards
Entrez_Gene (NCBI)DCUN1D4    defective in cullin neddylation 1 domain containing 4
Aliases
GeneCards (Weizmann)DCUN1D4
Ensembl hg19 (Hinxton)ENSG00000109184 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109184 [Gene_View]  ENSG00000109184 [Sequence]  chr4:51843000-51916837 [Contig_View]  DCUN1D4 [Vega]
ICGC DataPortalENSG00000109184
TCGA cBioPortalDCUN1D4
AceView (NCBI)DCUN1D4
Genatlas (Paris)DCUN1D4
SOURCE (Princeton)DCUN1D4
Genetics Home Reference (NIH)DCUN1D4
Genomic and cartography
GoldenPath hg38 (UCSC)DCUN1D4  -     chr4:51843000-51916837 +  4q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCUN1D4  -     4q12   [Description]    (hg19-Feb_2009)
GoldenPathDCUN1D4 - 4q12 [CytoView hg19]  DCUN1D4 - 4q12 [CytoView hg38]
ImmunoBaseENSG00000109184
genome Data Viewer NCBIDCUN1D4 [Mapview hg19]  
OMIM612977   
Gene and transcription
Genbank (Entrez)AK027051 AK124346 AK294894 AK294896 BC015240
RefSeq transcript (Entrez)NM_001040402 NM_001287755 NM_001287757 NM_015115
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCUN1D4
Alternative Splicing GalleryENSG00000109184
Gene ExpressionDCUN1D4 [ NCBI-GEO ]   DCUN1D4 [ EBI - ARRAY_EXPRESS ]   DCUN1D4 [ SEEK ]   DCUN1D4 [ MEM ]
Gene Expression Viewer (FireBrowse)DCUN1D4 [ Firebrowse - Broad ]
GenevisibleExpression of DCUN1D4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23142
GTEX Portal (Tissue expression)DCUN1D4
Human Protein AtlasENSG00000109184-DCUN1D4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92564   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92564  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92564
Splice isoforms : SwissVarQ92564
PhosPhoSitePlusQ92564
Domaine pattern : Prosite (Expaxy)DCUN1 (PS51229)   
Domains : Interpro (EBI)DCN-prot    DCN1-like_PONY    PONY_dom   
Domain families : Pfam (Sanger)Cullin_binding (PF03556)   
Domain families : Pfam (NCBI)pfam03556   
Conserved Domain (NCBI)DCUN1D4
Blocks (Seattle)DCUN1D4
PDB (RSDB)5V89   
PDB Europe5V89   
PDB (PDBSum)5V89   
PDB (IMB)5V89   
Structural Biology KnowledgeBase5V89   
SCOP (Structural Classification of Proteins)5V89   
CATH (Classification of proteins structures)5V89   
SuperfamilyQ92564
Human Protein Atlas [tissue]ENSG00000109184-DCUN1D4 [tissue]
Peptide AtlasQ92564
HPRD13791
IPIIPI00941798   IPI00385380   IPI00641124   IPI01009688   IPI00968286   IPI00966350   IPI00967145   IPI00965212   IPI00966604   IPI00964734   IPI00966930   IPI00966555   
Protein Interaction databases
DIP (DOE-UCLA)Q92564
IntAct (EBI)Q92564
BioGRIDDCUN1D4
STRING (EMBL)DCUN1D4
ZODIACDCUN1D4
Ontologies - Pathways
QuickGOQ92564
Ontology : AmiGOubiquitin ligase complex  molecular_function  protein binding  nucleus  biological_process  ubiquitin conjugating enzyme binding  ubiquitin-like protein binding  protein neddylation  positive regulation of ubiquitin-protein transferase activity  cullin family protein binding  
Ontology : EGO-EBIubiquitin ligase complex  molecular_function  protein binding  nucleus  biological_process  ubiquitin conjugating enzyme binding  ubiquitin-like protein binding  protein neddylation  positive regulation of ubiquitin-protein transferase activity  cullin family protein binding  
NDEx NetworkDCUN1D4
Atlas of Cancer Signalling NetworkDCUN1D4
Wikipedia pathwaysDCUN1D4
Orthology - Evolution
OrthoDB23142
GeneTree (enSembl)ENSG00000109184
Phylogenetic Trees/Animal Genes : TreeFamDCUN1D4
HOGENOMQ92564
Homologs : HomoloGeneDCUN1D4
Homology/Alignments : Family Browser (UCSC)DCUN1D4
Gene fusions - Rearrangements
Fusion : QuiverDCUN1D4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCUN1D4 [hg38]
dbVarDCUN1D4
ClinVarDCUN1D4
MonarchDCUN1D4
1000_GenomesDCUN1D4 
Exome Variant ServerDCUN1D4
GNOMAD BrowserENSG00000109184
Varsome BrowserDCUN1D4
Genomic Variants (DGV)DCUN1D4 [DGVbeta]
DECIPHERDCUN1D4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCUN1D4 
Mutations
ICGC Data PortalDCUN1D4 
TCGA Data PortalDCUN1D4 
Broad Tumor PortalDCUN1D4
OASIS PortalDCUN1D4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCUN1D4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCUN1D4
Mutations and Diseases : HGMDDCUN1D4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCUN1D4
DgiDB (Drug Gene Interaction Database)DCUN1D4
DoCM (Curated mutations)DCUN1D4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCUN1D4 (select a term)
intoGenDCUN1D4
Cancer3DDCUN1D4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612977   
Orphanet
DisGeNETDCUN1D4
MedgenDCUN1D4
Genetic Testing Registry DCUN1D4
NextProtQ92564 [Medical]
GENETestsDCUN1D4
Target ValidationDCUN1D4
Huge Navigator DCUN1D4 [HugePedia]
ClinGenDCUN1D4
Clinical trials, drugs, therapy
MyCancerGenomeDCUN1D4
Protein Interactions : CTD
Pharm GKB GenePA142672010
Clinical trialDCUN1D4
Miscellaneous
canSAR (ICR)DCUN1D4 (select the gene name)
HarmonizomeDCUN1D4
DataMed IndexDCUN1D4
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCUN1D4
EVEXDCUN1D4
GoPubMedDCUN1D4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:51:26 CET 2020
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